EKS-PAT-00260

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00260

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	467.2	1.9E-140	205	492	288

Status

Unreviewed

Ensembl Protein

ENSPTRP00000036200

UniProt Accession

H2QXK2;

Protein Name

Protein Synonyms/Alias

Transforming growth factor, beta receptor 1;

Gene Name

ENSG00000106799

Gene Synonyms/Alias

ENSG00000106799; TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000021182	ENSPTRP00000036200	ENSPTRT00000039172

Organism

Pan troglodytes

Functional Description

Protein Length

503

Protein Sequence
(FASTA)

MEAAAAAPRP RLLLLVLAAA AAAAAALLPG ATALQCFCHL CTKDNFTCVT DGLCFVSVTE 60

TTDKVIHNSM CIAEIDLIPR DRPFVCAPSS KTGSVTTTYC CNQDHCNKIE LPTTVKSSPG 120

LGPVELAAVI AGPVCFVCIS LMLMVYICHN RTVIHHRVPN EEDPSLDRPF ISEGTTLKDL 180

IYDMTTSGSG SGLPLLVQRT IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER 240

SWFREAEIYQ TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE 300

GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA DLGLAVRHDS 360

ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD IYAMGLVFWE IARRCSIGGI 420

HEDYQLPYYD LVPSDPSVEE MRKVVCEQKL RPNIPNRWQS CEALRVMAKI MRECWYANGA 480

ARLTALRIKK TLSQLSQQEG IKM 503

Nucleotide Sequence
(FASTA)

ATGGAGGCGG CGGCCGCTGC TCCGCGTCCC CGGCTGCTCC TCCTCGTGCT GGCGGCGGCG 60

GCGGCGGCGG CGGCGGCACT GCTCCCGGGG GCGACGGCGT TACAGTGTTT CTGCCACCTC 120

TGTACAAAAG ACAATTTTAC TTGTGTGACA GATGGGCTCT GCTTTGTCTC TGTCACAGAG 180

ACCACAGACA AAGTTATACA CAACAGCATG TGTATAGCTG AAATTGACTT AATTCCTCGA 240

GATAGGCCGT TTGTATGTGC ACCCTCTTCA AAAACTGGGT CTGTGACTAC AACATATTGC 300

TGCAATCAGG ACCATTGCAA TAAAATAGAA CTTCCAACTA CTGTAAAGTC ATCACCTGGC 360

CTTGGTCCTG TGGAACTGGC AGCTGTCATT GCTGGACCAG TGTGCTTCGT CTGCATCTCA 420

CTCATGTTGA TGGTCTATAT CTGCCACAAC CGCACTGTCA TTCACCATCG AGTGCCAAAT 480

GAAGAGGACC CTTCATTAGA TCGCCCTTTT ATTTCAGAGG GTACTACGTT GAAAGACTTA 540

ATTTATGATA TGACAACGTC AGGTTCTGGC TCAGGTTTAC CATTGCTTGT TCAGAGAACA 600

ATTGCGAGAA CTATTGTGTT ACAAGAAAGC ATTGGCAAAG GTCGATTTGG AGAAGTTTGG 660

AGAGGAAAGT GGCGGGGAGA AGAAGTTGCT GTTAAGATAT TCTCCTCTAG AGAAGAACGT 720

TCGTGGTTCC GTGAGGCAGA GATTTATCAA ACTGTAATGT TACGTCATGA AAACATCCTG 780

GGATTTATAG CAGCAGACAA TAAAGACAAT GGTACTTGGA CTCAGCTCTG GTTGGTGTCA 840

GATTATCATG AGCATGGATC CCTTTTTGAT TACTTAAACA GATACACAGT TACTGTGGAA 900

GGAATGATAA AACTTGCTCT GTCCACGGCG AGCGGTCTTG CCCATCTTCA CATGGAGATT 960

GTTGGTACCC AAGGAAAGCC AGCCATTGCT CATAGAGATT TGAAATCAAA GAATATCTTG 1020

GTAAAGAAGA ATGGAACTTG CTGTATTGCA GACTTAGGAC TGGCAGTAAG ACATGATTCA 1080

GCCACAGATA CCATTGATAT TGCTCCAAAC CACAGAGTGG GAACAAAAAG GTACATGGCC 1140

CCTGAAGTTC TCGATGATTC CATAAATATG AAACATTTTG AATCCTTCAA ACGTGCTGAC 1200

ATCTATGCAA TGGGCTTAGT ATTCTGGGAA ATTGCTCGAC GATGTTCCAT TGGTGGAATT 1260

CATGAAGATT ACCAACTGCC TTATTATGAT CTTGTACCTT CTGACCCATC AGTTGAAGAA 1320

ATGAGAAAAG TTGTTTGTGA ACAGAAGTTA AGGCCAAATA TCCCAAACAG ATGGCAGAGC 1380

TGTGAAGCCT TGAGAGTAAT GGCTAAAATT ATGAGAGAAT GTTGGTATGC CAATGGAGCA 1440

GCTAGGCTTA CAGCATTGCG GATTAAGAAA ACATTATCGC AACTCAGTCA ACAGGAAGGC 1500

ATCAAAATGT AA 1512

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 205   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  264

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 265   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  324

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 325   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  382

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem

Q: 383   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI-GGIHEDYQLPYYDLVPSDPSVEEM  441

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 442   RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  492

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGGIHEDY QLPYYDLVPS DPSVEEMRKV 240

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

ptr:472992

;

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013