EKS-PAT-00436

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00436

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	416.3	5.7E-125	26	321	296

Status

Unreviewed

Ensembl Protein

ENSPTRP00000030121

UniProt Accession

H2QS62;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase 9;

Gene Name

ENSG00000050748

Gene Synonyms/Alias

ENSG00000050748; MAPK9;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000017633	ENSPTRP00000030121	ENSPTRT00000032598

Organism

Pan troglodytes

Functional Description

Protein Length

424

Protein Sequence
(FASTA)

MSDSKCDSQF YSVQVADSTF TVLKRYQQLK PIGSGAQGIV CAAFDTVLGI NVAVKKLSRP 60

FQNQTHAKRA YRELVLLKCV NHKNIISLLN VFTPQKTLEE FQDVYLVMEL MDANLCQVIH 120

MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTACTNF 180

MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGELVK GCVIFQGTDH IDQWNKVIEQ 240

LGTPSAEFMK KLQPTVRNYV ENRPKYPGIK FEELFPDWIF PSESERDKIK TSQARDLLSK 300

MLVIDPDKRI SVDEALRHPY ITVWYDPAEA EAPPPQIYDA QLEEREHAIE EWKELIYKEV 360

MDWEERSKNG VVKDQPSDAA VSSNATPSQS SSINDISSMS TEQTLASDTD SSLDASTGPL 420

EGCR 424

Nucleotide Sequence
(FASTA)

ATGAGTGACA GTAAATGTGA CAGTCAGTTT TACAGTGTGC AAGTGGCAGA CTCAACCTTC 60

ACTGTCCTAA AACGTTACCA GCAGCTGAAA CCAATTGGCT CTGGGGCCCA AGGGATTGTT 120

TGTGCTGCAT TTGATACAGT TCTTGGGATA AATGTTGCAG TCAAGAAACT AAGCCGTCCT 180

TTTCAGAACC AAACTCATGC AAAGAGAGCT TATCGTGAAC TCGTCCTCTT AAAATGTGTC 240

AATCATAAAA ATATAATTAG TTTGTTAAAT GTGTTTACAC CACAAAAAAC TCTAGAAGAA 300

TTTCAAGATG TGTATTTGGT TATGGAATTA ATGGATGCTA ACTTATGTCA GGTTATTCAC 360

ATGGAGCTGG ATCATGAAAG AATGTCCTAC CTTCTTTACC AGATGCTTTG TGGTATTAAA 420

CATCTGCATT CAGCTGGTAT AATTCATAGA GATTTGAAGC CTAGCAACAT TGTTGTGAAA 480

TCAGACTGCA CCCTGAAGAT CCTTGACTTT GGCCTGGCCC GGACAGCGTG CACTAACTTC 540

ATGATGACCC CTTATGTGGT GACACGGTAC TACCGGGCGC CCGAAGTCAT CCTGGGTATG 600

GGCTACAAAG AGAACGTTGA TATCTGGTCA GTGGGTTGCA TCATGGGAGA GCTGGTGAAA 660

GGTTGTGTGA TATTCCAAGG CACTGACCAT ATTGATCAGT GGAATAAAGT TATTGAGCAG 720

CTGGGAACAC CATCAGCAGA GTTCATGAAG AAACTTCAGC CAACTGTGAG GAATTATGTC 780

GAAAACAGAC CAAAGTATCC TGGAATCAAA TTCGAAGAAC TCTTTCCAGA TTGGATATTC 840

CCATCAGAAT CTGAGCGAGA CAAAATAAAA ACAAGTCAAG CCAGAGATCT GTTATCAAAA 900

ATGTTAGTGA TTGATCCTGA CAAGCGGATC TCTGTAGATG AAGCTCTGCG TCACCCATAC 960

ATCACTGTTT GGTATGACCC TGCCGAAGCA GAAGCCCCAC CACCTCAAAT TTATGATGCC 1020

CAGTTGGAAG AAAGAGAACA TGCAATTGAA GAATGGAAAG AGCTAATTTA CAAAGAAGTC 1080

ATGGATTGGG AAGAAAGAAG CAAGAATGGT GTTGTAAAAG ATCAGCCTTC AGATGCAGCA 1140

GTAAGTAGCA ACGCCACTCC TTCTCAGTCT TCATCGATCA ATGACATTTC ATCCATGTCC 1200

ACTGAGCAGA CGCTGGCCTC AGACACAGAC AGCAGTCTTG ATGCCTCGAC GGGACCCCTT 1260

GAAGGCTGTC GATGA 1275

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  + +va+kklsrpfq++t+akr++REl llk+++h+Ni

Q: 26    YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNI  85

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 86    ISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLYQMLCGIKHLHS  144

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFM--MTPYVVTRYYRAPEVILG-MG  201

         ********************************99976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vDiWsvGCI++El++g ++f+g+d+idq++k++e+lgtps+ef+kk++  ++rny+

Q: 202   YKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQP-TVRNYV  260

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +feelfp+            ++++a+dLl+k+Lv+dpdkRisv+eaL+hpY

Q: 261   ENRPKYPGIKFEELFPDwifpseserdkiKTSQARDLLSKMLVIDPDKRISVDEALRHPY  320

         *****************************9******************************

S: 289   l  289

Q: 321   I  321

Domain Sequence
(FASTA)

YQQLKPIGSG AQGIVCAAFD TVLGINVAVK KLSRPFQNQT HAKRAYRELV LLKCVNHKNI 60

ISLLNVFTPQ KTLEEFQDVY LVMELMDANL CQVIHMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART ACTNFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDIWSVGCIM GELVKGCVIF QGTDHIDQWN KVIEQLGTPS AEFMKKLQPT VRNYVENRPK 240

YPGIKFEELF PDWIFPSESE RDKIKTSQAR DLLSKMLVID PDKRISVDEA LRHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

ptr:462336

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013