EKS-PAT-00370

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00370

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	325.0	4.1E-97	1240	1504	265

Status

Unreviewed

Ensembl Protein

ENSPTRP00000048240

UniProt Accession

H2R5K3;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000095015

Gene Synonyms/Alias

ENSG00000095015;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000016891	ENSPTRP00000048240	ENSPTRT00000031328

Organism

Pan troglodytes

Functional Description

Protein Length

1509

Protein Sequence
(FASTA)

MAAAAGNRAS SSGFPGAGAA SPEAGGGGGA LKASSAPAAA AGLLREAGSG GRERADWRRR 60

QLRKVRSVEL DQLPEQPLFL AASPPASSTS PSPEPADAAG SGTGFQPVAV PPPHGAASRG 120

GAHLAESVAA PDSGASSPAA AEPGEKRAPA AEPSPAAAPA GREMENKETL KGLHKMDDRP 180

EERMIREKLK ATCMPAWKHE WLERRNRRGP VVVKPIPVKG DGSEMNHLAA ESPGEVQASA 240

ASPASKGRRS PSPGNSPSGR TVKSESPGVR RKRVSPVPFQ SGRITPPRRA PSPDGFSPYS 300

PEETNRRVNK VMRARLYLLQ QIGPNSFLIG GDSPDNKYRV FIGPQNCSCA RGTFCIHLLF 360

VMLRVFQLEP SDPMLWRKTL KNFEVESLFQ KYHSRRSSRI KAPSRNTIQK FVSRMSNSHT 420

LSSSSTSTSS SENSIKDEEE QMCPICLLGM LDEESLTVCE DGCRNKLHHH CMSIWAEECR 480

RNREPLICPL CRSKWRSHDF YSHELSSPVD SPSSLRAAQQ QTVQQQPLAG SRRNQESNFN 540

LTHYGTQQIP LAYKDLAEPW IQVFGMELVG CLFSRNWNVR EMALRRLSHD VSGALLLANG 600

ESTGNSGGSS GSSPSGGATS GSSQTSISGD VVEACCSVLS MVCADPVYKV YVAALKTLRA 660

MLVYTPCHSL AERIKLQRLL QPVVDTILVK CADANSRTSQ LSISTLLELC KGQAGELAVG 720

REILKAGSIG IGGVDYVLNC ILGNQTESNN WQELLGRLCL IDRLLLEFPA EFYPHIVSTD 780

VSQAEPVEIR YKKLLSLLTF ALQSIDNSHS MVGKLSRRIY LSSARMVTTV PHVFSKLLEM 840

LSVSSSTHFT RMRRRLMAIA DEVEIAEAIQ LGVEDTLDGQ QDSFLQASVP NNYLETTENS 900

SPECTIHLEK TGKGLCTTKL SASSEDISER LASISVGPSS STTTTTEQPK PMVQTKGRPH 960

SQCLNSSPLS HHSQLMFPAL STPSSSTPSV PAGTATDVSK HRLQGFIPCR IPSASPQTQR 1020

KFSLQFHRNC PENKDSDKLS PVFTQSRPLP SSNIHRPKPS RPTPGNTSKQ GDPSKNSMTL 1080

DLNSSSKCDD SFGCSSNSSN AAIPSDETVF TPVEEKCRLD VNTELNSSIE DLLEASMPSS 1140

DTTVTFKSEV AVLSPEKAEN DDTYKDDVNH NQKCKEKMEA EEEEALAIAM AMSASQDALP 1200

IVPQLQVENG EDIIIIQQDT PETLPGHTKA KQPYREDTEW LKGQQIGLGA FSSCYQAQDV 1260

GTGTLMAVKQ VTYVRNTSSE QEEVVEALRE EIRMMSHLNH PNIIRMLGAT CEKSNYNLFI 1320

EWMAGGSVAH LLSKYGAFKE SVVINYTEQL LRGLSYLHEN QIIHRDVKGA NLLIDSTGQR 1380

LRIADFGAAA RLASKGTGAG EFQGQLLGTI AFMAPEVLRG QQYGRSCDVW SVGCAIIEMA 1440

CAKPPWNAEK HSNHLALIFK IASATTAPSI PSHLSPGLRD VALRCLELQP QDRPPSRELL 1500

KHPVFRTTW 1509

Nucleotide Sequence
(FASTA)

ATGGCGGCGG CGGCGGGGAA TCGCGCCTCG TCGTCGGGAT TCCCGGGCGC CGGGGCTGCG 60

AGCCCTGAGG CGGGCGGCGG CGGAGGAGCC CTCAAGGCGA GCAGCGCGCC CGCGGCTGCC 120

GCGGGACTGC TGCGGGAGGC GGGCAGCGGG GGCCGCGAGC GGGCGGACTG GCGGCGGCGG 180

CAGCTGCGCA AAGTGCGGAG TGTGGAGCTG GACCAGCTGC CTGAGCAGCC GCTCTTCCTT 240

GCCGCCTCAC CGCCGGCCTC CTCGACTTCC CCGTCGCCGG AGCCCGCGGA CGCAGCGGGG 300

AGTGGGACCG GCTTCCAGCC TGTGGCGGTG CCGCCGCCCC ACGGAGCCGC GAGCCGCGGC 360

GGCGCCCACC TTGCCGAGTC GGTGGCGGCG CCGGACAGCG GCGCCTCGAG TCCCGCAGCG 420

GCCGAGCCCG GGGAGAAGCG GGCGCCCGCC GCCGAGCCGT CTCCTGCAGC GGCCCCCGCC 480

GGTCGTGAGA TGGAGAATAA AGAAACTCTC AAAGGGTTGC ACAAGATGGA TGATCGTCCA 540

GAGGAACGAA TGATCAGGGA GAAACTGAAG GCAACCTGTA TGCCAGCCTG GAAGCACGAA 600

TGGTTGGAAA GGAGAAATAG GCGAGGGCCT GTGGTGGTAA AACCAATCCC AGTTAAAGGA 660

GATGGATCTG AAATGAATCA CTTAGCAGCT GAGTCTCCAG GAGAGGTCCA GGCAAGTGCG 720

GCTTCACCAG CTTCCAAAGG CCGACGCAGT CCTTCTCCTG GCAACTCCCC ATCAGGTCGC 780

ACAGTGAAAT CAGAATCTCC AGGAGTAAGG AGAAAAAGAG TTTCCCCAGT GCCTTTTCAG 840

AGTGGCAGAA TCACACCACC CCGAAGAGCC CCTTCACCAG ATGGCTTCTC ACCATATAGC 900

CCTGAGGAAA CAAACCGCCG TGTTAACAAA GTGATGCGGG CCAGACTGTA CTTACTGCAG 960

CAGATAGGGC CTAACTCTTT CCTGATTGGA GGAGACAGCC CAGACAATAA ATACCGGGTG 1020

TTTATTGGGC CTCAGAACTG CAGCTGTGCA CGTGGAACAT TCTGTATTCA TCTGCTATTT 1080

GTGATGCTCC GGGTGTTTCA ACTAGAACCT TCAGACCCAA TGTTATGGAG AAAAACTTTA 1140

AAGAATTTTG AGGTTGAGAG TTTGTTCCAG AAATATCACA GTAGGCGTAG CTCAAGGATC 1200

AAAGCTCCAT CTCGTAACAC CATCCAGAAG TTTGTTTCAC GCATGTCAAA TTCTCATACA 1260

TTGTCATCAT CTAGTACTTC TACATCTAGT TCAGAAAACA GCATAAAGGA TGAAGAGGAA 1320

CAGATGTGTC CTATTTGCTT GTTGGGCATG CTTGATGAAG AAAGTCTTAC AGTGTGTGAA 1380

GACGGCTGCA GGAACAAGCT GCACCACCAC TGCATGTCAA TTTGGGCAGA AGAGTGTAGA 1440

AGAAATAGAG AACCTTTAAT ATGTCCCCTT TGTAGATCTA AGTGGAGATC TCATGATTTC 1500

TACAGCCACG AGTTGTCAAG TCCTGTGGAT TCCCCTTCTT CCCTCAGAGC TGCACAGCAG 1560

CAAACCGTAC AGCAGCAGCC TTTGGCTGGA TCACGAAGGA ATCAAGAGAG CAATTTTAAC 1620

CTTACTCATT ATGGAACTCA GCAAATCCCT CTTGCTTACA AAGACTTAGC TGAGCCATGG 1680

ATTCAGGTGT TTGGAATGGA ACTCGTTGGC TGCTTATTTT CTAGAAACTG GAATGTGAGA 1740

GAGATGGCCC TCAGGCGTCT TTCCCATGAT GTCAGTGGGG CCCTGCTGTT GGCAAATGGG 1800

GAGAGCACTG GAAATTCTGG GGGCAGCAGT GGAAGCAGCC CGAGTGGGGG AGCCACCAGT 1860

GGGTCTTCCC AGACCAGTAT CTCAGGAGAT GTGGTGGAGG CATGCTGCAG CGTTCTGTCA 1920

ATGGTCTGTG CTGACCCTGT CTACAAAGTG TACGTTGCTG CTTTAAAAAC ATTGAGAGCC 1980

ATGCTGGTAT ATACTCCTTG CCACAGTTTA GCGGAAAGAA TCAAACTTCA GAGACTTCTC 2040

CAGCCAGTTG TAGACACCAT CCTAGTCAAA TGTGCAGATG CCAATAGCCG CACAAGTCAG 2100

CTGTCCATAT CAACACTGTT GGAACTGTGC AAAGGCCAAG CAGGAGAGTT GGCAGTTGGC 2160

AGAGAAATAC TAAAAGCTGG ATCCATTGGT ATTGGTGGTG TTGATTATGT CTTAAATTGT 2220

ATTCTTGGAA ACCAAACTGA ATCAAACAAT TGGCAAGAAC TTCTTGGCCG CCTTTGTCTT 2280

ATAGATAGAC TGTTGTTGGA ATTTCCTGCT GAATTTTATC CTCATATTGT CAGTACTGAT 2340

GTTTCACAAG CTGAGCCTGT TGAAATCAGG TATAAGAAGC TGCTGTCCCT CTTAACCTTT 2400

GCTTTGCAGT CCATTGATAA TTCCCACTCA ATGGTTGGCA AACTTTCCAG AAGGATCTAC 2460

TTGAGTTCTG CAAGAATGGT TACTACAGTA CCCCATGTGT TTTCAAAACT GTTAGAAATG 2520

CTGAGTGTTT CCAGTTCCAC TCACTTCACC AGGATGCGTC GCCGTTTGAT GGCTATTGCA 2580

GATGAGGTGG AAATTGCTGA AGCCATCCAG TTGGGCGTAG AAGACACTTT GGATGGTCAA 2640

CAGGACAGCT TCTTGCAGGC ATCTGTTCCC AACAACTATC TGGAAACCAC AGAGAACAGT 2700

TCCCCTGAGT GCACAATCCA TTTAGAGAAA ACTGGAAAAG GATTATGTAC TACAAAATTG 2760

AGTGCCAGTT CAGAGGACAT TTCGGAGAGA CTGGCCAGCA TTTCAGTAGG ACCTTCTAGT 2820

TCAACAACAA CAACAACAGA GCAACCAAAG CCAATGGTTC AAACAAAAGG CAGACCCCAC 2880

AGTCAGTGTT TGAACTCCTC TCCTTTATCT CATCATTCCC AATTAATGTT TCCAGCCTTG 2940

TCAACCCCTT CATCTTCTAC CCCATCTGTA CCAGCTGGCA CTGCAACAGA TGTCTCTAAG 3000

CATAGACTTC AGGGATTCAT TCCCTGCAGA ATACCTTCTG CATCTCCTCA AACACAGCGC 3060

AAGTTTTCTC TACAATTCCA CAGAAACTGT CCTGAAAACA AAGACTCAGA TAAACTTTCC 3120

CCAGTCTTTA CTCAGTCAAG ACCCTTGCCC TCCAGTAACA TACACAGGCC AAAGCCATCT 3180

CGACCTACCC CAGGTAATAC AAGTAAACAG GGAGATCCCT CAAAAAATAG CATGACACTT 3240

GATCTGAACA GTAGTTCCAA ATGTGATGAC AGCTTTGGCT GTAGCAGCAA TAGTAGTAAT 3300

GCTGCTATAC CCAGTGACGA GACAGTGTTC ACCCCAGTAG AGGAGAAATG CAGATTAGAT 3360

GTCAATACAG AGCTCAACTC CAGTATTGAG GACCTTCTTG AAGCATCTAT GCCTTCAAGT 3420

GATACAACAG TAACTTTTAA GTCAGAAGTT GCTGTCCTGT CTCCTGAAAA GGCTGAAAAT 3480

GATGATACCT ACAAAGATGA TGTGAATCAT AATCAAAAGT GCAAAGAGAA GATGGAAGCT 3540

GAAGAAGAAG AAGCTTTAGC AATTGCCATG GCAATGTCAG CGTCTCAGGA TGCCCTCCCC 3600

ATAGTTCCTC AGCTGCAGGT TGAAAATGGA GAAGATATCA TCATTATTCA ACAGGATACA 3660

CCAGAGACTC TACCAGGACA TACCAAAGCA AAACAACCAT ATAGAGAAGA CACTGAATGG 3720

CTGAAAGGTC AACAGATAGG CCTTGGAGCA TTTTCTTCTT GTTATCAGGC TCAAGATGTG 3780

GGAACTGGAA CTTTAATGGC TGTTAAACAG GTGACTTATG TCAGAAACAC ATCTTCTGAG 3840

CAAGAAGAAG TAGTAGAAGC ACTAAGAGAA GAGATAAGAA TGATGAGCCA TCTGAATCAT 3900

CCAAACATCA TTAGGATGTT GGGAGCCACG TGTGAGAAGA GCAATTACAA TCTCTTCATT 3960

GAATGGATGG CAGGGGGATC GGTGGCTCAT TTGCTGAGTA AATATGGAGC CTTCAAAGAA 4020

TCAGTAGTTA TTAACTACAC TGAACAGTTA CTCCGTGGCC TTTCATATCT CCATGAAAAC 4080

CAAATCATTC ACAGAGATGT CAAAGGTGCC AATTTGCTAA TTGACAGCAC TGGTCAGAGA 4140

CTAAGAATTG CAGATTTTGG AGCTGCAGCC AGGTTGGCAT CAAAAGGAAC TGGTGCAGGA 4200

GAGTTTCAGG GACAATTACT GGGGACAATT GCATTTATGG CACCCGAGGT ACTAAGAGGT 4260

CAACAGTATG GAAGGAGCTG TGATGTATGG AGTGTTGGCT GTGCTATTAT AGAAATGGCT 4320

TGTGCAAAAC CACCATGGAA TGCAGAAAAA CACTCCAATC ATCTTGCTTT GATATTTAAG 4380

ATTGCTAGTG CAACTACTGC TCCATCGATC CCTTCACATT TGTCTCCTGG TTTACGAGAT 4440

GTGGCTCTTC GTTGTTTAGA ACTTCAACCT CAGGACAGAC CTCCATCAAG AGAGCTACTG 4500

AAGCATCCAG TCTTTCGTAC TACATGGTAG 4530

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1240  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1299

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1300  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1359

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1360  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1419

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1420  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1477

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1478  LRDVALRCLELQPQDRPPSRELLKHPV  1504

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVALRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding

KEGG

ptr:471543

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013