EKS-PAT-00440

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00440

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	346.4	1.1E-103	20	316	297

Status

Unreviewed

Ensembl Protein

ENSPTRP00000012102

UniProt Accession

H2Q9G3;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase 6;

Gene Name

ENSG00000069956

Gene Synonyms/Alias

ENSG00000069956; MAPK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000020224	ENSPTRP00000012102	ENSPTRT00000013065

Organism

Pan troglodytes

Functional Description

Protein Length

721

Protein Sequence
(FASTA)

MAEKFESLMN IHGFDLGSRY MDLKPLGCGG NGLVFSAVDN DCDKRVAIKK IVLTDPQSVK 60

HALREIKIIR RLDHDNIVKV FEILGPSGSQ LTDDVGSLTE LNSVYIVQEY METDLANVLE 120

QGPLLEEHAR LFMYQLLRGL KYIHSANVLH RDLKPANLFI NTEDLVLKIG DFGLARIMDP 180

HYSHKGHLSE GLVTKWYRSP RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ 240

MQLILESIPV VHEEDRQELL SVIPVYIRND MTEPHKPLTQ LLPGISREAL DFLEQILTFS 300

PMDRLTAEEA LSHPYMSIYS FPMDEPISSH PFHIEDEVDD ILLMDETHSH IYNWERYHDC 360

QFSEHDWPVH NNFDIDEVQL DPRALSDVTD EEEVQVDPRK YLDGDREKYL EDPAFDTNYS 420

TEPCWQYSDH HENKYCDLEC SHTCNYKTRS SSYLDNLVWR ESEVNHYYEP KLIIDLSNWK 480

EQSKEKSDKK GKSKCERNGL VKAQIALEEA SQQLAGKERE KNQGFDFDSF IAGTIQLSSQ 540

HEPTDVVDKL NDLNSSVSQL ELKSLISKSV SQEKQEKGMA NLAQLEALYQ SSWDSQFVSG 600

GEDCFFINQF CEVRKDEQVE KENTYTSYLD KFFSRKEDTE MLETEPVEDG KLGERGHEEG 660

FLNNSGEFLF NKQLESIGIP QFHSPVGSPL KSIQATLTPS AMKSSPQIPH QTYSSILKHL 720

N 721

Nucleotide Sequence
(FASTA)

ATGGCAGAGA AATTTGAAAG TCTCATGAAC ATTCATGGTT TTGATCTGGG TTCTAGGTAT 60

ATGGACTTAA AACCATTGGG TTGTGGAGGC AATGGCTTGG TTTTTTCTGC TGTAGACAAT 120

GACTGTGACA AAAGAGTAGC CATCAAGAAA ATTGTCCTTA CTGATCCCCA AAGTGTCAAA 180

CATGCTCTAC GTGAAATCAA AATTATTAGA AGACTTGACC ATGATAACAT TGTGAAAGTG 240

TTTGAAATTC TTGGTCCCAG TGGAAGCCAA TTAACAGACG ATGTGGGCTC TCTTACGGAA 300

CTGAACAGTG TTTACATTGT TCAGGAGTAC ATGGAGACAG ACTTGGCTAA TGTGCTGGAG 360

CAGGGCCCTT TACTGGAAGA GCATGCCAGG CTTTTCATGT ATCAGCTGCT ACGGGGGCTC 420

AAGTATATTC ACTCTGCAAA TGTACTGCAC AGAGATCTCA AACCAGCTAA TCTTTTCATT 480

AATACGGAAG ACTTGGTGCT GAAGATAGGT GACTTTGGTC TTGCACGGAT CATGGATCCT 540

CATTATTCCC ATAAGGGTCA TCTTTCTGAA GGATTGGTTA CTAAATGGTA CAGATCTCCA 600

CGTCTTTTAC TTTCTCCTAA TAATTATACT AAAGCCATTG ACATGTGGGC TGCAGGCTGC 660

ATCTTTGCTG AAATGCTGAC TGGTAAAACC CTTTTTGCAG GTGCACATGA ACTTGAACAG 720

ATGCAGCTGA TTTTAGAATC TATTCCTGTC GTACATGAGG AAGATCGTCA GGAGCTTCTC 780

AGCGTAATTC CAGTTTACAT TAGAAATGAC ATGACTGAGC CACACAAACC TTTAACTCAG 840

CTGCTTCCAG GAATTAGTCG AGAAGCACTG GATTTCCTGG AACAAATTTT GACATTTAGC 900

CCCATGGATC GGTTAACAGC AGAAGAAGCA CTCTCCCATC CTTACATGAG CATATATTCT 960

TTTCCAATGG ATGAGCCAAT TTCAAGCCAT CCTTTTCATA TTGAAGATGA AGTTGATGAT 1020

ATTTTGCTTA TGGATGAAAC TCACAGTCAC ATTTATAACT GGGAAAGGTA TCATGATTGT 1080

CAGTTTTCAG AGCATGATTG GCCTGTACAT AACAACTTTG ATATTGATGA AGTTCAGCTT 1140

GATCCAAGAG CTCTGTCCGA TGTCACTGAT GAAGAAGAAG TACAAGTTGA TCCCCGAAAA 1200

TATTTGGATG GAGATCGGGA AAAGTATCTG GAGGATCCTG CTTTTGATAC CAATTACTCT 1260

ACTGAGCCTT GTTGGCAATA CTCAGATCAT CATGAAAACA AATATTGTGA TCTGGAGTGT 1320

AGCCATACTT GTAACTACAA AACGAGGTCA TCATCATATT TAGATAACTT AGTTTGGAGA 1380

GAGAGTGAAG TTAACCATTA CTATGAACCC AAGCTTATTA TAGATCTTTC CAATTGGAAA 1440

GAACAAAGCA AAGAAAAATC TGATAAGAAA GGCAAATCAA AATGTGAAAG GAATGGATTG 1500

GTTAAAGCCC AGATAGCGCT AGAGGAAGCA TCACAGCAAC TGGCTGGAAA AGAAAGGGAA 1560

AAGAATCAGG GATTTGATTT TGATTCCTTT ATTGCAGGAA CTATTCAGCT TAGTTCCCAG 1620

CATGAGCCTA CTGATGTTGT TGATAAATTA AATGACTTGA ATAGCTCAGT GTCCCAACTA 1680

GAATTGAAAA GTTTGATATC AAAGTCAGTA AGCCAAGAAA AACAGGAAAA AGGAATGGCA 1740

AATCTGGCTC AATTAGAAGC CTTGTACCAG TCTTCTTGGG ACAGCCAGTT TGTGAGTGGT 1800

GGGGAGGACT GTTTTTTCAT AAATCAGTTT TGTGAGGTAA GGAAGGATGA ACAAGTTGAG 1860

AAGGAAAACA CTTACACTAG TTACTTGGAC AAGTTCTTTA GCAGGAAAGA AGATACTGAA 1920

ATGCTAGAAA CTGAGCCAGT AGAGGATGGG AAGCTTGGGG AGAGAGGACA TGAGGAAGGA 1980

TTTCTGAACA ACAGTGGGGA GTTCCTCTTT AACAAGCAGC TCGAGTCCAT AGGCATCCCG 2040

CAGTTTCACA GTCCAGTTGG GTCACCACTT AAGTCAATAC AGGCCACATT AACACCTTCT 2100

GCTATGAAAT CTTCCCCTCA AATTCCTCAT CAAACATACA GCAGCATTCT GAAACATCTG 2160

AACTAA 2166

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkplg G +g+v+savd+++++rvaikk++  +++ +s+k++lRE+k++++l+h+Ni

Q: 20    YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIRRLDHDNI  77

         7899****************************9..9************************

S: 61    iklldvftpee........eleelkdvYlvtelmetdLkkviksqklsdehiklllyqil  112

         +k+++++ p+         +l+el++vY+v+e+metdL++v+++  l +eh++l++yq+l

Q: 78    VKVFEILGPSGsqltddvgSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLL  137

         *********999999999999***************************************

S: 113   rglkylHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwY  169

         rglky+Hsanv+HrDlKP+Nl++n++   lki dFGlar++d+++++k  l+e ++t+wY

Q: 138   RGLKYIHSANVLHRDLKPANLFINTEDLvLKIGDFGLARIMDPHYSHKghLSEGLVTKWY  197

         ************************876449**************999999**********

S: 170   raPeillslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflk  229

         r+P++lls ++ytka+D+W++GCI+aE+ltgk+lf+g++e++q+++ile ++ ++ee+ +

Q: 198   RSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQ  257

         ************************************************************

S: 230   kieseearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         ++ s  +  yi++ +++++k++++l+p  s+eald+le++L+++p++R+++eeaL+hpY+

Q: 258   ELLSV-IPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYM  316

         ****5.*****************************************************7

Domain Sequence
(FASTA)

YMDLKPLGCG GNGLVFSAVD NDCDKRVAIK KIVLTDPQSV KHALREIKII RRLDHDNIVK 60

VFEILGPSGS QLTDDVGSLT ELNSVYIVQE YMETDLANVL EQGPLLEEHA RLFMYQLLRG 120

LKYIHSANVL HRDLKPANLF INTEDLVLKI GDFGLARIMD PHYSHKGHLS EGLVTKWYRS 180

PRLLLSPNNY TKAIDMWAAG CIFAEMLTGK TLFAGAHELE QMQLILESIP VVHEEDRQEL 240

LSVIPVYIRN DMTEPHKPLT QLLPGISREA LDFLEQILTF SPMDRLTAEE ALSHPYM 297

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

ptr:453439

;

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013