EKS-PAT-00112
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-PAT-00112
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Met460.02.1E-13810831341259
StatusUnreviewed
Ensembl ProteinENSPTRP00000025788
UniProt AccessionH2QMM8;
Protein Name
Protein Synonyms/Alias
Gene NameENSG00000164078
Gene Synonyms/Alias ENSG00000164078;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPTRG00000014941ENSPTRP00000025788ENSPTRT00000027958
OrganismPan troglodytes
Functional Description
Protein Length1400
Protein Sequence
(FASTA)
MELLPPLPQS FLLLLLLPAK PAAGEDWQCP RTPYAASRDF DVKYVVPSFS AGGLVQAMVT 60
YEGDRNESAV FVAIRNRLHV LGPDLKSVQS LATGPAGDPG CQTCAACGPG PHGPPGDTDT 120
KVLVLDPALP ALVSCGSSLQ GRCFLHDLEP QGTAVHLAAP ACLFSAHHNR PDDCPDCVAS 180
PLGTRVTVVE QGQASYFYVA SSLDAAVAAS FSPRSVSIRR LKADASGFAP GFVALSVLPK 240
HLVSYSIEYV HSFHTGAFVY FLTVQPASVT DDPSALHTRL ARLSATEPEL GDYRELVLDC 300
RFAPKRRRRG APEGGQPYPV LRVAHSAPVG AQLATELSIA EGQEVLFGVF VTGKDGGPGV 360
GPNSVVCAFP IDLLDTLIDE GVERCCESPV HPGLRRGLDF FQSPSFCPNP PGLEALSPNT 420
SCRHFPLLVS SSFSRVDLFN GLLGPVQVTA LYVTRLDNVT VAHMGTMDGR ILQVELVRSL 480
NYLLYVSNFS LGDSGQPVQR DVSRLGDHLL FASGDQVFQV PIRGPGCRHF LTCGRCLRAW 540
HFMGCGWCGN MCSQQKECPG SWQQDHCPPK LTEFHPHSGP LRGSTRLTLC GSNFYLHPSG 600
LVPEGTHQVT VGQSPCRPLP KDSSKLRPVP RKDFVEEFEC ELEPLGTQAV GPTNVSLTVT 660
NMPPGKHFRV DGTSVLRGFS FMEPVLIAVQ PLFGPRAGGT CLTLEGQSLS VGTSRAVLVN 720
GTECLLERVS EGQLLCATPP GATVASVPLS LQVGGAQVPG SWTFQYREDP VVLSISPNCG 780
YINSHITICG QHLTSAWHLV LSFHDGLRAV ESRCERQLPE QQLCRLPEYV VRDPQGWVAG 840
NLSARGDGAA GFTLPGFRFL PPPHPPSANL VPLKPEEHAI KFEYIGLGAV ADCVGINVTV 900
GGESCQHEFR GDMVVCPLPP SLQLGQDGAP LQVCVDGECH ILGRVVRPGP DGVPQSTLLG 960
ILLPLLLLVA ALATALVFSY WWRRKQLVLP PNLNDLASLD QTAGATPLPI LYSGSDYRSG 1020
LALPAIDGLD STTCVHGASF SDSEDESCVP LLWKESIQLR DLDSALLAEV KDVLIPHERV 1080
VTHSDRVIGK GHFGVVYHGE YIDQAQNRIQ CAIKSLSRIT EMQQVEAFLR EGLLMRGLNH 1140
LNVLALIGIM LPPEGLPHVL LPYMCHGDLL QFIRSPQRNP TVKDLISFGL QVARGMEYLA 1200
EQKFVHRDLA ARNCMLDESF TVKVADFGLA RDILDREYYS VQQHRHARLP VKWMALESLQ 1260
TYRFTTKSDV WSFGVLLWEL LTRGAPPYRH IDPFDLTHFL AQGRRLPQPE YCPDSLYQVM 1320
QQCWEADPAV RPTFGVLVGE VEQIVSALLG DHYVQLPATY MNLGPSTSHE MNVRPEQPQF 1380
SPMPGNVRRP RPLSEPPQPT 1400
Nucleotide Sequence
(FASTA)
ATGGAGCTCC TCCCGCCGCT GCCTCAGTCC TTCCTGTTGC TGCTGCTGTT GCCTGCCAAG 60
CCCGCGGCGG GCGAGGACTG GCAGTGCCCG CGCACCCCCT ACGCGGCCTC TCGCGACTTT 120
GACGTGAAGT ACGTGGTGCC CAGCTTCTCC GCCGGAGGCC TGGTACAGGC CATGGTGACC 180
TACGAGGGCG ACAGAAATGA GAGTGCTGTG TTTGTAGCCA TACGCAATCG CCTGCATGTG 240
CTTGGGCCTG ACCTGAAGTC TGTCCAGAGC CTGGCCACGG GCCCTGCTGG AGACCCTGGC 300
TGCCAGACGT GTGCAGCCTG TGGCCCAGGA CCCCACGGCC CTCCCGGTGA CACAGACACA 360
AAGGTGCTGG TGCTGGATCC CGCGCTGCCT GCGCTGGTCA GTTGTGGCTC CAGCCTGCAG 420
GGCCGCTGCT TCCTGCATGA CCTAGAGCCC CAAGGGACAG CCGTGCATCT GGCAGCGCCA 480
GCCTGCCTCT TCTCAGCCCA CCATAACCGG CCCGATGACT GCCCCGACTG TGTGGCCAGC 540
CCATTGGGCA CCCGTGTAAC TGTGGTTGAG CAAGGCCAGG CCTCCTATTT CTACGTGGCA 600
TCCTCACTGG ACGCAGCCGT GGCTGCCAGC TTCAGCCCAC GCTCAGTGTC TATCAGGCGT 660
CTCAAGGCCG ACGCCTCCGG ATTCGCACCG GGCTTTGTGG CGTTGTCAGT GCTGCCCAAG 720
CATCTTGTCT CCTACAGTAT TGAATATGTG CACAGCTTCC ACACGGGAGC CTTCGTATAC 780
TTCCTGACTG TACAGCCGGC CAGCGTGACA GATGATCCTA GTGCCCTGCA CACACGCCTG 840
GCACGGCTTA GCGCCACTGA GCCAGAGTTG GGTGACTATC GGGAGCTGGT CCTCGACTGC 900
AGATTTGCTC CAAAACGCAG GCGCCGGGGG GCCCCAGAAG GCGGACAGCC CTACCCTGTG 960
CTGCGGGTGG CCCACTCCGC TCCAGTGGGT GCCCAACTTG CCACTGAGCT GAGCATCGCC 1020
GAGGGCCAGG AAGTACTATT TGGGGTCTTT GTGACTGGCA AGGATGGTGG TCCTGGCGTG 1080
GGCCCCAACT CTGTCGTCTG TGCCTTCCCC ATTGACCTGC TGGACACACT AATTGATGAG 1140
GGTGTGGAGC GCTGTTGTGA ATCCCCAGTC CATCCAGGCC TCCGGCGAGG CCTCGACTTC 1200
TTCCAGTCGC CCAGTTTTTG CCCCAACCCG CCTGGCCTGG AAGCCCTCAG CCCCAACACC 1260
AGCTGCCGCC ACTTCCCTCT GCTGGTCAGT AGCAGCTTCT CACGTGTGGA CCTATTCAAT 1320
GGGCTGTTGG GACCAGTACA GGTCACTGCA TTGTATGTGA CACGCCTTGA CAACGTCACA 1380
GTGGCGCACA TGGGCACAAT GGATGGGCGT ATCCTGCAGG TGGAGCTGGT CAGGTCACTA 1440
AACTACTTGC TGTATGTGTC CAACTTCTCA CTGGGTGACA GTGGGCAGCC CGTGCAGCGG 1500
GATGTCAGTC GTCTTGGGGA CCACCTACTC TTCGCCTCTG GGGACCAGGT TTTCCAGGTA 1560
CCAATCCGAG GCCCTGGCTG CCGCCACTTC CTGACCTGTG GGCGTTGCCT AAGGGCATGG 1620
CATTTCATGG GCTGTGGCTG GTGTGGGAAC ATGTGCAGCC AGCAGAAGGA GTGTCCTGGC 1680
TCCTGGCAAC AGGACCACTG CCCACCTAAG CTTACTGAGT TCCACCCCCA CAGTGGACCT 1740
CTAAGGGGCA GTACAAGGCT GACCCTGTGT GGCTCCAACT TCTACCTTCA CCCTTCTGGT 1800
CTGGTACCTG AGGGAACCCA TCAGGTCACT GTGGGCCAAA GTCCCTGCCG GCCACTGCCC 1860
AAGGACAGCT CAAAACTCAG ACCAGTGCCC CGGAAAGACT TTGTAGAGGA GTTTGAGTGT 1920
GAACTGGAGC CCTTGGGCAC CCAGGCAGTG GGGCCTACCA ACGTCAGCCT CACCGTGACT 1980
AACATGCCAC CGGGCAAGCA CTTCCGGGTA GACGGCACCT CCGTGCTGAG AGGCTTCTCT 2040
TTCATGGAGC CAGTGCTGAT AGCAGTGCAA CCCCTCTTTG GCCCACGGGC AGGAGGCACC 2100
TGTCTCACTC TTGAAGGCCA GAGTCTGTCT GTAGGCACCA GCCGGGCTGT GCTGGTCAAT 2160
GGGACTGAGT GTCTGCTAGA ACGGGTCAGT GAGGGGCAGC TTTTATGTGC CACACCCCCT 2220
GGGGCCACGG TGGCCAGTGT CCCCCTTAGC CTGCAGGTGG GGGGTGCCCA GGTACCTGGT 2280
TCCTGGACCT TCCAGTACAG AGAAGACCCT GTTGTGCTAA GCATCAGCCC CAACTGTGGC 2340
TACATCAACT CCCACATCAC CATCTGTGGC CAGCATCTAA CTTCAGCATG GCACTTAGTG 2400
CTGTCATTCC ATGACGGGCT TAGGGCAGTG GAAAGCAGGT GTGAGAGGCA GCTTCCAGAG 2460
CAGCAGCTGT GCCGCCTTCC TGAATATGTG GTCCGAGACC CCCAGGGATG GGTGGCAGGG 2520
AATCTGAGTG CCCGGGGGGA TGGAGCTGCT GGCTTTACAC TGCCTGGCTT TCGCTTCCTA 2580
CCCCCACCCC ATCCACCCAG TGCCAACCTA GTTCCACTGA AGCCTGAGGA GCATGCCATT 2640
AAGTTTGAGT ATATTGGGCT GGGCGCTGTG GCTGACTGTG TGGGTATCAA CGTGACCGTG 2700
GGTGGTGAGA GCTGCCAGCA CGAGTTCCGG GGGGACATGG TTGTCTGCCC CCTGCCCCCA 2760
TCCCTGCAGC TTGGCCAGGA TGGTGCCCCA TTGCAGGTCT GCGTAGATGG TGAATGTCAT 2820
ATCCTGGGTA GAGTGGTGCG GCCAGGGCCA GACGGGGTCC CACAGAGCAC GCTCCTTGGT 2880
ATCCTGCTGC CTTTGCTGCT GCTTGTGGCT GCACTGGCGA CTGCACTGGT CTTCAGCTAC 2940
TGGTGGCGGA GGAAGCAGCT AGTTCTTCCT CCCAACCTGA ATGACCTGGC ATCCCTGGAC 3000
CAGACTGCTG GAGCCACACC CCTGCCTATT CTGTACTCGG GCTCTGACTA CAGAAGTGGC 3060
CTTGCACTCC CTGCCATTGA TGGTCTGGAT TCCACCACTT GTGTCCATGG AGCATCCTTC 3120
TCCGATAGTG AAGATGAATC CTGTGTGCCA CTGCTGTGGA AAGAGTCCAT CCAGCTAAGG 3180
GACCTGGACT CTGCGCTCTT GGCTGAGGTC AAGGATGTGC TGATTCCCCA TGAGCGGGTG 3240
GTCACCCACA GTGACCGAGT CATTGGCAAA GGCCACTTTG GAGTTGTCTA CCACGGAGAA 3300
TACATAGACC AGGCCCAGAA TCGAATCCAA TGTGCCATCA AGTCACTAAG TCGCATCACA 3360
GAGATGCAGC AGGTGGAGGC CTTCCTGCGA GAGGGGCTGC TCATGCGTGG CCTGAACCAC 3420
CTGAATGTGC TGGCTCTCAT TGGTATCATG TTGCCACCTG AGGGCCTGCC CCATGTGCTG 3480
CTGCCCTATA TGTGCCACGG TGACCTGCTC CAGTTCATCC GCTCACCTCA GCGGAACCCC 3540
ACCGTGAAGG ACCTCATCAG CTTTGGCCTG CAGGTAGCCC GCGGCATGGA GTACCTGGCA 3600
GAGCAGAAGT TTGTGCACAG GGACCTGGCT GCGCGGAACT GCATGCTGGA CGAGTCATTC 3660
ACAGTCAAGG TGGCTGACTT TGGTTTGGCC CGCGACATCC TGGACAGGGA GTACTATAGT 3720
GTTCAACAGC ATCGCCACGC TCGCCTACCT GTGAAGTGGA TGGCGCTGGA GAGCCTGCAG 3780
ACCTATAGAT TTACCACCAA GTCTGATGTG TGGTCATTTG GTGTGCTGCT GTGGGAACTG 3840
CTGACACGGG GTGCCCCACC ATACCGCCAC ATTGACCCTT TTGACCTTAC CCACTTCCTG 3900
GCCCAGGGTC GGCGCCTGCC CCAGCCTGAG TATTGCCCTG ATTCTCTGTA CCAAGTGATG 3960
CAGCAATGCT GGGAGGCAGA CCCAGCAGTG CGACCCACCT TTGGAGTACT AGTTGGGGAG 4020
GTGGAGCAGA TAGTGTCTGC ACTGCTTGGG GACCATTATG TGCAGCTGCC AGCAACCTAC 4080
ATGAACTTGG GCCCCAGCAC CTCGCATGAG ATGAATGTGC GTCCAGAACA GCCGCAGTTC 4140
TCACCCATGC CAGGGAATGT ACGCCGGCCC CGGCCACTCT CAGAGCCTCC TCAGCCCACT 4200
TGA 4203
Domain Profile
S: 2     dkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhpn  61
         ++++viGkGhfGvvy+ge++d+a+++i++a+ksl+rit++++ve+flregl+m++l+h n
Q: 1083  HSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHLN  1142
         7899********************************************************
S: 62    vlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylask  121
         vl+l+Gi+l++eglp+v+lpym++Gdl +fir+++rn+tvkdl++f+lqva+gmeyla++
Q: 1143  VLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQ  1202
         ************************************************************
S: 122   kfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqtf  181
         kfvhrdlaarnc+lde++tvkvadfGlard+ld+e+y+v+++r+arlpvkw+aleslqt+
Q: 1203  KFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTY  1262
         ************************************************************
S: 182   kqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvml  241
         + fttksdvwsfGvllwelltrga+py+++++fdlt++l++grrl++peycpd+ly+vm+
Q: 1263  R-FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQ  1321
         *.**********************************************************
S: 242   kcwkakpaerpqfsdlvsii  261
         +cw+a+pa rp+f  lv  +
Q: 1322  QCWEADPAVRPTFGVLVGEV  1341
         *************9998765
Domain Sequence
(FASTA)
HSDRVIGKGH FGVVYHGEYI DQAQNRIQCA IKSLSRITEM QQVEAFLREG LLMRGLNHLN 60
VLALIGIMLP PEGLPHVLLP YMCHGDLLQF IRSPQRNPTV KDLISFGLQV ARGMEYLAEQ 120
KFVHRDLAAR NCMLDESFTV KVADFGLARD ILDREYYSVQ QHRHARLPVK WMALESLQTY 180
RFTTKSDVWS FGVLLWELLT RGAPPYRHID PFDLTHFLAQ GRRLPQPEYC PDSLYQVMQQ 240
CWEADPAVRP TFGVLVGEV 259
KeywordATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00116
EKS-BOT-00124
EKS-CAJ-00126
EKS-CAF-00127
EKS-CAP-00121
EKS-DAR-00380
EKS-ECT-00004
EKS-EQC-00120
EKS-FEC-00115
EKS-GAA-00144
EKS-GOG-00123
EKS-HOS-00126
EKS-ICT-00116
EKS-LOA-00119
EKS-MAM-00120
EKS-MOD-00121
EKS-MUM-00125
EKS-MUP-00125
EKS-MYL-00134
EKS-NOL-00116
EKS-ORN-00151
EKS-ORA-00102
EKS-ORC-00116
EKS-ORL-00140
EKS-PTV-00106
EKS-RAN-00121
EKS-SAH-00116
EKS-SOA-00004
EKS-SUS-00110
EKS-TAR-00155
EKS-TEN-00144
EKS-XET-00103
EKS-XIM-00148
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007275; P:multicellular organismal development
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
ptr:744480;
InterPros
IPR013783; Ig-like_fold.
IPR014756; Ig_E-set.
IPR002909; IPT_TIG_rcpt.
IPR011009; Kinase-like_dom.
IPR003659; Plexin-like.
IPR016201; Plexin-like_fold.
IPR002165; Plexin_repeat.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001627; Semaphorin/CD100_Ag.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016244; Tyr_kinase_HGF/MSP_rcpt.
IPR015943; WD40/YVTN_repeat-like_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF01437; PSI; 1.
PF01403; Sema; 1.
PF01833; TIG; 2.
SMARTs
SM00429; IPT; 3.
SM00423; PSI; 1.
SM00630; Sema; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS51004; SEMA; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013