EKS-PAT-00072

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00072

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/GSK	448.3	1.0E-134	120	403	284

Status

Unreviewed

Ensembl Protein

ENSPTRP00000018979

UniProt Accession

H2QGF9;

Protein Name

Protein Synonyms/Alias

Glycogen synthase kinase 3 alpha;

Gene Name

ENSG00000105723

Gene Synonyms/Alias

ENSG00000105723; GSK3A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000011049	ENSPTRP00000018979	ENSPTRT00000020531

Organism

Pan troglodytes

Functional Description

Protein Length

483

Protein Sequence
(FASTA)

MSGGGPSGGG PGGSGRARTS SFAEPGGGGG GGGGGPGGSA SGPGGTGGGK ASVGAMGGGV 60

GASSSGGGPG GSGGGGSGGP GAGTSFPPPG VKLGRDSGKV TTVVATLGQG PERSQEVAYT 120

DIKVIGNGSF GVVYQARLAE TRELVAIKKV LQDKRFKNRE LQIMRKLDHC NIVRLRYFFY 180

SSGEKKDELY LNLVLEYVPE TVYRVARHFT KAKLTIPILY IKVYMYQLFR SLAYIHSQGV 240

CHRDIKPQNL LVDPDTAVLK LCDFGSAKQL VRGEPNVSYI CSRYYRAPEL IFGATDYTSS 300

IDVWSAGCVL AELLLGQPIF PGDSGVDQLV EIIKVLGTPT REQIREMNPN YTEFKFPQIK 360

AHPWTKVFKS RTPPEAIALC SSLLEYTPSS RLSPLEACAH SFFDELRCLG TQLPNNRPLP 420

PLFNFSAGEL SIQPSLNAIL IPPHLRSPAG TTTLTQSSQA LTETPTSSDW QSTDATPTLT 480

NSS 483

Nucleotide Sequence
(FASTA)

ATGAGCGGCG GCGGGCCTTC GGGAGGCGGC CCTGGGGGCT CGGGCAGGGC GCGGACCAGC 60

TCGTTCGCGG AGCCCGGCGG CGGAGGCGGA GGAGGCGGCG GCGGCCCCGG AGGCTCGGCC 120

TCCGGCCCAG GCGGCACCGG CGGCGGAAAG GCATCTGTCG GGGCCATGGG TGGGGGCGTC 180

GGGGCCTCGA GCTCCGGGGG TGGACCCGGC GGCAGCGGCG GAGGAGGCAG CGGAGGCCCC 240

GGCGCAGGCA CTAGCTTCCC GCCGCCCGGG GTGAAGCTGG GCCGTGACAG CGGGAAGGTG 300

ACCACAGTCG TAGCCACTCT AGGCCAAGGC CCAGAGCGCT CCCAAGAAGT GGCTTACACA 360

GACATCAAAG TGATTGGCAA TGGCTCATTT GGGGTCGTGT ACCAGGCACG GCTGGCAGAG 420

ACCAGGGAAC TAGTCGCCAT CAAGAAGGTT CTCCAGGACA AGAGGTTCAA GAACCGAGAG 480

CTGCAGATCA TGCGTAAGCT GGACCACTGC AATATTGTGA GGCTGAGATA CTTTTTCTAC 540

TCCAGTGGCG AGAAGAAAGA CGAGCTTTAC CTAAATCTGG TGCTGGAATA TGTGCCCGAG 600

ACAGTGTACC GGGTGGCCCG CCACTTCACC AAGGCCAAGT TGACCATCCC TATCCTCTAT 660

ATCAAGGTGT ACATGTACCA GCTCTTCCGC AGCTTGGCCT ACATCCACTC CCAGGGCGTG 720

TGTCACCGCG ACATCAAGCC CCAGAACCTG CTGGTGGACC CTGACACTGC TGTCCTCAAG 780

CTCTGCGATT TTGGCAGTGC AAAGCAGTTG GTCCGAGGGG AGCCCAATGT CTCTTACATC 840

TGTTCTCGCT ACTACCGGGC CCCAGAGCTC ATCTTTGGAG CCACTGATTA CACCTCATCC 900

ATCGATGTTT GGTCAGCTGG CTGTGTACTG GCGGAGCTCC TCTTGGGCCA GCCCATCTTC 960

CCTGGGGACA GTGGGGTGGA CCAGCTGGTG GAGATCATCA AGGTGCTGGG AACACCAACC 1020

CGGGAACAAA TCCGAGAGAT GAACCCCAAC TACACGGAGT TCAAGTTCCC TCAGATTAAA 1080

GCTCACCCCT GGACAAAGGT GTTCAAATCT CGAACGCCGC CAGAGGCCAT CGCGCTCTGC 1140

TCTAGCCTGC TGGAGTACAC CCCATCCTCA AGGCTCTCCC CACTAGAGGC CTGTGCGCAC 1200

AGCTTCTTTG ATGAACTGCG ATGTCTGGGA ACCCAGCTGC CTAACAACCG CCCACTTCCC 1260

CCTCTCTTCA ACTTCAGTGC TGGTGAACTC TCCATCCAAC CGTCTCTCAA CGCCATTCTC 1320

ATCCCTCCTC ACTTGAGGTC CCCAGCGGGC ACTACCACCC TCACCCAGTC CTCACAAGCT 1380

TTAACTGAGA CTCCGACCAG CTCAGACTGG CAGTCGACCG ATGCCACACC TACCCTCACT 1440

AACTCCTCCT GA 1452

Domain Profile

S: 2     eelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLlyf  61

         +++k+ig+GsFg+Vyqa+l+e++e  vaiKkvlqdk++kn+El+i+rkl+H+nivrL+yf

Q: 120   TDIKVIGNGSFGVVYQARLAETREL-VAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYF  178

         789**********************.**********************************

S: 62    fsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhsl  121

         f++s ekkd++ylnlvley+Pet+++v+r+++++k ++++l++k+y+yQlfr+lay+hs+

Q: 179   FYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYIKVYMYQLFRSLAYIHSQ  238

         ************************************************************

S: 122   eivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakeyt  181

         +++HrDiKPqNllvd++t+vlKlcDfGsak+l+++epnvsYi+sRyYRaPEL++ga++yt

Q: 239   GVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYT  298

         ************************************************************

S: 182   tkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfkk  241

         ++iDvWsagcvlaEll+g+++f+g+s++dql++i+kvlGtpt+e+i+emn++y+e+kf++

Q: 299   SSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQ  358

         ************************************************************

S: 242   ikkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286

         ik+++++kv+k+++++ea++l++++l+y+p++Rls+le++ah+ff

Q: 359   IKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF  403

         ********************************************9

Domain Sequence
(FASTA)

TDIKVIGNGS FGVVYQARLA ETRELVAIKK VLQDKRFKNR ELQIMRKLDH CNIVRLRYFF 60

YSSGEKKDEL YLNLVLEYVP ETVYRVARHF TKAKLTIPIL YIKVYMYQLF RSLAYIHSQG 120

VCHRDIKPQN LLVDPDTAVL KLCDFGSAKQ LVRGEPNVSY ICSRYYRAPE LIFGATDYTS 180

SIDVWSAGCV LAELLLGQPI FPGDSGVDQL VEIIKVLGTP TREQIREMNP NYTEFKFPQI 240

KAHPWTKVFK SRTPPEAIAL CSSLLEYTPS SRLSPLEACA HSFF 284

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ptr:456071

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013