EKS-PAT-00138
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-PAT-00138
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR556.39.3E-168471747277
StatusUnreviewed
Ensembl ProteinENSPTRP00000027267
UniProt AccessionH2QP39;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR3
Gene Synonyms/Alias FGFR3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPTRG00000015836ENSPTRP00000027267ENSPTRT00000029554
OrganismPan troglodytes
Functional Description
Protein Length805
Protein Sequence
(FASTA)
MGAPACALAL CVAVAIVAGA SSESLGTEQR VVGRAAEVPG PEPGQQEQLV FGSGDAVELS 60
CPPPGGGPMG PTVWVKDGAG LVPSERVLVG PQRLQVLNAS HEDSGAYSCR QRLTQRVLCH 120
FSVRVTDAPS SGDDEDGEDE AEDTGVDTGA PYWTRPERMD KKLLAVPAAN TVRFRCPAAG 180
NPTPSISWLK NGREFRGEHR IGGIKLRHQQ WSLVMESVVP SDRGNYTCVV ENKFGSIRQT 240
YTLDVLERSP HRPILQAGLP ANQTAVLGSD VEFHCKVYSD AQPHIQWLKH VEVNGSKVGP 300
DGTPYVTVLK TAGANTDKEL EVLSLHNVTF EDAGEYTCLA GNSIGFSHHS AWLVVLPAEE 360
ELVEADEAGS VYAGILSYGV GFFLFILVVA AVTLCRLRSP PKKGLGSPTV HKISRFPLKR 420
QVSLESNASM SSNTPLVRIA RLSSGEGPTL ANVSELELPA DPKWELSRAR LTLGKPLGEG 480
CFGQVVMAEA IGIDKDRAAK PVTVAVKMLK DDATDKDLSD LVSEMEMMKM IGKHKNIINL 540
LGACTQGGPL YVLVEYAAKG NLREFLRARR PPGLDYSFDT CKPPEEQLTF KDLVSCAYQV 600
ARGMEYLASQ KCIHRDLAAR NVLVTEDNVM KIADFGLARD VHNLDYYKKT TNGRLPVKWM 660
APEALFDRVY THQSDVWSFG VLLWEIFTLG GSPYPGIPVE ELFKLLKEGH RMDKPANCTH 720
DLYMIMRECW HAAPSQRPTF KQLVEDLDRV LTVTSTDEYL DLSAPFEQYS PGGQDTPSSS 780
SSGDDSVFAH DLLPPAPPSS GGSRT 805
Nucleotide Sequence
(FASTA)
ATGGGCGCCC CTGCCTGCGC CCTCGCGCTC TGCGTGGCCG TGGCCATCGT AGCCGGCGCC 60
TCCTCGGAGT CCTTGGGGAC GGAGCAGCGC GTCGTGGGGC GAGCGGCAGA AGTCCCGGGC 120
CCAGAGCCCG GCCAGCAGGA GCAGTTGGTC TTCGGCAGCG GGGATGCTGT GGAGCTGAGC 180
TGTCCCCCGC CCGGGGGTGG TCCCATGGGG CCCACTGTCT GGGTCAAGGA TGGCGCAGGG 240
CTGGTGCCCT CGGAGCGTGT CCTGGTGGGC CCCCAGCGGC TGCAGGTGCT GAATGCCTCC 300
CACGAGGACT CCGGGGCCTA CAGCTGCCGG CAGCGGCTCA CGCAGCGCGT ACTGTGCCAC 360
TTCAGTGTGC GGGTGACAGA CGCTCCATCC TCGGGAGATG ACGAAGACGG GGAGGACGAG 420
GCTGAGGACA CAGGTGTGGA CACAGGGGCC CCTTACTGGA CACGGCCCGA GCGGATGGAC 480
AAGAAGCTGC TGGCCGTGCC GGCCGCCAAC ACCGTCCGCT TCCGCTGCCC AGCCGCCGGC 540
AACCCCACTC CCTCCATCTC CTGGCTGAAG AATGGCAGGG AGTTCCGCGG CGAGCACCGC 600
ATCGGAGGCA TCAAGCTGCG GCATCAGCAG TGGAGCCTGG TCATGGAAAG CGTGGTGCCC 660
TCGGACCGCG GCAACTACAC CTGCGTCGTG GAGAACAAGT TTGGCAGCAT CCGGCAGACG 720
TACACGCTGG ACGTGCTGGA GCGCTCCCCG CACCGGCCCA TCCTGCAGGC GGGGCTGCCG 780
GCCAACCAGA CGGCGGTGCT GGGCAGCGAC GTGGAGTTCC ACTGCAAGGT GTACAGTGAC 840
GCACAGCCCC ACATCCAGTG GCTCAAGCAC GTGGAGGTGA ACGGCAGCAA GGTGGGCCCG 900
GACGGCACAC CCTACGTTAC CGTGCTCAAG ACGGCGGGCG CTAACACCGA CAAGGAGCTA 960
GAGGTTCTCT CCTTGCACAA CGTCACCTTT GAGGACGCCG GGGAGTACAC CTGCCTGGCG 1020
GGCAATTCTA TTGGGTTTTC TCATCACTCT GCGTGGCTGG TGGTGCTGCC AGCCGAGGAG 1080
GAGCTGGTGG AGGCTGACGA GGCGGGCAGT GTGTATGCAG GCATCCTCAG CTACGGGGTG 1140
GGCTTCTTCC TGTTCATCCT GGTGGTGGCG GCTGTGACGC TCTGCCGCCT GCGCAGCCCC 1200
CCCAAGAAAG GCCTGGGCTC CCCCACCGTG CACAAGATCT CCCGCTTCCC GCTCAAGCGA 1260
CAGGTGTCCC TGGAGTCCAA CGCGTCCATG AGCTCCAACA CACCACTGGT GCGCATCGCA 1320
AGGCTGTCCT CAGGGGAGGG CCCCACGCTG GCCAATGTCT CCGAGCTCGA GCTGCCTGCC 1380
GACCCCAAAT GGGAGCTGTC TCGGGCCCGG CTGACCCTGG GCAAGCCCCT TGGGGAGGGC 1440
TGCTTCGGCC AGGTGGTCAT GGCGGAGGCC ATCGGCATTG ACAAGGACCG GGCCGCCAAG 1500
CCTGTCACCG TAGCCGTGAA GATGCTGAAA GACGATGCCA CTGACAAGGA CCTGTCGGAC 1560
CTGGTGTCTG AGATGGAGAT GATGAAGATG ATCGGGAAAC ACAAAAACAT CATCAACCTG 1620
CTGGGCGCCT GCACGCAGGG CGGGCCCCTG TACGTGCTGG TGGAGTACGC GGCCAAGGGT 1680
AACCTGCGGG AGTTCCTGCG GGCGCGGCGG CCCCCGGGCC TGGACTACTC CTTCGACACC 1740
TGCAAGCCGC CCGAGGAGCA GCTCACCTTC AAGGACCTGG TGTCCTGTGC CTACCAGGTG 1800
GCCCGGGGCA TGGAGTACTT GGCCTCCCAG AAGTGCATCC ACAGGGACCT GGCTGCCCGC 1860
AATGTGCTGG TGACCGAGGA CAACGTGATG AAGATCGCAG ACTTCGGGCT GGCCCGGGAC 1920
GTGCACAACC TCGACTACTA CAAGAAGACG ACCAACGGCC GGCTGCCCGT GAAGTGGATG 1980
GCGCCTGAGG CCTTGTTTGA CCGAGTCTAC ACTCACCAGA GTGACGTCTG GTCCTTTGGG 2040
GTCCTGCTCT GGGAGATCTT CACGCTGGGG GGCTCCCCGT ACCCCGGCAT CCCTGTGGAG 2100
GAGCTCTTCA AGCTGCTGAA GGAGGGCCAC CGCATGGACA AGCCCGCCAA CTGCACACAC 2160
GACCTGTACA TGATCATGCG GGAGTGCTGG CATGCCGCGC CCTCCCAGAG GCCCACCTTC 2220
AAGCAGCTGG TGGAGGACCT GGACCGTGTC CTTACCGTGA CGTCCACCGA CGAGTACCTG 2280
GACCTGTCGG CGCCTTTCGA GCAGTACTCC CCGGGTGGCC AGGACACCCC CAGCTCCAGC 2340
TCCTCAGGGG ACGACTCCGT GTTTGCCCAC GACCTGCTGC CCCCGGCCCC ACCCAGCAGT 2400
GGGGGCTCGC GGACGTGA 2418
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aeaig+dkd+++k vtvavkmlk+datdkdl+dlvseme++k+
Q: 471   LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKM  530
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyv+veyaakGnlreflrarrp+g ++s d++k +eeqlt+
Q: 531   IGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTF  590
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ayqvarGmeylas+kcihrdlaarnvlvtednv+kiadfGlardvh++dyykkt
Q: 591   KDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKT  650
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvwsfGvllwei+tlGgspypgi+veelfkllkeGh
Q: 651   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH  710
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kpa+ct++ly++mrecwha++s+rptfkqlvedl
Q: 711   RMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL  747
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA IGIDKDRAAK PVTVAVKMLK DDATDKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQGGPL YVLVEYAAKG NLREFLRARR PPGLDYSFDT CKPPEEQLTF 120
KDLVSCAYQV ARGMEYLASQ KCIHRDLAAR NVLVTEDNVM KIADFGLARD VHNLDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLLWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPANCTH DLYMIMRECW HAAPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00142
EKS-CAE-00120
EKS-CAF-00155
EKS-CAP-00149
EKS-DAR-00435
EKS-DRM-00072
EKS-EQC-00146
EKS-GAM-00077
EKS-GAG-00124
EKS-GAA-00174
EKS-GOG-00150
EKS-ICT-00141
EKS-LAC-00156
EKS-LOA-00146
EKS-MEG-00114
EKS-MOD-00146
EKS-MUM-00152
EKS-MUP-00153
EKS-ORN-00181
EKS-ORA-00127
EKS-ORL-00169
EKS-OTG-00154
EKS-PES-00131
EKS-PEM-00080
EKS-PTV-00141
EKS-RAN-00146
EKS-SAH-00141
EKS-TAG-00175
EKS-TAR-00190
EKS-TEN-00186
EKS-XET-00135
EKS-XIM-00175
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008284; P:positive regulation of cell proliferation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013