EKS-PAT-00226
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-PAT-00226
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Abl557.43.8E-168261512252
StatusUnreviewed
Ensembl ProteinENSPTRP00000036748
UniProt AccessionH2QY21;
Protein Name
Protein Synonyms/Alias C-abl oncogene 1, non-receptor tyrosine kinase;
Gene NameENSG00000097007
Gene Synonyms/Alias ENSG00000097007; ABL1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSPTRG00000021477ENSPTRP00000036748ENSPTRT00000039774
OrganismPan troglodytes
Functional Description
Protein Length1149
Protein Sequence
(FASTA)
MGQQPGKVLG DQRRPSLPAL HFIKGAGKKE SSRHGGPHCN VFVEHEALQR PVASDFEPQG 60
LSEAARWNSK ENLLAGPSEN DPNLFVALYD FVASGDNTLS ITKGEKLRVL GYNHNGEWCE 120
AQTKNGQGWV PSNYITPVNS LEKHSWYHGP VSRNAAEYLL SSGINGSFLV RESESSPGQR 180
SISLRYEGRV YHYRINTASD GKLYVSSESR FNTLAELVHH HSTVADGLIT TLHYPAPKRN 240
KPTVYGVSPN YDKWEMERTD ITMKHKLGGG QYGEVYEGVW KKYSLTVAVK TLKEDTMEVE 300
EFLKEAAVMK EIKHPNLVQL LGVCTREPPF YIITEFMTYG NLLDYLRECN RQEVNAVVLL 360
YMATQISSAM EYLEKKNFIH RDLAARNCLV GENHLVKVAD FGLSRLMTGD TYTAHAGAKF 420
PIKWTAPESL AYNKFSIKSD VWAFGVLLWE IATYGMSPYP GIDLSQVYEL LEKDYRMERP 480
EGCPEKVYEL MRACWQWNPS DRPSFAEIHQ AFETMFQESS ISDEVEKELG KQGIRGAVST 540
LLQAPELPTK TRTSRRAAEH RDTTDVPEMP HSKGQGESDP LDHEPAVSPL LPRKERGAPE 600
GGLNEDERLL PKDKKTNLFS ALIKKKKKTA PTPPKRSSSF REMDGQPERR GAGEEEGRDI 660
SNGALAFTPL DTADPAKSPK PSNGAGVPNG ALRESGGSGF RSPHLWKKSS TLTSSRLATG 720
EEEGGGSSSK RFLRSCSASC VPHGAKDTEW RSVTLPRDLQ STGRQFDSST FGGHKSEKPA 780
LPRKRAGENR SDQVTRGTVT PPPRLVKKNE EAADEVFKDI MESSPGSSPP NLTPKPLRRQ 840
VTVAPASGLP HKEEAGKGSA LGTPAAAEPV TPTSKASSGA PGGTSKGPAE ESRVRRHKHS 900
SESPGRDKGK LSRLKPAPPP PPAASAGKAG GKPSQSPSQE AAGEAVLGAK TKATSLVDAV 960
NSDAAKPSQP GEGLKKPVLP ATPKPQSAKP SGTPISPAPV PSTLPSASSA LAGDQPSSTA 1020
FIPLISTRVS LRKTRQPPER IASGAITKGV VLDSTEALCL AISRNSEQMA SHSAVLEAGK 1080
NLYTFCVSYV DSIQQMRNKF AFREAINKLE NNLRELQICP ATAGSGPAAT QDFSKLLSSV 1140
KEISDIVQR 1149
Nucleotide Sequence
(FASTA)
ATGGGGCAGC AGCCTGGAAA AGTTCTTGGG GACCAAAGAA GGCCAAGCTT GCCTGCCCTG 60
CATTTTATCA AAGGAGCAGG GAAGAAGGAA TCATCGAGGC ATGGGGGTCC ACACTGCAAT 120
GTTTTTGTGG AACATGAAGC CCTTCAGCGG CCAGTAGCAT CTGACTTTGA GCCTCAGGGT 180
CTGAGTGAAG CCGCTCGTTG GAACTCCAAG GAAAACCTTC TCGCTGGACC CAGTGAAAAT 240
GACCCCAACC TTTTCGTTGC ACTGTATGAT TTTGTGGCCA GTGGAGATAA CACTCTAAGC 300
ATAACTAAAG GTGAAAAGCT CCGGGTCTTA GGCTATAATC ACAATGGGGA ATGGTGTGAA 360
GCCCAAACCA AAAATGGCCA AGGCTGGGTC CCAAGCAACT ACATCACGCC AGTCAACAGT 420
CTGGAGAAAC ACTCCTGGTA CCATGGGCCT GTGTCCCGCA ATGCTGCTGA GTATCTGCTG 480
AGCAGCGGGA TCAATGGCAG CTTCTTGGTG CGTGAGAGTG AGAGCAGTCC TGGCCAGAGG 540
TCCATCTCGC TGAGATACGA AGGGAGGGTG TACCATTACA GGATCAACAC TGCTTCTGAT 600
GGCAAGCTCT ACGTCTCCTC CGAGAGCCGC TTCAACACCC TGGCCGAGTT GGTTCATCAT 660
CATTCAACGG TGGCCGACGG GCTCATCACC ACGCTCCATT ATCCAGCCCC AAAGCGCAAC 720
AAGCCCACTG TCTACGGTGT GTCCCCCAAC TACGACAAGT GGGAGATGGA ACGCACGGAC 780
ATCACCATGA AGCACAAGCT GGGTGGGGGC CAGTACGGGG AGGTGTACGA GGGTGTGTGG 840
AAGAAATACA GCCTGACGGT GGCCGTGAAG ACCTTGAAGG AGGACACCAT GGAGGTGGAA 900
GAGTTCTTGA AAGAAGCTGC AGTCATGAAA GAGATCAAAC ACCCTAACCT GGTGCAGCTC 960
CTTGGGGTCT GCACCCGGGA GCCCCCGTTC TATATCATCA CTGAGTTCAT GACCTACGGG 1020
AACCTCCTGG ACTACCTGAG GGAGTGCAAC CGGCAGGAGG TGAACGCCGT GGTGCTGCTG 1080
TACATGGCCA CTCAGATCTC GTCAGCCATG GAGTACCTGG AGAAGAAAAA CTTCATCCAC 1140
AGAGATCTTG CTGCCCGAAA CTGCCTGGTA GGGGAGAACC ACTTGGTGAA GGTAGCTGAT 1200
TTTGGCCTGA GCAGGTTGAT GACAGGGGAC ACCTACACAG CCCATGCTGG AGCCAAGTTC 1260
CCCATCAAAT GGACTGCACC CGAGAGCCTG GCCTACAACA AGTTCTCCAT CAAGTCCGAC 1320
GTCTGGGCAT TTGGAGTATT GCTTTGGGAA ATTGCTACCT ATGGCATGTC CCCTTACCCG 1380
GGAATTGACC TGTCCCAGGT GTATGAGCTG CTAGAGAAGG ACTACCGCAT GGAGCGCCCA 1440
GAAGGCTGCC CAGAGAAGGT CTATGAACTC ATGCGAGCAT GTTGGCAGTG GAATCCCTCT 1500
GACCGGCCCT CCTTTGCTGA AATCCACCAA GCCTTTGAAA CAATGTTCCA GGAATCCAGT 1560
ATCTCAGACG AAGTGGAAAA GGAGCTGGGG AAACAAGGCA TCCGTGGGGC TGTGAGTACC 1620
TTGCTGCAGG CCCCAGAGCT GCCCACCAAG ACAAGGACCT CCAGGAGAGC TGCAGAGCAC 1680
AGAGACACCA CTGACGTGCC TGAGATGCCT CACTCCAAGG GCCAGGGAGA GAGCGATCCT 1740
CTGGACCATG AGCCTGCCGT GTCTCCATTG CTCCCTCGAA AAGAGCGAGG TGCCCCGGAG 1800
GGCGGCCTGA ATGAAGATGA GCGCCTTCTC CCCAAAGACA AAAAGACCAA CTTGTTCAGC 1860
GCCTTGATCA AGAAGAAGAA GAAGACAGCC CCAACCCCTC CCAAACGCAG CAGCTCCTTC 1920
CGGGAGATGG ACGGCCAGCC GGAGCGCAGA GGGGCCGGCG AGGAAGAGGG CCGAGACATC 1980
AGCAACGGGG CGCTGGCTTT CACCCCCTTG GACACAGCTG ACCCAGCCAA GTCCCCAAAG 2040
CCCAGCAATG GGGCTGGGGT CCCCAATGGA GCCCTCCGGG AGTCCGGGGG CTCAGGCTTC 2100
CGGTCTCCCC ACCTGTGGAA GAAGTCCAGC ACGCTGACCA GCAGCCGCCT AGCCACCGGC 2160
GAGGAGGAGG GCGGTGGCAG CTCCAGCAAG CGCTTCCTGC GCTCCTGCTC GGCCTCCTGC 2220
GTTCCCCATG GGGCCAAGGA CACGGAGTGG AGGTCAGTCA CGCTGCCTCG GGACTTGCAG 2280
TCCACGGGAA GACAGTTTGA CTCGTCCACA TTTGGAGGGC ACAAAAGTGA GAAGCCGGCT 2340
CTGCCTCGGA AGAGGGCAGG GGAGAACAGG TCTGACCAGG TGACCCGAGG CACAGTAACG 2400
CCCCCTCCCA GGCTGGTGAA AAAGAATGAG GAAGCTGCTG ATGAGGTCTT CAAAGACATC 2460
ATGGAGTCCA GCCCGGGCTC CAGCCCGCCC AACCTGACTC CAAAACCCCT CCGGCGGCAG 2520
GTCACCGTGG CCCCTGCCTC GGGCCTCCCC CACAAGGAAG AAGCTGGAAA GGGCAGTGCC 2580
TTAGGGACCC CTGCTGCAGC TGAGCCAGTG ACCCCCACCA GCAAAGCAAG CTCAGGTGCA 2640
CCAGGGGGCA CCAGCAAGGG CCCCGCCGAG GAGTCCAGAG TGAGGAGGCA CAAGCACTCC 2700
TCTGAGTCGC CAGGGAGGGA CAAGGGGAAA TTGTCCAGGC TCAAACCTGC CCCGCCGCCC 2760
CCACCAGCAG CCTCTGCAGG GAAGGCTGGA GGAAAGCCCT CGCAGAGCCC GAGCCAGGAG 2820
GCGGCCGGGG AGGCAGTCCT GGGCGCAAAG ACAAAAGCCA CGAGTCTGGT TGATGCTGTG 2880
AACAGTGACG CTGCCAAGCC CAGCCAGCCG GGAGAGGGCC TCAAAAAGCC CGTGCTCCCG 2940
GCCACTCCAA AGCCACAGTC CGCCAAGCCG TCGGGGACCC CCATCAGCCC AGCCCCCGTT 3000
CCCTCCACGT TGCCATCAGC ATCCTCGGCC CTGGCAGGGG ACCAGCCATC TTCCACCGCC 3060
TTCATCCCTC TCATATCAAC CCGAGTGTCT CTTCGGAAAA CCCGCCAGCC TCCAGAGCGG 3120
ATCGCCAGTG GCGCCATCAC CAAGGGCGTG GTCCTGGACA GCACCGAGGC GCTGTGCCTC 3180
GCCATCTCTA GGAACTCCGA GCAGATGGCC AGCCACAGCG CAGTGCTGGA GGCCGGCAAA 3240
AACCTCTACA CGTTCTGCGT GAGCTACGTG GATTCCATCC AGCAAATGAG GAACAAGTTT 3300
GCCTTCCGAG AGGCCATCAA CAAACTGGAG AATAATCTCC GGGAGCTTCA GATCTGCCCG 3360
GCGACAGCAG GCAGTGGTCC GGCGGCCACT CAGGACTTCA GCAAGCTCCT CAGTTCGGTG 3420
AAGGAAATCA GTGACATAGT GCAGAGGTAG 3450
Domain Profile
S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60
         i+mkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmke+khpnlvql
Q: 261   ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQL  320
         89**********************************************************
S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120
         lgvctreppfyiitefm+ygnlldylre++r+ev+avvllymatqissameylekknfih
Q: 321   LGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIH  380
         ************************************************************
S: 121   rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsiksd  180
         rdlaarnclvgen+lvkvadfglsrlm++dtytahagakfpikwtapeslaynkfsiksd
Q: 381   RDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSD  440
         ************************************************************
S: 181   vwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmracwkwsps  240
         vwafgvllweiatygmspypgidlsqvyellek+yrmerpegcp+kvyelmracw+w+ps
Q: 441   VWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPS  500
         ************************************************************
S: 241   drpsfaeihqal  252
         drpsfaeihqa+
Q: 501   DRPSFAEIHQAF  512
         *********986
Domain Sequence
(FASTA)
ITMKHKLGGG QYGEVYEGVW KKYSLTVAVK TLKEDTMEVE EFLKEAAVMK EIKHPNLVQL 60
LGVCTREPPF YIITEFMTYG NLLDYLRECN RQEVNAVVLL YMATQISSAM EYLEKKNFIH 120
RDLAARNCLV GENHLVKVAD FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNKFSIKSD 180
VWAFGVLLWE IATYGMSPYP GIDLSQVYEL LEKDYRMERP EGCPEKVYEL MRACWQWNPS 240
DRPSFAEIHQ AF 252
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Receptor; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00218
EKS-ANC-00228
EKS-BOT-00257
EKS-CAE-00214
EKS-CAJ-00243
EKS-CAF-00245
EKS-CAP-00293
EKS-CII-00141
EKS-CIS-00017
EKS-DAR-00593
EKS-DAN-00005
EKS-DRM-00121
EKS-EQC-00230
EKS-FEC-00244
EKS-GAG-00198
EKS-GAA-00320
EKS-GOG-00256
EKS-HOS-00245
EKS-ICT-00225
EKS-LAC-00270
EKS-LOA-00268
EKS-MAM-00261
EKS-MEG-00204
EKS-MIM-00012
EKS-MOD-00237
EKS-MUM-00242
EKS-MUP-00256
EKS-MYL-00237
EKS-NOL-00240
EKS-ORN-00335
EKS-ORA-00227
EKS-ORC-00244
EKS-ORL-00286
EKS-OTG-00264
EKS-PES-00229
EKS-PEM-00134
EKS-POA-00230
EKS-PTV-00011
EKS-RAN-00272
EKS-SAH-00243
EKS-SUS-00223
EKS-TAG-00253
EKS-TAR-00332
EKS-TAS-00010
EKS-TEN-00297
EKS-TUT-00026
EKS-XET-00314
EKS-XIM-00328
Gene Ontology
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
KEGG
ptr:464802;
InterPros
IPR015015; F-actin_binding.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF08919; F_actin_bind; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00808; FABD; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013