EKS-PAT-00411

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00411

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	328.4	3.4E-98	4	254	251

Status

Unreviewed

Ensembl Protein

ENSPTRP00000022091

UniProt Accession

H2QJF4;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000163482

Gene Synonyms/Alias

ENSG00000163482;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000012926	ENSPTRP00000022091	ENSPTRT00000023958

Organism

Pan troglodytes

Functional Description

Protein Length

1315

Protein Sequence
(FASTA)

MEKYHVLEMI GEGSFGRVYK GRRKYSAQVV ALKFIPKLGR SEKELRNLQR EIEIMRGLRH 60

PNIVHMLDSF ETDKEVVVVT DYAEGELFQI LEDDGKLPED QVQAIAAQLV SALYYLHSHR 120

ILHRDMKPQN ILLAKGGGIK LCDFGFARAM STNTMVLTSI KGTPLYMSPE LVEERPYDHT 180

ADLWSVGCIL YELAVGTPPF YATSIFQLVS LILKDPVRWP STISPCFKNF LQGLLTKDPR 240

QRLSWPDLLY HPFIAGHVTI ITESAGPDLG TPFTSRLPPE LQVLKDEQAH RLAPKGNQSR 300

ILTQAYKRMA EEAMQKKHQN TGPALEQEDK TSKVAPGTAP LPRLGATPQE SSLLAGILAS 360

ELKSSWAESG TGEVPSAPRE NRTTPDCERA FPEERPEVLG QRSTDVVDLE NEEPDSDNEW 420

QHLLETTEPV PIQLKAPLTL LCNPDFCQRI QSQLHEAGGQ ILKGILEGAS HILPAFRVLS 480

SLLSSCSDSV ALYSFCREAG LPGLLLSLLR HSQESNSLQQ QSWYGTFLRD LMAVIQAYFA 540

CTFNLERSQT NDSLQVFQEA ANLFLDLLGK LLAQPDDSEQ TLRRDSLMCF TVLCEAMDGN 600

SRAISKAFYS SLLTTQQVVL DGLLHGLTVP QLPVHTPPGA PQVSQPLREQ SEDIPGAISS 660

ALAAICTAPV GLPDCWDAKE QVCWHLANQL TEDSSQLRPS LISGLQHPIL CLHLLKVLYS 720

CCLVSEGLCR LLGQEPLALE SLFMLIQGKV KVVDWEESTE VTLYFLSLLV FRLQNLPCGM 780

EKLGSDVATL FTHSHVVSLV SAAACLLGQL GQQGVTFDLQ PMEWMAAATH ALSAPAEVRL 840

TPPGSCGFYD GLLILLLQLL TEQGKASLIR DMCSSEMWTV LWHRFSMVLR LPEEASAQEG 900

ELSLSSPPSP EPDWTLISPQ GMAALLSLAM ATFTQEPQLC LSCLSQHGSI LMSILKHLLC 960

PSFLNQLRQA PHGSEFLPVV VLSVCQLLCF PFALDMDADL LIGVLADLRD SEVAAHLLQV 1020

CCYHLPLMQV ELPISLLTRL ALMDPTSLNQ FVNTVSASPR TIVSFLSVAL LSDQPLLTSD 1080

LLSLLAHTAR VLSPSHLSFI QELLAGSDES YRPLRSLLGH PENSVRAHTY RLLGHLLQHS 1140

MALRGALQSQ SGLLSLLLLG LGDKDPFVRC SASFAVGNAA YQAGLLRPAL AAAVPSMTQL 1200

LGDPQAGIRR NVASALGNLG PEGLGEELLQ CEVPQRLLEM ACGDPQPNVK EAALIALRSL 1260

QQEPGIHQVL VSLGASEKLS LLSLGNQSLP HSSPRPASAK HCRKLIHLLR PAHSM 1315

Nucleotide Sequence
(FASTA)

ATGGAAAAGT ACCACGTGTT GGAGATGATT GGAGAAGGCT CTTTTGGGAG GGTGTACAAG 60

GGTCGAAGAA AATACAGTGC TCAGGTCGTG GCCCTGAAGT TCATCCCAAA ATTGGGGCGC 120

TCAGAGAAGG AGCTGAGGAA TTTGCAACGA GAGATTGAAA TAATGCGGGG TCTGCGGCAT 180

CCCAACATTG TGCATATGCT TGACAGCTTT GAAACTGATA AAGAGGTGGT GGTGGTGACA 240

GACTATGCTG AGGGAGAGCT CTTTCAGATC CTAGAAGATG ACGGAAAACT TCCTGAAGAC 300

CAGGTTCAGG CCATTGCTGC CCAGTTGGTG TCAGCCCTGT ACTATCTGCA TTCCCACCGC 360

ATCCTACACC GAGACATGAA GCCTCAGAAC ATCCTCCTCG CCAAGGGTGG TGGCATCAAG 420

CTCTGTGACT TTGGATTTGC CCGGGCTATG AGCACCAATA CAATGGTGCT GACATCCATC 480

AAAGGCACAC CACTCTATAT GTCTCCAGAG CTGGTGGAGG AGCGACCATA CGACCACACA 540

GCGGACCTCT GGTCTGTTGG CTGCATACTA TATGAACTGG CAGTAGGCAC CCCTCCCTTC 600

TATGCTACAA GCATCTTTCA GCTGGTCAGC CTCATTCTCA AGGACCCTGT GCGCTGGCCC 660

TCAACCATCA GTCCCTGCTT TAAGAACTTC CTGCAGGGAC TGCTCACCAA AGACCCACGG 720

CAGCGACTGT CCTGGCCAGA CCTCTTATAT CACCCCTTTA TTGCTGGTCA TGTCACCATA 780

ATAACTGAGT CAGCAGGCCC AGATTTGGGG ACCCCATTCA CCAGCCGCCT ACCCCCAGAA 840

CTTCAGGTCC TAAAGGACGA ACAGGCCCAT CGGTTGGCCC CCAAGGGTAA TCAGTCTCGC 900

ATCTTGACTC AGGCCTATAA ACGCATGGCT GAGGAGGCCA TGCAGAAGAA ACATCAGAAT 960

ACAGGACCTG CCCTTGAGCA AGAGGACAAG ACCAGCAAGG TGGCTCCTGG CACAGCCCCT 1020

CTGCCCAGAC TCGGGGCCAC TCCTCAGGAA TCAAGCCTCC TGGCCGGGAT CTTAGCCTCA 1080

GAATTGAAGA GCAGCTGGGC TGAGTCAGGG ACTGGAGAGG TGCCCTCTGC ACCTCGGGAA 1140

AACCGGACCA CCCCAGACTG TGAACGAGCA TTCCCAGAGG AGAGGCCAGA GGTGCTGGGC 1200

CAGCGGAGCA CTGATGTAGT GGACCTGGAA AATGAGGAGC CAGACAGTGA CAATGAGTGG 1260

CAGCACCTGC TAGAGACCAC TGAGCCTGTG CCTATTCAAC TGAAGGCTCC TCTCACCTTG 1320

CTGTGTAATC CTGACTTCTG CCAGCGCATC CAGAGTCAGC TGCATGAAGC TGGAGGGCAG 1380

ATCCTGAAAG GCATCTTGGA GGGTGCTTCC CACATCCTGC CTGCATTCCG GGTCCTGAGC 1440

AGTCTTCTCT CCAGCTGCAG TGACTCTGTT GCCTTGTATT CCTTCTGCCG GGAGGCAGGG 1500

CTTCCTGGGC TGCTGCTGAG TCTACTCAGG CACAGTCAGG AGAGCAACAG CCTCCAGCAG 1560

CAATCTTGGT ATGGGACCTT CTTACGGGAC CTGATGGCTG TGATTCAGGC CTACTTTGCC 1620

TGTACCTTCA ATCTGGAGAG GAGCCAGACA AATGACAGCC TGCAGGTGTT TCAGGAGGCT 1680

GCCAACCTTT TTCTGGACCT GTTGGGGAAA CTGCTGGCCC AACCAGATGA CTCTGAGCAG 1740

ACTTTGCGGA GGGACAGCCT TATGTGCTTT ACTGTCCTGT GCGAAGCCAT GGATGGGAAC 1800

AGCCGGGCCA TCTCCAAAGC CTTTTACTCC AGCTTGCTGA CGACACAGCA GGTTGTCTTG 1860

GATGGGCTCC TTCATGGCTT GACAGTTCCA CAGCTCCCTG TCCACACTCC CCCAGGAGCC 1920

CCGCAAGTGA GCCAGCCACT GCGAGAGCAG AGTGAGGATA TACCTGGAGC CATTTCCTCT 1980

GCCCTGGCAG CCATATGCAC TGCTCCTGTG GGACTGCCCG ACTGCTGGGA TGCCAAGGAG 2040

CAGGTCTGTT GGCATTTGGC AAATCAGCTA ACTGAAGACA GCAGCCAGCT CAGGCCATCC 2100

CTCATCTCTG GCCTGCAGCA TCCCATCCTG TGCCTGCACC TTCTCAAGGT TCTATACTCC 2160

TGCTGCCTTG TCAGTGAGGG CCTGTGCCGT CTTCTGGGGC AGGAGCCCCT GGCCTTGGAA 2220

TCCCTGTTTA TGTTGATTCA GGGCAAGGTA AAAGTAGTAG ATTGGGAAGA GTCTACTGAA 2280

GTGACACTCT ACTTCCTCTC CCTTCTTGTC TTTCGGCTCC AAAACCTGCC TTGTGGAATG 2340

GAGAAGCTAG GCAGTGACGT TGCTACTCTC TTTACCCATT CGCATGTCGT CTCTCTTGTG 2400

AGTGCAGCAG CCTGTCTATT GGGACAGCTT GGTCAGCAAG GGGTGACCTT TGACCTCCAG 2460

CCCATGGAAT GGATGGCTGC AGCCACACAT GCCTTGTCTG CCCCTGCAGA GGTTCGGTTG 2520

ACTCCACCAG GTAGTTGTGG ATTCTATGAT GGCCTCCTTA TCCTTCTGTT GCAGCTCCTC 2580

ACTGAGCAGG GGAAGGCTAG CCTAATCAGG GATATGTGCA GTTCAGAAAT GTGGACCGTT 2640

TTGTGGCACC GCTTCTCCAT GGTCCTGAGG CTCCCCGAGG AGGCATCTGC ACAGGAAGGG 2700

GAGCTTTCGC TATCCAGTCC ACCAAGCCCT GAGCCAGACT GGACACTGAT TTCTCCCCAG 2760

GGCATGGCAG CCCTGCTGAG CCTGGCCATG GCCACCTTTA CCCAGGAGCC CCAGTTATGC 2820

CTGAGCTGCC TGTCCCAGCA TGGAAGTATC CTCATGTCCA TCCTGAAGCA TCTGCTTTGC 2880

CCCAGCTTCC TGAATCAACT GCGCCAGGCG CCTCATGGGT CTGAGTTTCT CCCTGTCGTG 2940

GTGCTCTCTG TCTGCCAGCT CCTTTGCTTC CCCTTTGCGC TGGACATGGA TGCTGACCTC 3000

CTTATAGGTG TCTTGGCCGA CCTCAGGGAC TCAGAAGTTG CAGCCCATCT GCTGCAGGTC 3060

TGCTGCTACC ATCTTCCGTT GATGCAAGTG GAGCTGCCCA TCAGCCTTCT CACACGCCTG 3120

GCCCTCATGG ATCCCACCTC TCTCAACCAG TTTGTGAACA CAGTGTCTGC CTCCCCTAGA 3180

ACCATCGTCT CATTTCTCTC AGTTGCCCTC CTGAGTGACC AGCCACTGCT GACCTCCGAC 3240

CTTCTCTCTC TGCTGGCCCA TACTGCCAGG GTCCTGTCTC CCAGCCACTT GTCCTTTATC 3300

CAAGAGCTTC TGGCTGGCTC TGATGAATCC TATCGGCCCC TGCGCAGCCT CCTGGGCCAC 3360

CCAGAGAATT CTGTGCGGGC ACACACTTAT AGGCTCCTGG GACACTTGCT CCAACACAGC 3420

ATGGCCCTGC GTGGGGCACT GCAGAGCCAG TCTGGACTGC TCAGCCTTCT GCTGCTTGGG 3480

CTTGGAGACA AGGATCCTTT TGTGCGGTGC AGTGCCAGCT TCGCTGTGGG CAATGCAGCC 3540

TACCAGGCTG GTCTTCTGAG ACCTGCCCTG GCAGCTGCAG TGCCCAGTAT GACCCAGCTG 3600

CTTGGAGATC CTCAGGCTGG TATCCGGCGC AATGTTGCAT CAGCTCTGGG CAACTTGGGA 3660

CCTGAAGGTT TGGGAGAGGA GCTGTTACAG TGCGAAGTAC CCCAGCGGCT CCTAGAAATG 3720

GCATGTGGAG ACCCCCAGCC AAATGTGAAG GAGGCTGCCC TCATTGCCCT CCGGAGCCTG 3780

CAACAGGAGC CTGGCATCCA TCAGGTACTG GTGTCCCTGG GTGCCAGTGA GAAACTATCC 3840

TTGCTCTCTC TGGGGAATCA GTCACTGCCA CACAGCAGTC CTAGGCCTGC CTCTGCCAAA 3900

CACTGCAGGA AACTCATTCA CCTCCTGAGG CCAGCCCATA GCATGTGA 3948

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkkl.kkslenlekeikilkelkhen  59

         y++ e+iG+Gsf+ vykgr rk ++qvvA+k++ k ++ +k+l+nl++ei+i++ l+h+n

Q: 4     YHVLEMIGEGSFGRVYKGR-RKYSAQVVALKFIPKLGRsEKELRNLQREIEIMRGLRHPN  62

         8999***************.******************9*********************

S: 60    ivalldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskki  119

         iv++ld++et+kev++v++y++ g+L ++l+++++L+ed+v+++++ql+sal++Lhs++i

Q: 63    IVHMLDSFETDKEVVVVTDYAE-GELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRI  121

         **********************.*************************************

S: 120   vhrDlkPqniLlsyadakkelkkvtlkladFglarvlkeesma.atlkGsplYmaPEvvk  178

         +hrD+kPqniLl+        k +++kl+dFg+ar++++++m  +++kG+plYm+PE+v+

Q: 122   LHRDMKPQNILLA--------KGGGIKLCDFGFARAMSTNTMVlTSIKGTPLYMSPELVE  173

         *************........89********************9****************

S: 179   eqqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdl  238

         e+ yd++aDlWS+G+ilyel+vG+pPf+a+si++Lv+ i k++v   ++p++is+++k++

Q: 174   ERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPV---RWPSTISPCFKNF  230

         ********************************************...*************

S: 239   lqsLLqrdpkkRisfeelfahpfl  262

         lq+LL++dp++R+s+ +l+ hpf+

Q: 231   LQGLLTKDPRQRLSWPDLLYHPFI  254

         **********************96

Domain Sequence
(FASTA)

YHVLEMIGEG SFGRVYKGRR KYSAQVVALK FIPKLGRSEK ELRNLQREIE IMRGLRHPNI 60

VHMLDSFETD KEVVVVTDYA EGELFQILED DGKLPEDQVQ AIAAQLVSAL YYLHSHRILH 120

RDMKPQNILL AKGGGIKLCD FGFARAMSTN TMVLTSIKGT PLYMSPELVE ERPYDHTADL 180

WSVGCILYEL AVGTPPFYAT SIFQLVSLIL KDPVRWPSTI SPCFKNFLQG LLTKDPRQRL 240

SWPDLLYHPF I 251

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ptr:459948

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013