EKS-PAT-00346

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00346

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	448.4	6.3E-135	276	525	250

Status

Unreviewed

Ensembl Protein

ENSPTRP00000023137

UniProt Accession

H2QKB4;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000197122

Gene Synonyms/Alias

ENSG00000197122;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000013474	ENSPTRP00000023137	ENSPTRT00000025070

Organism

Pan troglodytes

Functional Description

Protein Length

542

Protein Sequence
(FASTA)

MGSNKSKPKD ASQRRRSLEP AENVHGAGGG AFPASQTPSK PASADGHRGP SAAFAPAAAE 60

PKLFGGFNSS DTVTSPQRAG PLAGGVTTFV ALYDYESRTE TDLSFKKGER LQIVNNTRKV 120

DVREGDWWLA HSLSTGQTGY IPSNYVAPSD SIQAEEWYFG KITRRESERL LLNAENPRGT 180

FLVRESETTK GAYCLSVSDF DNAKGLNVKH YKIRKLDSGG FYITSRTQFN SLQQLVAYYS 240

KHADGLCHRL TTVCPTSKPQ TQGLAKDAWE IPRESLRLEV KLGQGCFGEV WMGTWNGTTR 300

VAIKTLKPGT MSPEAFLQEA QVMKKLRHEK LVQLYAVVSE EPIYIVTEYM SKGSLLDFLK 360

GETGKYLRLP QLVDMAAQIA SGMAYVERMN YVHRDLRAAN ILVGENLVCK VADFGLARLI 420

EDNEYTARQG AKFPIKWTAP EAALYGRFTI KSDVWSFGIL LTELTTKGRV PYPGMVNREV 480

LDQVERGYRM PCPPECPESL HDLMCQCWRK EPEERPTFEY LQAFLEDYFT STEPQYQPGE 540

NL 542

Nucleotide Sequence
(FASTA)

ATGGGTAGCA ACAAGAGCAA GCCCAAGGAT GCCAGCCAGC GGCGCCGCAG CCTGGAGCCC 60

GCCGAGAACG TGCACGGCGC TGGCGGGGGC GCTTTCCCCG CCTCGCAGAC CCCCAGCAAG 120

CCAGCCTCGG CCGACGGCCA CCGCGGCCCC AGCGCGGCCT TCGCCCCCGC GGCCGCCGAG 180

CCCAAGCTGT TCGGAGGCTT CAACTCCTCG GACACCGTCA CCTCCCCGCA GAGGGCGGGC 240

CCGCTGGCCG GTGGAGTGAC CACCTTTGTG GCCCTCTATG ACTATGAGTC TAGGACGGAG 300

ACAGACCTGT CCTTCAAGAA AGGCGAGCGG CTCCAGATTG TCAACAACAC GAGGAAGGTG 360

GATGTCAGAG AGGGAGACTG GTGGCTGGCC CACTCGCTCA GCACAGGACA GACAGGCTAC 420

ATCCCCAGCA ACTACGTGGC GCCCTCCGAC TCCATCCAGG CCGAGGAGTG GTATTTTGGC 480

AAGATCACCA GACGGGAGTC AGAGCGGTTA CTGCTCAATG CAGAGAACCC GAGAGGGACC 540

TTCCTCGTGC GAGAAAGTGA GACCACGAAA GGTGCCTACT GCCTCTCAGT GTCTGACTTC 600

GACAACGCCA AGGGCCTCAA CGTGAAGCAC TACAAGATCC GCAAGCTGGA CAGCGGTGGC 660

TTCTACATCA CCTCCCGCAC CCAGTTCAAC AGCCTGCAGC AGCTGGTGGC CTACTACTCC 720

AAACATGCCG ATGGCCTGTG CCACCGCCTC ACCACGGTGT GCCCCACGTC CAAGCCGCAG 780

ACTCAGGGCC TGGCCAAGGA TGCCTGGGAG ATCCCTCGGG AGTCGCTGCG GCTGGAGGTC 840

AAGCTGGGCC AGGGCTGCTT TGGCGAGGTG TGGATGGGGA CCTGGAACGG TACCACCAGG 900

GTGGCCATCA AAACCCTGAA GCCTGGCACG ATGTCTCCAG AGGCCTTCCT GCAGGAGGCC 960

CAGGTCATGA AGAAGCTGAG GCATGAGAAG CTGGTGCAGT TGTATGCTGT GGTTTCAGAG 1020

GAGCCCATTT ACATCGTCAC GGAGTACATG AGCAAGGGGA GTTTGCTGGA CTTTCTCAAG 1080

GGGGAGACAG GCAAGTACCT GCGGCTGCCT CAGCTGGTGG ACATGGCTGC TCAGATCGCC 1140

TCAGGCATGG CGTACGTGGA GCGGATGAAC TACGTCCACC GGGACCTTCG TGCAGCCAAC 1200

ATCCTGGTGG GAGAGAACCT GGTGTGCAAA GTGGCCGACT TTGGGCTGGC TCGGCTCATT 1260

GAAGACAATG AGTACACGGC GCGGCAAGGT GCCAAATTCC CCATCAAGTG GACGGCTCCA 1320

GAAGCTGCCC TCTATGGCCG CTTCACCATC AAGTCAGACG TGTGGTCCTT CGGGATCCTG 1380

CTGACTGAGC TCACCACAAA GGGACGGGTG CCCTACCCTG GGATGGTGAA CCGCGAGGTG 1440

CTGGACCAGG TGGAGCGGGG CTACCGGATG CCCTGCCCGC CGGAGTGTCC CGAGTCCCTG 1500

CACGACCTCA TGTGCCAGTG CTGGCGGAAG GAGCCTGAGG AGCGGCCCAC CTTCGAGTAC 1560

CTGCAGGCCT TCCTGGAGGA CTACTTCACG TCCACCGAGC CCCAGTACCA GCCCGGGGAG 1620

AACCTCTAG 1629

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly

Q: 276   LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  335

         68999*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflk e+gk+l+lp+lvd+aaq+a+Gmay+e++n++hr

Q: 336   AVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR  394

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvge+lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 395   DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  454

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte++tkG+vPypGm n+evl+qvergyr+p+p ecpe+l++l+++cw+k+pee

Q: 455   WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE  514

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq++l

Q: 515   RPTFEYLQAFL  525

         *******9876

Domain Sequence
(FASTA)

LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60

AVVSEEPIYI VTEYMSKGSL LDFLKGETGK YLRLPQLVDM AAQIASGMAY VERMNYVHRD 120

LRAANILVGE NLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMPCPPE CPESLHDLMC QCWRKEPEER 240

PTFEYLQAFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013