EKS-PAT-00297
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-PAT-00297
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20350.08.1E-10518269252
StatusUnreviewed
Ensembl ProteinENSPTRP00000052114
UniProt AccessionA4K2N7;
Protein Name
Protein Synonyms/Alias Serine/threonine kinase 4;
Gene NameSTK4
Gene Synonyms/Alias STK4; ENSG00000101109;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPTRG00000013533ENSPTRP00000052114ENSPTRT00000025187
OrganismPan troglodytes
Functional Description
Protein Length475
Protein Sequence
(FASTA)
QLKKLDEDSL TKQPEEVFDV LEKLGEGSYG SVYKAIHKET GQIVAIKQVP VESDLQEIIK 60
EISIMQQCDS PHVVKYYGSY FKNTDLWIVM EYCGAGSVSD IIRLRNKTLT EDEIATILQS 120
TLKGLEYLHF MRKIHRDIKA GNILLNTEGH AKLADFGVAG QLTDTMAKRN TVIGTPFWMA 180
PEVIQEIGYN CVADIWSLGI TAIEMAEGKP PYADIHPMRA IFMIPTNPPP TFRKPELWSD 240
NFTDFVKQCL VKSPEQRATA TQLLQHPFVR SAKGVSILRD LINEAMDVKL KRQESQQREV 300
DQDDEENSEE DEMDSGTMVR AVGDEMGTVR VASTMTDGAN TMIEHDDTLP SQLGTMVINA 360
EDEEEEGTMK RRDETMQPAK PSFLEYFEQK EKETQINSFG KSVPGPLKNS SDWKIPQDGD 420
YEFLKSWTVE DLQKRLLALD PMMEQEIEEI RQKYQSKRQP ILDAIEAKKR RQQNF 475
Nucleotide Sequence
(FASTA)
CAGCTGAAAA AGTTGGATGA AGATAGTTTA ACCAAACAAC CAGAAGAAGT ATTTGATGTC 60
TTAGAGAAAC TTGGAGAAGG GTCCTATGGC AGCGTATACA AAGCTATTCA TAAAGAGACC 120
GGCCAGATTG TTGCTATTAA GCAAGTTCCT GTGGAATCAG ACCTCCAGGA GATAATCAAA 180
GAAATCTCTA TAATGCAGCA ATGTGACAGC CCTCATGTAG TCAAATATTA TGGCAGTTAT 240
TTTAAGAACA CAGACTTATG GATCGTTATG GAGTACTGTG GGGCTGGTTC TGTATCTGAT 300
ATCATTCGAT TACGAAATAA AACGTTAACA GAAGATGAAA TAGCTACAAT ATTACAGTCA 360
ACTCTTAAGG GACTTGAATA CCTTCATTTT ATGAGAAAAA TACACCGAGA TATCAAGGCA 420
GGAAATATTT TGCTAAATAC AGAAGGACAT GCAAAACTTG CAGATTTTGG GGTAGCAGGT 480
CAACTTACAG ATACCATGGC CAAGAGGAAT ACAGTGATAG GAACACCATT TTGGATGGCT 540
CCAGAAGTGA TTCAGGAAAT TGGATACAAC TGTGTAGCAG ACATCTGGTC CCTGGGAATA 600
ACTGCCATAG AAATGGCTGA AGGAAAGCCC CCTTATGCTG ATATCCATCC AATGAGGGCA 660
ATCTTCATGA TTCCTACAAA TCCTCCTCCC ACATTCCGAA AACCAGAGCT ATGGTCAGAT 720
AACTTTACAG ATTTTGTGAA ACAGTGTCTT GTAAAGAGCC CTGAGCAGAG GGCCACAGCC 780
ACTCAGCTCC TGCAGCACCC ATTTGTCAGG AGTGCCAAAG GAGTGTCAAT ACTGCGAGAC 840
TTAATTAATG AAGCCATGGA TGTGAAACTG AAACGCCAGG AATCCCAGCA GCGGGAAGTG 900
GACCAGGACG ATGAAGAAAA CTCAGAAGAG GATGAAATGG ATTCTGGCAC GATGGTTCGA 960
GCAGTGGGTG ATGAGATGGG CACTGTCCGA GTAGCCAGCA CCATGACTGA TGGAGCCAAT 1020
ACTATGATTG AGCACGATGA CACGTTGCCA TCACAACTGG GCACCATGGT GATCAATGCA 1080
GAGGATGAGG AAGAGGAAGG AACTATGAAA AGAAGGGATG AGACCATGCA GCCTGCGAAA 1140
CCATCCTTTC TTGAATATTT TGAACAAAAA GAAAAGGAAA CCCAGATCAA CAGCTTTGGC 1200
AAGAGTGTAC CTGGTCCACT GAAAAATTCT TCAGATTGGA AAATACCACA GGACGGAGAC 1260
TACGAGTTTC TTAAGAGTTG GACAGTGGAG GACCTTCAGA AGAGGCTCTT GGCCCTGGAC 1320
CCCATGATGG AGCAGGAGAT TGAAGAGATC CGGCAGAAGT ACCAGTCCAA GCGGCAGCCC 1380
ATCCTGGATG CCATTGAGGC TAAGAAGAGA CGGCAACAAA ACTTCTGA 1428
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60
         +++le++g+G++g+vy+a +k+tg++vaik++ +e+  +l+e++keis+++++++p++v+
Q: 18    FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVES--DLQEIIKEISIMQQCDSPHVVK  75
         7899*******************************7..9*********************
S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120
         y++s++k+++lw+vmey+ +Gs+sd+++  ++++l+E++ia+il+++lk+LeylH +++i
Q: 76    YYGSYFKNTDLWIVMEYCGAGSVSDIIR-LRNKTLTEDEIATILQSTLKGLEYLHFMRKI  134
         ****************************.99*****************************
S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180
         Hrdika+niLl++eg+ kL+dfgva ql++t++kr+tv+gtp+wmAPEvi+  e gY++ 
Q: 135   HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ--EIGYNCV  192
         ***************************************************..9******
S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240
         aDiwslGItaie+aeg+pP++d++p++a+++i++n+pp++++++ +s++f++fv++cl k
Q: 193   ADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVK  252
         ************************************************************
S: 241   npekRpsasellkhkFl  257
         +pe+R++a++ll+h+F+
Q: 253   SPEQRATATQLLQHPFV  269
         ****************7
Domain Sequence
(FASTA)
FDVLEKLGEG SYGSVYKAIH KETGQIVAIK QVPVESDLQE IIKEISIMQQ CDSPHVVKYY 60
GSYFKNTDLW IVMEYCGAGS VSDIIRLRNK TLTEDEIATI LQSTLKGLEY LHFMRKIHRD 120
IKAGNILLNT EGHAKLADFG VAGQLTDTMA KRNTVIGTPF WMAPEVIQEI GYNCVADIWS 180
LGITAIEMAE GKPPYADIHP MRAIFMIPTN PPPTFRKPEL WSDNFTDFVK QCLVKSPEQR 240
ATATQLLQHP FV 252
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00294
EKS-ANC-00306
EKS-BOT-00313
EKS-CAJ-00321
EKS-CAF-00316
EKS-CAP-00348
EKS-FEC-00300
EKS-GAG-00267
EKS-GOG-00309
EKS-HOS-00321
EKS-ICT-00294
EKS-LAC-00325
EKS-LOA-00325
EKS-MAM-00328
EKS-MEG-00256
EKS-MOD-00310
EKS-MUM-00346
EKS-MUP-00308
EKS-MYL-00313
EKS-NOL-00288
EKS-ORN-00415
EKS-ORA-00276
EKS-ORC-00297
EKS-ORL-00377
EKS-OTG-00323
EKS-PES-00280
EKS-POA-00303
EKS-RAN-00329
EKS-SAH-00293
EKS-SOA-00034
EKS-TAG-00330
EKS-TUT-00072
EKS-XET-00388
EKS-XIM-00408
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0043539; F:protein serine/threonine kinase activator activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0060706; P:cell differentiation involved in embryonic placenta development
GO:0000902; P:cell morphogenesis
GO:0007417; P:central nervous system development
GO:0003157; P:endocardium development
GO:0035329; P:hippo signaling cascade
GO:0006917; P:induction of apoptosis
GO:0007243; P:intracellular protein kinase cascade
GO:0030216; P:keratinocyte differentiation
GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway
GO:0008285; P:negative regulation of cell proliferation
GO:0046621; P:negative regulation of organ growth
GO:0001841; P:neural tube formation
GO:0001569; P:patterning of blood vessels
GO:0018105; P:peptidyl-serine phosphorylation
GO:0060215; P:primitive hemopoiesis
GO:0046777; P:protein autophosphorylation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR011524; SARAH.
IPR024205; SARAH_domain.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF11629; Mst1_SARAH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50951; SARAH; 1.
Prints
Created Date20-Feb-2013