EKS-PAT-00161

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00161

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	471.3	8.6E-142	407	667	261

Status

Unreviewed

Ensembl Protein

ENSPTRP00000020411

UniProt Accession

H2QHV0;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000171132

Gene Synonyms/Alias

ENSG00000171132;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000011890	ENSPTRP00000020411	ENSPTRT00000022122

Organism

Pan troglodytes

Functional Description

Protein Length

736

Protein Sequence
(FASTA)

MVVFNGLLKK ICEAVSLKPT AWSLRHAVGP RPQTFLLDPY IALNVDDSRI GQTATKQKTN 60

SPAWHDEFVT DVCNGRKIEL AVFHDAPIGY DDFVANCTIQ FEELLQNGSR HFEDWIDLEP 120

EGRVYVIIDL SGSSGEAPKD NEERVFRERM RPRKRQGAVR RRVHQVNGHK FMATYLRQPT 180

YCSHCRDFIW GVIGKQGYQC QVCTCVVHKR CHELIITKCA GLKKQETPDQ VGSQRFSVNM 240

PHKFGIHNYK VPTFCDHCGS LLWGLLRQGL QCKVCKMNVH RRCETNVAPN CGVDARGIAK 300

VLADLGVTPD KITNSGQRRK KLIAGAESPQ PASGSSPSEE DRSKSAPTSP CDQEIKELEN 360

NIRKALSFDN RGEEHRAASS PDGQLMSPGE NGEVRQGQAK RLGLDEFNFI KVLGKGSFGK 420

VMLAELKGKD EVYAVKVLKK DVILQDDDVD CTMTEKRILA LARKHPYLTQ LYCCFQTKDR 480

LFFVMEYVNG GDLMFQIQRS RKFDEPRSRF YAAEVTSALM FLHQHGVIYR DLKLDNILLD 540

AEGHCKLADF GMCKEGILNG VTTTTFCGTP DYIAPEILQE LEYGPSVDWW ALGVLMYEMM 600

AGQPPFEADN EDDLFESILH DDVLYPVWLS KEAVSILKAF MTKNPHKRLG CVASQNGEDA 660

IKQHPFFKEI DWVLLEQKKI KPPFKPRIKT KRDVNNFDQD FTREEPVLTL VDEAIVKQIN 720

QEEFKGFSYF GEDLMP 736

Nucleotide Sequence
(FASTA)

ATGGTAGTGT TCAATGGCCT TCTTAAGAAA ATCTGCGAGG CCGTGAGCTT GAAGCCCACA 60

GCCTGGTCGC TGCGCCATGC GGTGGGACCC CGGCCGCAGA CTTTCCTTCT CGACCCCTAC 120

ATTGCCCTCA ATGTGGACGA CTCGCGCATC GGCCAAACGG CCACCAAGCA GAAGACCAAC 180

AGCCCGGCCT GGCACGACGA GTTCGTCACC GATGTGTGCA ACGGGCGCAA GATCGAGCTG 240

GCTGTCTTTC ACGATGCCCC CATAGGCTAC GACGACTTCG TGGCCAACTG CACCATCCAG 300

TTTGAGGAGC TGCTGCAGAA CGGGAGCCGC CACTTCGAGG ACTGGATTGA TCTGGAGCCA 360

GAAGGAAGAG TGTATGTGAT CATCGATCTC TCAGGGTCGT CAGGTGAAGC CCCTAAAGAC 420

AATGAAGAGC GTGTGTTCAG GGAACGCATG CGGCCGAGGA AGCGGCAGGG GGCCGTCAGG 480

CGCAGGGTCC ATCAGGTCAA CGGCCACAAG TTCATGGCCA CCTATCTTCG GCAGCCCACC 540

TACTGCTCCC ATTGCAGAGA CTTCATCTGG GGTGTCATAG GAAAGCAGGG ATACCAGTGT 600

CAAGTCTGCA CCTGCGTGGT CCACAAGCGG TGCCATGAGC TCATAATCAC AAAGTGTGCT 660

GGGTTAAAGA AGCAGGAGAC CCCCGACCAG GTGGGCTCCC AGCGGTTCAG CGTCAACATG 720

CCCCACAAGT TCGGTATCCA CAACTACAAG GTCCCTACCT TCTGCGATCA CTGTGGGTCC 780

CTGCTCTGGG GACTCTTGCG GCAGGGTTTG CAGTGTAAAG TCTGCAAAAT GAATGTTCAC 840

CGTCGATGTG AGACCAACGT GGCTCCCAAC TGTGGAGTGG ATGCCAGAGG AATCGCCAAA 900

GTACTGGCCG ACCTGGGCGT TACCCCAGAC AAAATCACCA ACAGCGGCCA GAGAAGGAAA 960

AAGCTCATTG CTGGTGCCGA GTCCCCGCAG CCTGCTTCTG GAAGCTCACC ATCTGAGGAA 1020

GATCGATCCA AGTCAGCACC CACCTCCCCT TGTGACCAGG AAATAAAAGA ACTTGAGAAC 1080

AACATTCGGA AAGCCTTGTC ATTTGACAAC CGAGGGGAGG AGCACCGGGC AGCATCGTCT 1140

CCTGATGGCC AGCTGATGAG CCCTGGTGAG AATGGCGAAG TCCGGCAAGG CCAGGCCAAG 1200

CGCCTGGGCC TGGATGAGTT CAACTTCATC AAGGTGTTGG GCAAAGGCAG CTTTGGCAAG 1260

GTCATGTTGG CAGAACTCAA GGGCAAAGAT GAAGTATATG CTGTGAAGGT CTTAAAGAAG 1320

GACGTCATCC TTCAGGATGA TGACGTGGAC TGCACAATGA CAGAGAAGAG GATTTTGGCT 1380

CTGGCACGGA AACACCCGTA CCTTACCCAA CTCTACTGCT GCTTCCAGAC CAAGGACCGC 1440

CTCTTTTTCG TCATGGAATA TGTAAATGGT GGAGACCTCA TGTTTCAGAT TCAGCGCTCC 1500

CGAAAATTCG ACGAGCCTCG TTCACGGTTC TATGCTGCAG AGGTCACATC GGCCCTCATG 1560

TTCCTCCACC AGCATGGAGT CATCTACAGG GATTTGAAAC TGGACAACAT CCTTCTGGAT 1620

GCAGAAGGTC ACTGCAAGCT GGCTGACTTC GGGATGTGCA AGGAAGGGAT TCTGAATGGT 1680

GTGACGACCA CCACGTTCTG TGGGACTCCT GACTACATAG CTCCTGAGAT CCTGCAGGAG 1740

TTGGAGTACG GCCCCTCCGT GGACTGGTGG GCCCTGGGGG TGCTGATGTA CGAGATGATG 1800

GCTGGACAGC CTCCCTTTGA GGCCGACAAT GAAGACGACC TATTTGAGTC CATCCTCCAT 1860

GACGACGTGC TGTACCCAGT CTGGCTCAGC AAGGAGGCTG TCAGCATCTT GAAAGCTTTC 1920

ATGACGAAGA ATCCCCACAA GCGCCTGGGC TGTGTGGCAT CGCAGAACGG CGAGGACGCC 1980

ATCAAGCAGC ACCCATTCTT CAAAGAGATT GACTGGGTGC TCCTGGAGCA GAAGAAGATC 2040

AAGCCACCCT TCAAACCACG CATTAAAACC AAAAGAGACG TCAATAATTT TGACCAAGAC 2100

TTTACCCGGG AAGAGCCGGT ACTCACCCTT GTGGACGAAG CAATTGTAAA GCAGATCAAC 2160

CAGGAGGAAT TCAAAGGTTT CTCCTACTTT GGTGAAGACC TGATGCCCTG A 2211

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+++kvlGkGsfgkv+laelk++de+ya+kvlkkdv+lqdddv++t++ekr+lala+k+p

Q: 407   FNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHP  466

         99**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         +l+ql++cfqt+drlffv+eyvnGGdlmf+iq++rk++e+r+rfyaae+++al+flh++g

Q: 467   YLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHG  526

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         +iyrdlkldn+lldaeGh+kladfG+cke+il+g tt+tfcGtPdyiaPeil+e eyg s

Q: 527   VIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPS  586

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdwwalGvl+yem+agq+Pfe+++ed+lfesil+++vlyP++lskeav+ilk+++tk+p+

Q: 587   VDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPH  646

         ************************************************************

S: 241   krlGv..keegeedikehaff  259

         krlG+  +++ge++ik+h+ff

Q: 647   KRLGCvaSQNGEDAIKQHPFF  667

         *****6559***********9

Domain Sequence
(FASTA)

FNFIKVLGKG SFGKVMLAEL KGKDEVYAVK VLKKDVILQD DDVDCTMTEK RILALARKHP 60

YLTQLYCCFQ TKDRLFFVME YVNGGDLMFQ IQRSRKFDEP RSRFYAAEVT SALMFLHQHG 120

VIYRDLKLDN ILLDAEGHCK LADFGMCKEG ILNGVTTTTF CGTPDYIAPE ILQELEYGPS 180

VDWWALGVLM YEMMAGQPPF EADNEDDLFE SILHDDVLYP VWLSKEAVSI LKAFMTKNPH 240

KRLGCVASQN GEDAIKQHPF F 261

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR018029	; C2_membr_targeting.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR014376	; Prot_kin_PKC_delta.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00168	; C2; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50004	; C2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013