EKS-PAT-00254

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00254

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	448.6	1.2E-134	159	479	321

Status

Unreviewed

Ensembl Protein

ENSPTRP00000023923

UniProt Accession

H2QL08;

Protein Name

Protein Synonyms/Alias

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A;

Gene Name

ENSG00000157540

Gene Synonyms/Alias

ENSG00000157540; DYRK1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000013901	ENSPTRP00000023923	ENSPTRT00000025924

Organism

Pan troglodytes

Functional Description

Protein Length

763

Protein Sequence
(FASTA)

MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMPHSHQY SDRRQPNISD QQVSALSYSD 60

QIQQPLTNQV MPDIVMLQRR MPQTFRDPAT APLRKLSVDL IKTYKHINEV YYAKKKRRHQ 120

QGQGDDSSHK KERKVYNDGY DDDNYDYIVK NGEKWMDRYE IDSLIGKGSF GQVVKAYDRV 180

EQEWVAIKII KNKKAFLNQA QIEVRLLELM NKHDTEMKYY IVHLKRHFMF RNHLCLVFEM 240

LSYNLYDLLR NTNFRGVSLN LTRKFAQQMC TALLFLATPE LSIIHCDLKP ENILLCNPKR 300

SAIKIVDFGS SCQLGQRIYQ YIQSRFYRSP EVLLGMPYDL AIDMWSLGCI LVEMHTGEPL 360

FSGANEVDQM NKIVEVLGIP PAHILDQAPK ARKFFEKLPD GTWNLKKTKD GKREYKPPGT 420

RKLHNILGVE TGGPGGRRAG ESGHTVADYL KFKDLILRML DYDPKTRIQP YYALQHSFFK 480

KTADEGTNTS NSVSTSPAME QSQSSGTTSS TSSSSGGSSG TSNSGRARSD PTHQHRHSGG 540

HFTAAVQAMD CETHSPQVRQ QFPAPLGWSG TEAPTQVTVE THPVQETTFH VAPQQNALHH 600

HHGNSSHHHH HHHHHHHHHG QQALGNRTRP RVYNSPTNSS STQDSMEVGH SHHSMTSLSS 660

STTSSSTSSS STGNQGNQAY QNRPVAANTL DFGQNGAMDV NLTVYSNPRQ ETGIAGHPTY 720

QFSANTGPAH YMTEGHLTMR QGADREESPM TGVCVQQSPV ASS 763

Nucleotide Sequence
(FASTA)

ATGCATACAG GAGGAGAGAC TTCAGCATGC AAACCTTCAT CTGTTCGGCT TGCACCGTCA 60

TTTTCATTCC ATGCTGCTGG CCTTCAGATG GCTGGACAGA TGCCCCATTC ACATCAGTAC 120

AGTGACCGTC GCCAGCCAAA CATAAGTGAC CAACAGGTTT CTGCCTTATC ATATTCTGAC 180

CAGATTCAGC AACCTCTAAC TAACCAGGTG ATGCCTGATA TTGTCATGTT ACAGAGGCGG 240

ATGCCCCAAA CCTTCCGTGA CCCAGCAACT GCTCCCCTGA GAAAACTTTC TGTTGACTTG 300

ATCAAAACAT ACAAGCATAT TAATGAGGTT TACTATGCAA AAAAGAAGCG AAGACACCAA 360

CAGGGCCAGG GAGACGATTC TAGTCATAAG AAGGAACGGA AGGTTTACAA TGATGGTTAT 420

GATGATGATA ACTATGATTA TATTGTAAAA AACGGAGAAA AGTGGATGGA TCGTTACGAA 480

ATTGACTCCT TGATAGGCAA AGGTTCCTTT GGACAGGTTG TAAAGGCATA TGATCGTGTG 540

GAGCAAGAAT GGGTTGCCAT TAAAATAATA AAGAACAAGA AGGCTTTTCT GAATCAAGCG 600

CAGATAGAAG TGCGACTTCT TGAGCTCATG AACAAACATG ACACTGAAAT GAAATACTAC 660

ATAGTGCATT TGAAACGCCA CTTTATGTTT CGAAACCATC TCTGTTTAGT TTTTGAAATG 720

CTGTCCTACA ACCTCTATGA CTTGCTGAGA AACACCAATT TCCGAGGGGT CTCTTTGAAC 780

CTAACACGAA AGTTTGCGCA ACAGATGTGC ACTGCACTGC TTTTCCTTGC GACTCCAGAA 840

CTTAGTATCA TTCACTGTGA TCTAAAACCT GAAAATATCC TTCTTTGTAA CCCCAAACGC 900

AGTGCAATCA AGATAGTTGA CTTTGGCAGT TCTTGTCAGT TGGGGCAGAG GATATACCAG 960

TATATTCAGA GTCGCTTTTA TCGGTCTCCA GAGGTGCTAC TGGGAATGCC TTATGACCTT 1020

GCCATTGATA TGTGGTCCCT CGGGTGTATT TTGGTTGAAA TGCACACTGG AGAACCTCTG 1080

TTCAGTGGTG CCAATGAGGT AGATCAGATG AATAAAATAG TGGAAGTTCT GGGTATTCCA 1140

CCTGCTCATA TTCTTGACCA AGCACCAAAA GCAAGAAAGT TCTTTGAGAA GTTGCCAGAT 1200

GGCACTTGGA ACTTGAAGAA GACCAAAGAT GGAAAACGGG AGTACAAACC ACCAGGAACC 1260

CGTAAACTTC ATAACATTCT TGGAGTGGAA ACAGGAGGAC CTGGTGGGCG ACGTGCTGGG 1320

GAGTCAGGTC ATACGGTCGC TGACTACTTG AAGTTCAAAG ACCTCATTTT AAGGATGCTT 1380

GATTATGACC CCAAAACTCG AATTCAACCT TATTATGCTC TGCAGCACAG TTTCTTCAAG 1440

AAAACAGCTG ATGAAGGTAC AAATACAAGT AATAGTGTAT CTACAAGCCC CGCCATGGAG 1500

CAGTCTCAGT CTTCGGGCAC CACCTCCAGT ACATCGTCAA GCTCAGGTGG CTCATCGGGG 1560

ACAAGCAACA GTGGGAGAGC CCGGTCGGAT CCGACGCACC AGCATCGGCA CAGTGGCGGG 1620

CACTTCACGG CTGCCGTGCA GGCCATGGAC TGCGAGACAC ACAGTCCCCA GGTGCGTCAG 1680

CAATTTCCTG CTCCTCTTGG TTGGTCAGGC ACTGAAGCTC CTACACAGGT CACTGTTGAA 1740

ACTCATCCTG TTCAAGAAAC AACCTTTCAT GTAGCCCCTC AACAGAATGC ATTGCATCAT 1800

CACCATGGTA ACAGTTCCCA TCACCATCAC CACCACCACC ACCACCACCA CCACCATGGA 1860

CAACAAGCCT TGGGTAACCG GACCAGGCCA AGGGTCTACA ATTCTCCAAC GAATAGCTCC 1920

TCTACCCAAG ATTCTATGGA GGTTGGCCAC AGTCACCACT CCATGACATC CCTGTCTTCC 1980

TCAACGACCT CTTCCTCGAC ATCTTCCTCC TCTACTGGTA ATCAAGGCAA CCAGGCCTAC 2040

CAGAATCGCC CAGTGGCTGC TAATACCTTG GACTTTGGAC AGAATGGAGC TATGGACGTT 2100

AATTTGACCG TCTACTCCAA TCCCCGCCAA GAGACTGGCA TAGCTGGACA TCCAACATAC 2160

CAATTTTCTG CTAATACAGG TCCTGCACAT TACATGACTG AAGGACATCT GACAATGAGG 2220

CAAGGGGCTG ATAGAGAAGA GTCCCCCATG ACAGGAGTTT GTGTGCAACA GAGTCCTGTA 2280

GCTAGCTCGT GA 2292

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye++++igkGsfgqVvka+d+ ++e+vaikiiknkk+f++qaq+Ev++Le +nk+d+e+k

Q: 159   YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK  218

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119

         y++v+l+++f+frnhlclvfe+ls+nLy+ll++++f+g+sl+l+rk+aqq+++aL +L+

Q: 219   YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAt  278

         **********************************************************99

S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++

Q: 279   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMP  337

         99*************************************.********************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238

         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq+++ivevlg+pp+++l++a ka+kff+k

Q: 338   YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEK  397

         ************************************************************

S: 239   keapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.f  288

           + ++ lk++          ++rk +++l+v++ +     p+ +++ge+ ++++d+l f

Q: 398   LPDGTWNLKKTkdgkreykpPGTRKLHNILGVETGG-----PGGRRAGESGHTVADYLkF  452

         ********9997777777777777777777777776.....99*****************

S: 289   kdllkrmleldpakRitpkealkhpfv  315

         kdl+ rml++dp++Ri+p++al+h+f+

Q: 453   KDLILRMLDYDPKTRIQPYYALQHSFF  479

         **************************7

Domain Sequence
(FASTA)

YEIDSLIGKG SFGQVVKAYD RVEQEWVAIK IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK 60

YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS LNLTRKFAQQ MCTALLFLAT 120

PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY 180

DLAIDMWSLG CILVEMHTGE PLFSGANEVD QMNKIVEVLG IPPAHILDQA PKARKFFEKL 240

PDGTWNLKKT KDGKREYKPP GTRKLHNILG VETGGPGGRR AGESGHTVAD YLKFKDLILR 300

MLDYDPKTRI QPYYALQHSF F 321

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ptr:458545

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013