EKS-PAT-00316

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00316

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	309.7	1.5E-92	26	292	267

Status

Unreviewed

Ensembl Protein

ENSPTRP00000038973

UniProt Accession

H2QZG8;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000071909

Gene Synonyms/Alias

ENSG00000071909;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000012624	ENSPTRP00000038973	ENSPTRT00000050175

Organism

Pan troglodytes

Functional Description

Protein Length

1340

Protein Sequence
(FASTA)

KHLYGLFHYN PMMLGLESLP DPTDTWEIIE TIGKGTYGKV YKVTNKRDGS LAAVKILDPV 60

SDMDEEIEAE YNILPFLPNH PNVVKFYGMF YKADHCVGGQ LWLVLELCNG GSVTELVKGL 120

LRCGQRLDEA MISYILYGAL LGLQHLHNNR IIHRDVKGNN ILLTTEGGVK LVDFGVSAQL 180

TSTRLRRNTS VGTPFWMAPE VIACEQQYDS SYDARCDVWS LGITAIELGD GDPPLFDMHP 240

VKTLFKIPRN PPPTLLHPEN WCEEFNHFIS QCLIKDFERR PSVTHLLDHP FIKGVHGKVL 300

FLQKQLAKVL QDQKHQNPVA KTRHERMHTR RTYHVEDAEK YCLEDDLVNL EVLDEDTIIH 360

QLQKRYADLL IYTYVGDILI ALNPFQNLSI YSPQFSRLYH GVKRASNPPH IFASADAAYQ 420

CMVTLSKDQC IVISGESGSG KTESAHLIVQ HLTFLGKANN QTLREKILQV NSLVEAFGNS 480

CTAINDNSSR FGKYLEMMFT PTGVVMGARI SEYLLEKSRV IKQAAGEKNF HIFYYIYAGL 540

HHQKKLSDFR LPEEKPPRYI ADEAGRVMHD ITSKESYRRQ FEAIQHCFRI IGFTDKEVHS 600

VYRILAGILN IGNIEFAAIS SQHQTDKSEV PNAEALQNAA SVLCISPEEL QEALTSHCVV 660

TRGETIIRAN TVDRAADVRD AISKALYGRL FSWIVNRINT LLQPDKNICS AGGGMNVGIL 720

DIFGFENFQR NSFEQLCINI ANEQIQYYFN QHVFALEQME YQNEGIDAIP VEYEDNRPLL 780

DMFLQKPLGL LALLDEESRF PQATDQTLVD KFEDNLRCKY FWRPKGVELC FGIQHYAGKV 840

LYDASGVLEK NRDTLPADVV VVLRTSENKL LQQLFSIPLT KTGNLAQTRA RITVASRSLP 900

PHFSAGKAKV DTLEVIRHPE ETTNMKRQTV ASYFRYSLMD LLSKMVVGQP HFVRCIKPND 960

DREALQFSRE RVLAQLRSTG ILETVSIRRQ GYSHRILFEE FVKRYYYLAF TAHQTPLASK 1020

ESCVAILEKS RLDHWVLGKT KVFLKYYHVE QLNLLLREVI GRVVVLQAYT KGWLGARRYK 1080

RVREKREKGA IAIQSAWRGY DARRKFKKIS NRRNESAAHN QAGDTSNQSG GPHSPVAAGT 1140

RGSAEVQDCS EPGDHKVLRG SVHRRSHSQA ESNNGHTQSS SNSPAVTEKN GHSQAQSSPK 1200

GCDISAGHAN KHSVSGTDLL SSRICHPAPD QQGLSLWGAP QKPGSENGLA QKHRTPRRRC 1260

QQPKMLSSPE DTMYYNQLNG TLEYQGSKRK PRKLGQIKVL DGEDEYYKSL SPVDCIPEEN 1320

NSAHPSFFSS SSKGDSFAPH 1340

Nucleotide Sequence
(FASTA)

AAACATCTGT ATGGATTATT TCACTATAAT CCTATGATGC TTGGACTTGA ATCGCTTCCA 60

GATCCCACAG ACACCTGGGA AATTATAGAG ACCATTGGTA AAGGCACCTA TGGCAAAGTC 120

TACAAGGTAA CTAACAAGAG AGATGGGAGC CTGGCTGCAG TGAAAATTCT GGATCCAGTC 180

AGTGATATGG ATGAAGAAAT TGAGGCAGAA TACAACATTC TGCCGTTCCT TCCTAATCAT 240

CCCAATGTTG TAAAGTTTTA TGGGATGTTC TACAAAGCGG ATCACTGTGT AGGGGGACAG 300

CTGTGGCTGG TCCTGGAGCT GTGTAATGGG GGCTCAGTCA CTGAGCTTGT CAAAGGTCTA 360

CTCAGATGTG GCCAGCGGTT GGATGAAGCA ATGATCTCAT ACATCTTGTA CGGGGCCCTC 420

TTGGGCCTTC AGCATTTGCA CAACAACCGA ATCATCCACC GTGATGTGAA GGGGAATAAC 480

ATTCTTCTGA CAACAGAAGG AGGAGTTAAG CTCGTTGACT TTGGTGTTTC AGCTCAACTC 540

ACCAGTACAC GTCTGCGGAG AAACACATCT GTTGGTACCC CATTCTGGAT GGCCCCTGAG 600

GTCATTGCCT GTGAGCAGCA GTATGACTCT TCCTATGACG CTCGCTGTGA CGTCTGGTCC 660

TTGGGGATCA CAGCTATTGA ACTGGGGGAT GGAGACCCTC CCCTCTTTGA CATGCATCCT 720

GTGAAAACAC TCTTTAAGAT TCCAAGAAAT CCTCCACCTA CTTTACTTCA TCCAGAAAAT 780

TGGTGTGAAG AATTCAACCA CTTTATTTCA CAGTGTCTTA TTAAGGATTT TGAAAGGCGA 840

CCTTCCGTCA CACATCTCCT TGACCACCCA TTTATTAAAG GAGTACATGG AAAAGTTCTG 900

TTTCTGCAAA AACAGCTGGC CAAGGTTCTC CAAGACCAGA AGCATCAAAA TCCTGTTGCT 960

AAAACCAGGC ATGAGAGGAT GCATACCAGA AGAACTTATC ATGTGGAAGA TGCTGAAAAA 1020

TACTGCCTTG AGGATGATTT GGTCAACCTA GAGGTTCTGG ATGAGGATAC AATTATCCAT 1080

CAGTTGCAGA AACGTTATGC AGACTTGCTA ATTTACACAT ATGTTGGAGA CATCTTAATT 1140

GCCTTAAACC CCTTCCAGAA TCTAAGCATA TACTCTCCAC AGTTTTCCAG ACTTTATCAT 1200

GGGGTGAAAC GCGCCTCCAA TCCCCCCCAC ATATTTGCAT CAGCAGATGC TGCTTACCAG 1260

TGCATGGTTA CTCTCAGCAA AGACCAGTGC ATTGTCATCA GCGGAGAGAG TGGCTCTGGG 1320

AAGACAGAAA GCGCCCACCT GATTGTTCAG CATTTGACTT TCTTGGGAAA GGCCAATAAT 1380

CAGACCTTGA GAGAGAAAAT TCTACAAGTC AACTCCCTGG TGGAAGCCTT TGGGAACTCA 1440

TGCACTGCCA TCAATGACAA CTCGAGCCGT TTTGGGAAAT ATCTGGAAAT GATGTTTACA 1500

CCAACTGGAG TTGTGATGGG GGCAAGAATC TCTGAATATC TCCTTGAAAA ATCCAGAGTT 1560

ATAAAACAGG CAGCGGGAGA GAAAAATTTT CACATATTTT ACTATATTTA TGCTGGTCTT 1620

CATCACCAAA AGAAGCTTTC TGACTTCAGA CTTCCTGAGG AAAAACCTCC TAGGTACATA 1680

GCTGATGAAG CTGGAAGGGT GATGCACGAC ATAACTTCCA AGGAGTCTTA CAGAAGACAA 1740

TTCGAAGCAA TTCAGCATTG CTTCAGGATT ATAGGGTTCA CGGACAAAGA GGTGCACTCA 1800

GTGTACAGAA TTTTGGCTGG GATTTTGAAT ATTGGGAACA TTGAGTTTGC AGCTATTTCC 1860

TCTCAACATC AGACTGATAA AAGTGAGGTG CCCAATGCTG AAGCTTTGCA AAATGCTGCC 1920

TCTGTTCTGT GCATTAGCCC TGAAGAGCTC CAGGAGGCCC TCACCTCCCA CTGTGTGGTC 1980

ACCCGGGGCG AGACCATCAT CCGTGCCAAC ACTGTAGACA GGGCTGCGGA CGTTCGAGAC 2040

GCCATATCCA AAGCCCTGTA TGGGAGGCTC TTCAGCTGGA TTGTGAATCG CATTAATACA 2100

CTCCTGCAGC CAGACAAAAA CATATGTAGT GCAGGAGGTG GAATGAATGT GGGGATCTTG 2160

GATATCTTTG GATTCGAGAA TTTTCAGAGA AATTCATTTG AGCAGCTCTG CATAAACATC 2220

GCCAATGAGC AAATCCAGTA CTATTTCAAT CAGCATGTTT TTGCTCTTGA GCAGATGGAA 2280

TATCAGAATG AAGGCATTGA TGCTATACCC GTGGAATATG AGGACAACCG CCCGCTCTTG 2340

GACATGTTCC TCCAGAAACC CCTGGGACTG CTTGCACTTC TGGATGAGGA AAGTCGGTTT 2400

CCCCAAGCAA CTGACCAGAC CCTGGTTGAT AAATTTGAAG ATAATCTACG ATGCAAATAC 2460

TTCTGGAGGC CCAAAGGAGT GGAACTGTGC TTTGGCATTC AGCATTATGC TGGAAAGGTA 2520

TTATATGATG CTTCTGGGGT TCTTGAGAAA AATAGAGACA CTCTCCCTGC CGATGTGGTT 2580

GTGGTCCTGA GAACGTCAGA AAACAAGCTT CTTCAGCAGC TCTTCTCAAT CCCTCTGACC 2640

AAAACAGGTA ATTTGGCCCA GACAAGAGCT AGGATAACAG TGGCCTCAAG ATCTTTGCCT 2700

CCACATTTCA GTGCTGGGAA AGCCAAGGTG GACACTCTGG AGGTGATACG GCATCCGGAA 2760

GAAACCACCA ACATGAAGAG GCAAACTGTG GCTTCTTACT TCCGGTATTC TCTGATGGAC 2820

CTGCTCTCCA AAATGGTGGT TGGACAGCCC CACTTTGTGC GCTGCATTAA ACCCAATGAT 2880

GACCGAGAGG CCCTGCAGTT CTCTCGAGAG AGGGTGCTGG CCCAGCTCCG CTCCACAGGG 2940

ATTCTGGAGA CAGTCAGCAT CCGCCGCCAG GGCTATTCCC ACCGCATCCT TTTTGAAGAA 3000

TTTGTGAAAA GGTATTATTA CTTGGCATTC ACAGCACATC AAACACCTCT TGCTAGCAAA 3060

GAGAGCTGTG TGGCTATCTT GGAAAAGTCC AGATTAGATC ACTGGGTGCT GGGAAAAACA 3120

AAGGTTTTTC TCAAATATTA CCATGTTGAG CAATTAAATT TGCTGCTTCG AGAAGTCATA 3180

GGCAGAGTGG TTGTGCTGCA GGCATATACC AAGGGGTGGC TTGGAGCCAG GAGATACAAA 3240

AGGGTCAGAG AGAAGAGAGA GAAGGGAGCC ATTGCCATCC AGTCAGCCTG GAGAGGATAT 3300

GATGCTCGGA GGAAATTTAA GAAAATAAGC AACAGAAGGA ATGAGTCTGC TGCTCATAAT 3360

CAAGCAGGGG ACACTTCAAA CCAAAGCGGT GGGCCACATT CCCCCGTCGC AGCAGGTACG 3420

AGGGGAAGTG CCGAGGTTCA AGACTGCAGC GAGCCTGGTG ACCATAAAGT TCTCAGGGGC 3480

TCTGTACATC GTAGAAGCCA TTCACAAGCA GAATCCAACA ATGGCCATAC ACAGAGTTCA 3540

AGCAACTCTC CTGCTGTCAC AGAGAAAAAT GGGCATTCAC AAGCCCAGAG TTCTCCAAAA 3600

GGGTGCGATA TCTCCGCAGG ACATGCAAAC AAGCACTCGG TTTCTGGGAC TGATTTGCTG 3660

TCTTCTCGGA TATGCCATCC TGCTCCAGAT CAGCAAGGAT TGAGTCTCTG GGGAGCCCCT 3720

CAAAAGCCTG GTTCAGAAAA TGGTCTTGCA CAGAAGCATC GAACACCTCG CCGACGATGT 3780

CAGCAGCCCA AAATGCTGAG TAGCCCTGAG GACACCATGT ACTATAACCA GTTAAATGGA 3840

ACTCTAGAAT ATCAAGGGAG CAAGAGGAAG CCAAGAAAAC TTGGCCAAAT CAAAGTACTT 3900

GATGGGGAAG ATGAATATTA CAAATCTCTG TCACCAGTGG ACTGTATCCC TGAGGAGAAC 3960

AACTCAGCCC ACCCTTCCTT TTTTTCTTCA TCCTCAAAAG GAGACTCTTT TGCTCCACAT 4020

TAA 4023

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkkl.khpniv  59

         +e++e+igkG++gkvy+ ++k+ g+l+a+k+++  + ++ ee++ e+++l  l +hpn+v

Q: 26    WEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVS-DMDEEIEAEYNILPFLpNHPNVV  84

         799******************************998.9************998356****

S: 60    eylesflk.....eeelwlvmeylagGslsdlvk..eelkselkEeqiayilrevlkaLe  112

         +++++f+k       +lwlv+e+++gGs+++lvk    + ++l+E  i+yil ++l +L+

Q: 85    KFYGMFYKadhcvGGQLWLVLELCNGGSVTELVKglLRCGQRLDEAMISYILYGALLGLQ  144

         *******99888889*******************777899********************

S: 113   ylHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaq  172

         +lH++++iHrd+k++niLlt+eg VkL+dfgv+aql++tr +r+t vgtp+wmAPEvia+

Q: 145   HLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIAC  204

         ************************************************************

S: 173   e...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfske  229

         e   +++Yd+++D+wslGItaiel +g+pP++d++p+k l+ki++n+pp+l +++++++e

Q: 205   EqqyDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPENWCEE  264

         9888899*****************************************************

S: 230   fkefvekclqknpekRpsasellkhkFl  257

         f++f+++cl k++e+Rps+++ll+h+F+

Q: 265   FNHFISQCLIKDFERRPSVTHLLDHPFI  292

         ***************************7

Domain Sequence
(FASTA)

WEIIETIGKG TYGKVYKVTN KRDGSLAAVK ILDPVSDMDE EIEAEYNILP FLPNHPNVVK 60

FYGMFYKADH CVGGQLWLVL ELCNGGSVTE LVKGLLRCGQ RLDEAMISYI LYGALLGLQH 120

LHNNRIIHRD VKGNNILLTT EGGVKLVDFG VSAQLTSTRL RRNTSVGTPF WMAPEVIACE 180

QQYDSSYDAR CDVWSLGITA IELGDGDPPL FDMHPVKTLF KIPRNPPPTL LHPENWCEEF 240

NHFISQCLIK DFERRPSVTH LLDHPFI 267

Keyword

ATP-binding; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016459	; C:myosin complex
GO:0005524	; F:ATP binding
GO:0003774	; F:motor activity
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000048	; IQ_motif_EF-hand-BS.
IPR011009	; Kinase-like_dom.
IPR001609	; Myosin_head_motor_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00612	; IQ; 1.
PF00063	; Myosin_head; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00015	; IQ; 2.
SM00242	; MYSc; 1.
SM00220	; S_TKc; 1.

Prosites

PS50096	; IQ; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00193

; MYOSINHEAVY.

Created Date

20-Feb-2013