EKS-PAT-00462

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00462

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RIPK	392.0	1.3E-117	18	287	270

Status

Unreviewed

Ensembl Protein

ENSPTRP00000034905

UniProt Accession

H2QWE5;

Protein Name

Protein Synonyms/Alias

Receptor-interacting serine-threonine kinase 2;

Gene Name

ENSG00000104312

Gene Synonyms/Alias

ENSG00000104312; RIPK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000020405	ENSPTRP00000034905	ENSPTRT00000037765

Organism

Pan troglodytes

Functional Description

Protein Length

539

Protein Sequence
(FASTA)

MNGEAICSAL PTIPYHKLAD LRYLSRGASG TVSSARHADW RVQVAVKHLH IHTPLLDSER 60

KDVLREAEIL HKARFSYILP ILGICNEPEF LGIVTEYMPN GSLNELLHRK TEYPDVAWPL 120

RFRILHEIAL GVNYLHNMTP PLLHHDLKTQ NILLDNEFHV KIADFGLSKW RMMSLSQSRS 180

SKSAPEGGTI IYMPPENYEP GQKSRASIKH DIYSYAVITW EVLSRKQPFE DVTNPLQIMY 240

SVSQGHRPVI NEESLPYDIP HRARMISLIE SGWAQNPDER PSFLKCLIEL EPVLRTFEEI 300

TFLEAVIQLK KTKLQSVSSA IHLCDKKKME LSLNIPVNHG PQEESCGSSQ LHENSGSPET 360

SRSLPAQDND FSSRKAQDCY FMKLHHCPGN HSWDSTISGS QRAAFCDHKT TPCSSAIINP 420

LSTAGNSERL QPGIAQQWIQ SKREDIVNQM TEACLNQSLD ALLSRDLIMK EDYELVSTKP 480

TRTSKVRQLL DTTDIQGEEF AKVIVQKLKD NKQMGLQPYP EILVVSRSSS LHLLQNKSM 539

Nucleotide Sequence
(FASTA)

ATGAACGGGG AGGCCATCTG CAGCGCCCTG CCCACCATTC CCTACCACAA ACTCGCCGAC 60

CTGCGCTACC TGAGCCGCGG CGCCTCTGGC ACTGTGTCGT CCGCCCGCCA CGCAGACTGG 120

CGCGTCCAGG TGGCCGTGAA GCACCTGCAC ATCCACACTC CGCTGCTCGA CAGTGAAAGA 180

AAGGATGTCT TAAGAGAAGC TGAAATTTTA CACAAAGCTA GATTTAGTTA CATTCTTCCA 240

ATTTTGGGAA TTTGCAATGA GCCTGAATTT TTGGGAATAG TTACTGAATA CATGCCAAAT 300

GGATCATTAA ATGAACTCCT ACATAGGAAA ACTGAATATC CTGATGTTGC TTGGCCATTG 360

AGATTTCGCA TCCTGCATGA AATTGCCCTT GGTGTAAATT ACCTGCACAA TATGACTCCT 420

CCTTTACTTC ATCATGACTT GAAGACTCAG AATATCTTAC TGGACAATGA ATTTCATGTT 480

AAGATTGCAG ATTTTGGTTT ATCAAAATGG CGCATGATGT CCCTCTCACA GTCACGAAGT 540

AGCAAATCTG CACCAGAAGG AGGGACAATT ATCTATATGC CACCTGAAAA CTATGAACCT 600

GGACAAAAAT CAAGGGCCAG TATCAAGCAC GATATATATA GCTATGCAGT TATCACATGG 660

GAAGTGTTAT CCAGAAAACA GCCTTTTGAA GATGTCACCA ATCCTTTGCA GATAATGTAT 720

AGTGTGTCAC AAGGACATCG ACCTGTTATT AATGAAGAAA GTTTGCCATA TGATATACCT 780

CACCGAGCAC GTATGATCTC TCTAATAGAA AGTGGATGGG CACAAAATCC AGATGAAAGA 840

CCATCTTTCT TAAAATGTTT AATAGAACTT GAACCAGTTT TGAGAACATT TGAAGAGATA 900

ACTTTTCTTG AAGCTGTTAT TCAGCTAAAG AAAACAAAGT TACAGAGTGT TTCAAGTGCC 960

ATTCACCTAT GTGACAAGAA GAAAATGGAA TTATCTCTGA ACATACCTGT AAATCATGGT 1020

CCACAAGAGG AATCATGTGG ATCCTCTCAG CTCCATGAAA ATAGTGGTTC TCCTGAAACT 1080

TCAAGGTCCC TGCCAGCTCA AGACAATGAT TTTTCATCTA GAAAAGCTCA AGACTGTTAT 1140

TTTATGAAGC TGCATCACTG TCCTGGAAAT CACAGTTGGG ATAGCACCAT TTCTGGATCT 1200

CAAAGGGCTG CATTCTGTGA TCACAAGACC ACTCCATGCT CTTCAGCAAT AATAAATCCA 1260

CTCTCAACTG CAGGAAACTC AGAACGTCTG CAGCCTGGTA TAGCCCAGCA GTGGATCCAG 1320

AGCAAAAGGG AAGACATTGT GAACCAAATG ACAGAAGCCT GCCTTAACCA GTCGCTAGAT 1380

GCCCTTCTGT CCAGGGACTT GATCATGAAA GAGGACTATG AACTTGTTAG TACCAAGCCT 1440

ACAAGGACCT CAAAAGTCAG ACAATTACTA GACACTACTG ACATCCAAGG AGAAGAATTT 1500

GCCAAAGTTA TAGTACAAAA ATTGAAAGAT AACAAACAAA TGGGTCTTCA GCCTTACCCG 1560

GAAATACTTG TGGTTTCTAG ATCATCATCT TTACATTTAC TTCAAAATAA AAGCATGTAA 1620

Domain Profile

S: 1     leelelvgsGgfgkvfkarhrkwrvevavkslvlktdaldserkelleeakkmeklrfsy  60

         l++l+++++G++g+v++arh++wrv+vavk+l+++t++ldserk++l+ea++++k+rfsy

Q: 18    LADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSY  77

         67899*******************************************************

S: 61    vlkllGvikeeeklglvmeymenGsLeklLkseielp...wplkfRilkevvlgmnyLhs  117

         +l++lG+++e+e+lg+v+eym+nGsL++lL++++e+p   wpl+fRil+e++lg+nyLh+

Q: 78    ILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPdvaWPLRFRILHEIALGVNYLHN  137

         ************************************9999********************

S: 118   lkPpllhkDLkpeniLlDnelhvkiaDfGlskf.meessqskevsssaegGtlaYlaPel  176

         ++Ppllh+DLk++niLlDne+hvkiaDfGlsk+ m++ sqs++++s++egGt++Y++Pe+

Q: 138   MTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWrMMSLSQSRSSKSAPEGGTIIYMPPEN  197

         ************************************************************

S: 177   leevnk.kaseksDvYsfaiviWavlakkepyeeeknslqiiivvkkgnRPeleevseel  235

         +e+ +k +as k+D+Ys+a+++W+vl++k+p+e+++n lqi+++v++g+RP ++e  e+l

Q: 198   YEPGQKsRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINE--ESL  255

         ****9999***********************************************..***

S: 236   Prevpq...lieLmkrcWeadpeeRPsFleie  264

         P+++p+   +i+L++++W+++p+eRPsFl++

Q: 256   PYDIPHrarMISLIESGWAQNPDERPSFLKCL  287

         *****************************986

Domain Sequence
(FASTA)

LADLRYLSRG ASGTVSSARH ADWRVQVAVK HLHIHTPLLD SERKDVLREA EILHKARFSY 60

ILPILGICNE PEFLGIVTEY MPNGSLNELL HRKTEYPDVA WPLRFRILHE IALGVNYLHN 120

MTPPLLHHDL KTQNILLDNE FHVKIADFGL SKWRMMSLSQ SRSSKSAPEG GTIIYMPPEN 180

YEPGQKSRAS IKHDIYSYAV ITWEVLSRKQ PFEDVTNPLQ IMYSVSQGHR PVINEESLPY 240

DIPHRARMIS LIESGWAQNP DERPSFLKCL 270

Keyword

Complete proteome; Kinase; Receptor; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0043065	; P:positive regulation of apoptotic process

KEGG

ptr:464277

;

InterPros

IPR001315	; CARD.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017322	; Rcpt-int_Ser/Thr_kinase-2.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00619	; CARD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00114

; CARD; 1.

Prosites

PS50209	; CARD; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013