EKS-PAT-00369

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00369

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	338.2	3.9E-101	1061	1324	264

Status

Unreviewed

Ensembl Protein

ENSPTRP00000049167

UniProt Accession

H2R6J5;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000176601

Gene Synonyms/Alias

ENSG00000176601;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000012490	ENSPTRP00000049167	ENSPTRT00000056425

Organism

Pan troglodytes

Functional Description

Protein Length

1328

Protein Sequence
(FASTA)

MSSMPKPERH AESLLDICHD TNCSPTDLMT VTKNQNIILQ SISKSEEFDQ DGDCSHSTLV 60

NEEEDPSGGR QDWQPRTEGV EITVTFPRDV SPPQEMSQED LKEKNLINSS HQEWAQAHAV 120

SHPNEIETVE LRTKKLTMRP LVLQKEESSR ELCNVNLGFL LPRSCLELNI SKSVTREDAS 180

HFLKEQQRKS EEFSTSRMKY SGRSIEFLLP PLSLLPTRSG VLTIPQNHKF PKEKERNIPS 240

LTSFVPKLSV SVRQSDDLSP SNKPPGALVK SLMDPTLRSS DGFIWSRNMC SFLKTNHHRQ 300

CLEKEENWKS KEIEECNKIE ITDFEKGQSL VSFENLKEGN IPEDREEDID CHGSKTRKPE 360

EENSQYLSSR KNENSVAKNY EQDPEIVCTI PSKFQETQHS EITPSQDEEM RNNKAASKRA 420

SLHTNEAMEP NNILEECTVL KSLSSVVFDD PIDKLPEGCS SMETNIKISI AERAKPEMSR 480

MVPLIHITFP VDGSPKEPVI AKPSLQKRKG TIHNNHSVNI PVHQENDKHK MNSHRSKLDS 540

KTKTSKKTPQ NFVISTEGPI KPTMRKTSIK TQIFPALGLV DPRPWQLPRF QKKMPQIAKK 600

QSTHRTQKPK KQSFPCICKN PGIQKSYVPL SVQPTEPRLN YLDLKYSDMF KEINSTANGP 660

GIYEMFGTPV YCHVRETERD ENKYYREICS APSGRRITNK CRSSHSERKS NIRTRLSQKK 720

THMKCPKTSF GIKQEHKVLI SKEKSSKAVH SNLHDIENGV GISEPDWQIK SSGNEFLSSK 780

DEIHPMNLAQ TPEQSMKQNE FPPVSDLSIV EEVSMEESTG DRDISNNQIL TTSLRDLQEL 840

EELHHQIPFI PSEDSWAVPS EKNSNKYVQQ EKQNTASLSK VNASRILTND LEFDSVSDHS 900

KTLTNFSFQE KQESASSQTY QYWVHYLDHG SLANKSITYQ MFGKTLSGTN SISQEIMDSV 960

NNEELTDELL GCLAAELLAL DEKDNNSCQK MANETDPENL NLVLRWRGST PKEMGRETTK 1020

VKIQRHSSGL RIYDREEKFL ISNEKKIFSE NSLKSEEPIL WTKGEILGKG AYGTVYCGLT 1080

SQGQLIAVKQ VALDTSNKLA AEKEYRKLQE EVDLLKALKH VNIVAYLGTC LQENTVSIFM 1140

EFVPGGSISS IINRFGPLPE MVFCKYTKQI LQGVAYLHEN CVVHRDIKGN NVMLMPTGII 1200

KLIDFGCARH LAWAGLNGTH SDMLKSMHGT PYWMAPEVIN ESGYGRKSDI WSIGCTVFEM 1260

ATGKPPLASM DRMAAMFYIG AHRGLMPPLP DHFSENAADF VRMCLTRDQH ERPSALQLLK 1320

HSFLERSH 1328

Nucleotide Sequence
(FASTA)

ATGAGTTCTA TGCCAAAACC AGAAAGACAT GCTGAGTCAT TGCTTGACAT TTGTCATGAT 60

ACAAACTGTT CTCCAACTGA TTTGATGACA GTTACCAAAA ATCAAAACAT CATCTTGCAA 120

AGCATCAGCA AAAGTGAGGA GTTCGACCAA GACGGTGACT GCAGTCATTC CACACTGGTT 180

AATGAAGAAG AAGATCCCAG TGGTGGTAGA CAGGACTGGC AACCCAGGAC AGAAGGTGTT 240

GAGATCACTG TAACTTTTCC AAGAGATGTC AGTCCTCCCC AAGAAATGAG CCAAGAAGAC 300

TTAAAAGAAA AGAATCTGAT AAACTCATCG CATCAAGAAT GGGCACAAGC ACATGCAGTT 360

TCTCATCCAA ATGAAATAGA AACGGTGGAG CTCAGGACAA AGAAGCTGAC CATGCGGCCC 420

TTAGTTTTGC AAAAAGAGGA AAGTTCCAGG GAGCTCTGCA ATGTGAACTT GGGCTTTTTG 480

CTGCCAAGAT CTTGTTTAGA ACTAAACATT TCCAAGTCTG TAACCAGAGA AGATGCTTCT 540

CATTTTCTGA AGGAGCAGCA AAGAAAATCT GAAGAGTTTT CGACCTCTCG TATGAAGTAC 600

AGTGGCCGAA GCATCGAGTT CCTTCTGCCA CCACTGTCAC TCTTGCCCAC GCGATCTGGT 660

GTCCTTACTA TCCCTCAAAA TCACAAGTTT CCAAAAGAAA AAGAAAGAAA CATTCCAAGC 720

CTCACATCTT TTGTGCCTAA GCTCTCAGTG TCTGTTCGTC AATCTGATGA CCTCAGCCCA 780

TCAAACAAGC CTCCGGGAGC CCTAGTTAAG TCGTTGATGG ATCCAACTCT CAGGTCTTCT 840

GATGGCTTCA TTTGGTCAAG AAACATGTGC TCTTTTCTTA AGACTAACCA TCACAGACAA 900

TGCCTGGAGA AGGAGGAGAA CTGGAAATCC AAGGAAATAG AAGAATGTAA CAAAATTGAA 960

ATCACTGACT TTGAAAAAGG GCAGTCTTTG GTGTCTTTTG AGAATTTGAA GGAAGGCAAT 1020

ATTCCTGAAG ATAGGGAAGA GGATATTGAC TGCCATGGTA GTAAAACGCG AAAACCTGAA 1080

GAAGAGAACT CTCAATATCT TTCATCAAGA AAGAATGAGA ATTCAGTAGC CAAAAACTAT 1140

GAACAAGATC CAGAAATAGT ATGTACCATT CCAAGCAAGT TCCAAGAAAC CCAGCATTCA 1200

GAAATAACTC CAAGCCAGGA TGAAGAGATG AGAAATAATA AAGCTGCTTC AAAAAGAGCT 1260

TCATTACATA CAAATGAAGC AATGGAACCA AACAATATTT TAGAAGAGTG TACTGTACTT 1320

AAAAGCTTAT CCAGTGTAGT CTTTGATGAC CCCATTGATA AACTCCCAGA AGGTTGTAGC 1380

AGCATGGAGA CAAACATAAA AATATCAATA GCAGAAAGAG CCAAACCAGA AATGAGTAGG 1440

ATGGTGCCTC TTATCCACAT CACCTTCCCT GTGGATGGAA GCCCCAAGGA ACCAGTGATA 1500

GCCAAACCAA GCCTCCAAAA AAGAAAGGGA ACCATTCATA ACAACCATAG TGTCAACATA 1560

CCTGTACACC AAGAAAATGA CAAGCATAAG ATGAATTCCC ATAGGAGTAA GTTGGATTCA 1620

AAGACCAAGA CAAGTAAGAA GACACCTCAG AATTTCGTGA TTTCTACTGA AGGTCCCATT 1680

AAGCCTACCA TGCGTAAAAC CAGCATAAAA ACACAAATTT TCCCGGCTTT GGGACTTGTT 1740

GACCCCAGGC CTTGGCAATT GCCCAGGTTT CAAAAGAAAA TGCCACAGAT AGCAAAGAAG 1800

CAATCAACTC ACCGGACTCA GAAACCCAAA AAGCAATCAT TTCCTTGCAT CTGTAAAAAT 1860

CCAGGAATAC AGAAGTCATA TGTTCCTCTC TCTGTTCAAC CGACAGAGCC AAGACTAAAT 1920

TACCTAGATC TTAAGTATAG TGATATGTTC AAAGAAATCA ATTCAACTGC TAATGGACCT 1980

GGAATCTATG AAATGTTTGG GACCCCTGTT TATTGTCATG TGCGAGAGAC TGAAAGGGAT 2040

GAAAACAAGT ATTACCGTGA GATATGTTCG GCTCCATCAG GCAGACGTAT CACCAATAAA 2100

TGTCGATCTT CACACAGTGA GAGGAAGAGC AATATCAGAA CAAGACTTTC TCAGAAAAAA 2160

ACACATATGA AATGCCCAAA GACTTCATTT GGCATTAAAC AAGAGCACAA AGTCTTAATT 2220

TCTAAAGAAA AGAGTTCCAA GGCTGTACAT AGCAACCTAC ATGACATTGA AAATGGTGTT 2280

GGTATTTCAG AACCAGACTG GCAGATAAAG TCTTCAGGAA ATGAGTTTCT ATCTTCCAAA 2340

GATGAAATTC ATCCCATGAA CTTGGCTCAG ACACCTGAGC AGTCCATGAA ACAGAATGAA 2400

TTCCCTCCTG TCTCAGATTT ATCCATTGTT GAAGAAGTTT CTATGGAAGA GTCTACTGGT 2460

GATAGAGACA TTTCTAACAA TCAAATACTC ACCACAAGCC TCAGAGATCT GCAAGAACTT 2520

GAAGAGCTAC ATCACCAGAT CCCATTTATC CCTTCAGAAG ACAGCTGGGC AGTGCCCAGT 2580

GAGAAGAATT CTAACAAGTA TGTACAGCAA GAAAAGCAGA ATACAGCATC TCTTAGTAAA 2640

GTAAATGCCA GCAGAATTTT AACTAATGAT CTAGAGTTTG ATAGTGTTTC AGATCACTCT 2700

AAAACACTTA CAAATTTCTC TTTCCAAGAA AAACAAGAAA GTGCATCTTC CCAGACATAT 2760

CAATATTGGG TACATTATTT GGATCATGGT AGTTTAGCAA ATAAGTCAAT CACATATCAA 2820

ATGTTTGGAA AAACCTTAAG TGGCACAAAT TCAATTTCCC AAGAAATTAT GGACTCTGTA 2880

AATAATGAAG AATTGACAGA TGAACTGTTA GGTTGTCTAG CTGCAGAATT ATTAGCTCTT 2940

GATGAGAAAG ATAACAACTC TTGCCAAAAA ATGGCAAATG AAACAGATCC TGAAAACCTA 3000

AATCTTGTCC TCAGATGGAG AGGAAGTACC CCAAAAGAAA TGGGCAGAGA GACAACAAAA 3060

GTCAAAATAC AGAGGCATAG TAGTGGGCTC AGGATATATG ACAGGGAGGA GAAATTTCTC 3120

ATCTCAAATG AAAAGAAGAT ATTTTCTGAA AATAGTTTAA AGTCTGAAGA ACCTATCCTA 3180

TGGACCAAGG GTGAGATTCT TGGAAAGGGA GCCTACGGCA CAGTATACTG TGGTCTCACT 3240

AGTCAAGGAC AGCTAATAGC TGTAAAACAG GTGGCTTTGG ATACCTCTAA TAAATTAGCT 3300

GCTGAAAAGG AATACCGGAA ACTACAGGAA GAAGTAGATT TGCTCAAAGC ACTGAAACAT 3360

GTCAACATTG TGGCCTATTT GGGGACATGC TTGCAAGAGA ACACTGTGAG CATTTTCATG 3420

GAGTTTGTTC CTGGTGGCTC AATCTCTAGT ATTATAAACC GTTTTGGGCC ATTGCCTGAG 3480

ATGGTGTTCT GTAAATATAC GAAACAAATT CTTCAAGGTG TTGCTTATCT CCATGAGAAC 3540

TGTGTGGTAC ATCGCGATAT CAAAGGAAAT AATGTTATGC TCATGCCAAC TGGAATAATA 3600

AAGCTGATTG ACTTTGGCTG TGCCAGGCAT TTGGCCTGGG CAGGTTTAAA TGGCACCCAC 3660

AGTGACATGC TTAAGTCCAT GCATGGGACT CCATATTGGA TGGCCCCAGA AGTCATCAAT 3720

GAGTCTGGCT ATGGACGGAA ATCAGATATC TGGAGCATTG GTTGTACTGT GTTTGAGATG 3780

GCTACAGGGA AGCCTCCACT GGCTTCCATG GACAGGATGG CCGCCATGTT TTACATCGGA 3840

GCACACCGAG GGCTGATGCC TCCTTTACCA GACCACTTCT CAGAAAATGC AGCAGACTTT 3900

GTGCGCATGT GCCTGACCAG GGACCAGCAT GAGCGACCTT CTGCTCTCCA GCTCCTGAAG 3960

CACTCCTTCT TGGAGAGAAG TCACTGA 3987

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekk.sekkevkalkeEikllkelk  59

         w+k+e++gkG++g+vy++l+ ++g+l+avK+v++++ +k +++ke+++l+eE++llk+lk

Q: 1061  WTKGEILGKGAYGTVYCGLT-SQGQLIAVKQVALDTSNKlAAEKEYRKLQEEVDLLKALK  1119

         89*****************8.89***********8765515667****************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H niv y+G++ +e++++if+E+v+gGs+ss+++++g+l e+v++kytkqil+g+ayLHe

Q: 1120  HVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHE  1179

         ************************************************************

S: 120   kkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaae...lesltGtlaymaPEvi  176

         +++vHRDiKg+N++l+ +g++kl DFG++++la++  + ++   l+s++Gt+++maPEvi

Q: 1180  NCVVHRDIKGNNVMLMPTGIIKLIDFGCARHLAWAGLNGTHsdmLKSMHGTPYWMAPEVI  1239

         **********************************999988877899**************

S: 177   kkkekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakk.tkPeipeklsee  235

         +++  gygrk+DiWs+gc+v+em+tgk+P a++ +++a+mf +ga++  +P++p+++se+

Q: 1240  NES--GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGAHRgLMPPLPDHFSEN  1296

         988..****************************.9**********9979***********

S: 236   gkdflekcleldpkkrpsaeeLLkhefl  263

         + df++ cl++d+++rpsa +LLkh+fl

Q: 1297  AADFVRMCLTRDQHERPSALQLLKHSFL  1324

         **************************96

Domain Sequence
(FASTA)

WTKGEILGKG AYGTVYCGLT SQGQLIAVKQ VALDTSNKLA AEKEYRKLQE EVDLLKALKH 60

VNIVAYLGTC LQENTVSIFM EFVPGGSISS IINRFGPLPE MVFCKYTKQI LQGVAYLHEN 120

CVVHRDIKGN NVMLMPTGII KLIDFGCARH LAWAGLNGTH SDMLKSMHGT PYWMAPEVIN 180

ESGYGRKSDI WSIGCTVFEM ATGKPPLASM DRMAAMFYIG AHRGLMPPLP DHFSENAADF 240

VRMCLTRDQH ERPSALQLLK HSFL 264

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ptr:470547

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013