EKS-PAT-00373

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00373

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	549.7	1.0E-165	587	851	265

Status

Unreviewed

Ensembl Protein

ENSPTRP00000021171

UniProt Accession

H2QIJ5;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000153208

Gene Synonyms/Alias

ENSG00000153208;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000012358	ENSPTRP00000021171	ENSPTRT00000022949

Organism

Pan troglodytes

Functional Description

Protein Length

999

Protein Sequence
(FASTA)

MGPAPLPLLL GLFLPALWRR AITEAREEAK PYPLFPGPFP GSLQTDHTPL LSLPHATGYQ 60

PALMFSPTQP GRPHTGNVAI PQVTSVESKP LPPLAFKHTV GHIILSEHKG VKFNCSISVP 120

NIYQDTTISW WKDGKELLGA HHAITQFYPD DEVTAIIASF SITSVQRSDN GSYICKMKIN 180

NEEIVSDPIY IEVQGLPHFT KQPESMNVTR NTAFNLTCQA VGPPEPVNIF WVQNSSRVNE 240

QPEKSPSVLT VPGLTEMAVF SCEAHNDKGL SVSKGVQINI KAIPSPPTEV SIRNSTAHSI 300

LISWVPGFDG YSPFRNCSIQ VKEADPLSNG SVMIFNTSAS PHLYQIKQLQ ALANYSIGVS 360

CMNEIGWSAV SPWILASTTE GAPSVAPLNV TVFLNESSDN VDIRWMKPPT KQQDGELVGY 420

RISHVWQSAG ISKELLEEVG QNGSRARISV QVHNATCTVR IAAVTKGGVG PFSDPVKIFI 480

PAHGWVDYAP SSTPAPGNAD PVLIIFGCFC GFILIGLVLY ISLAIRKRVQ ETKFGNAFTE 540

EDSELVVNYI AKKSFCRRAI ELTLHSLGVS EELQNKLEDV VIDRNLLILG KILGEGEFGS 600

VMEGNLKQED GTSLKVAVKT MKLDNFSQRE IEEFLSEAAC MKDFSHPNVI RLLGVCIEMS 660

SQGIPKPMVI LPFMKYGDLH TYLLYSRLET GPKHIPLQTL LKFMVDIALG MEYLSNRNFL 720

HRDLAARNCM LRDDMTVCVA DFGLSKKIYS GDYYRQGRIA KMPVKWIAIE SLADRVYTSK 780

SDVWAFGVTM WEIATRGMTP YPGVQNHEMY DYLLHGHRLK QPEDCLDELY EIMCSCWRTD 840

PLHRPTFSVL RLQLEKLLES LPDVRNQADV IYVNTQLLES SEGLAQGSTL APLDLNIDPD 900

SIIASCTPRA AISVVTAEIH DSKPHEGRYI LNGGSEEWED LTSAPSAAVT AEKNSVLPGE 960

RLVRNGVSWS HSSMLPLGSS LPDELLFADD SSEGSEVLM 999

Nucleotide Sequence
(FASTA)

ATGGGGCCGG CCCCGCTGCC GCTGCTGCTG GGCCTCTTCC TCCCCGCGCT CTGGCGTAGA 60

GCTATCACTG AGGCAAGGGA AGAAGCCAAG CCTTACCCGC TATTCCCGGG ACCTTTTCCA 120

GGGAGCCTGC AAACTGACCA CACACCGCTG TTATCCCTTC CTCACGCCAC TGGGTACCAG 180

CCTGCCTTGA TGTTTTCACC AACCCAGCCT GGAAGACCAC ATACAGGAAA CGTAGCCATT 240

CCGCAGGTGA CCTCTGTCGA ATCAAAGCCC CTACCGCCTC TTGCCTTCAA ACACACAGTT 300

GGACACATAA TACTTTCTGA ACATAAAGGT GTCAAATTTA ATTGCTCAAT CAGTGTACCT 360

AATATATACC AGGACACCAC AATTTCTTGG TGGAAAGATG GGAAGGAATT GCTTGGGGCA 420

CATCATGCAA TTACACAGTT TTATCCAGAT GATGAAGTTA CAGCAATAAT CGCTTCCTTC 480

AGCATAACCA GTGTGCAGCG TTCAGACAAT GGGTCGTATA TCTGTAAGAT GAAAATAAAC 540

AATGAAGAGA TCGTGTCTGA TCCCATCTAC ATCGAAGTAC AAGGACTTCC TCACTTTACT 600

AAGCAGCCTG AGAGCATGAA TGTCACCAGA AACACAGCCT TCAACCTCAC CTGTCAGGCT 660

GTGGGCCCGC CTGAGCCCGT CAACATTTTC TGGGTTCAAA ACAGTAGCCG TGTTAACGAA 720

CAGCCTGAAA AATCCCCCTC CGTGCTAACT GTTCCAGGCC TGACGGAGAT GGCGGTCTTC 780

AGTTGTGAGG CCCACAATGA CAAAGGGCTG AGCGTGTCCA AGGGAGTGCA GATCAACATC 840

AAAGCAATTC CCTCCCCACC AACTGAAGTC AGCATCCGTA ACAGCACTGC ACACAGCATT 900

CTGATCTCCT GGGTTCCTGG TTTTGATGGA TACTCCCCGT TCAGGAATTG CAGCATTCAG 960

GTCAAGGAAG CTGATCCGCT GAGTAATGGC TCAGTCATGA TTTTTAACAC CTCTGCCTCA 1020

CCACATCTGT ACCAAATCAA GCAGCTGCAA GCCCTGGCTA ATTACAGCAT TGGTGTTTCC 1080

TGCATGAATG AAATAGGCTG GTCTGCAGTG AGCCCTTGGA TTCTAGCCAG CACTACTGAA 1140

GGAGCCCCAT CAGTAGCACC TTTAAATGTC ACTGTGTTTC TGAATGAATC TAGTGATAAT 1200

GTGGACATCA GATGGATGAA GCCTCCGACT AAGCAGCAGG ATGGAGAACT GGTGGGCTAC 1260

CGGATATCCC ACGTGTGGCA GAGTGCAGGG ATTTCCAAAG AGCTCTTGGA GGAAGTTGGC 1320

CAGAATGGCA GCCGAGCTCG GATCTCTGTT CAAGTCCACA ATGCTACGTG CACAGTGAGG 1380

ATTGCAGCCG TCACCAAAGG GGGAGTTGGG CCCTTCAGTG ATCCAGTGAA AATATTTATC 1440

CCTGCACACG GTTGGGTAGA TTATGCCCCC TCTTCAACTC CGGCGCCTGG CAACGCAGAT 1500

CCTGTGCTCA TCATCTTTGG CTGCTTTTGT GGATTTATTT TGATTGGGTT GGTTTTATAC 1560

ATCTCCTTGG CCATCAGAAA AAGAGTCCAG GAGACAAAGT TTGGGAATGC ATTCACAGAG 1620

GAGGATTCTG AATTAGTGGT GAATTATATA GCCAAGAAAT CCTTCTGTCG GCGAGCCATT 1680

GAACTTACCT TACATAGCTT GGGAGTCAGT GAGGAACTAC AAAATAAACT AGAAGATGTT 1740

GTGATTGACA GGAATCTTCT AATTCTTGGA AAAATTCTGG GTGAAGGAGA GTTTGGGTCT 1800

GTAATGGAAG GAAATCTTAA GCAGGAAGAT GGGACCTCTC TGAAAGTGGC AGTGAAGACC 1860

ATGAAGTTGG ACAACTTTTC GCAGCGGGAG ATCGAGGAGT TTCTCAGTGA GGCAGCGTGC 1920

ATGAAAGACT TTAGCCACCC AAATGTCATT CGACTTCTAG GTGTGTGTAT AGAAATGAGC 1980

TCTCAAGGCA TCCCAAAGCC CATGGTAATT TTACCCTTCA TGAAATACGG GGACCTGCAT 2040

ACTTACTTAC TTTATTCCCG ATTGGAGACA GGACCAAAGC ATATTCCTCT GCAGACACTA 2100

TTGAAGTTCA TGGTGGATAT TGCCCTGGGA ATGGAGTATC TGAGCAACAG GAATTTTCTT 2160

CATCGAGATT TAGCTGCTCG AAACTGCATG TTGCGAGATG ACATGACTGT CTGTGTTGCG 2220

GACTTCGGCC TCTCTAAGAA GATTTACAGT GGCGATTATT ACCGCCAAGG CCGCATTGCT 2280

AAGATGCCTG TTAAATGGAT CGCCATAGAA AGTCTTGCAG ACCGAGTCTA CACAAGTAAA 2340

AGTGATGTGT GGGCATTTGG CGTGACCATG TGGGAAATAG CTACGCGGGG AATGACTCCC 2400

TATCCTGGGG TCCAGAACCA TGAGATGTAT GACTATCTTC TCCATGGCCA CAGGCTGAAG 2460

CAGCCCGAAG ACTGCCTGGA TGAACTCTAT GAAATCATGT GCTCTTGCTG GAGAACCGAT 2520

CCCTTACACC GCCCCACCTT TTCAGTATTG AGGCTGCAGC TAGAAAAACT CTTAGAAAGT 2580

TTGCCTGACG TTCGGAACCA AGCAGACGTT ATTTACGTCA ATACACAGTT GCTGGAGAGC 2640

TCTGAGGGCC TGGCCCAGGG CTCCACCCTT GCTCCACTAG ACTTGAACAT CGACCCTGAC 2700

TCTATAATTG CCTCCTGCAC TCCCCGCGCT GCCATCAGTG TGGTCACAGC AGAAATTCAT 2760

GACAGCAAAC CTCATGAAGG ACGGTACATC CTGAATGGGG GCAGTGAGGA ATGGGAAGAT 2820

CTGACTTCTG CCCCCTCTGC TGCAGTCACA GCTGAAAAGA ACAGTGTTTT ACCGGGGGAG 2880

AGACTTGTTA GGAATGGGGT CTCCTGGTCC CATTCGAGCA TGCTGCCCTT GGGAAGCTCA 2940

TTGCCCGATG AACTTTTGTT TGCTGACGAC TCCTCAGAAG GCTCAGAAGT CCTGATGTGA 3000

Domain Profile

S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60

         l+lgk+lgegefgsvmeg+lkqedg++lkvavkt+kld+++++eieeflseaacmk+f+h

Q: 587   LILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNFSQREIEEFLSEAACMKDFSH  646

         68**********************************************************

S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120

         pnvirl+gv++e+s++g +pkp+vilpfmkygdlh++llysrl+++p+++plqtl+kfmv

Q: 647   PNVIRLLGVCIEMSSQG-IPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMV  705

         ****************9.******************************************

S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180

         dia gmeyls+rnf+hrdlaarncml++dmtvcvadfglskkiysgdyyrqgriak+pvk

Q: 706   DIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVK  765

         ************************************************************

S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240

         wiaiesladrvytsksdvwafgvtmweiatrg+tpy+gv+n+e+ydyll+g+rlkqpedc

Q: 766   WIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDC  825

         ************************************************************

S: 241   ldelydlmyrcweadpkdrpsfsvlr  266

         ldely++m +cw++dp +rp+fsvlr

Q: 826   LDELYEIMCSCWRTDPLHRPTFSVLR  851

         *************************9

Domain Sequence
(FASTA)

LILGKILGEG EFGSVMEGNL KQEDGTSLKV AVKTMKLDNF SQREIEEFLS EAACMKDFSH 60

PNVIRLLGVC IEMSSQGIPK PMVILPFMKY GDLHTYLLYS RLETGPKHIP LQTLLKFMVD 120

IALGMEYLSN RNFLHRDLAA RNCMLRDDMT VCVADFGLSK KIYSGDYYRQ GRIAKMPVKW 180

IAIESLADRV YTSKSDVWAF GVTMWEIATR GMTPYPGVQN HEMYDYLLHG HRLKQPEDCL 240

DELYEIMCSC WRTDPLHRPT FSVLR 265

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

ptr:459492

;

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 1.
PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 2.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013