EKS-PAT-00323

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00323

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	371.8	2.2E-111	167	583	417

Status

Unreviewed

Ensembl Protein

ENSPTRP00000032290

UniProt Accession

H2QU55;

Protein Name

Protein Synonyms/Alias

Eukaryotic translation initiation factor 2-alpha kinase 1;

Gene Name

ENSG00000086232

Gene Synonyms/Alias

ENSG00000086232; EIF2AK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000018904	ENSPTRP00000032290	ENSPTRT00000034937

Organism

Pan troglodytes

Functional Description

Protein Length

630

Protein Sequence
(FASTA)

MQGGNSGVRK REEEGDGAGA VAAPPAIDFP AEGPDPKYDE SDVPAELQVL KEPLQQPTFP 60

FAVANQLLLV SLLEHLSHVH EPNPLRSRQV FKLLCQTFIK MGLLSSFTCS DEFSSLRLHH 120

NRAITHLMRS AKERVRQDPC EDISHIQKIR SREVALEAQT SRYLNEFEEL AILGKGGYGR 180

VYKVRNKLDG QYYAIKKILI KGATKTVCMK VLREVKVLAG LQHPNIVGYH TAWIEHVHVI 240

QPRADRAAIE LPSLEVLSDQ EEDREHCGVK NDESSSSSII FAEPTPEKEK RFGESDTENQ 300

NNKSVKYTTN LVIRDSGELE STLELQENGL AGLSASSIVE QQLPLRRNSH LEESFTSTEE 360

SSEENFNFLG QTEAQYHLML HIQMQLCELS LWDWIVERNK RGREYVDESA CPYVMANVAT 420

KIFQELVEGV FYIHNMGIVH RDLKPRNIFL HGPDQQVKIG DFGLACTDIL QKNTDWTNRN 480

GKRTPTHTSR VGTCLYASPE QLEGSEYDAK SDMYSLGVIL LELFQPFGTE MERAEVLTGL 540

RTGQLPESLR KRCPVQAKYI QHLTRRNSSQ RPSAIQLLQS ELFQNSGNVN LTLQMKIIEQ 600

EKEIAELKKQ LNLLSQDKGV RDDGKDGGVG 630

Nucleotide Sequence
(FASTA)

ATGCAGGGGG GCAACTCCGG GGTCCGCAAG CGCGAAGAGG AGGGCGACGG GGCTGGGGCT 60

GTGGCTGCGC CGCCGGCCAT CGACTTTCCC GCCGAGGGCC CGGACCCCAA ATATGACGAA 120

TCTGATGTTC CAGCAGAACT CCAGGTGTTA AAAGAACCCC TACAACAGCC AACCTTCCCT 180

TTTGCAGTTG CAAACCAACT CTTGTTGGTT TCTTTGCTGG AGCACTTGAG CCATGTGCAT 240

GAACCAAACC CACTTCGTTC AAGACAGGTG TTTAAGTTAC TTTGCCAGAC GTTTATCAAA 300

ATGGGGCTGC TGTCTTCTTT CACTTGTAGT GACGAGTTTA GCTCATTGAG ACTACATCAC 360

AACAGAGCTA TTACTCACTT AATGAGGTCT GCTAAAGAGA GAGTTCGTCA GGATCCTTGT 420

GAGGATATTT CTCATATCCA GAAAATCAGA TCAAGGGAAG TAGCCTTGGA AGCACAAACT 480

TCACGTTACT TAAATGAATT TGAAGAACTT GCCATCTTAG GAAAAGGTGG ATACGGAAGA 540

GTATACAAGG TCAGGAATAA ATTAGATGGT CAGTATTATG CCATAAAAAA AATCCTGATT 600

AAGGGTGCAA CTAAAACAGT TTGCATGAAG GTCCTACGGG AAGTGAAGGT GCTGGCAGGT 660

CTTCAGCACC CCAATATTGT TGGCTATCAC ACCGCGTGGA TAGAACATGT TCACGTGATT 720

CAGCCACGAG CAGACAGAGC TGCCATTGAG TTGCCATCTC TGGAAGTGCT CTCCGACCAG 780

GAAGAGGACA GAGAGCATTG TGGTGTTAAA AATGATGAAA GTAGCAGCTC ATCCATTATC 840

TTTGCTGAGC CCACCCCAGA AAAAGAAAAA CGCTTTGGAG AATCTGACAC TGAAAATCAG 900

AATAACAAGT CGGTGAAGTA CACCACCAAT TTAGTCATAA GAGACTCTGG TGAACTTGAG 960

TCGACCCTGG AGCTCCAGGA AAATGGCTTG GCTGGTTTGT CTGCCAGTTC AATTGTGGAA 1020

CAGCAGCTGC CACTCAGGCG TAATTCCCAC CTAGAGGAGA GTTTCACATC CACCGAAGAA 1080

TCTTCCGAAG AAAATTTCAA CTTTTTGGGT CAGACAGAGG CACAGTACCA CCTGATGCTG 1140

CACATCCAGA TGCAGCTGTG TGAGCTCTCG CTGTGGGATT GGATAGTCGA GAGAAACAAG 1200

CGGGGCCGGG AGTATGTGGA CGAGTCTGCC TGTCCTTATG TTATGGCCAA TGTTGCAACA 1260

AAAATTTTTC AAGAATTGGT AGAAGGTGTG TTTTACATAC ATAACATGGG AATTGTGCAC 1320

CGAGATCTGA AGCCAAGAAA TATTTTTCTT CATGGCCCTG ATCAGCAAGT AAAAATAGGA 1380

GACTTTGGTC TGGCCTGCAC AGACATCCTA CAGAAGAACA CAGACTGGAC CAACAGAAAC 1440

GGGAAGAGAA CACCAACACA TACGTCCAGA GTGGGTACTT GTCTGTACGC TTCACCTGAA 1500

CAGTTGGAAG GATCTGAGTA TGATGCCAAG TCAGATATGT ACAGCTTGGG TGTGATCCTG 1560

CTAGAGCTCT TTCAGCCGTT TGGAACAGAA ATGGAGCGAG CAGAAGTTCT AACAGGTTTA 1620

AGAACTGGTC AGTTGCCGGA ATCCCTCCGT AAAAGGTGTC CAGTGCAAGC CAAGTATATC 1680

CAGCACTTAA CGAGAAGGAA CTCATCGCAG AGACCATCTG CCATTCAGCT GCTGCAGAGT 1740

GAACTTTTCC AAAATTCTGG AAATGTTAAC CTCACCCTAC AGATGAAGAT AATAGAGCAA 1800

GAAAAAGAAA TTGCAGAACT AAAGAAGCAG CTAAACCTCC TTTCTCAAGA CAAAGGGGTG 1860

AGGGATGACG GAAAGGATGG GGGCGTGGGA TGA 1893

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakke.lekverevkaLaklehpni  59

         fee+++lGkGg+g+V+k++nkld+++yaik+i ++ a+k+ ++kv+revk+La l+hpni

Q: 167   FEELAILGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTvCMKVLREVKVLAGLQHPNI  226

         899*********************************************************

S: 60    vrYfaawleekeesl.................................tdsseveaeael  86

         v Y++aw+e+ + ++                                 ++ss ++ae ++

Q: 227   VGYHTAWIEHVHVIQpradraaielpslevlsdqeedrehcgvkndesSSSSIIFAEPTP  286

         ************999*******************************9544999*******

S: 87    eesesseesdtk................................................  98

         e+++++ esdt+

Q: 287   EKEKRFGESDTEnqnnksvkyttnlvirdsgelestlelqenglaglsassiveqqlplr  346

         ************************************************************

S: 99    ................................llyiqmelceketLkdwiderk......  120

                                         +l+iqm+lce  +L+dwi er+

Q: 347   rnshleesftsteesseenfnflgqteaqyhlMLHIQMQLCE-LSLWDWIVERNkrgrey  405

         ******************************************.*********99999999

S: 121   llesrselvm.....rlfkqllegleylHskgliHrdLkpsniFld.sddqvKigDFgLa  174

         ++es++ +vm     ++f++l+eg+ y+H++g++HrdLkp+niFl+  d+qvKigDFgLa

Q: 406   VDESACPYVManvatKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHgPDQQVKIGDFGLA  465

         9999999999************************************99************

S: 175   talaealkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGlilfeLly  234

         ++++ ++++d+++++ +++++ht++vgt+ly+sPeqle+s+Y++k+D++sLG+il+eL++

Q: 466   CTDILQKNTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVILLELFQ  525

         ************************************************************

S: 235   pfstemervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasellksell  292

         pf temer+e+lt lr+g++pe++++++p+++k++q+l++r++++Rpsa +ll+sel+

Q: 526   PFGTEMERAEVLTGLRTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELF  583

         *******************************************************986

Domain Sequence
(FASTA)

FEELAILGKG GYGRVYKVRN KLDGQYYAIK KILIKGATKT VCMKVLREVK VLAGLQHPNI 60

VGYHTAWIEH VHVIQPRADR AAIELPSLEV LSDQEEDREH CGVKNDESSS SSIIFAEPTP 120

EKEKRFGESD TENQNNKSVK YTTNLVIRDS GELESTLELQ ENGLAGLSAS SIVEQQLPLR 180

RNSHLEESFT STEESSEENF NFLGQTEAQY HLMLHIQMQL CELSLWDWIV ERNKRGREYV 240

DESACPYVMA NVATKIFQEL VEGVFYIHNM GIVHRDLKPR NIFLHGPDQQ VKIGDFGLAC 300

TDILQKNTDW TNRNGKRTPT HTSRVGTCLY ASPEQLEGSE YDAKSDMYSL GVILLELFQP 360

FGTEMERAEV LTGLRTGQLP ESLRKRCPVQ AKYIQHLTRR NSSQRPSAIQ LLQSELF 417

Keyword

ATP-binding; Complete proteome; Initiation factor; Kinase; Nucleotide-binding; Protein biosynthesis; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006950	; P:response to stress

KEGG

ptr:463255

;

InterPros

IPR015516	; Haem-reg_EIF2A_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013