EKS-PAT-00152

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00152

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	470.3	1.5E-141	398	653	256

Status

Unreviewed

Ensembl Protein

ENSPTRP00000037254

UniProt Accession

H2QYE0;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KA6

Gene Synonyms/Alias

RPS6KA6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000022064	ENSPTRP00000037953	ENSPTRT00000041085
ENSPTRG00000022064	ENSPTRP00000037254	ENSPTRT00000040319

Organism

Pan troglodytes

Functional Description

Protein Length

715

Protein Sequence
(FASTA)

MGLSTSAIWK NTRVEIVNPY EVKRKVKVNG LKMVDEPMEE GEADSCHDEG VVKEIPITHH 60

VKEGYEKADP AQFELLKVLG QGSFGKRDRV RTKMERDILV EVNHPFIVKL HYAFQTEGKL 120

YLILDFLRGG DVFTRLSKEV LFTEEDVKFY LAELALALDH LHQLGIVYRD LKPENILLDE 180

IGHIKLTDFG LSKESVDQEK KAYSFCGTVE YMAPEVVNRR GHSQSADWWS YGVLMFEMLT 240

GTLPFQGKDR NETMNMILKA KLGMPQFLSA EAQSLLRMLF KRNPANRLGS EGVEEIKRHL 300

FFANIDWDKL YKREVQPPFK PASGKPDDTF CFDPEFTAKT PKDSPGLPAS ANAHQLFKGF 360

SFVATSIAEE YKITPITSAN VLPIVQINGN AAQFGEVYEL KEDIGVGSYS VCKRCIHATT 420

NMEFAVKIID KSKRDPSEEI EILMRYGQHP NIITLKDFDD GRYVYVTDLM KGGELLDRIL 480

KQKCFSEREA SDILYVISKT VDYLHCQGVV HRDLKPSNIL YMDESASADS IRICDFGFAK 540

QLRGENGLLL TPCYTANFVA PEVLMQQGYD AACDIWSLGV LFYTMWAGYT PFANGPNDTP 600

EEILLRIGNG KFSLSGGNWD NISDGAKDLL SHMLHMDPHQ RYTAEQILKH SWITHRDQLP 660

NDQPKRNDVS HVVKGAMVAT YSALTHKTFQ PVLEPVAASS LAQRRSMKKR TSTGL 715

Nucleotide Sequence
(FASTA)

ATGGGTCTCT CTACCTCAGC AATTTGGAAA AATACTCGAG TGGAAATTGT TAATCCCTAT 60

GAAGTAAAAC GAAAGGTGAA GGTAAATGGT CTTAAAATGG TTGATGAGCC AATGGAAGAG 120

GGAGAAGCAG ATTCTTGTCA TGATGAAGGA GTTGTTAAAG AAATCCCTAT TACTCATCAT 180

GTTAAGGAAG GCTATGAGAA AGCAGATCCT GCACAGTTTG AGTTGCTCAA GGTTCTTGGT 240

CAGGGGTCAT TTGGAAAGCG AGACAGAGTT CGGACAAAGA TGGAGAGGGA TATACTGGTG 300

GAAGTAAATC ATCCATTTAT TGTCAAATTG CACTATGCCT TTCAGACTGA AGGGAAACTG 360

TACTTAATAC TGGATTTTCT CAGGGGAGGA GATGTTTTCA CAAGATTATC CAAAGAGGTT 420

CTGTTTACAG AGGAAGATGT GAAATTCTAC CTCGCAGAAC TGGCCCTTGC TTTGGATCAT 480

CTGCACCAAT TAGGAATTGT TTATAGAGAC CTGAAGCCAG AAAACATTTT GCTTGATGAA 540

ATAGGACATA TCAAATTAAC AGATTTTGGA CTCAGCAAGG AGTCAGTAGA TCAAGAAAAG 600

AAGGCTTACT CATTTTGTGG TACAGTAGAG TATATGGCTC CTGAAGTAGT AAATAGGAGA 660

GGCCATTCCC AGAGTGCTGA TTGGTGGTCA TATGGTGTTC TTATGTTTGA AATGCTTACT 720

GGTACTCTGC CATTTCAAGG TAAAGACAGA AATGAGACCA TGAATATGAT ATTAAAAGCA 780

AAACTTGGAA TGCCTCAATT TCTTAGTGCT GAAGCACAAA GTCTTCTAAG GATGTTATTC 840

AAAAGGAATC CAGCAAATAG ATTGGGATCA GAAGGAGTTG AAGAAATCAA AAGACATCTG 900

TTTTTTGCAA ATATTGACTG GGATAAATTA TATAAAAGAG AAGTTCAACC TCCTTTCAAA 960

CCTGCTTCTG GAAAACCAGA TGATACTTTT TGTTTTGATC CTGAATTTAC TGCAAAAACA 1020

CCTAAAGATT CTCCCGGTTT GCCAGCCAGT GCAAATGCTC ATCAGCTCTT CAAAGGATTC 1080

AGCTTTGTTG CAACTTCTAT TGCAGAAGAA TATAAAATCA CTCCTATCAC AAGTGCAAAT 1140

GTATTACCAA TTGTTCAGAT AAATGGAAAT GCTGCACAAT TTGGTGAAGT ATATGAATTG 1200

AAAGAGGATA TTGGTGTTGG CTCCTACTCT GTTTGCAAGC GATGCATACA TGCAACTACC 1260

AACATGGAAT TTGCAGTGAA GATCATTGAC AAAAGTAAGC GAGACCCTTC AGAAGAGATT 1320

GAAATATTGA TGCGCTATGG ACAACATCCC AACATTATTA CTTTGAAGGA TTTTGATGAT 1380

GGTAGATATG TTTACGTTAC GGATTTAATG AAAGGAGGAG AGTTACTTGA CCGTATTCTC 1440

AAACAAAAAT GTTTCTCGGA ACGGGAGGCT AGTGATATAC TATATGTAAT AAGTAAGACA 1500

GTTGACTATC TTCATTGTCA AGGAGTTGTT CATCGTGATC TTAAACCTAG TAATATTTTA 1560

TACATGGATG AATCAGCCAG TGCAGATTCA ATCAGGATAT GTGATTTTGG GTTTGCAAAA 1620

CAACTTCGAG GAGAAAATGG ACTTCTCTTA ACTCCATGCT ACACTGCAAA CTTTGTTGCA 1680

CCTGAGGTTC TTATGCAACA AGGATATGAT GCTGCTTGTG ATATCTGGAG TTTAGGAGTC 1740

CTTTTTTACA CAATGTGGGC TGGCTACACT CCATTTGCTA ATGGCCCCAA TGATACTCCT 1800

GAAGAGATAC TGCTGCGTAT AGGCAATGGA AAATTCTCTT TGAGTGGTGG AAACTGGGAC 1860

AATATTTCAG ACGGAGCAAA GGATTTGCTT TCCCATATGC TTCATATGGA CCCACATCAG 1920

CGGTATACTG CTGAACAAAT ATTAAAGCAC TCATGGATAA CTCACAGAGA CCAGTTGCCA 1980

AATGATCAGC CAAAGAGAAA TGATGTGTCA CATGTTGTTA AGGGAGCAAT GGTTGCAACA 2040

TACTCTGCCC TGACTCACAA GACCTTTCAA CCAGTCCTAG AGCCTGTAGC TGCTTCAAGC 2100

TTAGCCCAGC GACGGAGCAT GAAAAAGCGA ACATCAACTG GCCTGTAA 2148

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         ye+ked+GvGsysvckrc+h++tn+efavkiidkskrd+seeieil+ry+qhpni+tlkd

Q: 398   YELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKD  457

         789********************************************************9

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

          +ddg+yvy v++l+kGGelldri+k+k+fsereas+il++++k+v+ylh+qGvvhrdlk

Q: 458   -FDDGRYVY-VTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLK  515

         .9*******.79************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nily+des++a+si+i+dfGfak++r engll tpcyt+nfvapevl++qGyd+acd+

Q: 516   PSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDI  575

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslGvl+ytm aGy+pfangp+dt+eeil +i++GkfslsG++wd++s+ akdl+s++l+

Q: 576   WSLGVLFYTMWAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLH  635

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         +dp++r+++eq+lkhsw+

Q: 636   MDPHQRYTAEQILKHSWI  653

         *****************8

Domain Sequence
(FASTA)

YELKEDIGVG SYSVCKRCIH ATTNMEFAVK IIDKSKRDPS EEIEILMRYG QHPNIITLKD 60

FDDGRYVYVT DLMKGGELLD RILKQKCFSE REASDILYVI SKTVDYLHCQ GVVHRDLKPS 120

NILYMDESAS ADSIRICDFG FAKQLRGENG LLLTPCYTAN FVAPEVLMQQ GYDAACDIWS 180

LGVLFYTMWA GYTPFANGPN DTPEEILLRI GNGKFSLSGG NWDNISDGAK DLLSHMLHMD 240

PHQRYTAEQI LKHSWI 256

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013