EKS-PAT-00239

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00239

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	317.8	4.2E-95	11	263	253

Status

Unreviewed

Ensembl Protein

ENSPTRP00000035809

UniProt Accession

H2QX97;

Protein Name

Protein Synonyms/Alias

Maternal embryonic leucine zipper kinase;

Gene Name

ENSG00000165304

Gene Synonyms/Alias

ENSG00000165304; MELK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000020934	ENSPTRP00000035809	ENSPTRT00000038734

Organism

Pan troglodytes

Functional Description

Protein Length

651

Protein Sequence
(FASTA)

MKDYDELLKY YELHETIGTG GFAKVKLACH ILTGETVAIK IMDKNTLGSD LPRIKTEIEA 60

LKNLRHQHIC QLYHVLETAN KIFMVLEYCP GGELFDYIIS QDRLSEEETR VVFRQIVSAV 120

AYVHSQGYAH RDLKPENLLF DEYHKLKLID FGLCAKPKGN KDYHLQTCCG SLAYAAPELI 180

QGKSYLGSEA DVWSMGILLY VLMCGFLPFD DDNVMALYKK IMRGKYDVPK WLSPSSILLL 240

QQMLQVDPKK RISMKNLLNH PWIMQDYNYP VEWQSKNPFI HLDDDCVTEL SVHHRNNRQT 300

MEDLISLWQY DHLTATYLLL LAKKARGKPV HLRLSSFSCG QASATPFTDI KSNNWSLEDV 360

TASDKNYVAG LIDYDWCEDD LSTGAATPRT SQFTKYWTES NGVESKSLTP ALCRTPANKL 420

KNKENVYTPK SAVKNEEYFM FPEPKTPVNK NQHKREILTM PNRYTTPSKA RNQCLKETPI 480

KIPVNSTGTD KLMTGVISPE RRCRSVELDL NQAHMEETPK RKGAKVFGSL ERGLDKVITV 540

LTRSKRKGSA RDGPRRLKLH YNVTTTRLVN PDQLLNEIMS ILPKKHVDFV QKGYTLKCQT 600

QSDFGKVTMQ FELEVCQLQK PDVVGIRRQR LKGDAWVYKR LVEDILSSCK V 651

Nucleotide Sequence
(FASTA)

ATGAAAGATT ATGATGAACT TCTCAAATAT TATGAATTAC ATGAAACTAT TGGGACAGGT 60

GGCTTTGCAA AGGTCAAACT TGCCTGCCAT ATCCTTACTG GAGAGACGGT AGCTATAAAA 120

ATCATGGATA AAAACACACT AGGGAGTGAT TTGCCCCGGA TCAAAACGGA GATTGAGGCC 180

TTGAAGAACC TGAGACATCA GCATATATGT CAACTCTACC ATGTGCTAGA GACAGCCAAC 240

AAAATATTCA TGGTTCTTGA GTACTGCCCT GGAGGAGAGC TGTTTGACTA TATAATTTCC 300

CAGGATCGCC TGTCAGAAGA GGAGACCCGG GTTGTCTTCC GTCAGATAGT ATCTGCTGTT 360

GCTTACGTGC ACAGCCAGGG CTACGCTCAC AGGGACCTCA AGCCAGAAAA TTTGCTGTTT 420

GATGAATATC ATAAATTAAA GCTGATTGAC TTTGGTCTCT GTGCAAAACC CAAGGGTAAC 480

AAGGATTACC ATCTACAGAC ATGCTGTGGG AGTCTGGCTT ATGCAGCACC TGAGTTAATA 540

CAAGGCAAAT CATATCTTGG ATCAGAGGCA GATGTTTGGA GCATGGGCAT ACTGTTATAT 600

GTTCTTATGT GTGGATTTCT ACCATTTGAT GATGATAATG TAATGGCTTT ATACAAGAAG 660

ATTATGAGAG GAAAATATGA TGTTCCCAAG TGGCTCTCTC CCAGTAGCAT TCTGCTTCTT 720

CAACAAATGC TGCAGGTGGA CCCAAAGAAA CGGATTTCTA TGAAAAATCT ATTGAACCAT 780

CCCTGGATCA TGCAAGATTA CAACTATCCT GTTGAGTGGC AAAGCAAGAA TCCTTTTATT 840

CACCTTGATG ATGATTGCGT AACAGAACTT TCTGTACATC ACAGAAACAA CAGGCAAACG 900

ATGGAGGATT TAATTTCACT GTGGCAGTAT GATCACCTCA CGGCTACCTA TCTTCTGCTT 960

CTAGCCAAGA AGGCTCGGGG AAAACCAGTT CATTTAAGGC TTTCTTCTTT CTCCTGTGGA 1020

CAAGCCAGTG CTACCCCATT CACAGACATC AAGTCAAATA ACTGGAGTCT GGAAGATGTG 1080

ACCGCAAGTG ATAAAAATTA TGTGGCGGGA TTAATAGACT ATGATTGGTG TGAAGATGAT 1140

TTATCAACAG GTGCTGCTAC TCCCCGAACA TCACAGTTTA CCAAGTACTG GACAGAATCA 1200

AATGGGGTAG AATCTAAATC ATTAACTCCA GCCTTATGCA GAACACCTGC AAATAAATTA 1260

AAGAACAAAG AAAATGTTTA TACTCCTAAG TCTGCTGTAA AGAATGAAGA GTACTTTATG 1320

TTTCCTGAGC CAAAGACTCC AGTTAATAAG AACCAGCATA AGAGAGAAAT ACTCACTATG 1380

CCAAATCGTT ACACTACACC CTCAAAAGCT AGAAACCAGT GCCTGAAAGA AACTCCAATT 1440

AAAATACCAG TAAATTCAAC AGGAACAGAC AAGTTAATGA CAGGTGTCAT TAGCCCTGAG 1500

AGGCGGTGCC GCTCAGTGGA ATTGGATCTC AACCAAGCAC ATATGGAGGA GACTCCAAAA 1560

AGAAAGGGAG CCAAAGTGTT TGGGAGCCTT GAAAGGGGGT TGGATAAGGT TATCACTGTG 1620

CTCACCAGGA GCAAAAGGAA GGGTTCTGCC AGAGATGGGC CCAGAAGACT AAAGCTTCAC 1680

TATAATGTGA CTACAACTAG ATTAGTGAAT CCAGATCAAC TGTTGAATGA AATAATGTCT 1740

ATTCTTCCAA AGAAGCATGT TGACTTTGTA CAAAAGGGTT ATACACTGAA GTGTCAAACA 1800

CAGTCAGATT TTGGGAAAGT GACAATGCAA TTTGAATTAG AAGTGTGCCA GCTTCAAAAA 1860

CCCGATGTGG TGGGTATCAG GAGGCAGCGG CTTAAGGGCG ATGCCTGGGT TTACAAAAGA 1920

TTAGTGGAAG ACATCCTATC TAGCTGCAAG GTATAA 1956

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+l++t+G+g f+kVkla+h +t+e+va+Ki++k++l +  l +ik+Eie+lk+l+h++i

Q: 11    YELHETIGTGGFAKVKLACHILTGETVAIKIMDKNTLGS-DLPRIKTEIEALKNLRHQHI  69

         99********************************99875.589*****************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ++l++v+et +k+++vley+ ggeLfdyi ++ rl+e+e+r +f+q+vsav Y+hs+g +

Q: 70    CQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYA  129

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg..klletfcGsppYaaPellkgkkYegpk  178

         HrDlKpeNll+d+ +++k++DFGl+++ k +   +l+t+cGs++YaaPel++gk+Y g++

Q: 130   HRDLKPENLLFDEYHKLKLIDFGLCAKPKGNkdYHLQTCCGSLAYAAPELIQGKSYLGSE  189

         *************************9665443389*************************

S: 179   vDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpe  238

         +DvWs+G++Ly+l++g lPfd++n+ +l++ki++gk+++pk+ls++ + Ll+++L+vdp+

Q: 190   ADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPK  249

         ************************************************************

S: 239   kRatieeilkhewl  252

         kR++++++l+h+w+

Q: 250   KRISMKNLLNHPWI  263

         *************7

Domain Sequence
(FASTA)

YELHETIGTG GFAKVKLACH ILTGETVAIK IMDKNTLGSD LPRIKTEIEA LKNLRHQHIC 60

QLYHVLETAN KIFMVLEYCP GGELFDYIIS QDRLSEEETR VVFRQIVSAV AYVHSQGYAH 120

RDLKPENLLF DEYHKLKLID FGLCAKPKGN KDYHLQTCCG SLAYAAPELI QGKSYLGSEA 180

DVWSMGILLY VLMCGFLPFD DDNVMALYKK IMRGKYDVPK WLSPSSILLL QQMLQVDPKK 240

RISMKNLLNH PWI 253

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

ptr:465095

;

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013