EKS-PAT-00247

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00247

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	430.0	2.9E-129	82	334	253

Status

Unreviewed

Ensembl Protein

ENSPTRP00000060467

UniProt Accession

H2QQY0;

Protein Name

Protein Synonyms/Alias

Polo-like kinase 2;

Gene Name

ENSG00000145632

Gene Synonyms/Alias

ENSG00000145632; PLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000016896	ENSPTRP00000028937	ENSPTRT00000031334
ENSPTRG00000016896	ENSPTRP00000059951	ENSPTRT00000075049
ENSPTRG00000016896	ENSPTRP00000060467	ENSPTRT00000073670

Organism

Pan troglodytes

Functional Description

Protein Length

379

Protein Sequence
(FASTA)

MELLRTITYQ PAASTKMCEQ ALGKGCGADS KKKRPPQPPE ESQPPQSQAQ VPPAAPHHHH 60

HHSHSGPEIS RIIVDPTTGK RYCRGKVLGK GGFAKCYEMT DLTNNKVYAA KIIPHSRVAK 120

PHQREKIDKE IELHRILHHK HVVQFYHYFE DKENIYILLE YCSRRSMAHI LKARKVLTEP 180

EVRYYLRQIV SGLKYLHEQE ILHRDLKLGN FFINEAMELK VGDFGLAARL EPLEHRRRTI 240

CGTPNYLSPE VLNKQGHGCE SDIWALGCVM YTMLLGRPPF ETTNLKETYR CIREARYTMP 300

SSLLAPAKHL IASMLSKNPE DRPTLDDIIR HDFFLQGFTP DRLSSSCCHT VPDFHLSSPA 360

KNFFKRAAEH IISVGHQMG 379

Nucleotide Sequence
(FASTA)

ATGGAGCTTT TGCGGACTAT CACCTACCAG CCAGCCGCCA GCACCAAAAT GTGCGAGCAG 60

GCGCTGGGCA AGGGTTGCGG AGCGGACTCG AAGAAGAAGC GGCCGCCGCA GCCCCCCGAG 120

GAATCGCAGC CACCTCAGTC CCAGGCGCAA GTGCCACCGG CGGCCCCTCA CCACCATCAC 180

CACCATTCGC ACTCGGGGCC AGAGATCTCG CGGATTATCG TCGACCCCAC GACGGGGAAG 240

CGCTACTGCC GGGGCAAAGT GCTGGGAAAG GGTGGCTTTG CAAAATGTTA CGAGATGACA 300

GATTTGACAA ATAACAAAGT CTACGCCGCA AAAATTATTC CTCACAGCAG AGTAGCTAAA 360

CCTCATCAAA GGGAAAAGAT TGACAAAGAA ATAGAGCTTC ACAGAATTCT TCATCATAAG 420

CATGTAGTGC AGTTTTACCA CTACTTCGAG GACAAAGAAA ACATTTACAT TCTCTTGGAA 480

TACTGCAGTA GAAGGTCAAT GGCTCATATT TTGAAAGCAA GAAAGGTGTT GACAGAGCCA 540

GAAGTTCGAT ACTACCTCAG GCAGATTGTG TCTGGACTGA AATACCTTCA TGAACAAGAA 600

ATCTTGCACA GAGATCTCAA ACTAGGGAAC TTTTTTATTA ATGAAGCCAT GGAACTAAAA 660

GTTGGGGACT TCGGTCTGGC AGCCAGGCTA GAACCCTTGG AACACAGAAG GAGAACGATA 720

TGTGGTACCC CAAATTATCT CTCTCCTGAA GTCCTCAACA AACAAGGACA TGGCTGTGAA 780

TCAGACATTT GGGCCCTGGG CTGTGTAATG TATACAATGT TACTAGGGAG GCCCCCATTT 840

GAAACTACAA ATCTCAAAGA AACTTATAGG TGCATAAGGG AAGCAAGGTA TACAATGCCG 900

TCCTCATTGC TGGCTCCTGC CAAGCACTTA ATTGCTAGTA TGTTGTCCAA AAACCCAGAG 960

GATCGTCCCA CTTTGGATGA CATCATTCGA CATGACTTTT TTTTGCAGGG CTTCACTCCG 1020

GACAGACTGT CTTCTAGCTG TTGTCATACA GTTCCAGATT TCCACTTATC AAGCCCAGCT 1080

AAGAATTTCT TTAAAAGAGC AGCTGAGCAC ATCATTTCAG TGGGTCACCA AATGGGTTGA 1140

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y+rgk+lGkGgfakcye++dl++++v+a+k++p+s++ak++qrek++keie+hr l+hk+

Q: 82    YCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKH  141

         99**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v++y++fedken+y++le+csrrs+a++lk+rk+ltepevryylrqivsglkylhe++i

Q: 142   VVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI  201

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+ne++e+k+gdfGla+rle+ e+r++t+cGtPny++Pevl+k+gh++e+

Q: 202   LHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCES  261

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         diW+lGc++yt+l+G+PPfet++lkety++i++a+y++Pssl ++ak+lia++l+k+Pe+

Q: 262   DIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPED  321

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp+l+++++++f+

Q: 322   RPTLDDIIRHDFF  334

         ************8

Domain Sequence
(FASTA)

YCRGKVLGKG GFAKCYEMTD LTNNKVYAAK IIPHSRVAKP HQREKIDKEI ELHRILHHKH 60

VVQFYHYFED KENIYILLEY CSRRSMAHIL KARKVLTEPE VRYYLRQIVS GLKYLHEQEI 120

LHRDLKLGNF FINEAMELKV GDFGLAARLE PLEHRRRTIC GTPNYLSPEV LNKQGHGCES 180

DIWALGCVMY TMLLGRPPFE TTNLKETYRC IREARYTMPS SLLAPAKHLI ASMLSKNPED 240

RPTLDDIIRH DFF 253

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ptr:461861

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013