EKS-PAT-00381
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-PAT-00381
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR604.28.1E-182589924336
StatusUnreviewed
Ensembl ProteinENSPTRP00000027637
UniProt AccessionH2QPH5;
Protein Name
Protein Synonyms/Alias V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog;
Gene NameENSG00000157404
Gene Synonyms/Alias ENSG00000157404; KIT;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPTRG00000016067ENSPTRP00000060983ENSPTRT00000072891
ENSPTRG00000016067ENSPTRP00000027637ENSPTRT00000029947
OrganismPan troglodytes
Functional Description
Protein Length976
Protein Sequence
(FASTA)
MRGARGAWDF LCVLLLLLRV QTGSSQPSVS PGEPSPPSIH PGKSDLIVRV GDEIRLLCTD 60
PGFVKWTFEI LDETNENKQN EWITEKAEAT NTGKYTCTNK HGLSNSIYVF VRDPAKLFLV 120
DRSLYGKEDN DTLVRCPLTD PEVTNYSLKG CQGKPLPKDL RFVPDPKAGI MIKSVKRAYH 180
RLCLHCSVDQ EGKSVLSEKF ILKVRPAFKA VPVVSVSKAS YLLREGEEFT VTCTIKDVSS 240
SVYSTWKREN SQTKLQEKYN SWHHGDFNYE RQATLTISSA RVNDSGVFMC YANNTFGSAN 300
VTTTLEVVDK GFINIFPMIN TTVFVNDGEN VDLIVEYEAF PKPEHQQWIY MNRTFTDKWE 360
DYPKSENESN IRYVSELHLT RLKGTEGGTY TFLVSNSDVN ASIAFNVYVN TKPEILTYDR 420
LVNGMLQCVA AGFPEPTIDW YFCPGTEQRC SASVLPVDVQ TLNSSGPPFG KLVVQSSIDS 480
SAFKHNGTVE CKAYNDVGKT SAYFNFAFKG NNKEQIHPHT LFTPLLIGFV IVAGMMCIIV 540
MILTYKYLQK PMYEVQWKVV EEINGNNYVY IDPTQLPYDH KWEFPRNRLS FGKTLGAGAF 600
GKVVEATAYG LIKSDAAMTV AVKMLKPSAH LTEREALMSE LKVLSYLGNH MNIVNLLGAC 660
TIGGPTLVIT EYCCYGDLLN FLRRKRDSFI CSKQEDHAEA ALYKNLLHSK ESSCSDSTNE 720
YMDMKPGVSY VVPTKADKRR SARIGSYIER DVTPAIMEDD ELALDLEDLL SFSYQVAKGM 780
AFLASKNCIH RDLAARNILL THGRITKICD FGLARDIKND SNYVVKGNAR LPVKWMAPES 840
IFNCVYTFES DVWSYGIFLW ELFSLGSSPY PGMPVDSKFY KMIKEGFRML SPEHAPAEMY 900
DIMKTCWDAD PLKRPTFKQI VQLIEKQISE STNHIYSNLA NCSPNRQKPV VDHSVRINSV 960
GSTASSSQPL LVHDDV 976
Nucleotide Sequence
(FASTA)
ATGAGAGGCG CTCGCGGCGC CTGGGATTTT CTCTGCGTTC TGCTCCTACT GCTTCGCGTC 60
CAGACAGGCT CTTCTCAACC ATCTGTGAGT CCAGGGGAAC CGTCTCCACC ATCCATCCAT 120
CCAGGAAAAT CAGACTTAAT AGTCCGCGTG GGCGACGAGA TTAGGCTGTT ATGCACTGAT 180
CCGGGCTTTG TCAAATGGAC TTTTGAGATC CTGGATGAAA CGAATGAGAA TAAGCAGAAT 240
GAATGGATCA CGGAGAAGGC AGAAGCCACC AACACTGGCA AATACACGTG CACCAACAAA 300
CACGGCTTAA GCAATTCCAT TTATGTGTTT GTTAGAGATC CTGCCAAGCT TTTCCTTGTT 360
GACCGCTCCT TGTATGGGAA AGAAGACAAC GACACGCTGG TCCGCTGTCC TCTCACAGAC 420
CCAGAAGTGA CCAATTATTC CCTCAAAGGG TGCCAGGGGA AGCCTCTTCC CAAGGACTTG 480
AGGTTTGTTC CTGACCCCAA GGCGGGCATC ATGATCAAAA GTGTGAAACG CGCCTACCAT 540
CGGCTCTGTC TGCATTGTTC TGTGGACCAG GAGGGCAAGT CAGTGCTGTC GGAAAAATTC 600
ATCCTGAAAG TGAGGCCAGC CTTCAAAGCT GTGCCTGTTG TGTCTGTGTC CAAAGCAAGC 660
TATCTTCTTA GGGAAGGGGA AGAATTCACA GTGACGTGCA CAATAAAAGA TGTGTCTAGT 720
TCTGTGTACT CAACGTGGAA AAGAGAAAAC AGTCAGACTA AACTACAGGA GAAATATAAT 780
AGCTGGCATC ACGGTGACTT CAATTATGAA CGTCAGGCAA CGTTGACTAT CAGTTCAGCG 840
AGAGTTAATG ATTCTGGAGT GTTCATGTGT TATGCCAATA ATACTTTTGG ATCAGCAAAT 900
GTCACAACAA CCTTGGAAGT AGTAGATAAA GGATTCATTA ATATCTTCCC CATGATAAAC 960
ACTACAGTAT TTGTAAATGA TGGAGAAAAT GTAGATTTGA TTGTTGAATA TGAAGCATTC 1020
CCCAAACCTG AACACCAGCA GTGGATCTAT ATGAACAGAA CCTTCACTGA TAAATGGGAA 1080
GATTATCCCA AGTCTGAGAA TGAAAGTAAT ATCAGATACG TAAGTGAACT TCATCTAACG 1140
AGATTAAAAG GCACCGAAGG AGGCACTTAC ACATTCCTAG TGTCCAATTC TGACGTCAAT 1200
GCTTCCATAG CATTTAATGT TTATGTGAAT ACAAAACCAG AAATCCTGAC TTACGACAGG 1260
CTCGTGAATG GCATGCTCCA ATGTGTGGCA GCAGGATTCC CAGAGCCCAC AATAGATTGG 1320
TATTTTTGTC CAGGAACTGA GCAGAGATGC TCTGCTTCTG TACTGCCAGT GGATGTGCAG 1380
ACACTAAACT CATCTGGGCC ACCGTTTGGA AAGCTAGTGG TTCAGAGTTC TATAGATTCT 1440
AGTGCATTCA AGCACAATGG CACGGTTGAA TGTAAGGCTT ACAACGATGT GGGCAAGACT 1500
TCTGCCTATT TTAACTTTGC ATTTAAAGGT AACAACAAAG AGCAAATCCA TCCCCACACC 1560
CTGTTCACTC CTTTGCTGAT TGGTTTCGTA ATCGTAGCTG GCATGATGTG CATTATTGTG 1620
ATGATTCTGA CCTACAAATA TTTACAGAAA CCCATGTATG AAGTACAGTG GAAGGTTGTT 1680
GAGGAGATAA ATGGAAACAA TTATGTTTAC ATAGACCCAA CACAACTTCC TTATGATCAC 1740
AAATGGGAGT TTCCCAGAAA CAGGCTGAGT TTTGGGAAAA CCCTGGGTGC TGGAGCTTTC 1800
GGGAAGGTTG TTGAGGCAAC TGCTTATGGC TTAATTAAGT CAGATGCGGC CATGACTGTC 1860
GCTGTGAAGA TGCTCAAACC AAGTGCCCAT TTAACAGAAC GGGAAGCCCT CATGTCTGAA 1920
CTCAAAGTCC TGAGTTACCT TGGTAATCAC ATGAATATTG TGAATCTACT TGGAGCCTGC 1980
ACCATTGGAG GGCCCACCCT GGTCATTACA GAATATTGTT GCTATGGTGA TCTTTTGAAT 2040
TTTTTGAGAA GAAAACGTGA TTCATTTATT TGTTCAAAGC AGGAAGATCA TGCAGAAGCT 2100
GCACTTTATA AGAATCTTCT GCATTCAAAG GAGTCTTCCT GCAGCGATAG TACTAATGAG 2160
TACATGGACA TGAAACCTGG AGTTTCTTAT GTTGTCCCAA CCAAGGCCGA CAAAAGGAGA 2220
TCTGCGAGAA TAGGCTCATA CATAGAAAGA GATGTGACTC CCGCCATCAT GGAGGATGAC 2280
GAGTTGGCCC TAGACTTAGA AGACTTGCTG AGCTTTTCTT ACCAGGTGGC AAAGGGCATG 2340
GCTTTCCTCG CCTCCAAGAA TTGTATTCAC AGAGACTTGG CAGCCAGAAA TATCCTCCTT 2400
ACTCATGGTC GGATCACAAA GATTTGTGAT TTTGGTCTAG CCAGAGACAT CAAGAATGAT 2460
TCTAATTATG TGGTTAAAGG AAACGCTCGA CTACCTGTGA AGTGGATGGC ACCTGAAAGC 2520
ATTTTCAACT GTGTATACAC GTTTGAAAGC GACGTCTGGT CCTATGGGAT TTTTCTTTGG 2580
GAGCTGTTCT CTTTAGGAAG CAGCCCCTAT CCTGGAATGC CGGTCGATTC TAAGTTCTAC 2640
AAGATGATCA AGGAAGGCTT CCGGATGCTC AGCCCTGAAC ACGCACCTGC TGAAATGTAT 2700
GACATAATGA AGACTTGCTG GGATGCAGAT CCCCTAAAAA GACCAACATT CAAGCAAATT 2760
GTTCAGCTAA TTGAGAAGCA GATTTCAGAG AGCACCAATC ATATTTACTC CAACTTAGCA 2820
AACTGCAGCC CCAACCGACA GAAGCCCGTG GTGGACCATT CTGTGCGGAT CAATTCTGTC 2880
GGCAGCACCG CTTCCTCCTC CCAGCCTCTG CTTGTGCACG ACGATGTCTG A 2931
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveatayGl+ksda+++vavkmlk++a+ +e+ealmselk+ls+lG
Q: 589   LSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG  648
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGact gGp++viteyccyGdlln+lrrkr+sf+   ++k+++++e++ +k+
Q: 649   NHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFI---CSKQEDHAEAALYKN  705
         ******************************************...99999*********9
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
         l     l+sk+s++s+s++ey+d+k++vs+v ++kadk++s+++ s++er+v++a++e+d
Q: 706   L-----LHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSARIGSYIERDVTPAIMEDD  760
         9.....9*****************************************************
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
         + +l+ledllsfsyqvakGm+flasknc+hrdlaarn+llt+G+++kicdfGlardi++d
Q: 761   ELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKND  820
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvvkGnarlpvkwmapesif+++yt++sdvwsyGi+lwe+fslGs+pypg++vdskfy
Q: 821   SNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFY  880
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         k+ikeG+rm +p++a++e+y+im++cw+a+p krp+fkq+v+l+
Q: 881   KMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLI  924
         *****************************************996
Domain Sequence
(FASTA)
LSFGKTLGAG AFGKVVEATA YGLIKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG 60
NHMNIVNLLG ACTIGGPTLV ITEYCCYGDL LNFLRRKRDS FICSKQEDHA EAALYKNLLH 120
SKESSCSDST NEYMDMKPGV SYVVPTKADK RRSARIGSYI ERDVTPAIME DDELALDLED 180
LLSFSYQVAK GMAFLASKNC IHRDLAARNI LLTHGRITKI CDFGLARDIK NDSNYVVKGN 240
ARLPVKWMAP ESIFNCVYTF ESDVWSYGIF LWELFSLGSS PYPGMPVDSK FYKMIKEGFR 300
MLSPEHAPAE MYDIMKTCWD ADPLKRPTFK QIVQLI 336
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-DAR-00787
EKS-FEC-00386
EKS-GAG-00341
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORN-00514
EKS-ORA-00347
EKS-ORC-00378
EKS-ORL-00472
EKS-OTG-00405
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013