EKS-PAT-00459

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00459

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/CCK4	544.1	5.2E-164	796	1061	266

Status

Unreviewed

Ensembl Protein

ENSPTRP00000031080

UniProt Accession

H2QT20;

Protein Name

Protein Synonyms/Alias

PTK7 protein tyrosine kinase 7;

Gene Name

ENSG00000112655

Gene Synonyms/Alias

ENSG00000112655; PTK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000018188	ENSPTRP00000031080	ENSPTRT00000033631

Organism

Pan troglodytes

Functional Description

Protein Length

1070

Protein Sequence
(FASTA)

MGAARGSPAR PRRLPLLSVL LLPLLGGTQT AIVFIKQPSS QDALQGRRAL LRCEVEAPGP 60

VHVYWLLDGA PVQDTERRFA QGSSLSFAAV DRLQDSGTFQ CVARDDVTGE EALSANASFN 120

IKWIEAGPVV LKHPASEAEI QPQTQVTLRC HIDGHPRPTY QWFRDGTPLS DGQSNHTVSS 180

KERNLTLRPA GPEHSGLYSC CAHNAFGQAC SSQNFTLSIA DESFARVVLA PQDVVVARNE 240

EAMFHCQFSA QPPPSLQWLF EDETPITNRS RPPHLRRATV FANGSLLLTQ VRPRNAGIYR 300

CIGQGQRGPP IILEATLHLA EIEDMPLFEP RVFTAGSEER VTCLPPKGLP EPSVWWEHAG 360

VRLPTHGRVY QKGHELVLAN IAESDAGVYT CHAANLAGQR RQDVNITVAT VPSWLKKPQD 420

SQLEEGKPGY LDCQTQATPK PTVVWYRNQM LISEDSRFEV FKNGTLRINN VEVYDGTWYR 480

CVSSTPAGSI EAQARVQVLE KLKFTPPPQP QQCMEFDKEA TVPCSATGRE KPTIKWERAD 540

GSSLPEWVTD NAGTLHFARV TRDDAGNYTC IASNGPQGQI RAHVQLTVAV FITFKVEPER 600

TTVYQGHTAL LQCEAQGDPK PLIQWKGKDR ILDPTKLGPR MHIFQNGSLV IHDVAPEDSG 660

RYTCIAGNSC NIKHTEAPLY VVDKPVPEES EGPGSPPPYK MIQTIGLSVG AAVAYIIAVL 720

GLMFYCKKRC KAKRLQKQPE GEEPEMECLN GGPLQNGQPS AEIQEEVALT SLGSGPAATN 780

KRHSTSDKMH FPRSSLQPIT TLGKSEFGEV FLAKAQGLEE GVAETLVLVK SLQSKDEQQQ 840

LDFRRELEMF GKLNHANVVR LLGLCREAEP HYMVLEYVDL GDLKQFLRIS KSKDEKLKSQ 900

PLSTKQKVAL CTQVALGMEH LSNNRFVHKD LAARNCLVSA QRQVKVSALG LSKDVYNSEY 960

YHFRQAWVPL RWMSPEAILE GDFSTKSDVW AFGVLMWEVF THGEMPHGGQ ADDEVLADLQ 1020

AGKARLPQPE GCPSKLYRLM QRCWALSPKD RPSFSEIASA LGDSPVDSKP 1070

Nucleotide Sequence
(FASTA)

ATGGGAGCTG CGCGGGGATC CCCGGCCAGA CCCCGCCGGT TGCCTCTGCT CAGCGTCCTG 60

CTGCTGCCGC TGCTGGGCGG TACCCAGACA GCCATTGTCT TCATCAAGCA GCCGTCCTCC 120

CAGGATGCAC TGCAGGGGCG CCGGGCGCTG CTTCGCTGTG AGGTTGAGGC TCCGGGCCCG 180

GTACATGTGT ACTGGCTGCT CGATGGGGCC CCTGTCCAGG ACACGGAGCG GCGTTTCGCC 240

CAGGGCAGCA GCCTGAGCTT TGCAGCTGTG GACCGGCTGC AGGACTCTGG CACCTTCCAG 300

TGTGTGGCTC GGGATGATGT CACTGGAGAA GAAGCCCTCA GTGCCAACGC CTCCTTCAAC 360

ATCAAATGGA TTGAGGCAGG TCCTGTGGTC CTGAAGCATC CAGCCTCGGA AGCTGAGATC 420

CAGCCACAGA CCCAGGTCAC ACTTCGTTGC CACATTGATG GGCACCCTCG GCCCACCTAC 480

CAATGGTTCC GAGATGGGAC CCCCCTTTCT GATGGTCAGA GCAACCACAC AGTCAGCAGC 540

AAGGAGCGGA ACCTGACGCT CCGGCCAGCT GGTCCTGAGC ATAGTGGGCT GTATTCCTGC 600

TGCGCCCACA ATGCTTTTGG CCAGGCTTGC AGCAGCCAGA ACTTCACCTT GAGCATTGCT 660

GATGAAAGCT TTGCCAGGGT GGTGCTGGCA CCCCAGGACG TGGTAGTAGC GAGGAATGAG 720

GAGGCCATGT TCCATTGCCA GTTCTCAGCC CAGCCACCCC CGAGCCTGCA GTGGCTCTTT 780

GAGGATGAGA CTCCCATCAC TAACCGCAGT CGCCCCCCAC ACCTCCGCAG AGCCACAGTG 840

TTTGCCAACG GGTCTCTGCT GCTGACCCAG GTCCGGCCAC GCAATGCAGG GATCTACCGC 900

TGCATTGGCC AGGGGCAGAG GGGCCCACCC ATCATCCTGG AAGCCACACT TCACCTAGCA 960

GAGATTGAAG ACATGCCGCT ATTTGAGCCA CGGGTGTTTA CAGCTGGCAG CGAGGAGCGT 1020

GTGACCTGCC TTCCCCCCAA GGGTCTGCCA GAGCCCAGCG TGTGGTGGGA GCACGCGGGA 1080

GTCCGGCTGC CCACCCATGG CAGGGTCTAC CAGAAGGGCC ACGAGCTGGT GTTGGCCAAT 1140

ATTGCTGAAA GTGATGCTGG TGTCTACACC TGCCACGCGG CCAACCTGGC TGGTCAGCGG 1200

AGACAGGATG TCAACATCAC TGTGGCCACT GTGCCCTCCT GGCTGAAGAA GCCCCAAGAC 1260

AGCCAGCTGG AGGAGGGCAA ACCCGGCTAC TTGGATTGCC AGACCCAGGC CACACCAAAA 1320

CCTACAGTTG TCTGGTACAG AAACCAGATG CTTATCTCAG AGGACTCACG GTTCGAGGTC 1380

TTCAAGAATG GGACCTTGCG CATCAACAAC GTGGAGGTGT ACGATGGGAC ATGGTACCGT 1440

TGTGTGAGCA GCACCCCAGC CGGCAGCATC GAGGCGCAAG CCCGTGTCCA AGTGCTGGAA 1500

AAGCTCAAGT TCACACCACC ACCCCAGCCA CAGCAGTGCA TGGAGTTTGA CAAGGAGGCC 1560

ACGGTGCCCT GTTCAGCCAC AGGCCGAGAG AAGCCCACTA TTAAGTGGGA ACGGGCAGAT 1620

GGGAGCAGCC TCCCAGAGTG GGTGACAGAC AATGCTGGGA CCCTGCATTT TGCCCGGGTG 1680

ACTCGAGATG ATGCTGGCAA CTACACTTGC ATTGCGTCCA ACGGGCCGCA GGGCCAGATT 1740

CGTGCCCATG TCCAGCTCAC TGTGGCAGTT TTTATCACCT TCAAAGTGGA ACCAGAGCGT 1800

ACAACTGTGT ACCAAGGCCA CACAGCCCTA CTGCAGTGCG AGGCCCAGGG GGACCCCAAG 1860

CCGCTGATTC AGTGGAAAGG CAAGGACCGC ATCCTGGACC CCACCAAGCT GGGACCCAGG 1920

ATGCACATCT TCCAGAATGG CTCCCTGGTG ATCCATGACG TGGCCCCTGA GGACTCAGGC 1980

CGCTACACCT GCATTGCAGG CAACAGCTGC AACATCAAGC ACACGGAGGC CCCCCTCTAT 2040

GTCGTGGACA AGCCTGTGCC GGAGGAGTCG GAGGGCCCTG GCAGCCCTCC CCCTTACAAG 2100

ATGATCCAGA CCATTGGGTT GTCGGTGGGT GCCGCTGTGG CCTACATCAT TGCCGTGCTG 2160

GGCCTCATGT TCTACTGCAA GAAGCGCTGC AAAGCCAAGC GGCTGCAGAA GCAGCCCGAG 2220

GGCGAGGAGC CAGAGATGGA ATGCCTCAAT GGTGGGCCTT TGCAGAATGG GCAGCCCTCA 2280

GCAGAGATCC AAGAGGAAGT GGCCTTGACC AGCTTGGGCT CCGGCCCCGC GGCCACCAAC 2340

AAACGCCACA GCACAAGTGA TAAGATGCAC TTCCCACGGT CTAGCCTGCA GCCCATCACC 2400

ACGCTGGGGA AGAGTGAGTT TGGGGAGGTG TTCCTGGCAA AGGCTCAGGG CTTGGAGGAG 2460

GGAGTGGCAG AGACCCTGGT ACTTGTGAAG AGCCTGCAGA GCAAGGATGA GCAGCAGCAG 2520

CTGGACTTCC GGAGGGAGTT GGAGATGTTT GGGAAGCTGA ACCACGCCAA CGTGGTGCGG 2580

CTCCTGGGGC TGTGCCGGGA GGCTGAGCCC CACTACATGG TGCTGGAATA TGTGGATCTG 2640

GGAGACCTCA AGCAGTTCCT GAGGATTTCC AAGAGCAAGG ATGAAAAATT GAAGTCACAG 2700

CCCCTCAGCA CCAAGCAGAA GGTGGCCCTG TGCACCCAGG TAGCCCTGGG CATGGAGCAC 2760

CTGTCCAACA ACCGCTTTGT GCATAAGGAC TTGGCTGCGC GTAACTGCCT GGTCAGTGCC 2820

CAGAGACAAG TGAAGGTGTC TGCCCTGGGC CTCAGCAAGG ATGTGTACAA CAGTGAGTAC 2880

TACCACTTCC GCCAGGCCTG GGTGCCGCTG CGCTGGATGT CCCCCGAGGC CATCCTGGAG 2940

GGTGACTTCT CTACCAAGTC TGATGTCTGG GCCTTCGGTG TGCTGATGTG GGAAGTGTTT 3000

ACACATGGAG AGATGCCCCA TGGTGGGCAG GCAGATGATG AAGTACTGGC AGATTTGCAG 3060

GCTGGGAAGG CTAGACTTCC TCAGCCTGAG GGCTGCCCTT CCAAGCTCTA TCGGCTGATG 3120

CAGCGCTGCT GGGCCCTCAG CCCCAAGGAC CGGCCCTCCT TCAGTGAGAT TGCCAGCGCC 3180

CTGGGAGACA GCCCCGTGGA CAGCAAGCCG TGA 3213

Domain Profile

S: 1     lqelitlgksefgevflaklkgleegatetlvlvkslqkkdeqaqldfrrelellgklnh  60

         lq+++tlgksefgevflak++gleeg++etlvlvkslq+kdeq+qldfrrele++gklnh

Q: 796   LQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNH  855

         79**********************************************************

S: 61    anvvrllglcreaephymvleyvdlgdlkqflkiskakdeklksqplstkqkvalasqva  120

         anvvrllglcreaephymvleyvdlgdlkqfl+isk+kdeklksqplstkqkval++qva

Q: 856   ANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVA  915

         ************************************************************

S: 121   lgmealsrarfvhkdlaarnclisaerqvkvsalalskdvynseyykfrqalvplrwlsp  180

         lgme+ls++rfvhkdlaarncl+sa+rqvkvsal+lskdvynseyy+frqa+vplrw+sp

Q: 916   LGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSP  975

         ************************************************************

S: 181   eaileddfstksdvfafgvlvwevftqaelpheeladdevladlqagklrlsqaeatpsk  240

         eaile+dfstksdv+afgvl+wevft++e+ph+++addevladlqagk+rl+q+e++psk

Q: 976   EAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSK  1035

         ************************************************************

S: 241   lyrlllrcwasnpkdrpsfselasal  266

         lyrl++rcwa++pkdrpsfse+asal

Q: 1036  LYRLMQRCWALSPKDRPSFSEIASAL  1061

         ************************97

Domain Sequence
(FASTA)

LQPITTLGKS EFGEVFLAKA QGLEEGVAET LVLVKSLQSK DEQQQLDFRR ELEMFGKLNH 60

ANVVRLLGLC REAEPHYMVL EYVDLGDLKQ FLRISKSKDE KLKSQPLSTK QKVALCTQVA 120

LGMEHLSNNR FVHKDLAARN CLVSAQRQVK VSALGLSKDV YNSEYYHFRQ AWVPLRWMSP 180

EAILEGDFST KSDVWAFGVL MWEVFTHGEM PHGGQADDEV LADLQAGKAR LPQPEGCPSK 240

LYRLMQRCWA LSPKDRPSFS EIASAL 266

Keyword

Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

ptr:462708

;

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07679	; I-set; 6.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00408	; IGc2; 6.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 7.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013