EKS-PAT-00367

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00367

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	364.4	4.0E-109	356	616	261

Status

Unreviewed

Ensembl Protein

ENSPTRP00000021280

UniProt Accession

H2QIN7;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase kinase 2;

Gene Name

ENSG00000169967

Gene Synonyms/Alias

ENSG00000169967; MAP3K2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000012427	ENSPTRP00000021280	ENSPTRT00000023073

Organism

Pan troglodytes

Functional Description

Protein Length

619

Protein Sequence
(FASTA)

MDDQQALNSI MQDLAVLHKA SRPALSLQET RKAKSSSPKK QNDVRVKFEH RGEKRILQFP 60

RPVKLEDLRS KAKIAFGQSM DLHYTNNELV IPLTTQDDLD KAVELLDRSI HMKSLKILLV 120

INGSTQATHL EPLPSLEDLD NTVFGAERKK RLSIIGPTSR DRSSPPPGYI PDELHQVARN 180

GSFTSINSEG EFIPESMDQM LDPLSLSSPE NSGSGSCPSL DSPLDGESYP KSRMPRAQSY 240

PDNHQEFSDY DNPIFEKFGK GGTYPRRYHV SYHHQEYNDG RKTFPRARRT QGTSLRSPVS 300

FSPTDHSLST SSGSSIFTPE YDDSRIRRRG SDIDNPTLTV MDISPPSRSP RAPTNWRLGK 360

LLGQGAFGRV YLCYDVDTGR ELAVKQVQFD PDSPETSKEV NALECEIQLL KNLLHERIVQ 420

YYGCLRDPQE KTLSIFMEYM PGGSIKDQLK AYGALTENVT RKYTRQILEG VHYLHSNMIV 480

HRDIKGANIL RDSTGNVKLG DFGASKRLQT ICLSGTGMKS VTGTPYWMSP EVISGEGYGR 540

KADIWSVACT VVEMLTEKPP WAEFEAMAAI FKIATQPTNP KLPPHVSDYT RDFLKRIFVE 600

AKLRPSADEL LRHMFVHYH 619

Nucleotide Sequence
(FASTA)

ATGGATGATC AGCAAGCTTT GAACTCAATC ATGCAAGATT TGGCTGTCCT TCATAAGGCC 60

AGTCGACCAG CATTATCCTT GCAGGAAACC AGAAAAGCAA AATCTTCATC ACCAAAAAAA 120

CAGAATGATG TCCGAGTCAA ATTTGAACAT AGAGGAGAAA AAAGAATCCT TCAGTTCCCC 180

AGACCAGTTA AACTGGAAGA TCTGAGATCT AAAGCTAAAA TTGCCTTTGG ACAGTCTATG 240

GATCTACATT ATACCAATAA CGAGTTGGTA ATTCCATTAA CTACTCAAGA TGACTTGGAC 300

AAAGCTGTGG AACTGCTGGA TCGTAGTATT CATATGAAGA GCCTCAAGAT ATTACTTGTA 360

ATAAATGGAA GTACACAGGC TACTCATTTA GAACCATTGC CATCACTAGA AGATTTGGAT 420

AATACAGTAT TTGGAGCAGA GAGGAAAAAA CGGCTATCTA TAATAGGTCC TACTAGTAGA 480

GATAGAAGTT CTCCTCCCCC AGGTTACATT CCAGATGAAT TACACCAGGT TGCCCGGAAT 540

GGGTCATTCA CTAGTATCAA CAGTGAAGGA GAGTTCATTC CAGAGAGCAT GGACCAAATG 600

CTGGATCCAT TATCTTTAAG CAGCCCTGAA AATTCTGGCT CAGGAAGTTG TCCATCACTT 660

GATAGTCCTT TGGATGGAGA GAGCTATCCA AAATCACGAA TGCCTAGGGC TCAGAGCTAC 720

CCAGATAATC ATCAGGAATT TTCAGACTAT GATAACCCTA TCTTTGAGAA ATTTGGAAAA 780

GGAGGAACAT ATCCAAGAAG GTATCATGTT TCATATCATC ATCAAGAGTA TAATGATGGT 840

CGTAAAACTT TTCCAAGAGC TAGAAGGACC CAGGGGACTA GCTTACGGTC TCCTGTGAGT 900

TTCAGTCCTA CTGATCATTC CTTAAGCACT AGTAGTGGAA GCAGTATCTT TACCCCAGAG 960

TATGATGATA GTCGAATAAG AAGAAGGGGA AGTGACATAG ACAATCCTAC TTTGACCGTA 1020

ATGGACATCA GCCCACCCAG CCGTTCACCT CGAGCTCCGA CCAACTGGAG ATTGGGCAAA 1080

CTGCTTGGCC AAGGAGCCTT TGGAAGGGTC TACCTCTGTT ATGATGTTGA TACAGGAAGA 1140

GAATTGGCTG TTAAGCAAGT TCAGTTTGAC CCCGATAGTC CTGAGACCAG CAAGGAAGTA 1200

AATGCACTTG AGTGTGAAAT TCAGTTGCTG AAAAACTTGC TACATGAGCG AATTGTTCAG 1260

TATTATGGCT GTTTGAGGGA TCCCCAGGAA AAAACACTTT CCATATTTAT GGAATATATG 1320

CCAGGGGGTT CAATTAAGGA CCAATTAAAA GCATATGGCG CTCTTACTGA GAATGTGACT 1380

AGGAAATACA CCCGTCAGAT TCTGGAGGGT GTCCATTATT TGCACAGTAA TATGATTGTC 1440

CATAGAGATA TCAAAGGCGC AAATATCCTG CGAGATTCAA CAGGCAACGT CAAACTAGGA 1500

GATTTTGGGG CCAGCAAACG GCTTCAGACC ATCTGTCTCT CAGGGACAGG AATGAAGTCT 1560

GTCACGGGCA CACCATACTG GATGAGCCCT GAAGTTATCA GTGGAGAAGG CTATGGAAGA 1620

AAAGCAGACA TCTGGAGTGT TGCATGTACT GTGGTAGAAA TGCTAACTGA AAAGCCGCCT 1680

TGGGCTGAAT TTGAAGCAAT GGCTGCCATC TTTAAAATCG CCACTCAGCC AACAAACCCA 1740

AAGCTGCCAC CTCATGTCTC AGACTATACT CGAGATTTCC TCAAACGGAT TTTTGTAGAG 1800

GCCAAACTGA GACCTTCAGC TGATGAACTC TTAAGGCACA TGTTTGTGCA TTATCACTAG 1860

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         w+ ++++g+G+fg+vy+++dvdtg+ lavK+v+++p++ +++kev+al++Ei+llk+l H

Q: 356   WRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKEVNALECEIQLLKNLLH  415

         78899*******************************************************

S: 61    enivkyyGv..eveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLH  118

         e+iv+yyG+  + +e++l+if+Ey++gGs++++l++yg+l+e+v++kyt+qileg++yLH

Q: 416   ERIVQYYGClrDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLH  475

         *********777899*********************************************

S: 119   ekkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk  178

         +++ivHRDiKgaNil ds+g+vkl+DFGaskrl++++ + + ++s+tGt+++m+PEvi++

Q: 476   SNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISG  535

         **********************************************************99

S: 179   kekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkd  238

         +  gygrkaDiWs++c+v+emlt+k+P+ae+ e++a++fk++++ t+P++p ++s+ ++d

Q: 536   E--GYGRKADIWSVACTVVEMLTEKPPWAEF-EAMAAIFKIATQPTNPKLPPHVSDYTRD  592

         8..****************************.9***************************

S: 239   flekcleldpkkrpsaeeLLkhefl  263

         fl++++ +++k rpsa+eLL+h+f+

Q: 593   FLKRIF-VEAKLRPSADELLRHMFV  616

         ******.899*************96

Domain Sequence
(FASTA)

WRLGKLLGQG AFGRVYLCYD VDTGRELAVK QVQFDPDSPE TSKEVNALEC EIQLLKNLLH 60

ERIVQYYGCL RDPQEKTLSI FMEYMPGGSI KDQLKAYGAL TENVTRKYTR QILEGVHYLH 120

SNMIVHRDIK GANILRDSTG NVKLGDFGAS KRLQTICLSG TGMKSVTGTP YWMSPEVISG 180

EGYGRKADIW SVACTVVEML TEKPPWAEFE AMAAIFKIAT QPTNPKLPPH VSDYTRDFLK 240

RIFVEAKLRP SADELLRHMF V 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>