EKS-PAT-00275
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-PAT-00275
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/DDR502.63.1E-151606901296
StatusReviewed
Ensembl ProteinENSPTRP00000030612
UniProt AccessionQ7YR43;
Protein NameEpithelial discoidin domain-containing receptor 1
Protein Synonyms/Alias Epithelial discoidin domain receptor 1; CD167 antigen-like family member A; Discoidin receptor tyrosine kinase; Tyrosine kinase DDR;
Gene NameDDR1
Gene Synonyms/Alias DDR1; EDDR1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPTRG00000017942ENSPTRP00000030612ENSPTRT00000033132
OrganismPan troglodytes
Functional DescriptionTyrosine kinase that functions as cell surface receptorfor fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity).
Protein Length909
Protein Sequence
(FASTA)
MGPEALSSLL LLLLVASGDA DMKGHFDPAK CRYALGMQDR TIPDSDISAS SSWSDSTAAR 60
HSSDGDGAWC PAGSVFPKEE EYLQVDLQRL HLVALVGTQG RHAGGLGKEF SRSYRLRYSR 120
DGRRWMGWKD RWGQEVISGN EDPEGVVLKD LGPPMVARLV RFYPRADRVM SVCLRVELYG 180
CLWRDGLLSY TAPVGQTMYL SEAVYLNDST YDGHTVGGLQ YGGLGQLADG VVGLDDFRKS 240
QELRVWPGYD YVGWSNHSFS SGYVEMEFEF DRLRAFQAMQ VHCNNMHTLG ARLPGGVECR 300
FRRGPAMAWE GEPMRHNLGG NLGDPRARAV SVPLGGRVAR FLQCRFLFAG PWLLFSEISF 360
ISDVVNNSSP ALGGTFPPAP WWPPGPPPTN FSSLELEPRG QQPVAKAEGS PTAILIGCLV 420
AIILLLLLII ALMLWRLHWR RLLSKAERRV LEEELTVHLS VPGDTILINN RPGPREPPPY 480
QEPRPRGNPP HSAPCVPNGS ALLLSNPAYR LLLATYARPP RGPGPPTPAW AKPTNTQAYS 540
GDYMEPEKPG APLLPPPPQN SVPHYAEADI VTLQGVTGGN TYAVPALPPG AVGDGPPRVD 600
FPRSRLRFKE KLGEGQFGEV HLCEVDSPQD LVSLDFPLNV RKGHPLLVAV KILRPDATKN 660
ARNDFLKEVK IMSRLKDPNI IRLLGVCVQD DPLCMITDYM ENGDLNQFLS AHQLEDKAAE 720
GAPGDGQAAQ GPTISYPMLL HVAAQIASGM RYLATLNFVH RDLATRNCLV GENFTIKIAD 780
FGMSRNLYAG DYYRVQGRAV LPIRWMAWEC ILMGKFTTAS DVWAFGVTLW EVLMLCRAQP 840
FGQLTDEQVI ENAGEFFRDQ GRQVYLSRPP ACPQGLYELM LRCWSRESEQ RPPFSQLHRF 900
LAEDALNTV 909
Nucleotide Sequence
(FASTA)
ATGGGGCCAG AGGCCCTGTC ATCTTTACTG CTGCTGCTCT TGGTGGCAAG TGGAGATGCT 60
GACATGAAGG GACATTTTGA TCCTGCCAAA TGCCGCTATG CCCTGGGCAT GCAGGACCGG 120
ACCATCCCAG ACAGTGACAT CTCTGCTTCC AGCTCCTGGT CAGATTCCAC TGCTGCCCGC 180
CACAGCAGTG ACGGGGATGG GGCCTGGTGC CCCGCAGGGT CGGTGTTTCC CAAGGAGGAG 240
GAGTACTTGC AGGTGGATCT ACAACGACTG CACCTGGTGG CTCTGGTGGG CACCCAGGGA 300
CGGCATGCCG GGGGCCTGGG CAAGGAGTTC TCCCGGAGCT ACCGGCTGCG TTACTCCCGG 360
GATGGTCGCC GCTGGATGGG CTGGAAGGAC CGCTGGGGTC AGGAGGTGAT CTCAGGCAAT 420
GAGGACCCTG AGGGAGTGGT GCTGAAGGAC CTTGGGCCCC CCATGGTTGC CCGACTGGTT 480
CGCTTCTACC CCCGGGCTGA CCGGGTCATG AGCGTCTGTC TGCGGGTAGA GCTCTATGGC 540
TGCCTCTGGA GGGATGGACT CCTGTCTTAC ACCGCCCCTG TGGGGCAGAC AATGTATTTA 600
TCTGAGGCCG TGTACCTCAA CGACTCCACC TATGATGGAC ATACCGTGGG CGGACTGCAG 660
TATGGGGGTC TGGGCCAGCT GGCAGATGGT GTGGTGGGGC TGGATGACTT TAGGAAGAGT 720
CAGGAGCTGC GGGTCTGGCC AGGCTATGAC TATGTGGGAT GGAGCAACCA CAGCTTCTCC 780
AGTGGCTATG TGGAGATGGA GTTTGAGTTT GACCGGCTGA GGGCCTTCCA GGCTATGCAG 840
GTCCACTGTA ACAACATGCA CACGCTGGGA GCCCGTCTGC CTGGCGGGGT GGAATGTCGC 900
TTCCGGCGTG GCCCTGCCAT GGCCTGGGAG GGGGAGCCCA TGCGCCACAA CCTAGGGGGC 960
AACCTCGGGG ACCCCAGAGC CCGGGCTGTC TCAGTGCCCC TTGGCGGCCG TGTGGCTCGC 1020
TTTCTGCAGT GCCGCTTCCT CTTTGCGGGG CCCTGGTTAC TCTTCAGCGA AATCTCCTTC 1080
ATCTCTGATG TGGTGAACAA TTCCTCTCCG GCACTGGGAG GCACCTTCCC GCCAGCCCCC 1140
TGGTGGCCGC CTGGCCCACC TCCCACCAAC TTCAGCAGCT TGGAGCTGGA GCCCAGAGGC 1200
CAGCAGCCCG TGGCCAAGGC CGAGGGGAGC CCGACCGCCA TCCTCATCGG CTGCCTGGTG 1260
GCCATCATCC TGCTCCTGCT GCTCATCATT GCCCTCATGC TCTGGCGGCT GCACTGGCGC 1320
AGGCTCCTCA GCAAGGCTGA ACGGAGGGTG TTGGAAGAGG AGCTGACGGT TCACCTCTCT 1380
GTCCCTGGGG ACACTATCCT CATCAACAAC CGCCCAGGTC CTAGAGAGCC ACCCCCGTAC 1440
CAGGAGCCCC GGCCTCGTGG GAATCCGCCC CACTCCGCTC CCTGTGTCCC CAATGGCTCT 1500
GCGTTGCTGC TCTCCAATCC AGCCTACCGC CTCCTTCTGG CCACTTACGC CCGTCCCCCT 1560
CGAGGCCCGG GCCCCCCCAC ACCCGCCTGG GCCAAACCCA CCAACACCCA GGCCTACAGT 1620
GGGGACTATA TGGAGCCTGA GAAGCCAGGC GCCCCGCTTC TGCCCCCACC TCCCCAGAAC 1680
AGCGTCCCCC ATTATGCCGA GGCTGACATT GTTACCCTGC AGGGCGTCAC CGGGGGCAAC 1740
ACCTATGCTG TGCCTGCACT GCCCCCAGGG GCAGTCGGGG ATGGGCCCCC CAGAGTGGAT 1800
TTCCCTCGAT CTCGACTTCG CTTCAAGGAG AAGCTTGGCG AGGGCCAGTT TGGGGAGGTG 1860
CACCTGTGTG AGGTCGACAG CCCTCAAGAT CTGGTCAGTC TTGATTTCCC CCTTAATGTG 1920
CGTAAGGGAC ACCCTTTGCT GGTAGCTGTC AAGATCTTAC GGCCAGATGC CACCAAGAAT 1980
GCCAGGAATG ATTTCCTGAA AGAGGTGAAG ATCATGTCGA GGCTCAAGGA CCCAAACATC 2040
ATTCGGCTGC TGGGCGTGTG TGTGCAGGAC GACCCCCTCT GCATGATTAC TGACTACATG 2100
GAGAACGGCG ACCTCAACCA GTTCCTCAGT GCCCACCAGC TGGAGGACAA GGCAGCCGAG 2160
GGGGCCCCTG GGGACGGGCA GGCTGCGCAG GGGCCCACCA TCAGCTACCC AATGCTGCTG 2220
CATGTGGCAG CCCAGATCGC CTCCGGCATG CGCTATCTGG CCACACTCAA CTTTGTACAT 2280
CGGGACCTGG CCACGCGGAA CTGCCTAGTT GGGGAAAATT TCACCATCAA AATCGCAGAC 2340
TTTGGCATGA GCCGGAACCT CTATGCTGGG GACTATTACC GTGTGCAGGG CCGGGCAGTG 2400
CTGCCCATCC GCTGGATGGC CTGGGAGTGC ATCCTCATGG GGAAGTTCAC GACTGCGAGT 2460
GACGTGTGGG CCTTTGGTGT GACCCTGTGG GAGGTGCTGA TGCTCTGTAG GGCCCAGCCC 2520
TTTGGGCAGC TCACCGACGA GCAGGTCATC GAGAATGCGG GGGAGTTCTT CCGGGACCAG 2580
GGCCGGCAGG TGTACCTGTC CCGGCCGCCT GCCTGCCCGC AGGGCCTATA TGAGCTGATG 2640
CTTCGGTGCT GGAGCCGGGA GTCTGAGCAG CGACCACCCT TTTCCCAGCT GCATCGGTTC 2700
CTGGCAGAGG ATGCACTCAA CACGGTGTGA 2730
Domain Profile
S: 1     LlikeklGeGkfgevklCevegledlkekd.....skgsallvavkslredanknarkdf  55
         L++keklGeG+fgev+lCev++++dl++ d     +kg++llvavk+lr+da+knar+df
Q: 606   LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDfplnvRKGHPLLVAVKILRPDATKNARNDF  665
         789*********************************************************
S: 56    lkeikilsrlkdPnivrllgvcvrdeplclileyvenGdlnqflsehe.........aed  106
         lke+ki+srlkdPni+rllgvcv+d+plc+i++y+enGdlnqfls+h+         ++d
Q: 666   LKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQledkaaegaPGD  725
         ********************************************************99**
S: 107   selakektlsyellvsiatqiasglkyLeslnfvhrdlatrnclvgeeftvkiadfglsr  166
         +++a+ +t+sy++l+++a+qiasg++yL++lnfvhrdlatrnclvge+ft+kiadfg+sr
Q: 726   GQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSR  785
         ************************************************************
S: 167   slyagdyyrvqGravlPiRwmawesillgkfttasDvWafgvtlweiltlcreqPyeelt  226
         +lyagdyyrvqGravlPiRwmawe+il+gkfttasDvWafgvtlwe+l+lcr+qP+++lt
Q: 786   NLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLT  845
         ************************************************************
S: 227   deqvienagelfrdqkrkvvlsrPavcpselyelllrCwrrdeseRPsfeelhkll  282
         deqvienage+frdq+r+v+lsrP++cp+ lyel+lrCw+r++++RP+f++lh++l
Q: 846   DEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFL  901
         ******************************************************97
Domain Sequence
(FASTA)
LRFKEKLGEG QFGEVHLCEV DSPQDLVSLD FPLNVRKGHP LLVAVKILRP DATKNARNDF 60
LKEVKIMSRL KDPNIIRLLG VCVQDDPLCM ITDYMENGDL NQFLSAHQLE DKAAEGAPGD 120
GQAAQGPTIS YPMLLHVAAQ IASGMRYLAT LNFVHRDLAT RNCLVGENFT IKIADFGMSR 180
NLYAGDYYRV QGRAVLPIRW MAWECILMGK FTTASDVWAF GVTLWEVLML CRAQPFGQLT 240
DEQVIENAGE FFRDQGRQVY LSRPPACPQG LYELMLRCWS RESEQRPPFS QLHRFL 296
KeywordATP-binding; Calcium; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Lactation; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Pregnancy; Receptor; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00272
EKS-ANC-00280
EKS-BOT-00290
EKS-CAJ-00296
EKS-CAF-00296
EKS-CAP-00325
EKS-CII-00170
EKS-DAR-00637
EKS-DIO-00025
EKS-FEC-00276
EKS-GAA-00358
EKS-GOG-00289
EKS-HOS-00296
EKS-ICT-00275
EKS-LAC-00304
EKS-LOA-00300
EKS-MAM-00293
EKS-MOD-00285
EKS-MUM-00321
EKS-MUP-00286
EKS-NOL-00267
EKS-ORA-00255
EKS-ORC-00272
EKS-ORL-00348
EKS-OTG-00296
EKS-PES-00259
EKS-POA-00281
EKS-PTV-00046
EKS-RAN-00305
EKS-SAH-00272
EKS-SUS-00255
EKS-TEN-00376
EKS-XET-00363
EKS-XIM-00369
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005518; F:collagen binding
GO:0046872; F:metal ion binding
GO:0038062; F:protein tyrosine kinase collagen receptor activity
GO:0060444; P:branching involved in mammary gland duct morphogenesis
GO:0043583; P:ear development
GO:0007566; P:embryo implantation
GO:0007595; P:lactation
GO:0060749; P:mammary gland alveolus development
GO:0008285; P:negative regulation of cell proliferation
GO:0038083; P:peptidyl-tyrosine autophosphorylation
GO:0001558; P:regulation of cell growth
GO:0001952; P:regulation of cell-matrix adhesion
GO:0010715; P:regulation of extracellular matrix disassembly
GO:0014909; P:smooth muscle cell migration
GO:0061302; P:smooth muscle cell-matrix adhesion
GO:0044319; P:wound healing, spreading of cells
KEGG
ptr:462548;
InterPros
IPR000421; Coagulation_fac_5/8-C_type_dom.
IPR008979; Galactose-bd-like.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00754; F5_F8_type_C; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00231; FA58C; 1.
SM00219; TyrKc; 1.
Prosites
PS01285; FA58C_1; 1.
PS01286; FA58C_2; 1.
PS50022; FA58C_3; 1.
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013