EKS-PAT-00321

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00321

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	404.3	2.8E-121	592	1076	485

Status

Unreviewed

Ensembl Protein

ENSPTRP00000020876

UniProt Accession

H2QIB3;

Protein Name

Protein Synonyms/Alias

Eukaryotic translation initiation factor 2-alpha kinase 3;

Gene Name

ENSG00000172071

Gene Synonyms/Alias

ENSG00000172071; EIF2AK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000012173	ENSPTRP00000020876	ENSPTRT00000022621

Organism

Pan troglodytes

Functional Description

Protein Length

1115

Protein Sequence
(FASTA)

MERAISPGLL VRALLLLLLL LGLAARTVAA GRARGLPAPT AEAAFGLGAA AAPTSATRVP 60

AAGAVAAAEV TVEDAEALPA AAGEQEPRGP EPDDETELQP RGRSLVIIST LDGRIAALDP 120

ENHGKKQWDL DVGSGSLVSS SLSKPEVFGN KMIIPSLDGD LFQWDRDRES METVPFTVES 180

LLESSYKFGD DVVLVGGKSL TTYGLSAYSG KVRYICSALG CRQWDSDEME QEEDILLLQR 240

TQKTVRAVGP RSGNEKWNFS VGHFELRYIP DMETRAGFIE STFKPNENTE ESKIISDVEE 300

QEAAIMDIVI KVSVADWKVM AFSKKGGHLE WEYQFCTPIA SAWLLKDGKV IPISLFDDTS 360

YTSNDDVLED EEDIVEAARG ATENSVYLGM YRGQLYLQSS VRISEKFPSS PKALESVNEN 420

AIIPLPTIKW KPLIHSPSRT PVLVGSDEFD KCLSNDKFSH EEYSNGALSI LQYPYDNGYY 480

LPYYKRERNK RSTQITVRFL DNPHYNKNIR KKDPVLLLHW WKEIVATILF CIIATTFIVR 540

RLFHPHPHRQ RKESETQCQT ENKYDSVSGE ANDSSWNDIK NSGYISRYLT DFEPIQCLGR 600

GGFGVVFEAK NKVDDCNYAI KRIRLPNREL AREKVMREVK ALAKLEHPGI VRYFNAWLEA 660

PPEKWQEKMD EIWLKDESTD WPLSSPSPMD APSVKIRRMD PFSTKEHIEI IAPSPQRSRS 720

FSVGISCDQT SSSESQFSPL EFSGMDHEDI SESVDAAYNL QDSCLTDCDV EDGTMDGNDE 780

GPSFELCPSE ASPYVRSRER TSSSIVFEDS GCDNASSKEE PKTNRLHIGN HCANKLTAFK 840

PTSSKSSSEA TLSISPPRPT TLSLDLTKNT TEKLQPSSPK VYLYIQMQLC RKENLKDWMN 900

GRCTIEERER SMCLHIFLQI AEAVEFLHSK GLMHRDLKPS NIFFTMDDVV KVGDFGLVTA 960

MDQDEEEQTV LTPMPAYARH TGQVGTKLYM SPEQIHGNSY SHKVDIFSLG LILFELLYPF 1020

STQMERVRTL TDVRNLKFPP LFTQKYPCEY VMVQDMLSPS PMERPEAINI IENAVFEDLD 1080

FPGKTVLRQR SRSLSSSGTK HSRQSNNSHS PLPSN 1115

Nucleotide Sequence
(FASTA)

ATGGAGCGCG CCATCAGCCC GGGGCTGCTG GTACGGGCGC TGCTGCTGCT GCTGCTGCTG 60

CTGGGGCTCG CGGCAAGGAC GGTGGCCGCG GGGCGCGCCC GTGGCCTCCC AGCGCCGACG 120

GCGGAGGCGG CGTTCGGCCT CGGGGCGGCC GCTGCTCCCA CCTCAGCGAC GCGAGTACCG 180

GCGGCGGGCG CCGTGGCTGC GGCCGAGGTG ACTGTGGAGG ACGCTGAGGC GCTGCCGGCA 240

GCCGCGGGAG AGCAGGAGCC TCGGGGTCCG GAACCAGACG ATGAGACAGA GTTGCAACCG 300

CGCGGCAGGT CATTAGTAAT TATCAGCACT TTAGATGGGA GAATTGCTGC CTTGGATCCT 360

GAAAATCATG GTAAAAAGCA GTGGGATTTG GATGTGGGAT CTGGTTCCTT GGTGTCATCC 420

AGCCTTAGCA AACCAGAGGT ATTTGGGAAT AAGATGATCA TTCCTTCCCT GGATGGAGAC 480

CTCTTCCAGT GGGACCGAGA CCGTGAGAGC ATGGAAACAG TTCCTTTCAC AGTTGAATCA 540

CTTCTTGAAT CTTCTTATAA ATTTGGAGAT GATGTTGTTT TGGTTGGAGG AAAATCTCTG 600

ACTACATATG GACTCAGTGC ATATAGTGGA AAGGTGAGGT ATATCTGTTC AGCTCTGGGT 660

TGTCGCCAAT GGGATAGTGA CGAAATGGAA CAAGAGGAAG ACATCCTGCT TCTACAGCGT 720

ACCCAAAAAA CTGTTAGAGC TGTCGGACCT CGCAGTGGCA ATGAGAAGTG GAATTTCAGT 780

GTTGGCCACT TTGAACTTCG GTATATTCCA GACATGGAAA CGAGAGCAGG ATTTATTGAA 840

AGCACCTTTA AGCCCAATGA GAACACAGAA GAGTCTAAAA TTATTTCAGA TGTGGAAGAA 900

CAGGAAGCTG CCATAATGGA CATAGTGATA AAGGTTTCGG TTGCTGACTG GAAAGTTATG 960

GCATTCAGTA AGAAGGGAGG ACATCTGGAA TGGGAGTACC AGTTTTGTAC TCCAATTGCA 1020

TCTGCCTGGT TACTTAAGGA TGGGAAGGTC ATTCCCATCA GTCTTTTTGA TGATACAAGT 1080

TATACATCTA ATGATGATGT TTTAGAAGAT GAAGAAGACA TTGTAGAAGC TGCCAGAGGA 1140

GCCACAGAAA ACAGTGTTTA CTTGGGAATG TATAGAGGCC AGCTGTATCT GCAGTCATCA 1200

GTCAGAATTT CAGAAAAGTT TCCTTCAAGT CCCAAGGCTT TGGAATCTGT CAATGAAAAC 1260

GCAATTATTC CTTTGCCAAC AATCAAATGG AAACCCTTAA TTCATTCTCC TTCCAGAACT 1320

CCTGTCTTGG TAGGATCTGA TGAATTTGAC AAATGTCTCA GTAATGATAA GTTTTCTCAT 1380

GAAGAATATA GTAATGGTGC ACTTTCAATC TTGCAGTATC CATATGATAA TGGTTATTAT 1440

CTACCATACT ACAAGAGGGA AAGGAACAAA CGAAGCACAC AGATTACAGT CAGATTCCTC 1500

GACAACCCAC ATTACAACAA GAATATCCGC AAAAAGGATC CTGTTCTTCT TTTACACTGG 1560

TGGAAAGAAA TAGTTGCAAC GATTTTGTTT TGTATCATAG CAACAACGTT TATTGTGCGC 1620

AGGCTTTTCC ATCCTCATCC TCACAGGCAA AGGAAGGAGT CTGAAACTCA GTGTCAAACT 1680

GAAAATAAAT ATGATTCCGT AAGTGGTGAA GCCAATGACA GTAGCTGGAA TGACATAAAA 1740

AACTCTGGAT ATATATCACG ATATCTAACT GATTTTGAGC CAATTCAATG CCTGGGACGT 1800

GGTGGCTTTG GAGTTGTTTT TGAAGCTAAA AACAAAGTAG ATGACTGCAA TTATGCTATC 1860

AAGAGGATCC GTCTCCCCAA TAGGGAATTG GCTCGGGAAA AGGTAATGCG AGAAGTTAAA 1920

GCCTTAGCCA AGCTTGAACA CCCGGGCATT GTTAGATATT TCAATGCCTG GCTCGAAGCA 1980

CCACCAGAGA AGTGGCAAGA AAAGATGGAT GAAATTTGGC TGAAAGATGA AAGCACAGAC 2040

TGGCCACTCA GCTCTCCTAG CCCAATGGAT GCACCATCAG TTAAAATACG CAGAATGGAT 2100

CCTTTCTCTA CAAAAGAACA TATTGAAATC ATAGCTCCTT CACCACAAAG AAGCAGGTCT 2160

TTTTCAGTAG GGATTTCCTG TGACCAGACA AGTTCATCTG AGAGCCAGTT CTCACCACTG 2220

GAATTCTCAG GAATGGACCA TGAGGACATC AGTGAGTCAG TGGATGCAGC ATACAACCTC 2280

CAGGACAGTT GCCTTACAGA CTGTGATGTG GAAGATGGGA CTATGGATGG CAATGATGAG 2340

GGGCCCTCCT TTGAACTTTG TCCTTCTGAA GCTTCTCCTT ATGTAAGGTC AAGGGAGAGA 2400

ACCTCCTCTT CAATAGTATT TGAAGATTCT GGCTGTGATA ATGCTTCCAG TAAAGAAGAG 2460

CCGAAAACTA ATCGATTGCA TATTGGCAAC CATTGTGCTA ATAAACTAAC TGCTTTCAAG 2520

CCCACCAGTA GCAAATCTTC TTCTGAAGCT ACATTGTCTA TTTCTCCTCC GAGACCAACC 2580

ACTTTAAGTT TAGATCTCAC TAAAAACACC ACAGAAAAAC TCCAGCCCAG TTCACCAAAG 2640

GTGTATCTTT ACATTCAAAT GCAGCTGTGC AGAAAAGAAA ACCTCAAAGA CTGGATGAAT 2700

GGACGATGTA CCATAGAGGA GAGAGAGAGG AGCATGTGTC TGCACATCTT CCTGCAGATC 2760

GCAGAGGCAG TGGAGTTTCT TCACAGTAAA GGACTGATGC ACAGGGACCT CAAGCCATCC 2820

AACATATTCT TTACAATGGA TGATGTGGTC AAGGTTGGAG ACTTTGGGTT AGTGACTGCA 2880

ATGGACCAGG ATGAGGAAGA GCAGACGGTT CTGACCCCAA TGCCAGCTTA TGCCAGACAC 2940

ACAGGACAAG TAGGGACCAA ACTGTATATG AGCCCAGAGC AGATTCATGG AAACAGCTAT 3000

TCTCATAAAG TGGACATCTT TTCTTTAGGC CTGATTCTAT TTGAATTGCT GTATCCATTC 3060

AGCACTCAGA TGGAGAGAGT CAGGACCTTA ACTGATGTAA GAAATCTCAA ATTTCCACCA 3120

TTATTTACTC AGAAATATCC TTGTGAGTAT GTGATGGTTC AAGACATGCT CTCTCCATCC 3180

CCCATGGAAC GACCTGAAGC TATAAACATC ATTGAAAATG CTGTATTTGA GGACTTGGAC 3240

TTTCCAGGAA AAACAGTGCT CAGACAGAGG TCTCGCTCCT TGAGTTCATC GGGAACAAAA 3300

CATTCAAGAC AGTCCAACAA CTCCCATAGC CCTTTGCCAA GCAATTAG 3348

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60

         fe i++lG+GgfgvV++aknk+d+++yaikri+l++++ ++ekv+revkaLaklehp+iv

Q: 592   FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIV  651

         799*********************************************************

S: 61    rYfaawleekeesl..............................................  74

         rYf+awle ++e++

Q: 652   RYFNAWLEAPPEKWqekmdeiwlkdestdwplsspspmdapsvkirrmdpfstkehieii  711

         ************************************************************

S: 75    ............................................................  74

Q: 712   apspqrsrsfsvgiscdqtsssesqfsplefsgmdhedisesvdaaynlqdscltdcdve  771

         ************************************************************

S: 75    ..td.sseveaeaeleesesseesdtk.................................  98

           t+ ++++  ++el++se+s++++++

Q: 772   dgTMdGNDEGPSFELCPSEASPYVRSRertsssivfedsgcdnasskeepktnrlhignh  831

         *9666888888899999999888888889999999999999999999999999*******

S: 99    ..................................................llyiqmelce  108

                                                           +lyiqm+lc+

Q: 832   cankltafkptsskssseatlsispprpttlsldltkntteklqpsspkvYLYIQMQLCR  891

         ************************************************************

S: 109   ketLkdwiderkllesrselvm.rlfkqllegleylHskgliHrdLkpsniFldsddqvK  167

         ke+Lkdw++ r+++e+r++ ++ ++f q++e++e+lHskgl+HrdLkpsniF+++dd vK

Q: 892   KENLKDWMNGRCTIEERERSMClHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVK  951

         ************************************************************

S: 168   igDFgLatalaealkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGl  227

         +gDFgL+ta++++++e+++ ++++++a+htgqvgtklymsPeq+++++Y++kvDifsLGl

Q: 952   VGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGL  1011

         ************************************************************

S: 228   ilfeLlypfstemervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasell  287

         ilfeLlypfst+merv+tlt++r++k+p  f++k+p+e+ ++q++ls +p+eRp+a +++

Q: 1012  ILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINII  1071

         ************************************************************

S: 288   ksell  292

         +++++

Q: 1072  ENAVF  1076

         *9875

Domain Sequence
(FASTA)

FEPIQCLGRG GFGVVFEAKN KVDDCNYAIK RIRLPNRELA REKVMREVKA LAKLEHPGIV 60

RYFNAWLEAP PEKWQEKMDE IWLKDESTDW PLSSPSPMDA PSVKIRRMDP FSTKEHIEII 120

APSPQRSRSF SVGISCDQTS SSESQFSPLE FSGMDHEDIS ESVDAAYNLQ DSCLTDCDVE 180

DGTMDGNDEG PSFELCPSEA SPYVRSRERT SSSIVFEDSG CDNASSKEEP KTNRLHIGNH 240

CANKLTAFKP TSSKSSSEAT LSISPPRPTT LSLDLTKNTT EKLQPSSPKV YLYIQMQLCR 300

KENLKDWMNG RCTIEERERS MCLHIFLQIA EAVEFLHSKG LMHRDLKPSN IFFTMDDVVK 360

VGDFGLVTAM DQDEEEQTVL TPMPAYARHT GQVGTKLYMS PEQIHGNSYS HKVDIFSLGL 420

ILFELLYPFS TQMERVRTLT DVRNLKFPPL FTQKYPCEYV MVQDMLSPSP MERPEAINII 480

ENAVF 485

Keyword

ATP-binding; Complete proteome; Initiation factor; Kinase; Nucleotide-binding; Protein biosynthesis; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ptr:459388

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR011047	; Quinonprotein_ADH-like.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013