EKS-PAT-00263

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00263

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	450.8	1.9E-135	233	520	288

Status

Unreviewed

Ensembl Protein

ENSPTRP00000027988

UniProt Accession

H2QPW8;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000138696

Gene Synonyms/Alias

ENSG00000138696;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000016293	ENSPTRP00000027988	ENSPTRT00000030320

Organism

Pan troglodytes

Functional Description

Protein Length

531

Protein Sequence
(FASTA)

MGWLEELNWQ LHIFLLILLS MHTRANFLDN MLLRSAGKLN VGTKKEDGES TAPTPRPKVL 60

RCKCHHHCPE DSVNNICSTD GYCFTMIEED DSGLPVVTSG CLGLEGSDFQ CRDTPIPHQR 120

RSIECCTERN ECNKDLHPTL PPLKNRFVDG PIHHKALLIS VTVCSLLLVL IILFCYFRYK 180

RQETRPRYSI GLEQDETYIP PGESLRDLIE QSQSSGSGSG LPLLVQRTIA KQIQMVKQIG 240

KGRYGEVWLG KWRGEKVAVK VFFTTEEASW FRETEIYQTV LMRHENILGF IAADIKGTGS 300

WTQLYLITDY HENGSLYDYL KSTTLDTKSM LKLAYSSVSG LCHLHTEIFS TQGKPAIAHR 360

DLKSKNILVK KNGTCCIADL GLAVKFISDT NEVDIPPNTR VGTKRYMPPE VLDESLNRNH 420

FQSYIMADMY SFGLILWEVA RRCVSGGIVE EYQLPYHDLV PSDPSYEDMR EIVCIKKLRP 480

SFPNRWSSDE CLRQMGKLMT ECWAHNPASR LTALRVKKTL AKMSESQDIK L 531

Nucleotide Sequence
(FASTA)

ATGGGTTGGC TGGAAGAACT AAACTGGCAG CTTCACATTT TCTTGCTCAT TCTTCTCTCT 60

ATGCACACAA GGGCAAACTT CCTTGATAAC ATGCTTTTGC GAAGTGCAGG AAAATTAAAT 120

GTGGGCACCA AGAAAGAGGA TGGTGAGAGT ACAGCCCCCA CCCCCCGTCC AAAGGTCTTA 180

CGTTGTAAAT GCCACCACCA TTGTCCAGAA GACTCAGTCA ACAATATTTG CAGCACAGAC 240

GGATATTGTT TCACGATGAT AGAAGAGGAT GACTCTGGGT TGCCTGTGGT CACTTCTGGA 300

TGCCTAGGAC TAGAAGGCTC AGATTTTCAG TGTCGGGACA CTCCCATTCC TCATCAAAGA 360

AGATCAATTG AATGCTGCAC AGAAAGGAAC GAATGTAATA AAGACCTACA CCCTACACTG 420

CCTCCATTGA AAAACAGATT TGTTGATGGA CCTATACACC ACAAAGCTTT ACTTATATCT 480

GTGACTGTCT GTAGTTTGCT CTTGGTCCTT ATCATATTAT TTTGTTACTT CCGGTATAAA 540

AGACAAGAAA CCAGACCTCG ATACAGCATT GGGTTAGAAC AGGATGAAAC TTACATTCCT 600

CCTGGAGAAT CCCTGAGAGA CTTAATTGAG CAGTCTCAGA GCTCAGGAAG TGGATCAGGC 660

CTCCCTCTGC TGGTCCAAAG GACTATAGCT AAGCAGATTC AGATGGTGAA ACAGATTGGA 720

AAAGGTCGCT ATGGGGAAGT TTGGTTGGGA AAGTGGCGTG GCGAAAAGGT AGCTGTGAAA 780

GTGTTCTTCA CCACAGAGGA AGCCAGCTGG TTCAGAGAGA CAGAAATATA TCAGACAGTG 840

TTGATGAGGC ATGAAAACAT TTTGGGTTTC ATTGCTGCAG ATATCAAAGG GACAGGGTCC 900

TGGACCCAGT TGTACCTAAT CACAGACTAT CATGAAAATG GTTCCCTTTA TGATTATCTG 960

AAGTCCACCA CCCTAGACAC TAAATCAATG CTGAAGTTAG CCTACTCTTC TGTCAGTGGC 1020

TTATGTCATT TACACACAGA AATCTTTAGT ACTCAAGGCA AACCAGCAAT TGCCCATCGA 1080

GATCTGAAAA GTAAAAACAT TCTGGTGAAG AAAAATGGAA CTTGCTGTAT TGCTGACCTG 1140

GGCCTGGCTG TTAAATTTAT TAGTGATACA AATGAAGTTG ACATACCACC TAACACTCGA 1200

GTTGGCACCA AACGCTATAT GCCTCCAGAA GTGTTGGACG AGAGCTTGAA CAGAAATCAC 1260

TTCCAGTCTT ACATCATGGC TGACATGTAT AGTTTTGGCC TCATCCTTTG GGAGGTTGCT 1320

AGGAGATGTG TATCAGGAGG TATAGTGGAA GAATACCAGC TTCCTTATCA TGACCTAGTG 1380

CCCAGTGACC CCTCTTATGA GGACATGAGG GAGATTGTGT GCATCAAGAA GTTACGCCCC 1440

TCATTCCCAA ACCGGTGGAG CAGTGATGAG TGTCTAAGGC AGATGGGGAA ACTCATGACA 1500

GAATGCTGGG CTCACAATCC TGCATCAAGG CTGACAGCCC TGCGGGTTAA GAAAACACTT 1560

GCCAAAATGT CAGAGTCCCA GGACATTAAA CTCTGA 1596

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++++++igkGrygeVw +k+rge+vAvK+f+t++easw+rE+eiyqtvl+rhenil+fia

Q: 233   IQMVKQIGKGRYGEVWLGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIA  292

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t+l+l+t+yhe+gsL+dyLk++tld++++l+la+s +sGl+hLH+ei+ t+

Q: 293   ADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDTKSMLKLAYSSVSGLCHLHTEIFSTQ  352

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa+k+ ++++e+d+  n++vGtkRYm PE

Q: 353   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPE  410

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e+ln ++f+++ +aD+Ys+gL+lWEva+Rc + +++veey+lp+++ v+sdPs+e+m

Q: 411   VLDESLNRNHFQSYIMADMYSFGLILWEVARRCVS-GGIVEEYQLPYHDLVPSDPSYEDM  469

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +e+v+ kklrP++p++w+++e+l+++ kl++ecW+++p++Rltalrvkk+l

Q: 470   REIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTL  520

         *************************************************97

Domain Sequence
(FASTA)

IQMVKQIGKG RYGEVWLGKW RGEKVAVKVF FTTEEASWFR ETEIYQTVLM RHENILGFIA 60

ADIKGTGSWT QLYLITDYHE NGSLYDYLKS TTLDTKSMLK LAYSSVSGLC HLHTEIFSTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVKFISDTNE VDIPPNTRVG TKRYMPPEVL 180

DESLNRNHFQ SYIMADMYSF GLILWEVARR CVSGGIVEEY QLPYHDLVPS DPSYEDMREI 240

VCIKKLRPSF PNRWSSDECL RQMGKLMTEC WAHNPASRLT ALRVKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013