EKS-PAT-00435

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00435

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	431.5	1.3E-129	25	313	289

Status

Unreviewed

Ensembl Protein

ENSPTRP00000024313

UniProt Accession

H2QLB4;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase 1;

Gene Name

ENSG00000100030

Gene Synonyms/Alias

ENSG00000100030; MAPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000014120	ENSPTRP00000024313	ENSPTRT00000026378

Organism

Pan troglodytes

Functional Description

Protein Length

360

Protein Sequence
(FASTA)

MAAAAAAGAG PEMVRGQVFD VGPRYTNLSY IGEGAYGMVC SAYDNVNKVR VAIKKISPFE 60

HQTYCQRTLR EIKILLRFRH ENIIGINDII RAPTIEQMKD VYIVQDLMET DLYKLLKTQH 120

LSNDHICYFL YQILRGLKYI HSANVLHRDL KPSNLLLNTT CDLKICDFGL ARVADPDHDH 180

TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI 240

LGILGSPSQE DLNCIINLKA RNYLLSLPHK NKVPWNRLFP NADSKALDLL DKMLTFNPHK 300

RIEVEQALAH PYLEQYYDPS DEPIAEAPFK FDMELDDLPK EKLKELIFEE TARFQPGYRS 360

Nucleotide Sequence
(FASTA)

ATGGCGGCGG CGGCGGCGGC GGGCGCGGGC CCGGAGATGG TCCGCGGGCA GGTGTTCGAC 60

GTGGGGCCGC GCTACACCAA CCTCTCGTAC ATCGGCGAGG GCGCCTACGG CATGGTGTGC 120

TCTGCTTATG ATAATGTCAA CAAAGTTCGA GTAGCTATCA AGAAAATCAG CCCCTTTGAG 180

CACCAGACCT ACTGCCAGAG AACCCTGAGG GAGATAAAAA TCTTACTGCG CTTCAGACAT 240

GAGAACATCA TTGGAATCAA TGACATTATT CGAGCACCAA CCATCGAGCA AATGAAAGAT 300

GTATATATAG TACAGGACCT CATGGAAACA GATCTTTACA AGCTCTTGAA GACACAACAC 360

CTCAGCAATG ACCATATCTG CTATTTTCTC TACCAGATCC TCAGAGGGTT AAAATATATC 420

CATTCAGCTA ACGTTCTGCA CCGTGACCTC AAGCCTTCCA ACCTGCTGCT CAACACCACC 480

TGTGATCTCA AGATCTGTGA CTTTGGCCTG GCCCGTGTTG CAGATCCAGA CCATGATCAC 540

ACAGGGTTCC TGACAGAATA TGTGGCCACA CGTTGGTACA GGGCTCCAGA AATTATGTTG 600

AATTCCAAGG GCTACACCAA GTCCATTGAT ATTTGGTCTG TAGGCTGCAT TCTGGCAGAA 660

ATGCTTTCTA ACAGGCCCAT CTTTCCAGGG AAGCATTATC TTGACCAGCT GAACCACATT 720

TTGGGTATTC TTGGATCCCC ATCACAAGAA GACCTGAATT GTATAATAAA TTTAAAAGCT 780

AGGAACTATT TGCTTTCTCT TCCACACAAA AATAAGGTGC CATGGAACAG GCTGTTCCCA 840

AATGCTGACT CCAAAGCTCT GGACTTATTG GACAAAATGT TGACATTCAA CCCACACAAG 900

AGGATTGAAG TAGAACAGGC TCTGGCCCAC CCATATCTGG AGCAGTATTA CGACCCGAGT 960

GACGAGCCCA TCGCCGAAGC ACCATTCAAG TTCGACATGG AATTGGATGA CTTGCCTAAG 1020

GAAAAGCTCA AAGAACTAAT TTTTGAAGAG ACTGCTAGAT TCCAGCCAGG ATACAGATCT 1080

TAA 1083

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++l+++geGayg+v+sa+d+ ++ rvaikk+s pf+++t ++rtlRE+k+l +++heNi

Q: 25    YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENI  83

         78999***************************9.**************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i + d++++ + +e++kdvY+v++lmetdL+k++k+q+ls++hi ++lyqilrglky+Hs

Q: 84    IGINDIIRAPT-IEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHS  142

         ********999.************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekk..lteyvatrwYraPeillsl  178

         anv+HrDlKPsNll+n++c+lki+dFGlar+ad++++++  lteyvatrwYraPei+l++

Q: 143   ANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgfLTEYVATRWYRAPEIMLNS  202

         ***********************************999999*******************

S: 179   keytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearn  238

         k ytk++DiWsvGCIlaE+l+++p+fpgk+++dql++il +lg+ps+e+l++i + +arn

Q: 203   KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARN  262

         ************************************************************

S: 239   yikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         y+ slp+k+k ++++lfp+a+++aldLl+k+L+++p+kRi+ve+aL+hpYl

Q: 263   YLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL  313

         **************************************************7

Domain Sequence
(FASTA)

YTNLSYIGEG AYGMVCSAYD NVNKVRVAIK KISPFEHQTY CQRTLREIKI LLRFRHENII 60

GINDIIRAPT IEQMKDVYIV QDLMETDLYK LLKTQHLSND HICYFLYQIL RGLKYIHSAN 120

VLHRDLKPSN LLLNTTCDLK ICDFGLARVA DPDHDHTGFL TEYVATRWYR APEIMLNSKG 180

YTKSIDIWSV GCILAEMLSN RPIFPGKHYL DQLNHILGIL GSPSQEDLNC IINLKARNYL 240

LSLPHKNKVP WNRLFPNADS KALDLLDKML TFNPHKRIEV EQALAHPYL 289

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

ptr:458680

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008349	; MAPK_ERK1/2.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01770

; ERK1ERK2MAPK.

Created Date

20-Feb-2013