EKS-PAT-00299

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00299

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	348.8	1.9E-104	16	273	258

Status

Unreviewed

Ensembl Protein

ENSPTRP00000020357

UniProt Accession

H2QHS7;

Protein Name

Mitogen-activated protein kinase kinase kinase kinase

Protein Synonyms/Alias

Gene Name

ENSG00000011566

Gene Synonyms/Alias

ENSG00000011566;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000011858	ENSPTRP00000020357	ENSPTRT00000022066

Organism

Pan troglodytes

Functional Description

Protein Length

879

Protein Sequence
(FASTA)

MNPGFDLSRR NPQEDFELIQ RIGSGTYGDV YKARNVNTGE LAAIKVIKLE PGEDFAVVQQ 60

EIIMMKDCKH PNIVAYFGSY LRRDKLWICM EFCGGGSLQD IYHVTGPLSE LQIAYVSRET 120

LQGLYYLHSK GKMHRDIKGA NILLTDNGHV KLADFGVSAQ ITATIAKRKS FIGTPYWMAP 180

EVAAVERKGG YNQLCDLWAV GITAIELAEL QPPMFDLHPM RALFLMTKSN FQPPKLKDKM 240

KWSNSFHHFV KMALTKNPKK RPTAEKLLQH PFVTQHLTRS LAIELLDKVN NPDHSTYHDF 300

DDDDPEPLVA VPHRIHSTSR NVREEKTRSE INFGQVKFDP PLRKETEPHH ELPDSDGFLD 360

SSEEIYYTAR SNLDLQLEYG QGHQGSYFLG ANKSLLKSVE EELHQRGHVA HLEDDEGDDD 420

ESKHSTLKAK VPPPLPPKPK SIFIPQEMHS TEDENQGTIK RCPMSGSPAK PSQVPPRPPP 480

PRLPPHKPVA LGNGMSSFQL NGERDGSLCQ QQNEHRGTNL SRKEKKDVPK PISNGLPPTP 540

KVHMGACFSK VFNGCPLKIH CASSWINPDT REEYLIFGAE EGILFPRRCT WLYVMNNCLL 600

SISGKASQLY SHNLPGLFDY ARQMQKLPVA IPAHKLPDRI LPRKFSVSAK IPETKWCQKC 660

CVVRNPYTGH KYLCGALQTS IVLLEWVEPM QKFMLIKHID FPIPCPLRMF EMLVVPEQEY 720

PLVCVGVSRG RDFNQVVRFE TVNPNSTSSW FTESDTPQTN VTHVTQLERD TILVCLDCCI 780

KIVNLQGRLK SSRKLSSELT FDFQIESIVC LQDSVLAFWK HGMQGRSFRS NEVTQEISDS 840

TRIFRLLGSD RVVVLESRPT DNPTANSNLY ILAGHENSY 879

Nucleotide Sequence
(FASTA)

ATGAACCCCG GCTTCGATTT GTCCCGCCGG AACCCGCAGG AGGACTTCGA GCTGATTCAG 60

CGCATCGGCA GCGGCACCTA CGGCGACGTC TACAAGGCAC GGAATGTTAA CACTGGTGAA 120

TTAGCAGCAA TTAAAGTAAT AAAATTGGAA CCAGGAGAAG ACTTTGCAGT TGTGCAGCAA 180

GAAATTATTA TGATGAAAGA CTGTAAACAC CCAAATATTG TTGCTTATTT TGGAAGCTAT 240

CTCAGGCGAG ATAAGCTTTG GATTTGCATG GAGTTTTGTG GAGGTGGTTC TTTACAGGAT 300

ATTTATCACG TAACTGGACC TCTGTCAGAA CTGCAGATTG CATATGTTAG CAGAGAAACA 360

CTGCAGGGAT TATATTATCT TCACAGTAAA GGAAAAATGC ACAGAGATAT AAAGGGAGCT 420

AACATTCTAT TAACGGATAA TGGTCATGTG AAACTGGCTG ATTTTGGAGT ATCTGCACAG 480

ATAACAGCTA CAATTGCCAA ACGGAAGTCT TTCATTGGCA CACCATATTG GATGGCTCCA 540

GAAGTTGCAG CTGTTGAGAG GAAGGGGGGT TACAATCAAC TCTGTGATCT CTGGGCAGTG 600

GGAATCACTG CCATAGAACT TGCAGAGCTT CAGCCTCCTA TGTTTGACTT ACACCCAATG 660

AGAGCATTAT TTCTAATGAC AAAAAGCAAT TTTCAGCCTC CTAAACTAAA GGATAAAATG 720

AAATGGTCAA ATAGTTTTCA TCACTTTGTG AAAATGGCAC TTACCAAAAA TCCGAAAAAA 780

AGACCTACTG CTGAAAAATT ATTACAGCAT CCTTTTGTAA CACAACATTT GACACGGTCT 840

TTGGCAATCG AGCTGTTGGA TAAAGTAAAT AATCCAGATC ATTCCACTTA CCATGATTTC 900

GATGATGATG ATCCTGAGCC TCTTGTTGCT GTACCACATA GAATTCACTC AACAAGTAGA 960

AACGTGAGAG AAGAAAAAAC ACGCTCAGAG ATAAACTTTG GCCAAGTGAA ATTTGATCCA 1020

CCCTTAAGAA AGGAGACAGA ACCACATCAT GAACTTCCCG ACAGTGATGG TTTTTTGGAC 1080

AGTTCAGAAG AAATATACTA CACTGCAAGA TCTAATCTGG ATCTGCAACT GGAATATGGA 1140

CAAGGACACC AAGGTAGTTA CTTTTTAGGT GCAAACAAGA GTCTTCTCAA GTCTGTTGAA 1200

GAAGAATTGC ATCAGCGAGG ACACGTCGCA CATTTAGAAG ATGATGAAGG AGATGATGAT 1260

GAATCTAAAC ACTCAACTCT GAAAGCAAAA GTTCCACCTC CTTTGCCACC AAAGCCTAAG 1320

TCTATCTTCA TACCACAGGA AATGCATTCT ACTGAGGATG AAAATCAAGG AACAATCAAG 1380

AGATGTCCCA TGTCAGGGAG CCCAGCAAAG CCATCCCAAG TTCCACCTAG ACCACCACCT 1440

CCCAGATTAC CCCCACACAA ACCTGTTGCC TTAGGAAATG GAATGAGCTC CTTCCAGTTA 1500

AATGGTGAAC GAGATGGCTC ATTATGTCAA CAACAGAATG AACATAGAGG CACAAACCTT 1560

TCAAGAAAAG AAAAGAAAGA TGTACCAAAG CCTATTAGTA ATGGTCTTCC TCCAACACCT 1620

AAAGTGCATA TGGGTGCATG TTTTTCAAAA GTTTTTAATG GGTGTCCCTT GAAAATTCAC 1680

TGTGCATCAT CATGGATAAA CCCAGATACA AGAGAGGAGT ACTTGATATT TGGTGCCGAA 1740

GAAGGGATTC TATTCCCTCG AAGGTGTACA TGGTTGTATG TAATGAACAA TTGCTTGCTA 1800

TCAATATCTG GTAAAGCTTC TCAGCTTTAT TCCCATAATT TACCAGGGCT TTTTGATTAT 1860

GCAAGACAAA TGCAAAAGTT ACCTGTTGCT ATTCCAGCAC ACAAACTCCC TGACAGAATA 1920

CTGCCAAGGA AATTTTCTGT ATCAGCAAAA ATCCCTGAAA CCAAATGGTG CCAGAAGTGT 1980

TGTGTTGTAA GAAATCCTTA CACGGGCCAT AAATACCTAT GTGGAGCACT TCAGACTAGC 2040

ATTGTTCTAT TAGAATGGGT TGAACCAATG CAGAAATTTA TGTTAATTAA GCACATAGAT 2100

TTTCCTATAC CATGTCCACT TAGAATGTTT GAAATGCTGG TAGTTCCTGA ACAGGAGTAC 2160

CCTTTAGTTT GTGTTGGTGT CAGTAGAGGT AGAGACTTCA ACCAAGTGGT TCGATTTGAG 2220

ACGGTCAATC CAAATTCTAC CTCTTCGTGG TTTACAGAAT CAGATACCCC ACAGACAAAT 2280

GTTACTCATG TAACCCAACT GGAGAGAGAT ACCATCCTTG TATGCTTGGA CTGTTGTATA 2340

AAAATAGTAA ATCTCCAAGG AAGATTAAAA TCTAGCAGGA AATTATCATC AGAACTCACC 2400

TTTGATTTCC AGATTGAATC AATAGTGTGC CTACAAGACA GTGTGCTAGC TTTCTGGAAA 2460

CATGGAATGC AAGGTAGAAG TTTTAGATCT AATGAGGTAA CACAAGAAAT TTCAGATAGC 2520

ACAAGAATTT TCAGGCTGCT TGGATCTGAC AGGGTCGTGG TTTTGGAAAG TAGGCCAACT 2580

GATAACCCCA CAGCAAATAG CAATTTGTAC ATCCTGGCGG GTCATGAAAA CAGTTACTGA 2640

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +el+++ig+G++g+vy+ar+++tgel+aik+i+le  e+ + +q+ei ++k++khpniv+

Q: 16    FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVA  75

         899*********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y++s+l++++lw++me++ gGsl+d+++  ++ +l+E qiay+ re+l++L ylHsk+++

Q: 76    YFGSYLRRDKLWICMEFCGGGSLQDIYH--VTGPLSELQIAYVSRETLQGLYYLHSKGKM  133

         ****************************..******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYde  179

         Hrdik++niLlt++g+VkL+dfgv+aq+++t +krk+++gtpywmAPEv a+e + gY++

Q: 134   HRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVErKGGYNQ  193

         ****************************************************98889***

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkne..ppklkskkkfskefkefvekc  237

          +D+w++GItaielae +pP++dl+p++al++++k++  ppklk+k k+s++f++fv+ +

Q: 194   LCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNfqPPKLKDKMKWSNSFHHFVKMA  253

         ******************************999999888*********************

S: 238   lqknpekRpsasellkhkFl  257

         l+knp+kRp+a++ll+h+F+

Q: 254   LTKNPKKRPTAEKLLQHPFV  273

         *******************7

Domain Sequence
(FASTA)

FELIQRIGSG TYGDVYKARN VNTGELAAIK VIKLEPGEDF AVVQQEIIMM KDCKHPNIVA 60

YFGSYLRRDK LWICMEFCGG GSLQDIYHVT GPLSELQIAY VSRETLQGLY YLHSKGKMHR 120

DIKGANILLT DNGHVKLADF GVSAQITATI AKRKSFIGTP YWMAPEVAAV ERKGGYNQLC 180

DLWAVGITAI ELAELQPPMF DLHPMRALFL MTKSNFQPPK LKDKMKWSNS FHHFVKMALT 240

KNPKKRPTAE KLLQHPFV 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR021160	; MAPKKKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013