EKS-PAT-00008

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00008

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	507.2	6.3E-153	356	655	300

Status

Unreviewed

Ensembl Protein

ENSPTRP00000026129

UniProt Accession

H2QMZ3;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHA6

Gene Synonyms/Alias

EPHA6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000015134	ENSPTRP00000026129	ENSPTRT00000028314

Organism

Pan troglodytes

Functional Description

Protein Length

761

Protein Sequence
(FASTA)

MTACRPGFYK AFAGNTKCSK CPPHSLTYME ATSVCQCEKG YFRAEKDPPS MACTRPPSAP 60

RNVVFNINET ALILEWSPPS DTGGRKDLTY SVICKKCGLD TSQCEDCGGG LRFIPRHTGL 120

INNSVIVLDF VSHVNYTFEI EAMNGVSELS FSPKPFTAIT VTTDQDAPSL IGVVRKDWAS 180

QNSIALSWQA PAFSNGAILD YEIKYYEKEH EQLTYSSTRS KAPSVIITGL KPATKYVFHI 240

RVRTATGYSG YSQKFEFETG DETSDMAAEQ GQILVIATAA VGGFTLLVIL TLFFLITGRC 300

QWYIKAKMKS EEKRRNHLQN GHLRFPGIKT YIDPDTYEDP SLAVHEFAKE IDPSRIRIER 360

VIGAGEFGEV CSGRLKTPGK REIPVAIKTL KGGHMDRQRR DFLREASIMG QFDHPNIIRL 420

EGVVTKRSFP AIGVEAFCPS FLRAGFLNSI QAPHPVPGGG SLPPRIPAGR PVMIVVEYME 480

NGSLDSFLRK HDGHFTVIQL VGMLRGIASG MKYLSDMGYV HRDLAARNIL VNSNLVCKVS 540

DFGLSRVLED DPEAAYTTTG GKIPIRWTAP EAIAYRKFSS ASDAWSYGIV MWEVMSYGER 600

PYWEMSNQDV ILSIEEGYRL PAPMGCPASL HQLMLHCWQK ERNHRPKFTD IVSFLDKLIR 660

NPSALHTLVE DILVMPESPG EVPEYPLFVT VGDWLDSIKM GQYKNNFVAA GFTTFDLISR 720

MSIDDIRRIG VILIGHQRRI VSSIQTLRLH MMHIQEKGFH V 761

Nucleotide Sequence
(FASTA)

ATGACAGCTT GCAGACCAGG ATTCTATAAA GCTTTTGCTG GGAACACAAA ATGTTCTAAA 60

TGTCCTCCAC ACAGTTTAAC ATACATGGAA GCAACTTCTG TTTGTCAGTG TGAAAAGGGT 120

TATTTCCGAG CTGAAAAAGA CCCACCTTCT ATGGCATGTA CCAGGCCACC TTCAGCTCCT 180

AGGAATGTGG TTTTTAACAT CAATGAAACA GCCCTTATTT TGGAATGGAG CCCACCAAGT 240

GACACAGGAG GGAGAAAAGA TCTCACATAC AGTGTAATCT GTAAGAAATG TGGCTTAGAC 300

ACCAGCCAGT GTGAGGACTG TGGTGGAGGA CTCCGCTTCA TCCCAAGACA TACAGGCCTG 360

ATCAACAATT CCGTGATAGT ACTTGACTTT GTGTCTCACG TGAATTACAC CTTTGAAATA 420

GAAGCAATGA ATGGAGTTTC TGAGTTGAGT TTTTCTCCCA AGCCATTCAC AGCTATTACA 480

GTGACCACGG ATCAAGATGC ACCTTCCCTG ATAGGTGTGG TAAGGAAGGA CTGGGCATCC 540

CAAAATAGCA TTGCCCTATC ATGGCAAGCA CCTGCTTTTT CCAATGGAGC CATTCTGGAC 600

TACGAGATCA AGTACTATGA GAAAGAACAT GAGCAGCTGA CCTACTCTTC CACAAGGTCC 660

AAAGCCCCCA GTGTCATCAT CACAGGTCTC AAGCCAGCCA CCAAGTATGT ATTTCACATC 720

CGAGTGAGAA CTGCGACAGG ATACAGTGGC TACAGTCAGA AATTTGAATT TGAAACAGGA 780

GATGAAACTT CTGACATGGC AGCAGAACAA GGACAGATTC TCGTGATAGC CACCGCCGCT 840

GTTGGCGGAT TCACTCTCCT CGTCATCCTC ACTTTATTCT TCTTGATCAC TGGGAGATGT 900

CAGTGGTACA TAAAAGCCAA GATGAAGTCA GAAGAGAAGA GAAGAAACCA CTTACAGAAT 960

GGGCATTTGC GCTTCCCGGG AATTAAAACT TACATTGATC CAGATACATA TGAAGACCCA 1020

TCCCTAGCAG TCCATGAATT TGCAAAGGAG ATTGATCCCT CAAGAATTCG TATTGAGAGA 1080

GTCATTGGGG CAGGTGAATT TGGAGAAGTC TGTAGTGGGC GTTTGAAGAC ACCAGGGAAA 1140

AGAGAGATCC CAGTTGCCAT TAAAACTTTG AAAGGTGGCC ACATGGATCG GCAAAGAAGA 1200

GATTTTCTAA GAGAAGCTAG TATCATGGGC CAGTTTGACC ATCCAAACAT CATTCGCCTA 1260

GAAGGGGTTG TCACCAAAAG ATCCTTCCCG GCCATTGGGG TGGAGGCGTT TTGCCCCAGC 1320

TTCCTGAGGG CAGGGTTTTT AAATAGCATC CAGGCCCCGC ATCCAGTGCC AGGGGGAGGA 1380

TCTTTGCCCC CCAGGATTCC TGCTGGCAGA CCAGTAATGA TTGTGGTGGA ATATATGGAG 1440

AATGGATCCC TAGACTCCTT TTTGCGGAAG CATGATGGCC ACTTCACAGT CATCCAGTTG 1500

GTCGGAATGC TCCGAGGCAT TGCATCAGGC ATGAAGTATC TTTCTGATAT GGGTTATGTT 1560

CATCGAGACC TAGCGGCTCG GAATATACTG GTCAATAGCA ACTTAGTATG CAAAGTTTCT 1620

GATTTTGGTC TCTCCAGAGT GCTGGAAGAT GATCCAGAAG CTGCTTATAC GACAACTGGT 1680

GGAAAAATCC CCATAAGGTG GACAGCCCCA GAAGCCATCG CCTACAGAAA ATTCTCCTCA 1740

GCAAGCGATG CATGGAGCTA TGGCATTGTC ATGTGGGAGG TCATGTCCTA TGGAGAGAGA 1800

CCTTATTGGG AAATGTCTAA CCAAGATGTC ATTCTGTCCA TTGAAGAAGG GTACAGACTT 1860

CCAGCTCCCA TGGGCTGTCC AGCATCTCTA CACCAACTGA TGCTCCATTG CTGGCAGAAG 1920

GAGAGAAATC ACAGACCAAA ATTTACTGAC ATTGTCAGCT TCCTTGACAA ACTGATCCGA 1980

AATCCCAGTG CCCTTCACAC CCTGGTGGAG GACATCCTTG TAATGCCAGA GTCCCCTGGT 2040

GAAGTTCCGG AATATCCTTT GTTTGTCACA GTTGGTGACT GGCTAGATTC TATAAAGATG 2100

GGGCAATACA AGAATAACTT TGTGGCAGCA GGGTTTACAA CATTTGACCT GATTTCAAGA 2160

ATGAGCATTG ATGACATTAG AAGAATTGGA GTCATACTTA TTGGACACCA GAGACGAATA 2220

GTCAGCAGCA TACAGACTTT ACGTTTACAC ATGATGCACA TACAGGAGAA GGGATTTCAT 2280

GTATGA 2286

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         ++ie+viGaGefGevcsGrlk+pgkrei+vaiktlk+g++++qrrdfl+easi+Gqfdhp

Q: 356   IRIERVIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHP  415

         78**********************************************************

S: 61    niirleGvvtk..........................................skpvmiv  78

         niirleGvvtk                                          ++pvmiv

Q: 416   NIIRLEGVVTKrsfpaigveafcpsflragflnsiqaphpvpgggslppripaGRPVMIV  475

         ************************************************************

S: 79    teymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmgyvhrdlaarnilvnsnl  138

         +eymeng+ldsflrk+dg+ftviqlvgmlrGiasgmkylsdmgyvhrdlaarnilvnsnl

Q: 476   VEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNL  535

         ************************************************************

S: 139   vckvsdfGlsrvleddseaayttsggkipirwtapeaiayrkftsasdvwsyGivlwevl  198

         vckvsdfGlsrvledd+eaaytt+ggkipirwtapeaiayrkf+sasd+wsyGiv+wev+

Q: 536   VCKVSDFGLSRVLEDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSSASDAWSYGIVMWEVM  595

         ************************************************************

S: 199   syGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcwqkdraerpkfeqivsil  258

         syGerpyw+msnqdvi +ieegyrlp+pm+cpa+l+qlml+cwqk+r++rpkf++ivs+l

Q: 596   SYGERPYWEMSNQDVILSIEEGYRLPAPMGCPASLHQLMLHCWQKERNHRPKFTDIVSFL  655

         *********************************************************975

Domain Sequence
(FASTA)

IRIERVIGAG EFGEVCSGRL KTPGKREIPV AIKTLKGGHM DRQRRDFLRE ASIMGQFDHP 60

NIIRLEGVVT KRSFPAIGVE AFCPSFLRAG FLNSIQAPHP VPGGGSLPPR IPAGRPVMIV 120

VEYMENGSLD SFLRKHDGHF TVIQLVGMLR GIASGMKYLS DMGYVHRDLA ARNILVNSNL 180

VCKVSDFGLS RVLEDDPEAA YTTTGGKIPI RWTAPEAIAY RKFSSASDAW SYGIVMWEVM 240

SYGERPYWEM SNQDVILSIE EGYRLPAPMG CPASLHQLML HCWQKERNHR PKFTDIVSFL 300

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 2.
PF00536	; SAM_1; 1.

SMARTs

SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013