EKS-PAT-00139

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00139

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	555.1	2.1E-167	479	755	277

Status

Unreviewed

Ensembl Protein

ENSPTRP00000043214

UniProt Accession

H2R210;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

ENSG00000077782

Gene Synonyms/Alias

ENSG00000077782;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000020176	ENSPTRP00000043214	ENSPTRT00000042198

Organism

Pan troglodytes

Functional Description

Protein Length

823

Protein Sequence
(FASTA)

MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD 60

VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD 120

ALPSSEDDDD DDDDSSSEEK ETDNTKPNRM PVAPYWTSPE KMEKKLHAVP AAKTVKFKCP 180

SSGTPNPTLR WLKNGKEFKP DHRIGGYKVR YATWSIIMDS VVPSDKGNYT CIVENEYGSI 240

NHTYQLDVVE RSPHRPILQA GLPANKTVAL GSNVEFMCKV YSDPQPHIQW LKHIEVNGSK 300

IGPDNLPYVQ ILKTAGVNTT DKEMEVLHLR NVSFEDAGEY TCLAGNSIGL SHHSAWLTVL 360

EALEERPAVM TSPLYLEIII YCTGAFLISC MVGSVIVYKM KSGTKKSDFH SQMAVHKLAK 420

SIPLRRQVTV SADSSASMNS GVLLVRPSRL SSSGTPMLAG VSEYELPEDP RWELPRDRLV 480

LGKPLGEGCF GQVVLAEAIG LDKDKPNRVT KVAVKMLKSD ATEKDLSDLI SEMEMMKMIG 540

KHKNIINLLG ACTQDGPLYV IVEYASKGNL REYLQARRPP GLEYCYNPSH NPEEQLSSKD 600

LVSCAYQVAR GMEYLASKKC IHRDLAARNV LVTEDNVMKI ADFGLARDIH HIDYYKKTTN 660

GRLPVKWMAP EALFDRIYTH QSDVWSFGVL LWEIFTLGGS PYPGVPVEEL FKLLKEGHRM 720

DKPSNCTNEL YMMMRDCWHA VPSQRPTFKQ LVEDLDRIVA LTSNQEYLDL SMPLDQYSPS 780

FPDTRSSTCS SGEDSVFSHE PLPEEPCLPR HPAQLANGGL KRR 823

Nucleotide Sequence
(FASTA)

ATGTGGAGCT GGAAGTGCCT CCTCTTCTGG GCTGTGCTGG TCACAGCCAC ACTCTGCACC 60

GCTAGGCCGT CCCCGACCTT GCCTGAACAA GCCCAGCCCT GGGGAGCCCC TGTGGAAGTG 120

GAGTCCTTCC TGGTCCACCC CGGTGACCTG CTGCAGCTTC GCTGTCGGCT GCGGGACGAT 180

GTGCAGAGCA TCAACTGGCT GCGGGACGGG GTGCAGCTGG CGGAAAGCAA CCGCACCCGC 240

ATCACAGGGG AGGAGGTGGA GGTGCAGGAC TCCGTGCCCG CAGACTCCGG CCTCTATGCT 300

TGCGTAACCA GCAGCCCCTC GGGCAGTGAC ACCACCTACT TCTCCGTCAA TGTTTCAGAT 360

GCTCTCCCCT CCTCGGAGGA TGATGATGAT GATGATGATG ACTCCTCTTC AGAGGAGAAA 420

GAAACAGATA ACACCAAACC AAACCGTATG CCCGTAGCTC CATATTGGAC ATCCCCAGAA 480

AAGATGGAAA AGAAATTGCA TGCAGTGCCG GCTGCCAAGA CAGTGAAGTT CAAATGCCCT 540

TCCAGTGGGA CCCCAAACCC CACACTGCGC TGGTTGAAAA ATGGCAAAGA ATTCAAACCT 600

GACCACAGAA TTGGAGGCTA CAAGGTCCGT TATGCCACCT GGAGCATCAT AATGGACTCT 660

GTGGTGCCCT CTGACAAGGG CAACTACACC TGCATTGTGG AGAATGAGTA CGGCAGCATC 720

AACCACACAT ACCAGCTGGA TGTCGTGGAG CGGTCCCCTC ACCGGCCCAT CCTGCAAGCA 780

GGGTTGCCCG CCAACAAGAC AGTGGCCCTG GGTAGCAACG TGGAGTTCAT GTGTAAGGTG 840

TACAGTGACC CGCAGCCGCA TATCCAGTGG CTAAAGCACA TCGAGGTGAA CGGGAGCAAG 900

ATTGGCCCAG ACAACCTGCC TTATGTCCAG ATCCTGAAGA CTGCTGGAGT TAATACCACC 960

GACAAAGAGA TGGAGGTGCT TCACTTAAGA AATGTCTCCT TTGAGGACGC AGGGGAGTAT 1020

ACGTGCTTGG CGGGTAACTC TATCGGACTC TCCCATCACT CTGCATGGTT GACCGTTCTG 1080

GAAGCCCTGG AAGAGAGGCC GGCAGTGATG ACCTCGCCCC TGTACCTGGA GATCATCATC 1140

TATTGCACAG GGGCCTTCCT CATCTCCTGC ATGGTGGGGT CGGTCATCGT CTACAAGATG 1200

AAGAGTGGTA CCAAGAAGAG TGACTTCCAC AGCCAGATGG CTGTGCACAA GCTGGCCAAG 1260

AGCATCCCTC TGCGCAGACA GGTAACAGTG TCTGCTGACT CCAGTGCATC CATGAACTCT 1320

GGGGTTCTTC TGGTTCGGCC ATCACGGCTC TCCTCCAGTG GGACTCCCAT GCTAGCAGGG 1380

GTCTCTGAGT ATGAGCTTCC CGAAGACCCT CGCTGGGAGC TGCCTCGGGA CAGACTGGTC 1440

TTAGGCAAAC CCCTGGGAGA GGGCTGCTTT GGGCAGGTGG TGTTGGCAGA GGCTATCGGG 1500

CTGGACAAGG ACAAACCCAA CCGTGTGACC AAAGTGGCTG TGAAGATGTT GAAGTCGGAC 1560

GCAACAGAGA AAGACTTGTC AGACCTGATC TCAGAAATGG AGATGATGAA GATGATCGGG 1620

AAGCATAAGA ATATCATCAA CCTGCTGGGG GCCTGCACGC AGGATGGTCC CTTGTATGTC 1680

ATCGTGGAGT ATGCCTCCAA GGGCAACCTG CGGGAGTACC TGCAGGCCCG GAGGCCCCCA 1740

GGGCTGGAAT ACTGCTACAA CCCCAGCCAC AACCCAGAGG AGCAGCTCTC CTCCAAGGAC 1800

CTGGTGTCCT GCGCCTACCA GGTGGCCCGA GGCATGGAGT ATCTGGCCTC CAAGAAGTGC 1860

ATACACCGAG ACCTGGCAGC CAGGAATGTC CTGGTGACAG AGGACAATGT GATGAAGATA 1920

GCAGACTTTG GCCTCGCACG GGACATTCAC CACATCGACT ACTATAAAAA GACAACCAAC 1980

GGCCGACTGC CTGTGAAGTG GATGGCACCC GAGGCATTAT TTGACCGGAT CTACACCCAC 2040

CAGAGTGATG TGTGGTCTTT CGGGGTGCTC CTGTGGGAGA TCTTCACTCT GGGCGGCTCC 2100

CCATACCCCG GTGTGCCTGT GGAGGAACTT TTCAAGCTGC TGAAGGAGGG TCACCGCATG 2160

GACAAGCCCA GTAACTGCAC CAACGAGCTG TACATGATGA TGCGGGACTG CTGGCATGCA 2220

GTGCCCTCAC AGAGACCCAC CTTCAAGCAG CTGGTGGAAG ACCTGGACCG CATCGTGGCC 2280

TTGACCTCCA ACCAGGAGTA CCTGGACCTG TCCATGCCCC TGGACCAGTA CTCCCCCAGC 2340

TTTCCCGACA CCCGGAGCTC TACGTGCTCC TCAGGGGAGG ATTCCGTCTT CTCTCATGAG 2400

CCGCTGCCCG AGGAGCCCTG CCTGCCCCGA CACCCAGCCC AGCTTGCCAA TGGCGGACTC 2460

AAACGCCGCT GA 2472

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 479   LVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  538

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++s+++eeql++

Q: 539   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSS  598

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 599   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  658

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 659   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  718

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl

Q: 719   RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  755

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGLEYCYNP SHNPEEQLSS 120

KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPSNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008284	; P:positive regulation of cell proliferation

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013