EKS-PAT-00071

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00071

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Musk	626.5	5.4E-189	581	861	281

Status

Unreviewed

Ensembl Protein

ENSPTRP00000049076

UniProt Accession

H2R6F7;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000030304

Gene Synonyms/Alias

ENSG00000030304;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000021248	ENSPTRP00000049076	ENSPTRT00000056357

Organism

Pan troglodytes

Functional Description

Protein Length

875

Protein Sequence
(FASTA)

MRELVNIPLV HILTLVAFSG TEKLPKAPVI TTPLETVDAL VEEVATFMCA VESYPQPEIS 60

WTRNKILIKL FDTRYSIREN GQLLTILSVE DSDDGIYCCT ANNGVGGAVE SCGALQVKMK 120

PKITRPPINV KIIEGLKAVL PCTTMGNPKP SVSWIKGDSP LRENSRIAVL ESGSLRIHNV 180

QKEDAGQYRC VAKNSLGTAY SKVVKLEVEV FARILRAPES HNVTFGSFVT LHCTATGIPV 240

PTITWIENGN AVSSGSIEES VKDRVIDSRL QLFITKPGLY TCIATNKHGE KFSTAKAAAT 300

ISIAEMLFIS SFSKPQKDNK GYCAQYRGEV CNAVLAKDAL VFLNTSYADP EEAQELLVHT 360

AWNELKVVSP VCRPAAEALL CNHIFQECSP GVVPTPIPIC REYCLAVKEL FCAKEWLAME 420

EKTHRGLYRS EMHLLSVPEC SKLPSMHWDP TACARLPHLD YNKENLKTFP PMTSSKPSVD 480

IPNLPSSSSS SFSVSPTYSM TVIISIMSSF AIFVLLTITT LYCCRRRKQW KNKKRESAAV 540

TLTTLPSELL LDRLHPNPMY QRMPLLLNPK LLSLEYPRNN IEYVRDIGEG AFGRVFQARA 600

PGLLPYEPFT MVAVKMLKEE ASADMQADFQ REAALMAEFD NPNIVKLLGV CAVGKPMCLL 660

FEYMAYGDLN EFLRSMSPHT VCSLSHSDLS MRAQVSSPGP PPLSCAEQLC IARQVAAGMA 720

YLSERKFVHR DLATRNCLVG ENMVVKIADF GLSRNIYSAD YYKANENDAI PIRWMPPESI 780

FYNRYTTESD VWAYGVVLWE IFSYGLQPYY GMAHEEVIYY VRDGNILSCP ENCPVELYNL 840

MRLCWSKLPA DRPSFTSIHR ILERMCERAE GTVSV 875

Nucleotide Sequence
(FASTA)

ATGAGAGAGC TCGTCAACAT TCCACTGGTA CATATTCTTA CTCTGGTTGC CTTCAGCGGA 60

ACTGAGAAAC TTCCAAAAGC TCCTGTCATC ACCACTCCTC TTGAAACAGT GGATGCCTTA 120

GTTGAAGAAG TGGCTACTTT CATGTGTGCA GTGGAATCCT ATCCCCAGCC TGAGATTTCC 180

TGGACTAGAA ATAAAATTCT CATTAAGCTC TTTGACACCC GGTACAGCAT CCGGGAGAAT 240

GGGCAGCTCC TCACCATCCT GAGTGTGGAA GACAGTGATG ATGGCATTTA CTGCTGCACG 300

GCCAACAATG GTGTGGGAGG AGCTGTGGAG AGTTGTGGAG CCCTGCAAGT GAAGATGAAA 360

CCTAAAATAA CTCGTCCTCC CATAAATGTG AAAATAATAG AGGGATTAAA AGCAGTCCTA 420

CCATGTACTA CAATGGGTAA TCCCAAACCA TCAGTGTCTT GGATAAAGGG AGACAGCCCT 480

CTCAGGGAAA ATTCTCGAAT TGCAGTTCTT GAATCTGGGA GCTTGAGGAT TCATAACGTA 540

CAAAAGGAAG ATGCAGGACA GTATCGATGT GTGGCAAAAA ACAGCCTCGG GACAGCATAT 600

TCCAAAGTGG TGAAGCTGGA AGTTGAGGTT TTTGCCAGGA TCCTGCGGGC TCCTGAATCC 660

CACAATGTCA CCTTTGGCTC CTTTGTGACC CTGCACTGTA CAGCAACAGG CATTCCTGTC 720

CCCACCATCA CCTGGATTGA AAACGGAAAT GCTGTTTCTT CTGGGTCCAT TGAAGAGAGT 780

GTGAAAGACC GAGTGATTGA CTCAAGACTG CAGCTGTTTA TCACCAAGCC AGGACTGTAC 840

ACATGCATAG CTACCAATAA GCATGGGGAG AAGTTCAGTA CTGCCAAGGC TGCAGCCACC 900

ATCAGCATAG CAGAAATGTT GTTCATTTCT TCTTTCAGTA AACCACAGAA AGATAACAAA 960

GGCTACTGCG CCCAGTACAG AGGGGAGGTG TGTAATGCAG TCCTGGCAAA AGATGCTCTT 1020

GTTTTTCTCA ACACCTCCTA TGCGGACCCT GAGGAGGCCC AAGAGCTACT GGTCCACACG 1080

GCCTGGAATG AACTGAAAGT AGTGAGCCCA GTCTGCCGGC CAGCTGCTGA GGCTTTGTTG 1140

TGTAACCACA TCTTCCAGGA GTGCAGTCCT GGAGTAGTGC CTACTCCTAT TCCCATTTGC 1200

AGGGAGTACT GCTTGGCAGT AAAGGAGCTC TTCTGTGCAA AAGAATGGCT GGCAATGGAG 1260

GAGAAGACCC ACAGAGGACT CTACAGATCC GAGATGCATT TGCTGTCCGT GCCAGAATGC 1320

AGCAAGCTTC CCAGCATGCA TTGGGACCCC ACGGCCTGTG CCAGACTGCC ACATCTAGAT 1380

TATAACAAAG AAAACCTAAA AACATTCCCA CCAATGACGT CCTCAAAGCC AAGTGTGGAC 1440

ATTCCAAATC TGCCTTCCTC CTCCTCTTCT TCCTTCTCTG TCTCACCTAC ATACTCCATG 1500

ACTGTAATAA TCTCCATCAT GTCCAGCTTT GCAATATTTG TGCTTCTTAC CATAACTACT 1560

CTCTATTGCT GCCGAAGAAG AAAACAATGG AAAAATAAGA AAAGAGAATC AGCAGCAGTA 1620

ACCCTCACCA CACTGCCTTC TGAGCTCTTA CTAGATAGAC TTCATCCCAA CCCCATGTAC 1680

CAGAGGATGC CGCTCCTTCT GAACCCCAAA TTGCTCAGCC TGGAGTATCC AAGGAATAAC 1740

ATTGAATATG TGAGAGACAT CGGAGAGGGA GCGTTTGGAA GGGTGTTTCA AGCAAGGGCA 1800

CCAGGCTTAC TTCCCTATGA ACCTTTCACT ATGGTGGCAG TAAAGATGCT CAAAGAAGAA 1860

GCCTCGGCAG ATATGCAAGC GGACTTTCAG AGGGAGGCAG CCCTCATGGC AGAATTTGAC 1920

AACCCTAACA TTGTGAAGCT ATTAGGAGTG TGTGCTGTCG GGAAGCCAAT GTGCCTGCTC 1980

TTTGAATACA TGGCCTATGG TGACCTCAAT GAGTTCCTCC GCAGCATGTC CCCTCACACC 2040

GTGTGCAGCC TCAGTCACAG TGACTTGTCT ATGAGGGCTC AGGTCTCCAG CCCTGGGCCC 2100

CCACCCCTCT CCTGTGCTGA GCAGCTTTGC ATTGCCAGGC AGGTGGCAGC TGGCATGGCT 2160

TACCTCTCGG AACGTAAGTT TGTTCACCGA GATTTAGCCA CCAGGAACTG CCTGGTGGGC 2220

GAGAACATGG TGGTGAAAAT TGCTGACTTT GGCCTCTCCA GGAACATCTA CTCAGCAGAC 2280

TACTACAAAG CTAATGAAAA CGACGCTATC CCTATCCGTT GGATGCCACC AGAGTCCATT 2340

TTTTATAACC GCTACACTAC AGAGTCTGAT GTGTGGGCCT ATGGCGTGGT CCTCTGGGAG 2400

ATCTTCTCCT ATGGCCTGCA GCCCTACTAT GGGATGGCCC ATGAGGAGGT CATTTACTAC 2460

GTGCGAGATG GCAACATCCT CTCCTGCCCT GAGAACTGCC CCGTGGAGCT GTACAATCTC 2520

ATGCGTCTAT GTTGGAGCAA GCTGCCTGCA GACAGACCCA GTTTCACCAG TATTCACCGA 2580

ATTCTGGAAC GCATGTGTGA GAGGGCAGAG GGAACTGTGA GTGTCTAA 2628

Domain Profile

S: 1     ieyvrdlgegafgrvfqarapgllpyeefllvavkmlkeeasadmqadfereaallaefd  60

         ieyvrd+gegafgrvfqarapgllpye+f++vavkmlkeeasadmqadf+reaal+aefd

Q: 581   IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFD  640

         89**********************************************************

S: 61    npnivkllgvcavgkpmcllfeymaygdlneflrslspytvcslshsdlslraqvsspdr  120

         npnivkllgvcavgkpmcllfeymaygdlneflrs+sp+tvcslshsdls+raqvssp++

Q: 641   NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGP  700

         ************************************************************

S: 121   lplseaellciarqvaagmaylserkfvhrdlatrnclvgetmvvkiadfglsrkiysad  180

         +pls+ae+lciarqvaagmaylserkfvhrdlatrnclvge+mvvkiadfglsr+iysad

Q: 701   PPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSAD  760

         ************************************************************

S: 181   yykadendaipirwmplesilynrytlesdvwaygvvlweifsyalqpyyglaheeviky  240

         yyka+endaipirwmp+esi+ynryt+esdvwaygvvlweifsy+lqpyyg+aheevi+y

Q: 761   YYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYY  820

         ************************************************************

S: 241   vrdgnilacpentplelyalmrlcwsklpadrpsfasihri  281

         vrdgnil+cpen+p+ely+lmrlcwsklpadrpsf+sihri

Q: 821   VRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRI  861

         ***************************************98

Domain Sequence
(FASTA)

IEYVRDIGEG AFGRVFQARA PGLLPYEPFT MVAVKMLKEE ASADMQADFQ REAALMAEFD 60

NPNIVKLLGV CAVGKPMCLL FEYMAYGDLN EFLRSMSPHT VCSLSHSDLS MRAQVSSPGP 120

PPLSCAEQLC IARQVAAGMA YLSERKFVHR DLATRNCLVG ENMVVKIADF GLSRNIYSAD 180

YYKANENDAI PIRWMPPESI FYNRYTTESD VWAYGVVLWE IFSYGLQPYY GMAHEEVIYY 240

VRDGNILSCP ENCPVELYNL MRLCWSKLPA DRPSFTSIHR I 281

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR020067	; Frizzled_dom.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF01392	; Fz; 1.
PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50038	; FZ; 1.
PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013