EKS-PAT-00433

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00433

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/VPS15	507.2	1.1E-152	26	310	285

Status

Unreviewed

Ensembl Protein

ENSPTRP00000026520

UniProt Accession

H2QND4;

Protein Name

Protein Synonyms/Alias

Phosphoinositide-3-kinase, regulatory subunit 4;

Gene Name

ENSG00000196455

Gene Synonyms/Alias

ENSG00000196455; PIK3R4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000015388	ENSPTRP00000026520	ENSPTRT00000028739

Organism

Pan troglodytes

Functional Description

Protein Length

1358

Protein Sequence
(FASTA)

MGNQLAGIAP SQILSVESYF SDIHDFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP 60

TLPLTSYKQE LEELKIRLNS AQNCLPFQKA SEKASEKAAM LFRQYVRDNL YDRISTRPFL 120

NNIEKRWIAF QILTAVDQAH KSGVRHGDIK TENVMVTSWN WVLLTDFASF KPTYLPEDNP 180

ADFNYFFDTS RRRTCYIAPE RFVDGGMFAT ELEYMRDPST PLVDLNSNQR TRGELKRAMD 240

IFSAGCVIAE LFTEGVPLFD LSQLLAYRNG HFFPEQVLNK IEDRSIRELV TQMIHREPDK 300

RLEAEDYLKQ QRGNAFPEIF YTFLQPYMAQ FAKETFLSAD ERILVIRKDL GNIIHNLCGH 360

DLPEKAEGEP KENGLVILVS VITSCLQTLK YCDSKLAALE LILHLAPRLS VEILLDRITP 420

YLLHFSNDSV PRVRAEALRT LTKVLALVKE VPRNDINIYP EYILPGIAHL AQDDATIVRL 480

AYAENIALLA ETALRFLELV QLKNLNMEND PNNEEIDEVT HPNGNYDTEL QALHEMVQQK 540

VVTLLSDPEN IVKQTLMENG ITRLCVFFGR QKANDVLLSH MITFLNDKND WHLRGAFFDS 600

IVGVAAYVGW QSSSILKPLL QQGLSDAEEF VIVKALYALT CMCQLGLLQK PHVYEFASDI 660

APFLCHPNLW IRYGAVGFIT VVARQISTAD VYCKLMPYLD PYITQPIIQI ERKLVLLSVL 720

KEPVSRSIFD YALRSKDITS LFRHLHMRQK KRNGSLPDCP PPEDPAIAQL LKKLLSQGMT 780

EEEEDKLLAL KDFMMKSNKA KANIVDQSHL HDSSQKGVID LAALGITGRQ VDLVKTKQEP 840

DDKRARKHVK QDSNVNEEWK SMFGSLDPPN MPQALPKGSD QEVIQTGKPP RSESSAGICV 900

PLSTSSQVPE VTTVQNKKPV IPVLSSTILP STYQIRITTC KTELQQLIQQ KREQCNAERI 960

AKQMMENAEW ESKPPPPGWR PKGLLVAHLH EHKSAVNRIR VSDEHSLFAT CSNDGTVKIW 1020

NSQKMEGKTT TTRSILTYSR IGGRVKTLTF CQGSHYLAIA SDNGAVQLLG IEASKLPKSP 1080

KIHPLQSRIL DQKEDGCVVD MHHFNSGAQS VLAYATVNGS LVGWDLRSSS NAWTLKHDLK 1140

SGLITSFAVD IHQCWLCIGT SSGTMACWDM RFQLPISSHC HPSRARIRRL SMHPLYQSWV 1200

IAAVQGNNEV SMWDMETGDR RFTLWASSAP PLSELQPSPH SVHGIYCSPA DGNPILLTAG 1260

SDMKIRFWDL AYPERSYVVA GSTSSPSVSY YRKIIEGTEV VQEIQNKQKV GPSDDTPRRG 1320

PESLPVGHHD IITDVATFQT TQGFIVTASR DGIVKVWK 1358

Nucleotide Sequence
(FASTA)

ATGGGAAATC AGCTTGCTGG CATTGCTCCC TCCCAGATCC TTTCTGTAGA GAGTTATTTT 60

TCAGATATTC ATGACTTTGA ATATGATAAA AGCCTGGGGA GTACTCGGTT TTTTAAAGTT 120

GCTCGAGCCA AGCACCGAGA AGGCCTGGTC GTTGTGAAGG TTTTTGCAAT TCAGGATCCC 180

ACATTGCCTT TAACCAGCTA TAAACAAGAG CTGGAGGAAC TGAAAATCAG GCTTAATTCT 240

GCACAGAATT GTCTACCTTT CCAGAAAGCA TCAGAAAAAG CATCTGAGAA AGCAGCTATG 300

CTCTTTAGGC AGTATGTGCG AGACAATCTC TATGATCGCA TCAGTACCCG TCCATTCTTG 360

AATAACATTG AGAAGCGCTG GATTGCTTTC CAGATCCTGA CAGCTGTGGA CCAAGCACAC 420

AAATCTGGAG TTCGTCATGG GGACATCAAG ACTGAGAATG TGATGGTCAC CAGTTGGAAT 480

TGGGTTCTTC TAACTGATTT TGCCAGTTTT AAGCCCACTT ATCTTCCAGA AGACAACCCG 540

GCAGATTTCA ATTATTTCTT TGACACATCA CGGAGGAGAA CTTGCTATAT TGCTCCTGAA 600

CGTTTTGTTG ATGGTGGGAT GTTTGCCACT GAGTTAGAAT ATATGAGAGA TCCTTCAACT 660

CCGCTTGTAG ACTTAAATAG CAATCAGAGA ACAAGAGGAG AGTTGAAGAG AGCAATGGAC 720

ATCTTTTCAG CAGGTTGTGT GATAGCTGAG CTTTTTACAG AAGGTGTACC ATTATTTGAT 780

CTCTCTCAAC TTTTGGCTTA TAGAAATGGA CATTTTTTCC CTGAACAAGT GCTAAATAAA 840

ATTGAAGATC GCAGTATCAG AGAATTGGTA ACTCAGATGA TTCACCGTGA GCCAGATAAA 900

CGTTTAGAGG CAGAAGATTA CTTAAAACAG CAGCGTGGCA ACGCCTTTCC TGAAATATTT 960

TACACTTTTC TTCAGCCCTA CATGGCCCAG TTTGCCAAGG AAACGTTTCT TTCTGCAGAT 1020

GAGCGTATTC TGGTTATACG GAAGGATTTG GGCAACATTA TTCACAATCT CTGTGGACAT 1080

GATCTGCCAG AAAAAGCCGA AGGAGAGCCT AAGGAAAATG GGCTGGTTAT CTTGGTATCT 1140

GTTATAACAT CCTGCCTACA GACCCTTAAA TACTGTGATT CCAAACTAGC TGCTTTGGAA 1200

CTTATTCTTC ATTTGGCTCC AAGATTAAGT GTTGAAATCC TTTTGGATCG TATTACTCCA 1260

TATCTTTTGC ATTTCAGCAA TGACTCTGTT CCTAGGGTGA GGGCTGAAGC CTTGAGGACG 1320

TTGACCAAAG TTCTTGCTCT CGTCAAAGAG GTTCCTCGTA ATGATATCAA TATTTATCCG 1380

GAATACATTC TGCCAGGCAT AGCCCACTTA GCCCAAGATG ATGCTACTAT CGTTAGACTA 1440

GCCTATGCTG AAAACATAGC TCTGCTGGCA GAAACAGCTC TGAGATTCCT GGAATTAGTA 1500

CAGTTAAAAA ATCTTAATAT GGAAAATGAC CCCAATAATG AAGAAATAGA TGAAGTTACA 1560

CATCCAAATG GAAATTATGA CACAGAGCTC CAAGCCTTAC ATGAAATGGT CCAGCAGAAA 1620

GTTGTTACTT TGCTAAGTGA CCCTGAAAAT ATTGTAAAAC AAACCCTGAT GGAAAATGGA 1680

ATAACACGGC TGTGTGTATT CTTTGGACGT CAGAAAGCCA ACGATGTTTT GTTGTCCCAC 1740

ATGATTACTT TCCTAAATGA TAAGAATGAT TGGCATCTAC GTGGAGCATT TTTTGATAGT 1800

ATAGTTGGTG TTGCTGCCTA TGTTGGCTGG CAAAGCTCCT CAATTCTCAA GCCCCTGCTG 1860

CAACAAGGTC TTAGTGATGC TGAGGAATTT GTCATTGTGA AAGCTCTTTA TGCCCTTACT 1920

TGTATGTGCC AGTTAGGACT GCTACAAAAA CCCCATGTTT ACGAATTTGC CAGTGATATT 1980

GCCCCCTTCC TGTGTCATCC CAATTTATGG ATACGTTATG GTGCCGTGGG ATTTATCACA 2040

GTGGTAGCTC GTCAAATAAG TACAGCTGAT GTCTACTGTA AACTGATGCC TTATCTTGAC 2100

CCATATATTA CCCAACCAAT AATACAGATT GAAAGAAAAC TTGTTCTGCT CAGTGTTTTA 2160

AAGGAACCAG TAAGTCGTTC TATATTTGAT TATGCTTTGA GGTCTAAAGA TATTACTAGC 2220

TTGTTCAGAC ATCTTCACAT GCGTCAGAAG AAACGAAATG GTTCTCTTCC CGACTGCCCT 2280

CCGCCAGAGG ATCCTGCCAT AGCACAGCTT CTGAAGAAGC TGCTCTCACA GGGAATGACA 2340

GAGGAAGAGG AAGACAAACT TCTGGCACTG AAAGACTTCA TGATGAAATC TAATAAAGCA 2400

AAGGCCAATA TAGTGGACCA GAGCCATCTT CATGATAGTA GTCAGAAAGG TGTAATTGAC 2460

TTGGCAGCTT TAGGCATAAC TGGGAGACAA GTTGATCTTG TTAAAACCAA ACAAGAACCA 2520

GATGACAAAC GGGCCAGAAA ACATGTAAAA CAAGACTCAA ATGTAAATGA AGAATGGAAA 2580

AGCATGTTTG GGTCACTGGA CCCACCAAAC ATGCCACAGG CCCTACCTAA AGGGAGTGAT 2640

CAGGAGGTGA TTCAGACTGG GAAACCTCCT CGTTCCGAGT CCTCTGCTGG CATTTGTGTC 2700

CCTTTGTCAA CTTCTTCACA GGTTCCAGAA GTGACAACTG TCCAAAATAA AAAACCAGTA 2760

ATACCGGTTT TAAGTAGTAC AATCTTACCA TCCACCTATC AGATTCGAAT TACAACTTGT 2820

AAAACTGAAC TTCAGCAACT CATCCAGCAA AAGCGGGAGC AGTGCAATGC TGAGAGAATA 2880

GCTAAGCAGA TGATGGAAAA TGCTGAATGG GAGAGTAAAC CACCACCACC TGGATGGCGT 2940

CCTAAAGGGC TGTTAGTTGC CCATCTTCAT GAGCATAAAT CTGCTGTGAA TCGAATTAGA 3000

GTCTCTGATG AACACTCACT TTTTGCAACA TGTTCAAATG ATGGCACAGT GAAAATCTGG 3060

AACAGTCAAA AGATGGAGGG GAAGACCACC ACTACCAGAT CTATTCTTAC ATACAGCCGA 3120

ATTGGAGGAC GAGTCAAGAC GCTCACATTC TGCCAAGGCT CCCACTATTT AGCCATAGCA 3180

TCTGATAATG GTGCTGTCCA GCTTCTTGGA ATTGAGGCTT CTAAGCTGCC CAAGTCTCCT 3240

AAAATCCATC CTCTACAAAG CAGAATTCTA GATCAGAAGG AGGACGGTTG TGTTGTGGAT 3300

ATGCATCACT TCAACTCTGG GGCACAGTCT GTTCTTGCCT ATGCCACTGT GAATGGCTCT 3360

CTGGTTGGCT GGGACCTTAG GTCTTCAAGC AATGCGTGGA CTTTAAAGCA TGATTTAAAG 3420

TCGGGCCTCA TCACTTCCTT TGCTGTGGAC ATCCACCAAT GCTGGCTCTG CATTGGTACA 3480

AGCAGTGGTA CCATGGCTTG TTGGGACATG AGGTTCCAGT TGCCAATTTC AAGTCACTGT 3540

CATCCTTCCA GGGCTCGAAT CAGACGCCTC TCAATGCACC CTCTGTATCA GTCCTGGGTG 3600

ATTGCAGCTG TTCAGGGCAA CAACGAAGTG TCCATGTGGG ACATGGAGAC TGGTGACAGA 3660

AGATTTACTC TCTGGGCCAG CAGTGCACCA CCACTTTCTG AATTACAGCC TTCTCCTCAT 3720

AGCGTCCATG GTATCTACTG TAGTCCTGCA GATGGAAATC CTATCCTGCT AACAGCTGGC 3780

TCAGATATGA AAATAAGGTT TTGGGACTTG GCTTACCCAG AAAGGTCCTA TGTTGTTGCA 3840

GGAAGTACTA GTTCCCCATC TGTGTCCTAC TACAGGAAAA TAATTGAAGG CACTGAAGTT 3900

GTCCAGGAAA TTCAGAATAA GCAGAAAGTA GGACCAAGTG ATGACACCCC TCGAAGGGGC 3960

CCAGAGTCCC TGCCCGTGGG ACATCATGAC ATCATCACTG ATGTCGCCAC ATTCCAGACC 4020

ACACAGGGCT TCATCGTAAC TGCTTCTAGA GATGGGATTG TGAAGGTGTG GAAATAA 4077

Domain Profile

S: 1     veyvknlgstrflkvakakteeGeivvkvfvkqdptlslesfkqrleelklklakaqncl  60

         +ey+k+lgstrf+kva+ak++eG++vvkvf++qdptl+l+s+kq+leelk++l++aqncl

Q: 26    FEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELKIRLNSAQNCL  85

         68**********************************************************

S: 61    pfqkvlek..ekaavllrqyvkdnlydrlstrPflneiekkwiafqllkaldqihksgvv  118

         pfqk++ek  ekaa+l+rqyv+dnlydr+strPfln+iek+wiafq+l+a+dq+hksgv+

Q: 86    PFQKASEKasEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVR  145

         *******999**************************************************

S: 119   hGdiktenvlvtswnWvlltdfasfkPtylpednPadftyffdtsrrrtcyiaPerfvsa  178

         hGdiktenv+vtswnWvlltdfasfkPtylpednPadf+yffdtsrrrtcyiaPerfv++

Q: 146   HGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDG  205

         ************************************************************

S: 179   lasdekl...rdgstelvdldsiqrlrgelkkamdifsaGcvilelftegrplfelsqll  235

         ++++++l   rd+st+lvdl+s+qr+rgelk+amdifsaGcvi+elfteg+plf+lsqll

Q: 206   GMFATELeymRDPSTPLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEGVPLFDLSQLL  265

         ******9999**************************************************

S: 236   ayrsgeflvekvlekiededlrnlvlqliqlepekrksaedllkk  280

         ayr+g+f++e+vl+kied+++r+lv+q+i++ep+kr++aed+lk+

Q: 266   AYRNGHFFPEQVLNKIEDRSIRELVTQMIHREPDKRLEAEDYLKQ  310

         *******************************************97

Domain Sequence
(FASTA)

FEYDKSLGST RFFKVARAKH REGLVVVKVF AIQDPTLPLT SYKQELEELK IRLNSAQNCL 60

PFQKASEKAS EKAAMLFRQY VRDNLYDRIS TRPFLNNIEK RWIAFQILTA VDQAHKSGVR 120

HGDIKTENVM VTSWNWVLLT DFASFKPTYL PEDNPADFNY FFDTSRRRTC YIAPERFVDG 180

GMFATELEYM RDPSTPLVDL NSNQRTRGEL KRAMDIFSAG CVIAELFTEG VPLFDLSQLL 240

AYRNGHFFPE QVLNKIEDRS IRELVTQMIH REPDKRLEAE DYLKQ 285

Keyword

Complete proteome; Kinase; Reference proteome; Repeat; Transferase; WD repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ptr:460692

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR001680	; WD40_repeat.
IPR019775	; WD40_repeat_CS.
IPR017986	; WD40_repeat_dom.

Pfam

PF00069	; Pkinase; 1.
PF00400	; WD40; 3.

SMARTs

SM00320

; WD40; 6.

Prosites

PS50077	; HEAT_REPEAT; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00678	; WD_REPEATS_1; 2.
PS50082	; WD_REPEATS_2; 2.
PS50294	; WD_REPEATS_REGION; 2.

Prints

Created Date

20-Feb-2013