EKS-PAT-00054

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00054

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	402.2	1.1E-120	4	286	283

Status

Unreviewed

Ensembl Protein

ENSPTRP00000034032

UniProt Accession

H2QVM3;

Protein Name

Protein Synonyms/Alias

Cyclin-dependent kinase 5;

Gene Name

ENSG00000164885

Gene Synonyms/Alias

ENSG00000164885; CDK5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000019872	ENSPTRP00000034032	ENSPTRT00000036811

Organism

Pan troglodytes

Functional Description

Protein Length

292

Protein Sequence
(FASTA)

MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH 60

KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP EIVKSFLFQL LKGLGFCHSR 120

NVLHRDLKPQ NLLINRNGEL KLADFGLARA FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS 180

TSIDMWSAGC IFAELANAGR PLFPGNDVDD QLKRIFRLLG TPTEEQWPSM TKLPDYKPYP 240

MYPATTSLVN VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP 292

Nucleotide Sequence
(FASTA)

ATGCAGAAAT ACGAGAAACT GGAAAAGATT GGGGAAGGCA CCTACGGAAC TGTGTTCAAG 60

GCCAAAAACC GGGAGACTCA TGAGATCGTG GCTCTGAAAC GGGTGAGGCT GGATGACGAT 120

GATGAGGGTG TGCCGAGTTC AGCCCTCCGG GAGATCTGCC TACTCAAGGA GCTGAAGCAC 180

AAGAACATCG TCAGGCTTCA TGATGTCCTG CACAGCGACA AGAAGCTGAC TTTGGTTTTT 240

GAATTCTGTG ACCAGGACCT GAAGAAGTAT TTTGACAGTT GCAATGGTGA CCTCGATCCT 300

GAGATTGTAA AGTCATTCCT CTTCCAGCTA CTAAAAGGGC TGGGATTCTG TCATAGCCGC 360

AATGTGCTAC ACAGGGACCT GAAGCCCCAG AACCTGCTAA TAAACAGGAA TGGGGAGCTG 420

AAATTGGCTG ATTTTGGCCT GGCTCGAGCC TTTGGGATTC CCGTCCGCTG TTACTCAGCT 480

GAGGTGGTCA CACTGTGGTA CCGCCCACCG GATGTCCTCT TTGGGGCCAA GCTGTACTCC 540

ACGTCCATCG ACATGTGGTC AGCCGGCTGC ATCTTTGCAG AGCTGGCCAA TGCTGGGCGG 600

CCTCTTTTTC CCGGCAATGA TGTCGATGAC CAGTTGAAGA GGATCTTCCG ACTGCTGGGG 660

ACGCCCACCG AGGAGCAGTG GCCCTCTATG ACCAAGCTGC CAGACTATAA GCCCTATCCG 720

ATGTACCCGG CCACAACATC CCTGGTGAAC GTCGTGCCCA AACTCAATGC CACAGGGAGG 780

GACCTGCTGC AGAACCTTCT GAAGTGTAAC CCTGTCCAGC GTATCTCAGC AGAAGAGGCC 840

CTGCAGCACC CCTACTTCTC CGACTTCTGT CCGCCCTAG 879

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         yeklekigeGtyg+v+kak++et+e+vAlK++rl++++egvp++alrEi llkelkhkni

Q: 4     YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI  63

         99**********************************************************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L++v++ ++kkl+Lvfef++qdLkk++++++  +l++e vks+l+qll+gl ++Hs++

Q: 64    VRLHDVLH-SDKKLTLVFEFCDQDLKKYFDSCNG-DLDPEIVKSFLFQLLKGLGFCHSRN  121

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         +lHRDlKpqNlLi+++g+lklaDfGlaraf+ p++ y+ evvTlwYr+P++L+gak Yst

Q: 122   VLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYST  181

         ************************************************************

S: 181   avDiWsvgcilaellt.rkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfp  239

         ++D+Ws+gci+ael++  +plf+g++  dql+rif+llgtp+e++wp+++klp+yk  +p

Q: 182   SIDMWSAGCIFAELANaGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK-PYP  240

         **************97369*************************************.555

S: 240   kkkkk.klkekvkklkekaldllekllaldpkkRisakealqhkyf  284

          ++++ +l ++v+kl+ +++dll++ll+++p +Risa+ealqh+yf

Q: 241   MYPATtSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF  286

         5555559**************************************9

Domain Sequence
(FASTA)

YEKLEKIGEG TYGTVFKAKN RETHEIVALK RVRLDDDDEG VPSSALREIC LLKELKHKNI 60

VRLHDVLHSD KKLTLVFEFC DQDLKKYFDS CNGDLDPEIV KSFLFQLLKG LGFCHSRNVL 120

HRDLKPQNLL INRNGELKLA DFGLARAFGI PVRCYSAEVV TLWYRPPDVL FGAKLYSTSI 180

DMWSAGCIFA ELANAGRPLF PGNDVDDQLK RIFRLLGTPT EEQWPSMTKL PDYKPYPMYP 240

ATTSLVNVVP KLNATGRDLL QNLLKCNPVQ RISAEEALQH PYF 283

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ptr:463891

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013