EKS-PAT-00166

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00166

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	435.7	6.5E-131	160	414	255

Status

Unreviewed

Ensembl Protein

ENSPTRP00000025952

UniProt Accession

H2QMS9;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000163932

Gene Synonyms/Alias

ENSG00000163932;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000015023	ENSPTRP00000025952	ENSPTRT00000028129

Organism

Pan troglodytes

Functional Description

Protein Length

487

Protein Sequence
(FASTA)

QECNAAIHKK CIDKIIGRCT GTAANSRDTI FQKERFNIDM PHRFKVHNYM SPTFCDHCGS 60

LLWGLVKQGL KCEDCGMNVH HKCREKVANL CGINQKLLAE ALNQVTQRAS RRSDSASTEP 120

VGIYQGFEKK TGVAGEDMQD NSGTYGKIWE GSSKCNINNF IFHKVLGKGS FGKVLLGELK 180

GRGEYFAIKA LKKDVVLIDD DVECTMVEKR VLTLAAENPF LTHLICTFQT KDHLFFVMEF 240

LNGGDLMYHI QDKGRFELYR ATFYAAEIMC GLQFLHSKGI IYRDLKLDNV LLDRDGHIKI 300

ADFGMCKENI FGENRASTFC GTPDYIAPEI LQGLKYTFSV DWWSFGVLLY EMLIGQSPFH 360

GDDEDELFES IRVDTPHYPR WITKESKDIL EKLFEREPTK RLGVTGNIKI HPFFKTINWT 420

LLEKRRLEPP FRPKVKSPRD YSNFDQEFLN EKARLSYSDK NLIDSMDQSA FAGFSFVNPK 480

FEHLLED 487

Nucleotide Sequence
(FASTA)

CAAGAATGTA ACGCTGCCAT CCACAAGAAA TGCATCGACA AGATCATCGG CAGATGCACT 60

GGCACCGCGG CCAACAGCCG GGACACTATA TTCCAGAAAG AACGCTTCAA CATCGACATG 120

CCGCACCGCT TCAAGGTTCA CAACTACATG AGCCCCACCT TCTGTGACCA CTGCGGCAGC 180

CTGCTCTGGG GACTGGTGAA GCAGGGATTG AAGTGTGAAG ACTGCGGCAT GAATGTGCAC 240

CATAAATGCC GGGAGAAGGT GGCCAACCTC TGCGGCATCA ACCAGAAGCT TTTGGCTGAG 300

GCCTTGAACC AAGTCACCCA GAGAGCCTCC CGGAGATCAG ACTCAGCCTC CACAGAGCCT 360

GTTGGGATAT ATCAGGGTTT CGAGAAGAAG ACCGGAGTTG CTGGGGAGGA CATGCAAGAC 420

AACAGTGGGA CCTACGGCAA GATCTGGGAG GGCAGCAGCA AGTGCAACAT CAACAACTTC 480

ATCTTCCACA AGGTCCTGGG CAAAGGCAGC TTCGGGAAGG TGCTGCTTGG AGAGCTGAAG 540

GGCAGAGGAG AGTACTTTGC CATCAAGGCC CTCAAGAAGG ATGTGGTTCT GATTGACGAC 600

GACGTGGAAT GCACCATGGT TGAGAAGCGG GTGCTGACAC TTGCCGCAGA GAATCCCTTT 660

CTCACCCACC TCATCTGCAC CTTCCAGACC AAGGACCACC TGTTCTTTGT GATGGAGTTC 720

CTCAACGGGG GGGACCTGAT GTACCACATC CAGGACAAAG GCCGCTTTGA ACTCTACCGT 780

GCCACGTTTT ATGCCGCTGA GATAATGTGT GGACTGCAGT TTCTACACAG CAAGGGCATC 840

ATTTACAGGG ACCTCAAACT GGACAATGTG CTGCTGGACC GGGATGGCCA CATCAAGATT 900

GCCGACTTTG GGATGTGCAA AGAGAACATA TTCGGGGAGA ACCGGGCCAG CACCTTCTGC 960

GGCACCCCTG ACTATATCGC CCCTGAGATC CTACAGGGCC TGAAGTACAC ATTCTCTGTG 1020

GACTGGTGGT CTTTCGGGGT CCTTCTGTAC GAGATGCTCA TTGGCCAGTC CCCCTTCCAT 1080

GGTGATGATG AGGATGAACT CTTCGAGTCC ATCCGTGTGG ACACGCCACA TTATCCCCGC 1140

TGGATCACCA AGGAGTCCAA GGACATCCTG GAGAAGCTCT TTGAAAGGGA ACCAACCAAG 1200

AGGCTGGGAG TGACCGGAAA CATCAAAATC CACCCCTTCT TCAAGACCAT AAACTGGACT 1260

CTGCTGGAAA AGCGGAGGTT GGAGCCACCC TTCAGGCCCA AAGTGAAGTC ACCCAGAGAC 1320

TACAGTAACT TTGACCAGGA GTTCCTGAAC GAGAAGGCGC GCCTCTCCTA CAGCGACAAG 1380

AACCTCATCG ACTCCATGGA CCAATCTGCA TTCGCTGGCT TCTCCTTTGT GAATCCCAAA 1440

TTCGAGCACC TCCTGGAAGA TTGA 1464

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f ++kvlGkGsfgkvll elk++ e++aik lkkdvvl dddve+t+vekrvl+la+++p

Q: 160   FIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENP  219

         889*********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl++l+++fqt+d+lffv+e++nGGdlm+hiq++++++  ra+fyaaei+++l+flh+kg

Q: 220   FLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKG  279

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnvlld++Ghik+adfG+cke+i+ ++++stfcGtPdyiaPeil++ +y++s

Q: 280   IIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGENRASTFCGTPDYIAPEILQGLKYTFS  339

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdww++Gvllyeml+gqsPf+g+dedelfesi+ ++++yP++++ke+++il++l++++p+

Q: 340   VDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPT  399

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlGv  +g  +ik h+ff

Q: 400   KRLGV--TG--NIKIHPFF  414

         *****..56..79999998

Domain Sequence
(FASTA)

FIFHKVLGKG SFGKVLLGEL KGRGEYFAIK ALKKDVVLID DDVECTMVEK RVLTLAAENP 60

FLTHLICTFQ TKDHLFFVME FLNGGDLMYH IQDKGRFELY RATFYAAEIM CGLQFLHSKG 120

IIYRDLKLDN VLLDRDGHIK IADFGMCKEN IFGENRASTF CGTPDYIAPE ILQGLKYTFS 180

VDWWSFGVLL YEMLIGQSPF HGDDEDELFE SIRVDTPHYP RWITKESKDI LEKLFEREPT 240

KRLGVTGNIK IHPFF 255

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Callithrix jacchus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013