EKS-PAT-00437

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00437

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	416.2	6.0E-125	64	359	296

Status

Unreviewed

Ensembl Protein

ENSPTRP00000027906

UniProt Accession

H2QPU2;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000109339

Gene Synonyms/Alias

ENSG00000109339;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000016244	ENSPTRP00000027906	ENSPTRT00000030233

Organism

Pan troglodytes

Functional Description

Protein Length

464

Protein Sequence
(FASTA)

MSLHFLYYCS EPTLDVKIAF CQGFDKQVDV SYIAKHYNMS KSKVDNQFYS VEVGDSTFTV 60

LKRYQNLKPI GSGAQGIVCA AYDAVLDRNV AIKKLSRPFQ NQTHAKRAYR ELVLMKCVNH 120

KNIISLLNVF TPQKTLEEFQ DVYLVMELMD ANLCQVIQME LDHERMSYLL YQMLCGIKHL 180

HSAGIIHRDL KPSNIVVKSD CTLKILDFGL ARTAGTSFMM TPYVVTRYYR APEVILGMGY 240

KENVDIWSVG CIMGEMVRHK ILFPGRDYID QWNKVIEQLG TPCPEFMKKL QPTVRNYVEN 300

RPKYAGLTFP KLFPDSLFPA DSEHNKLKAS QARDLLSKML VIDPAKRISV DDALQHPYIN 360

VWYDPAEVEA PPPQIYDKQL DEREHTIEEW KELIYKEVMN SEEKTKNGVV KGQPSPSGAA 420

VNSSESLPPS SSVNDISSMS TDQTLASDTD SSLEASAGPL GCCR 464

Nucleotide Sequence
(FASTA)

ATGAGCCTCC ATTTCTTATA CTACTGCAGT GAACCAACAT TGGATGTGAA AATTGCCTTT 60

TGTCAGGGAT TCGATAAACA AGTGGATGTG TCATATATTG CCAAACATTA CAACATGAGC 120

AAAAGCAAAG TTGACAACCA GTTCTACAGT GTGGAAGTGG GAGACTCAAC CTTCACAGTT 180

CTCAAGCGCT ACCAGAATCT AAAGCCTATT GGCTCTGGGG CTCAGGGCAT AGTTTGTGCG 240

GCGTATGATG CTGTCCTTGA CAGAAATGTG GCCATTAAGA AGCTCAGCAG ACCCTTTCAG 300

AACCAAACAC ATGCCAAGAG AGCGTACCGG GAGCTGGTCC TCATGAAGTG TGTGAACCAT 360

AAAAACATTA TTAGTTTATT AAATGTCTTC ACACCCCAGA AAACGCTGGA GGAGTTCCAA 420

GATGTTTACT TAGTAATGGA ACTGATGGAT GCCAACTTAT GTCAAGTGAT TCAGATGGAA 480

TTAGACCATG AGCGAATGTC TTACCTGCTG TACCAAATGT TGTGTGGCAT TAAGCACCTC 540

CATTCTGCTG GAATTATTCA CAGGGATTTA AAACCAAGTA ACATTGTAGT CAAGTCTGAT 600

TGCACATTGA AAATCCTGGA CTTTGGACTG GCCAGGACAG CAGGCACAAG CTTCATGATG 660

ACTCCATATG TGGTGACACG TTATTACAGA GCCCCTGAGG TCATCCTGGG GATGGGCTAC 720

AAGGAGAACG TGGATATATG GTCTGTGGGA TGCATTATGG GAGAAATGGT TCGCCACAAA 780

ATCCTCTTTC CAGGAAGGGA CTATATTGAC CAGTGGAATA AGGTAATTGA ACAACTAGGA 840

ACACCATGTC CAGAATTCAT GAAGAAATTG CAACCCACAG TAAGAAACTA TGTGGAGAAT 900

CGGCCCAAGT ATGCGGGACT CACCTTCCCC AAACTCTTCC CAGATTCCCT CTTCCCAGCG 960

GACTCCGAGC ACAATAAACT CAAAGCCAGC CAAGCCAGGG ACTTGTTGTC AAAGATGCTA 1020

GTGATTGACC CAGCAAAAAG AATATCAGTG GACGACGCCT TACAGCATCC CTACATCAAC 1080

GTCTGGTATG ACCCAGCCGA AGTGGAGGCG CCTCCACCTC AGATATATGA CAAGCAGTTG 1140

GATGAAAGAG AACACACAAT CGAAGAATGG AAAGAACTTA TCTACAAGGA AGTAATGAAT 1200

TCAGAAGAAA AGACTAAAAA TGGTGTAGTA AAAGGACAGC CTTCTCCTTC AGGTGCAGCA 1260

GTGAACAGCA GTGAGAGTCT CCCTCCATCC TCGTCTGTCA ATGACATCTC CTCCATGTCC 1320

ACCGACCAGA CCCTGGCATC TGACACTGAC AGCAGCCTGG AAGCCTCGGC AGGACCCCTG 1380

GGTTGTTGCA GGTGA 1395

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  +++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 64    YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  123

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 124   ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  182

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 183   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  239

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++E++++k+lfpg+d+idq++k++e+lgtp  ef+kk++  ++rny+

Q: 240   YKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRNYV  298

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +f +lfp+            + ++a+dLl+k+Lv+dp kRisv++aL+hpY

Q: 299   ENRPKYAGLTFPKLFPDslfpadsehnklKASQARDLLSKMLVIDPAKRISVDDALQHPY  358

         *****************************99*****************************

S: 289   l  289

Q: 359   I  359

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AVLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

ISLLNVFTPQ KTLEEFQDVY LVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GEMVRHKILF PGRDYIDQWN KVIEQLGTPC PEFMKKLQPT VRNYVENRPK 240

YAGLTFPKLF PDSLFPADSE HNKLKASQAR DLLSKMLVID PAKRISVDDA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

ptr:461358

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013