EKS-PAT-00348

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00348

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	442.4	4.2E-133	247	497	251

Status

Unreviewed

Ensembl Protein

ENSPTRP00000046608

UniProt Accession

H2R453;

Protein Name

Protein Synonyms/Alias

V-yes-1 Yamaguchi sarcoma viral related oncogene homolog;

Gene Name

ENSG00000254087

Gene Synonyms/Alias

ENSG00000254087; LYN;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000020263	ENSPTRP00000046608	ENSPTRT00000044800

Organism

Pan troglodytes

Functional Description

Protein Length

512

Protein Sequence
(FASTA)

MGCIKSKGKD SLSDDGVDLK TQPVRNTERT IYVRDPTSNK QQRPVPESQL LPGQRFQTKD 60

PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEEHGEWW KAKSLLTKKE GFIPSNYVAK 120

LNTLETEEWF FKDITRKDAE RQLLAPGNSA GAFLIRESET LKGSFSLSVR DFDPVHGDVI 180

KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQADGLCR RLEKACISPK PQKPWDKDAW 240

EIPRESIKLV KRLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD 300

KLVRLYAVVT REEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ IAEGMAYIER 360

KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF 420

TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRVENCPD ELYDIMKMCW 480

KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP 512

Nucleotide Sequence
(FASTA)

ATGGGATGTA TAAAATCAAA AGGGAAAGAC AGCTTGAGTG ACGATGGAGT AGATTTGAAG 60

ACTCAACCAG TACGTAATAC TGAAAGAACT ATTTATGTGA GAGATCCAAC GTCCAATAAA 120

CAGCAAAGGC CAGTTCCAGA ATCTCAGCTT TTACCTGGAC AGAGGTTTCA AACTAAAGAT 180

CCAGAGGAAC AAGGAGACAT TGTGGTAGCC TTGTACCCCT ATGATGGCAT CCACCCGGAC 240

GACTTGTCTT TCAAGAAAGG AGAGAAGATG AAAGTCCTGG AGGAGCATGG AGAATGGTGG 300

AAAGCAAAGT CCCTTTTAAC AAAAAAAGAA GGCTTCATCC CCAGCAACTA TGTGGCCAAA 360

CTCAACACCT TAGAAACAGA AGAGTGGTTT TTCAAGGATA TAACCAGGAA GGACGCAGAA 420

AGGCAGCTTT TGGCACCAGG AAATAGCGCT GGAGCTTTCC TTATTAGAGA AAGTGAAACA 480

TTAAAAGGAA GCTTCTCTCT GTCTGTCAGA GACTTTGACC CTGTGCATGG TGATGTTATT 540

AAGCACTACA AAATTAGAAG TCTGGATAAT GGGGGCTATT ACATCTCTCC ACGAATCACT 600

TTTCCCTGTA TCAGCGACAT GATTAAACAT TACCAAAAGC AGGCAGATGG CTTGTGCAGA 660

AGATTGGAGA AGGCTTGTAT TAGTCCCAAG CCACAGAAGC CATGGGATAA AGATGCCTGG 720

GAGATCCCCC GGGAGTCCAT CAAGTTGGTG AAAAGGCTTG GCGCTGGGCA GTTTGGGGAA 780

GTCTGGATGG GTTACTATAA CAACAGTACC AAGGTGGCTG TGAAAACCCT GAAGCCAGGA 840

ACTATGTCTG TGCAAGCCTT CCTGGAAGAA GCCAACCTCA TGAAGACCCT GCAGCATGAC 900

AAGCTCGTGA GGCTCTATGC TGTGGTCACC AGGGAGGAGC CCATTTACAT CATCACCGAG 960

TACATGGCCA AGGGCAGTTT GTTGGATTTC CTGAAAAGCG ATGAAGGTGG CAAAGTGCTG 1020

CTTCCAAAGC TCATTGACTT TTCTGCTCAG ATTGCAGAGG GAATGGCATA CATCGAGCGG 1080

AAGAACTACA TTCACCGGGA CCTGCGAGCA GCTAATGTTC TGGTCTCCGA GTCACTCATG 1140

TGCAAAATTG CAGATTTTGG CCTTGCTAGA GTAATTGAAG ATAATGAGTA CACAGCAAGG 1200

GAAGGTGCTA AGTTCCCTAT TAAGTGGACG GCTCCAGAAG CAATCAACTT TGGATGTTTC 1260

ACTATTAAGT CTGATGTGTG GTCCTTTGGA ATCCTCCTAT ACGAAATCGT CACCTATGGG 1320

AAAATTCCCT ACCCAGGGAG AACTAATGCC GACGTGATGA CCGCCCTTTC CCAGGGCTAC 1380

AGGATGCCCC GTGTGGAGAA CTGCCCAGAT GAGCTCTATG ACATTATGAA AATGTGCTGG 1440

AAAGAAAAGG CAGAAGAGAG ACCAACGTTT GATTACTTAC AGAGCGTCCT GGATGATTTC 1500

TACACAGCCA CGGAAGGGCA ATACCAGCAG CAGCCTTAG 1539

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         +klvk+lG+GqfGevw+g++++s+kvavktlk+gt+s +afleea+++k+l+h+klv+ly

Q: 247   IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY  306

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++eePiyi+te+makGslldflk++eg k+ lpkl+d++aq+aeGmay+e+kn+ihr

Q: 307   AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR  366

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+nvlv+esl++k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv

Q: 367   DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV  426

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGill+eivt+Gk+PypG tn++v++++++gyr+pr e+cp+ely+++++cwk+++ee

Q: 427   WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEE  486

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtf++lq+vl

Q: 487   RPTFDYLQSVL  497

         ********986

Domain Sequence
(FASTA)

IKLVKRLGAG QFGEVWMGYY NNSTKVAVKT LKPGTMSVQA FLEEANLMKT LQHDKLVRLY 60

AVVTREEPIY IITEYMAKGS LLDFLKSDEG GKVLLPKLID FSAQIAEGMA YIERKNYIHR 120

DLRAANVLVS ESLMCKIADF GLARVIEDNE YTAREGAKFP IKWTAPEAIN FGCFTIKSDV 180

WSFGILLYEI VTYGKIPYPG RTNADVMTAL SQGYRMPRVE NCPDELYDIM KMCWKEKAEE 240

RPTFDYLQSV L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Erinaceus europaeus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

ptr:472771

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013