EKS-PAT-00282

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00282

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	501.3	4.8E-151	692	949	258

Status

Unreviewed

Ensembl Protein

ENSPTRP00000022026

UniProt Accession

H2QJC5;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000178568

Gene Synonyms/Alias

ENSG00000178568;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000012883	ENSPTRP00000022026	ENSPTRT00000023888

Organism

Pan troglodytes

Functional Description

Protein Length

1282

Protein Sequence
(FASTA)

AVCAGTENKL SSLSDLEQQY RALRKYYENC EVVMGNLEIT SIEHNRDLSF LRSVREVTGY 60

VLVALNQFRY LPLENLRIIR GTKLYEDRYA LAIFLNYRKD GNFGLQELGL KNLTEILNGG 120

VYVDQNKFLC YADTIHWQDI VRNPWPSNLT LVSTNGSSGC GRCHKSCTGR CWGPTENHCQ 180

TLTRTVCAEQ CDGRCYGPYV SDCCHRECAG GCSGPKDTDC FACMNFNDSG ACVTQCPQTF 240

VYNPTTFQLE HNFNAKYTYG AFCVKKCPHN FVVDSSSCVR ACPSSKMEVE ENGIKMCKPC 300

TDICPKACDG IGTGSLMSAQ TVDSSNIDKF INCTKINGNL IFLVTGIHGD PYNAIEAIDP 360

EKLNVFRTVR EITGFLNIQS WPPNMTDFSV FSNLVTIGGR VLYSGLSLLI LKQQGITSLQ 420

FQSLKEISAG NIYITDNSNL CYYHTINWTT LFSTINQRIV IRDNRKAENC TAEGMVCNHL 480

CSSDGCWGPG PDQCLLCRRF SRGRICIESC NLYDGEFREF ENGSICVECD PQCEKMEDGL 540

LTCHGPGPDN CTKCSHFKDG PNCVEKCPDG LQGANSFIFK YADPDRECHP CHPNCTQGCN 600

GPTSHDCIYY PWTGHSTLPQ HARTPLIAAG VIGGLFILVI VGLTFAVYVR RKSIKKKRAL 660

RRFLETELVE PLTPSGTAPN QAQLRILKET ELKRVKVLGS GAFGTVYKGI WVPEGETVKI 720

PVAIKILNET TGPKANVEFM DEALIMASMD HPHLVRLLGV CLSPTIQLVT QLMPHGCLLE 780

YVHEHKDNIG SQLLLNWCVQ IAKGMMYLEE RRLVHRDLAA RNVLVKSPNH VKITDFGLAR 840

LLEGDEKEYN ADGGKMPIKW MALECIHYRK FTHQSDVWSY GVTIWELMTF GGKPYDGIPT 900

REIPDLLEKG ERLPQPPICT IDVYMVMVKC WMIDADSRPK FKELAAEFSR MARDPQRYLV 960

IQGDDRMKLP SPNDSKFFQN LLDEEDLEDM MDAEEYLVPQ AFNIPPPIYT SRARIDSNRS 1020

EIGHSPPPAY TPMSGNQFVY RDGGFAAEQG VSVPYRAPTS TIPEAPVAQG ATAEIFDDSC 1080

CNGTLRKPVA PHVQEDSSTQ RYSADPTVFA PERSPRGELD EEGYMTPMRD KPKQEYLNPV 1140

EENPFVSRRK NGDLQALDNP EYHNASNGPP KAEDEYVNEP LYLNTFANTL GKAEYLKNNI 1200

LSMPEKAKKA FDNPDYWNHS LPPRSTLQHP DYLQEYSTKY FYKQNGRIRP IVAENPEYLS 1260

EFSLKPGTVL PPPPYRHRNT VV 1282

Nucleotide Sequence
(FASTA)

GCAGTGTGTG CAGGAACGGA GAATAAACTG AGCTCTCTCT CTGACCTGGA ACAGCAGTAC 60

CGAGCCTTGC GCAAGTACTA TGAAAACTGT GAGGTTGTCA TGGGCAACCT GGAGATAACC 120

AGCATTGAGC ACAACCGGGA CCTCTCCTTC CTGCGGTCTG TTCGAGAAGT CACAGGCTAC 180

GTGTTAGTGG CTCTTAATCA GTTTCGTTAC CTGCCTCTGG AGAATTTACG CATTATTCGT 240

GGGACAAAAC TTTATGAGGA TCGATATGCC TTGGCAATAT TTTTAAACTA CAGAAAAGAT 300

GGAAACTTTG GACTTCAAGA ACTTGGATTA AAGAACTTGA CAGAAATCCT AAATGGTGGA 360

GTCTATGTAG ACCAGAACAA ATTCCTTTGT TACGCAGACA CCATTCATTG GCAAGATATT 420

GTTCGGAACC CATGGCCTTC CAACTTGACT CTCGTGTCAA CAAATGGTAG TTCAGGATGT 480

GGACGTTGCC ATAAGTCCTG TACTGGCCGT TGCTGGGGAC CCACAGAAAA TCATTGCCAG 540

ACTTTGACAA GGACGGTGTG TGCAGAACAA TGTGACGGCA GATGCTACGG ACCTTACGTC 600

AGTGACTGCT GCCATCGAGA ATGTGCTGGA GGCTGCTCAG GACCTAAGGA CACAGACTGC 660

TTTGCCTGCA TGAATTTCAA TGACAGTGGA GCATGTGTTA CTCAGTGTCC CCAAACCTTT 720

GTTTACAATC CAACCACTTT TCAACTGGAG CACAATTTCA ATGCAAAGTA CACATATGGA 780

GCATTCTGTG TCAAGAAATG TCCACATAAC TTTGTGGTAG ATTCCAGTTC TTGTGTGCGT 840

GCCTGCCCTA GTTCCAAGAT GGAAGTAGAA GAAAATGGGA TTAAAATGTG TAAACCTTGC 900

ACTGACATTT GCCCAAAAGC TTGTGATGGC ATTGGCACAG GATCATTGAT GTCAGCTCAG 960

ACTGTGGATT CCAGTAACAT TGACAAATTC ATAAACTGTA CCAAGATCAA TGGGAATTTG 1020

ATCTTTCTAG TCACTGGTAT TCATGGGGAC CCTTACAATG CAATTGAAGC CATAGACCCA 1080

GAGAAACTGA ATGTCTTTCG GACCGTCAGA GAGATAACAG GTTTCCTGAA CATACAGTCA 1140

TGGCCACCAA ACATGACTGA CTTCAGTGTT TTTTCTAACC TGGTGACCAT TGGTGGAAGA 1200

GTACTCTATA GTGGCCTGTC CTTGCTTATC CTCAAGCAAC AGGGCATCAC CTCTCTACAG 1260

TTCCAGTCCC TGAAGGAAAT CAGCGCAGGA AACATCTATA TTACTGACAA CAGCAACCTG 1320

TGTTATTATC ATACCATTAA CTGGACAACA CTCTTCAGCA CAATCAACCA AAGAATAGTA 1380

ATCCGGGACA ATAGAAAAGC TGAAAATTGT ACTGCTGAAG GAATGGTGTG CAACCATCTG 1440

TGTTCCAGTG ATGGCTGTTG GGGACCTGGG CCAGACCAAT GTCTGTTGTG TCGCCGCTTC 1500

AGTAGAGGAA GGATCTGCAT AGAGTCTTGT AACCTCTATG ATGGTGAATT TCGGGAGTTT 1560

GAGAATGGCT CCATCTGTGT GGAGTGTGAC CCCCAGTGTG AGAAGATGGA AGATGGCCTC 1620

CTCACATGCC ATGGACCGGG TCCTGACAAC TGTACGAAGT GCTCTCATTT TAAAGATGGC 1680

CCAAACTGTG TGGAAAAATG TCCAGATGGC TTACAGGGGG CAAACAGTTT CATTTTCAAG 1740

TATGCTGATC CAGATCGGGA GTGCCACCCA TGCCATCCAA ACTGCACCCA AGGGTGTAAC 1800

GGTCCTACTA GTCATGACTG CATTTACTAC CCATGGACGG GCCATTCCAC TTTACCACAA 1860

CATGCTAGAA CTCCCCTGAT TGCAGCTGGA GTAATTGGTG GGCTCTTCAT TCTGGTCATT 1920

GTGGGTCTGA CATTTGCTGT TTATGTTAGA AGGAAGAGCA TCAAAAAGAA AAGAGCCTTG 1980

AGAAGATTCT TGGAAACAGA GTTGGTGGAA CCATTAACTC CCAGTGGCAC AGCACCCAAT 2040

CAAGCTCAAC TTCGTATTTT GAAAGAAACT GAGCTGAAGA GGGTGAAAGT CCTTGGCTCA 2100

GGTGCTTTTG GAACGGTTTA TAAAGGTATT TGGGTACCTG AAGGAGAAAC TGTGAAGATT 2160

CCTGTGGCTA TTAAGATTCT TAATGAGACA ACTGGTCCCA AGGCAAATGT GGAGTTCATG 2220

GATGAAGCTC TGATCATGGC AAGTATGGAT CATCCACACC TAGTCCGGTT GCTGGGTGTG 2280

TGTCTGAGCC CAACCATCCA GCTGGTTACT CAACTTATGC CCCATGGCTG CCTGTTGGAG 2340

TATGTCCACG AGCACAAGGA TAACATTGGA TCACAACTGC TGCTTAACTG GTGTGTCCAG 2400

ATAGCTAAGG GAATGATGTA CCTGGAAGAA AGACGACTCG TTCATCGGGA TTTGGCAGCC 2460

CGTAATGTCT TAGTGAAATC TCCAAACCAT GTGAAAATCA CAGATTTTGG GCTAGCCAGA 2520

CTCTTGGAAG GAGATGAAAA AGAGTACAAT GCTGATGGAG GAAAGATGCC AATTAAATGG 2580

ATGGCTCTGG AGTGTATACA TTACAGGAAA TTCACCCATC AGAGTGACGT TTGGAGCTAT 2640

GGAGTTACTA TATGGGAACT GATGACCTTT GGAGGAAAAC CCTATGATGG AATTCCAACG 2700

CGAGAAATCC CTGATTTATT AGAGAAAGGA GAACGTTTGC CTCAGCCTCC CATCTGCACT 2760

ATTGACGTTT ACATGGTCAT GGTCAAATGT TGGATGATTG ATGCTGACAG TAGACCTAAA 2820

TTTAAGGAAC TGGCTGCTGA GTTTTCAAGG ATGGCTCGAG ACCCTCAAAG ATACCTAGTT 2880

ATTCAGGGTG ATGATCGTAT GAAGCTTCCC AGTCCAAATG ACAGCAAGTT CTTTCAGAAT 2940

CTCTTGGATG AAGAGGATTT GGAAGATATG ATGGATGCTG AGGAGTACTT GGTCCCTCAG 3000

GCTTTCAACA TCCCACCTCC CATCTATACT TCCAGAGCAA GAATTGACTC GAATAGGAGT 3060

GAAATTGGAC ACAGCCCTCC TCCTGCCTAC ACCCCCATGT CAGGAAACCA GTTTGTATAC 3120

CGAGATGGAG GTTTTGCTGC TGAACAAGGA GTGTCTGTGC CCTACAGAGC CCCAACTAGC 3180

ACAATTCCAG AAGCTCCTGT GGCACAGGGT GCTACTGCTG AGATTTTTGA TGACTCCTGC 3240

TGTAATGGCA CCCTACGCAA GCCAGTGGCA CCCCATGTCC AAGAGGACAG TAGCACCCAG 3300

AGGTACAGTG CTGACCCCAC CGTGTTTGCC CCAGAACGGA GCCCACGAGG AGAGCTGGAT 3360

GAGGAAGGTT ACATGACTCC TATGCGAGAC AAACCCAAAC AAGAATACCT AAATCCAGTG 3420

GAGGAGAACC CTTTTGTTTC TCGGAGAAAA AATGGAGACC TTCAAGCATT GGATAATCCC 3480

GAATATCACA ATGCATCCAA TGGTCCACCC AAGGCCGAGG ATGAGTATGT GAACGAGCCA 3540

CTGTACCTCA ACACCTTTGC CAACACCTTG GGAAAAGCTG AGTACCTGAA GAACAACATA 3600

CTGTCAATGC CAGAGAAGGC CAAGAAAGCG TTTGACAACC CTGACTACTG GAACCACAGC 3660

CTGCCACCTC GGAGCACCCT TCAGCACCCA GACTACCTGC AGGAGTACAG CACAAAATAT 3720

TTTTATAAAC AGAATGGGCG GATCCGGCCT ATTGTGGCAG AGAATCCTGA ATACCTCTCT 3780

GAGTTCTCCC TGAAGCCAGG CACTGTGCTG CCGCCTCCAC CTTACAGACA CCGGAATACT 3840

GTGGTGTAA 3849

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         lk++kvlGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as+dh

Q: 692   LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDH  751

         699*********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         ++lvrllg+cls t+qlvtql+p+Gcll+yv+ehkd++Gsq llnwcvqiakGm+ylee+

Q: 752   PHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  811

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlvkspnhvkitdfGla+lle deke++a+ggk+pikw+ale+i++rk+

Q: 812   RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF  871

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvt+wel+tfG kpydgip++eipdllekGerl+qppictidvymv+vkcw

Q: 872   THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW  931

         ************************************************************

S: 241   midaesrpkfkelaeefs  258

         mida+srpkfkela+efs

Q: 932   MIDADSRPKFKELAAEFS  949

         ****************96

Domain Sequence
(FASTA)

LKRVKVLGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD EALIMASMDH 60

PHLVRLLGVC LSPTIQLVTQ LMPHGCLLEY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120

RLVHRDLAAR NVLVKSPNHV KITDFGLARL LEGDEKEYNA DGGKMPIKWM ALECIHYRKF 180

THQSDVWSYG VTIWELMTFG GKPYDGIPTR EIPDLLEKGE RLPQPPICTI DVYMVMVKCW 240

MIDADSRPKF KELAAEFS 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 5.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013