EKS-PAT-00325

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00325

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DCAMKL	456.3	2.9E-137	394	651	258

Status

Unreviewed

Ensembl Protein

ENSPTRP00000028330

UniProt Accession

H2QQ98;

Protein Name

Protein Synonyms/Alias

Doublecortin-like kinase 2;

Gene Name

ENSG00000170390

Gene Synonyms/Alias

ENSG00000170390; DCLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000016504	ENSPTRP00000028330	ENSPTRT00000030676

Organism

Pan troglodytes

Functional Description

Protein Length

766

Protein Sequence
(FASTA)

MASTRSIELE HFEERDKRPR PGSRRGAPSS SGGSSSSGPK GNGLIPSPAH SAHCSFYRTR 60

TLQALSSEKK AKKARFYRNG DRYFKGLVFA ISSDRFRSFD ALLIELTRSL SDNVNLPQGV 120

RTIYTIDGSR KVTSLDELLE GESYVCASNE PFRKVDYTKN INPNWSVNIK GGTSRALAAA 180

SSVKSEVKES KDFIKPKLVT VIRSGVKPRK AVRILLNKKT AHSFEQVLTD ITEAIKLDSG 240

VVKRLCTLDG KQVTCLQDFF GDDDVFIACG PEKFRYAQDD FVLDHSECRV LKSSYSRSSA 300

VKYSGSKSPG PSRRSKSPAS VNGTPSSQLS TPKSTKSSSS SPTSPGSFRG LKQISAHGRS 360

SSNVNGGPEL DRCISPEGVN GNRCSESSTL LEKYKIGKVI GDGNFAVVKE CIDRSTGKEF 420

ALKIIDKAKC CGKEHLIENE VSILRRVKHP NIIMLVEEME TATELFLVME LVKGGDLFDA 480

ITSSTKYTER DGSAMVYNLA NALRYLHGLS IVHRDIKPEN LLVCEYPDGT KSLKLGDFGL 540

ATVVEGPLYT VCGTPTYVAP EIIAETGYGL KVDIWAAGVI TYILLCGFPP FRSENNLQED 600

LFDQILAGKL EFPAPYWDNI TDSAKELISQ MLQVNVEARC TAGQILSHPW VSDDASQENN 660

MQAEVTGKLK QHFNNALPKQ NSTTTGVSVI MNTALDKEGQ IFCSKHCQDS GRPGMEPISP 720

VPPSVEETPV PGEAVPAPTP PESPTLHCPP AATGGERAGT WRRHRD 766

Nucleotide Sequence
(FASTA)

ATGGCCAGCA CCAGGAGTAT CGAGCTGGAG CACTTTGAGG AACGGGACAA AAGGCCGCGG 60

CCGGGGTCGC GGAGAGGGGC CCCCAGCTCC TCCGGGGGCA GCAGCAGCTC GGGCCCCAAG 120

GGGAACGGGC TCATCCCCAG TCCGGCGCAC AGTGCCCACT GCAGCTTCTA CCGCACGCGG 180

ACCCTGCAGG CCCTCAGCTC GGAGAAGAAG GCCAAGAAGG CGCGCTTCTA CCGGAACGGG 240

GACCGCTACT TCAAGGGCCT GGTGTTTGCC ATCTCCAGCG ACCGCTTCCG GTCCTTCGAT 300

GCGCTCCTCA TAGAGCTCAC CCGCTCCCTG TCGGACAACG TGAACCTGCC CCAGGGTGTC 360

CGCACTATCT ACACCATCGA CGGCAGCCGG AAGGTCACCA GCCTGGACGA GCTGCTGGAA 420

GGTGAGAGTT ACGTGTGTGC ATCCAATGAA CCATTTCGTA AAGTCGATTA CACCAAAAAT 480

ATTAATCCAA ACTGGTCTGT GAACATCAAG GGTGGGACAT CCCGAGCGCT GGCTGCTGCC 540

TCCTCTGTGA AAAGTGAAGT AAAAGAAAGT AAAGATTTCA TCAAACCCAA GTTAGTGACT 600

GTGATTCGAA GTGGAGTGAA GCCTAGAAAA GCCGTGCGGA TCCTTCTGAA TAAAAAGACT 660

GCTCATTCCT TTGAACAAGT CTTAACAGAT ATCACCGAAG CCATTAAACT AGACTCAGGA 720

GTCGTCAAGA GGCTCTGCAC CCTGGATGGA AAGCAGGTTA CTTGTCTGCA AGACTTTTTT 780

GGTGATGACG ATGTTTTTAT TGCATGTGGA CCAGAAAAAT TCCGTTATGC CCAAGATGAC 840

TTTGTCCTGG ATCATAGTGA ATGTCGTGTC CTGAAGTCAT CTTATTCTCG ATCCTCAGCT 900

GTTAAGTATT CTGGATCCAA AAGCCCTGGG CCCTCTCGAC GCAGCAAATC ACCAGCTTCA 960

GTTAATGGAA CTCCCAGCAG CCAACTTTCT ACTCCTAAAT CTACGAAATC CTCCAGTTCC 1020

TCTCCAACTA GTCCAGGAAG TTTCAGAGGA TTAAAGCAGA TTTCTGCTCA TGGCAGATCT 1080

TCTTCCAATG TAAACGGTGG ACCTGAGCTT GACCGTTGCA TAAGTCCTGA AGGTGTGAAT 1140

GGAAACAGAT GCTCTGAATC ATCAACTCTT CTTGAGAAAT ACAAAATTGG AAAGGTCATT 1200

GGTGATGGCA ATTTTGCAGT AGTCAAAGAG TGTATAGACA GGTCCACTGG AAAGGAGTTT 1260

GCCCTAAAGA TTATAGACAA AGCCAAATGT TGTGGAAAGG AACACCTGAT TGAGAATGAA 1320

GTGTCAATAC TGCGCCGAGT GAAACATCCC AATATCATTA TGCTGGTCGA GGAGATGGAA 1380

ACAGCAACTG AGCTCTTTCT GGTGATGGAA TTGGTCAAAG GTGGAGATCT CTTTGATGCA 1440

ATTACTTCGT CGACCAAGTA CACTGAGAGA GATGGCAGTG CCATGGTGTA CAACTTAGCC 1500

AATGCCCTCA GGTATCTCCA TGGCCTCAGC ATCGTGCACA GAGACATCAA ACCAGAGAAT 1560

CTCTTGGTGT GTGAATATCC TGATGGAACC AAGTCTTTGA AACTGGGAGA CTTTGGGCTT 1620

GCAACTGTGG TAGAAGGCCC TTTATACACA GTCTGTGGCA CACCCACTTA TGTGGCTCCA 1680

GAAATCATTG CTGAAACTGG CTATGGCCTG AAGGTGGACA TTTGGGCAGC TGGTGTGATC 1740

ACATACATAC TTCTCTGTGG ATTCCCACCA TTCCGAAGTG AGAACAATCT CCAGGAAGAT 1800

CTCTTCGACC AGATCTTGGC TGGGAAGCTG GAGTTTCCGG CCCCCTACTG GGATAACATC 1860

ACGGACTCTG CCAAGGAATT AATCAGTCAA ATGCTTCAGG TAAATGTTGA AGCTCGGTGT 1920

ACCGCGGGAC AAATCCTGAG TCACCCCTGG GTGTCAGATG ATGCCTCCCA GGAGAATAAC 1980

ATGCAAGCTG AGGTGACAGG TAAACTAAAA CAGCACTTTA ATAATGCGCT CCCCAAACAG 2040

AACAGCACTA CCACCGGGGT CTCCGTCATC ATGAACACGG CTCTAGATAA GGAGGGGCAG 2100

ATTTTCTGCA GCAAGCACTG TCAAGACAGC GGCAGGCCTG GGATGGAGCC CATCTCTCCA 2160

GTTCCTCCCT CAGTGGAGGA GACCCCTGTG CCTGGGGAAG CAGTCCCGGC CCCCACCCCT 2220

CCGGAATCTC CCACCCTCCA CTGTCCTCCC GCTGCCACGG GTGGTGAGCG GGCAGGAACC 2280

TGGCGCCGCC ACCGAGACTG A 2301

Domain Profile

S: 1     yeigrviGdGnfavvkevreretgkeyalkiidksklkGkehlidneveilkkvkhpniv  60

         y+ig+viGdGnfavvke+++r+tgke+alkiidk+k++Gkehli+nev+il++vkhpni+

Q: 394   YKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNII  453

         9***********************************************************

S: 61    klieeletetelylvlelvkgGdlfdaitkstkleerdaaimilelakalkylhelnivh  120

         +l+ee+et+tel+lv+elvkgGdlfdait+stk++erd+++m+++la+al+ylh l+ivh

Q: 454   MLVEEMETATELFLVMELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVH  513

         ************************************************************

S: 121   rdvkpenllvvekedgskslkladfGlaaevegplytvcGtPtyvaPeilaetGyglkvd  180

         rd+kpenllv+e+ dg+kslkl+dfGla++vegplytvcGtPtyvaPei+aetGyglkvd

Q: 514   RDIKPENLLVCEYPDGTKSLKLGDFGLATVVEGPLYTVCGTPTYVAPEIIAETGYGLKVD  573

         ************************************************************

S: 181   iWaaGvilyillvGfpPfrssdedqeelfdlilsgklefpsPyWdnisdkakdlvsrlle  240

         iWaaGvi+yill+GfpPfrs+++ qe+lfd+il+gklefp+PyWdni+d+ak+l+s++l+

Q: 574   IWAAGVITYILLCGFPPFRSENNLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQ  633

         ************************************************************

S: 241   vdeekrltaeqilehpwv  258

         v++e+r+ta qil+hpwv

Q: 634   VNVEARCTAGQILSHPWV  651

         *****************8

Domain Sequence
(FASTA)

YKIGKVIGDG NFAVVKECID RSTGKEFALK IIDKAKCCGK EHLIENEVSI LRRVKHPNII 60

MLVEEMETAT ELFLVMELVK GGDLFDAITS STKYTERDGS AMVYNLANAL RYLHGLSIVH 120

RDIKPENLLV CEYPDGTKSL KLGDFGLATV VEGPLYTVCG TPTYVAPEII AETGYGLKVD 180

IWAAGVITYI LLCGFPPFRS ENNLQEDLFD QILAGKLEFP APYWDNITDS AKELISQMLQ 240

VNVEARCTAG QILSHPWV 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

ptr:461534

;

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR003533	; Doublecortin_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF03607	; DCX; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00537	; DCX; 2.
SM00220	; S_TKc; 1.

Prosites

PS50309	; DC; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013