EKS-PAT-00345

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00345

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	451.3	8.3E-136	271	520	250

Status

Unreviewed

Ensembl Protein

ENSPTRP00000031615

UniProt Accession

H2QTK7;

Protein Name

Protein Synonyms/Alias

FYN oncogene related to SRC, FGR, YES;

Gene Name

ENSG00000010810

Gene Synonyms/Alias

ENSG00000010810; FYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000018511	ENSPTRP00000031615	ENSPTRT00000034206

Organism

Pan troglodytes

Functional Description

Protein Length

537

Protein Sequence
(FASTA)

MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG 60

LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW 120

EARSLTTGET GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTFLIRESET 180

TKGAYSLSIR DWDDMKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC 240

RLVVPCHKGM PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT 300

LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR 360

ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN GLICKIADFG LARLIEDNEY 420

TARQGAKFPI KWTAPEAALY GRFTIKSDVW SFGILLTELV TKGRVPYPGM NNREVLEQVE 480

RGYRMPCPQD CPISLHELMI HCWKKDPEER PTFEYLQSFL EDYFTATEPQ YQPGENL 537

Nucleotide Sequence
(FASTA)

ATGGGCTGTG TGCAATGTAA GGATAAAGAA GCAACAAAAC TGACGGAGGA GAGGGACGGC 60

AGCCTGAACC AGAGCTCTGG GTACCGCTAT GGCACAGACC CCACCCCTCA GCACTACCCC 120

AGCTTCGGCG TGACCTCCAT CCCCAACTAC AACAACTTCC ATGCAGCCGG GGGCCAAGGA 180

CTCACCGTCT TTGGAGGTGT GAACTCTTCG TCTCATACGG GGACCTTGCG TACGAGAGGA 240

GGAACAGGAG TGACACTCTT TGTGGCCCTT TATGACTATG AAGCACGGAC AGAAGATGAC 300

CTAAGTTTTC ACAAAGGAGA AAAATTTCAA ATATTGAACA GCTCGGAAGG AGATTGGTGG 360

GAAGCCCGCT CCTTGACAAC TGGAGAGACA GGTTACATTC CCAGCAATTA TGTGGCTCCA 420

GTTGACTCTA TCCAGGCAGA AGAGTGGTAC TTTGGAAAAC TTGGCCGAAA AGATGCTGAG 480

CGACAGCTAT TGTCCTTTGG AAACCCAAGA GGTACCTTTC TTATCCGCGA GAGTGAAACC 540

ACCAAAGGTG CCTATTCACT TTCTATCCGT GATTGGGATG ATATGAAAGG AGACCATGTC 600

AAACATTATA AAATTCGCAA ACTTGACAAT GGTGGATACT ACATTACCAC CCGGGCCCAG 660

TTTGAAACAC TTCAGCAGCT TGTACAACAT TACTCAGAGA GAGCTGCAGG TCTCTGCTGC 720

CGCCTAGTAG TTCCCTGTCA CAAAGGGATG CCAAGGCTTA CCGATCTGTC TGTCAAAACC 780

AAAGATGTCT GGGAAATCCC TCGAGAATCC CTGCAGTTGA TCAAGAGACT GGGAAATGGG 840

CAGTTTGGGG AAGTATGGAT GGGTACCTGG AATGGAAACA CAAAAGTAGC CATAAAGACT 900

CTTAAACCAG GCACAATGTC CCCCGAATCA TTCCTTGAGG AAGCGCAGAT CATGAAGAAG 960

CTGAAGCACG ACAAGCTGGT CCAGCTCTAT GCAGTGGTGT CTGAGGAGCC CATCTACATC 1020

GTCACCGAGT ATATGAACAA AGGAAGTTTA CTGGATTTCT TAAAAGATGG AGAAGGAAGA 1080

GCTCTGAAAT TACCAAATCT TGTGGACATG GCAGCACAGG TGGCTGCAGG AATGGCTTAC 1140

ATCGAGCGCA TGAATTATAT CCATAGAGAT CTGCGATCAG CAAACATTCT AGTGGGGAAT 1200

GGACTCATAT GCAAGATTGC TGACTTCGGA TTGGCCCGAT TGATCGAAGA CAATGAGTAC 1260

ACAGCAAGAC AAGGTGCAAA GTTCCCCATC AAGTGGACGG CCCCCGAGGC AGCCCTGTAC 1320

GGGAGGTTCA CAATCAAGTC TGACGTGTGG TCTTTTGGAA TCTTACTCAC AGAGCTGGTC 1380

ACCAAAGGAA GAGTGCCATA CCCAGGCATG AACAACCGGG AGGTGCTGGA GCAGGTCGAG 1440

CGAGGCTACA GGATGCCCTG CCCGCAGGAC TGCCCCATCT CTCTGCATGA GCTCATGATC 1500

CACTGCTGGA AAAAGGACCC TGAAGAACGC CCCACTTTTG AGTACTTGCA GAGCTTCCTG 1560

GAAGACTACT TTACCGCGAC AGAGCCCCAG TACCAACCTG GTGAAAACCT GTAA 1614

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+k+lG+GqfGevw+g+w+g++kva+ktlk+gt+spe+fleeaqi+kkl+h+klv+ly

Q: 271   LQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLY  330

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflk+ eg++lklp+lvd+aaqva+Gmay+e++n+ihr

Q: 331   AVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHR  389

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+++n+lvg+ l++k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 390   DLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  449

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte+vtkG+vPypGm+n+evleqvergyr+p+p++cp +l+el+++cwkkdpee

Q: 450   WSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEE  509

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq++l

Q: 510   RPTFEYLQSFL  520

         ********986

Domain Sequence
(FASTA)

LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT LKPGTMSPES FLEEAQIMKK LKHDKLVQLY 60

AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR ALKLPNLVDM AAQVAAGMAY IERMNYIHRD 120

LRSANILVGN GLICKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELV TKGRVPYPGM NNREVLEQVE RGYRMPCPQD CPISLHELMI HCWKKDPEER 240

PTFEYLQSFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

ptr:462944

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013