EKS-PAT-00003

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00003

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	516.1	1.2E-155	632	888	257

Status

Unreviewed

Ensembl Protein

ENSPTRP00000031479

UniProt Accession

H2QTF1;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000135333

Gene Synonyms/Alias

ENSG00000135333;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000018428	ENSPTRP00000031479	ENSPTRT00000034059

Organism

Pan troglodytes

Functional Description

Protein Length

997

Protein Sequence
(FASTA)

MVFQTRYPSW IILCYIWLLR FAHTGEAQAA KEVLLLDSKA QQTELEWISS PPNGWEEISG 60

LDENYTPIRT YQVCQVMEPN QNNWLRTNWI SKGNAQRIFV ELKFTLRDCN SLPGVLGTCK 120

ETFNLYYYET DYDTGRNIRE NLYVKIDTIA ADESFTQGDL GERKMKLNTE VREIGPLSKK 180

GFYLAFQDVG ACIALVSVKV YYKKCWSIIE NLAIFPDTVT GSEFSSLVEV RGTCVSSAEE 240

EAENAPRMHC SAEGEWLVPI GKCICKAGYQ QKGDTCEPCG RGFYKSSSQD LQCSRCPTHS 300

FSDKEGSSRC ECEDGYYRAP SDPPYVACTR PPSAPQNLIF NINQTTVSLE WSPPADNGGR 360

NDVTYRILCK RCSWEQGECV PCGSNIGYMP QQTGLEDNYV TVMDLLAHAN YTFEVEAVNG 420

VSDLSRSQRL FAAVSITTGQ AAPSQVSGVM KERVLQRSVE LSWQEPEHPN GVITEYEIKY 480

YEKDQRERTY STVKTKSTSA SINNLKPGTV YVFQIRAFTA AGYGNYSPRL DVATLEEATG 540

KMFEATAVSS EQNPVIIIAV VAVAGTIILV FMVGFIIGRR HCGYSKADQE GDEELYFHCK 600

FPGTKTYIDP ETYEDPNRAV HQFAKELDAS CIKIERVIGA GEFGEVCSGR LKLPGKRDVA 660

VAIKTLKVGY TEKQRRDFLC EASIMGQFDH PNVVHLEGVV TRGKPVMIVI EFMENGALDA 720

FLRKHDGQFT VIQLVGMLRG IAAGMRYLAD MGYVHRDLAA RNILVNSNLV CKVSDFGLSR 780

VIEDDPEAVY TTTGGKIPVR WTAPEAIQYR KFTSASDVWS YGIVMWEVMS YGERPYWDMS 840

NQDVIKAIEE GYRLPAPMDC PAGLHQLMLD CWQKERAERP KFEQIVGILD KMIRNPNSLK 900

TPLGTCSRPM SPLLDQNTPD FTTFCSVGEW LQAIKMERYK DNFTAAGYNS LESVARMTIE 960

DVMSLGITLV GHQKKIMSSI QTMRAQMLHL HGTGIQV 997

Nucleotide Sequence
(FASTA)

ATGGTTTTTC AAACTCGGTA CCCTTCATGG ATTATTTTAT GCTACATCTG GCTGCTCCGC 60

TTTGCACACA CAGGGGAGGC GCAGGCTGCG AAGGAAGTAC TACTGCTGGA TTCTAAAGCA 120

CAACAAACAG AGTTGGAGTG GATTTCCTCT CCACCCAATG GGTGGGAAGA AATTAGTGGT 180

TTGGATGAGA ACTATACCCC GATACGAACA TACCAGGTGT GCCAAGTCAT GGAGCCCAAC 240

CAAAACAACT GGCTGCGGAC TAACTGGATT TCCAAAGGCA ATGCACAAAG GATTTTTGTA 300

GAATTGAAAT TCACCCTGAG GGATTGTAAC AGTCTTCCTG GAGTACTGGG AACTTGCAAG 360

GAAACATTTA ATTTGTACTA TTATGAAACA GACTATGACA CTGGCAGGAA TATAAGAGAA 420

AACCTCTATG TAAAAATAGA CACCATTGCT GCAGATGAAA GTTTTACCCA AGGTGACCTT 480

GGTGAAAGAA AGATGAAGCT TAACACTGAG GTGAGAGAGA TTGGACCTTT GTCCAAAAAG 540

GGATTCTATC TTGCCTTTCA GGATGTAGGG GCTTGCATAG CTTTGGTTTC TGTCAAAGTG 600

TACTACAAGA AGTGCTGGTC CATTATTGAG AACTTAGCTA TCTTTCCAGA TACAGTGACT 660

GGTTCAGAAT TTTCCTCTTT AGTCGAGGTT CGAGGGACAT GTGTCAGCAG TGCAGAGGAA 720

GAAGCGGAAA ACGCCCCCAG GATGCACTGC AGTGCAGAAG GAGAATGGTT AGTGCCCATT 780

GGAAAATGTA TCTGCAAAGC AGGCTACCAG CAAAAAGGAG ACACTTGTGA ACCCTGTGGC 840

CGTGGGTTCT ACAAGTCTTC CTCTCAAGAT CTTCAGTGCT CTCGTTGTCC AACTCACAGT 900

TTTTCTGATA AAGAAGGCTC CTCCAGATGT GAATGTGAAG ATGGGTATTA CAGGGCTCCA 960

TCTGACCCAC CGTACGTTGC ATGCACAAGG CCTCCATCTG CACCACAGAA CCTCATTTTC 1020

AACATCAACC AAACCACAGT AAGTTTGGAA TGGAGTCCTC CTGCAGACAA TGGGGGAAGA 1080

AACGATGTGA CCTACAGAAT ATTGTGTAAG CGGTGCAGTT GGGAGCAGGG CGAATGTGTT 1140

CCCTGTGGGA GTAACATTGG ATACATGCCC CAGCAGACTG GATTAGAGGA TAACTATGTC 1200

ACTGTCATGG ACCTGCTAGC CCACGCTAAT TATACTTTTG AAGTTGAAGC TGTAAATGGA 1260

GTTTCTGACT TAAGCCGATC CCAGAGGCTC TTTGCTGCTG TCAGTATCAC CACTGGTCAA 1320

GCAGCTCCCT CGCAAGTGAG CGGAGTAATG AAGGAGAGAG TACTGCAGCG GAGTGTCGAG 1380

CTTTCCTGGC AGGAACCAGA GCATCCCAAT GGAGTCATCA CAGAATATGA AATCAAGTAT 1440

TACGAGAAAG ATCAAAGGGA ACGGACCTAC TCAACAGTAA AAACCAAGTC TACTTCAGCC 1500

TCCATTAATA ATCTGAAACC AGGAACAGTG TATGTTTTCC AGATTCGGGC TTTTACTGCT 1560

GCTGGTTATG GAAATTACAG TCCCAGACTT GATGTTGCTA CACTAGAGGA AGCTACAGGT 1620

AAAATGTTTG AAGCTACAGC TGTCTCCAGT GAACAGAATC CTGTTATTAT CATTGCTGTG 1680

GTTGCTGTGG CTGGGACCAT CATTTTGGTG TTCATGGTCG GCTTCATCAT TGGGAGAAGG 1740

CACTGTGGTT ACAGCAAAGC TGACCAAGAA GGCGATGAAG AGCTTTACTT TCATTGTAAA 1800

TTTCCAGGCA CCAAAACNTA CATTGACCCT GAAACCTATG AGGACCCAAA TAGAGCTGTC 1860

CATCAATTCG CCAAGGAGCT AGATGCCTCC TGTATTAAAA TTGAGCGTGT GATTGGTGCA 1920

GGAGAATTTG GTGAAGTCTG CAGTGGCCGT TTGAAACTTC CAGGGAAAAG AGATGTTGCA 1980

GTAGCCATAA AAACCCTGAA AGTTGGTTAC ACAGAGAAAC AAAGGAGAGA CTTTTTGTGT 2040

GAAGCAAGCA TCATGGGGCA GTTTGACCAC CCAAATGTTG TCCATTTGGA AGGGGTTGTT 2100

ACAAGAGGGA AACCAGTCAT GATAGTAATA GAGTTCATGG AAAATGGAGC CCTAGATGCA 2160

TTTCTCAGGA AACATGATGG GCAATTTACA GTCATTCAGT TAGTAGGAAT GCTGAGAGGA 2220

ATTGCTGCTG GAATGAGATA TTTGGCTGAT ATGGGATATG TTCACAGGGA CCTTGCAGCT 2280

CGCAATATTC TTGTCAACAG CAATCTCGTT TGTAAAGTGT CAGATTTTGG CCTGTCCCGA 2340

GTTATAGAGG ATGATCCAGA AGCTGTCTAT ACAACTACTG GTGGAAAAAT TCCAGTAAGG 2400

TGGACGGCAC CCGAAGCCAT CCAGTACCGG AAATTCACAT CAGCCAGTGA TGTATGGAGC 2460

TATGGAATAG TCATGTGGGA AGTTATGTCT TACGGAGAAA GACCTTATTG GGACATGTCA 2520

AATCAAGATG TTATAAAAGC AATAGAAGAA GGTTATCGTT TACCAGCACC CATGGACTGC 2580

CCAGCTGGCC TTCACCAGCT AATGTTGGAT TGTTGGCAAA AGGAGCGTGC TGAAAGGCCA 2640

AAATTTGAAC AGATAGTTGG AATTCTAGAC AAAATGATTC GAAACCCAAA TAGTCTGAAA 2700

ACTCCCCTGG GAACTTGTAG TAGGCCAATG AGCCCTCTTC TGGATCAAAA CACTCCTGAT 2760

TTCACTACCT TTTGTTCAGT TGGAGAATGG CTACAAGCTA TTAAGATGGA AAGATATAAA 2820

GATAACTTCA CGGCAGCTGG CTACAATTCC CTTGAATCAG TAGCCAGGAT GACTATTGAG 2880

GATGTGATGA GTTTAGGGAT CACACTGGTT GGTCATCAAA AGAAAATCAT GAGCAGCATT 2940

CAGACTATGA GAGCACAAAT GCTACATTTA CATGGAACTG GCATTCAAGT GTGA 2994

Domain Profile

S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60

         +kie+viGaGefGevcsGrlklpgkr++avaiktlk g+tekqrrdfl+easi+Gqfdhp

Q: 632   IKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHP  691

         79**********************************************************

S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120

         n+++leGvvt++kpvmiv+e+mengald+flrk+dgqftviqlvgmlrGia+gm+yl+dm

Q: 692   NVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADM  751

         ************************************************************

S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180

         gyvhrdlaarnilvnsnlvckvsdfGlsrv+edd+ea+ytt+ggkip+rwtapeai+yrk

Q: 752   GYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRK  811

         ************************************************************

S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240

         ftsasdvwsyGiv+wev+syGerpywdmsnqdvikaieegyrlp+pmdcpa+l+qlmldc

Q: 812   FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDC  871

         ************************************************************

S: 241   wqkdraerpkfeqivsi  257

         wqk+raerpkfeqiv i

Q: 872   WQKERAERPKFEQIVGI  888

         **************987

Domain Sequence
(FASTA)

IKIERVIGAG EFGEVCSGRL KLPGKRDVAV AIKTLKVGYT EKQRRDFLCE ASIMGQFDHP 60

NVVHLEGVVT RGKPVMIVIE FMENGALDAF LRKHDGQFTV IQLVGMLRGI AAGMRYLADM 120

GYVHRDLAAR NILVNSNLVC KVSDFGLSRV IEDDPEAVYT TTGGKIPVRW TAPEAIQYRK 180

FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG YRLPAPMDCP AGLHQLMLDC 240

WQKERAERPK FEQIVGI 257

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity

KEGG

InterPros

IPR001090	; Ephrin_rcpt_lig-bd_dom.
IPR003961	; Fibronectin_type3.
IPR008979	; Galactose-bd-like.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641	; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016257	; Tyr_kinase_ephrin_rcpt.
IPR001426	; Tyr_kinase_rcpt_V_CS.

Pfam

PF01404	; Ephrin_lbd; 1.
PF00041	; fn3; 2.
PF07699	; GCC2_GCC3; 1.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00615	; EPH_lbd; 1.
SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS51550	; EPH_LBD; 1.
PS50853	; FN3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00790	; RECEPTOR_TYR_KIN_V_1; 1.
PS00791	; RECEPTOR_TYR_KIN_V_2; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013