EKS-PAT-00384

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00384

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/IRAK	418.6	1.2E-125	212	518	307

Status

Unreviewed

Ensembl Protein

ENSPTRP00000038647

UniProt Accession

H2QZA3;

Protein Name

Protein Synonyms/Alias

Interleukin-1 receptor-associated kinase 1;

Gene Name

ENSG00000184216

Gene Synonyms/Alias

ENSG00000184216; IRAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000022423	ENSPTRP00000038647	ENSPTRT00000041849

Organism

Pan troglodytes

Functional Description

Protein Length

712

Protein Sequence
(FASTA)

MAGGPGPGEP AAPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV RDQTELRLCE 60

RSGQRTASVL WPWINRNARV ADLVHILTHL QLLRARDIIT AWHPPALLPS PSTTAPRPSS 120

IPAPAEAEAW SPRKLPSSAS TLLSPAFPGS QTHSGPELGL VPSPASLWPP PPSPAPSSTK 180

PGPESSVSLL QGARPSPFCW PLCEISRGTH NFSEELKIGE GGFGCVYRAV MRNTVYAVKR 240

LKEDADLEWT AVKQSFLTEV EQLSRFRHPN IVDFAGYCAQ NGFYCLVYGF LPNGSLEDRL 300

HCQTQACPPL SWPQRLDILL GTARAIQFLH QDSPSLIHGD IKSSNVLLDE RLTPKLGDFG 360

LARFSRFAGS SPSQSSMVAR TQTVRGTLAY LPEEYIKTGR LAVDTDTFSF GVVVLETLAG 420

QRAVKTHGAR TKYLKDLVEE EAEEAGVALR STQSTLHAGL AADAWAAPIA MQIYKKHLDP 480

RPGPCPPELG LGLGQLACCC LHRRAKRRPP MTQVYERLEK LQAVVAGVPG HSEAASCIPP 540

SPQENSYVSS TGSAHSGAAP WQPLAAPSGA SAQAAEQLQR GPNQPVESDE SLGGLSAALR 600

SWHLTPSCPL DPAPLREAGC PQGDTAGESS WGSGPGSRPT AVEGLALGSS ASSSSEPPQI 660

IINPARQKMV QKLALYEDGA LDSLQLLSSS SLPGLGLEQD RQGPEESDEF QS 712

Nucleotide Sequence
(FASTA)

ATGGCCGGGG GGCCGGGCCC GGGGGAGCCC GCAGCCCCCG GCGCCCAGCA CTTCTTGTAC 60

GAGGTGCCGC CCTGGGTCAT GTGCCGCTTC TACAAAGTGA TGGACGCCCT GGAGCCCGCC 120

GACTGGTGCC AGTTCGCCGC CCTGATCGTG CGCGACCAGA CCGAGCTGCG GCTGTGCGAG 180

CGCTCCGGGC AGCGCACGGC CAGCGTCCTG TGGCCCTGGA TCAACCGCAA CGCCCGTGTG 240

GCCGACCTCG TGCACATCCT CACGCACCTG CAGCTGCTCC GTGCGCGGGA CATCATCACA 300

GCCTGGCACC CTCCCGCCCT GCTTCCGTCC CCAAGCACCA CTGCCCCGAG GCCCAGCAGC 360

ATCCCTGCAC CCGCCGAGGC CGAGGCCTGG AGCCCCCGGA AGTTGCCATC CTCAGCCTCC 420

ACCCTCCTCT CCCCAGCTTT TCCAGGCTCC CAGACCCATT CAGGGCCTGA GCTCGGCCTG 480

GTCCCAAGCC CTGCTTCCCT GTGGCCTCCA CCGCCATCTC CAGCCCCTTC CTCTACCAAG 540

CCAGGCCCAG AGAGCTCAGT GTCCCTCCTG CAGGGAGCCC GCCCCTCTCC GTTTTGCTGG 600

CCCCTCTGTG AGATTTCCCG GGGCACCCAC AACTTCTCAG AGGAGCTCAA GATCGGGGAG 660

GGTGGCTTTG GGTGCGTGTA CCGGGCGGTG ATGAGGAACA CGGTGTATGC TGTGAAGAGG 720

CTGAAGGAGG ACGCTGACCT GGAGTGGACT GCAGTGAAGC AGAGCTTCCT GACCGAGGTG 780

GAGCAGCTGT CCAGGTTTCG TCACCCAAAC ATTGTGGACT TTGCTGGCTA CTGTGCTCAG 840

AACGGCTTCT ACTGCCTGGT GTACGGCTTC CTGCCCAACG GCTCCCTGGA GGACCGTCTC 900

CACTGCCAGA CCCAGGCCTG CCCACCTCTC TCCTGGCCTC AGCGACTGGA CATCCTTCTG 960

GGTACAGCCC GGGCAATTCA GTTTCTACAT CAGGACAGCC CCAGCCTCAT CCATGGAGAC 1020

ATCAAGAGTT CCAACGTCCT TCTGGATGAG AGGCTGACAC CCAAGCTGGG AGACTTTGGC 1080

CTGGCCCGGT TCAGCCGCTT TGCCGGGTCC AGCCCCAGCC AGAGCAGCAT GGTGGCCCGG 1140

ACACAGACAG TGCGGGGCAC CCTGGCCTAC CTGCCCGAGG AGTACATCAA GACGGGAAGG 1200

CTGGCTGTGG ACACGGACAC CTTCAGCTTT GGGGTGGTAG TGCTAGAGAC CTTGGCTGGT 1260

CAGAGGGCTG TGAAGACGCA CGGTGCCAGG ACCAAGTATC TGAAAGACCT GGTGGAAGAG 1320

GAGGCTGAGG AGGCTGGAGT GGCTTTGAGA AGCACCCAGA GCACACTGCA CGCAGGTCTG 1380

GCTGCAGATG CCTGGGCTGC TCCCATCGCC ATGCAGATCT ACAAGAAGCA CCTGGACCCC 1440

AGGCCCGGGC CCTGCCCACC TGAGCTGGGC CTGGGCCTGG GCCAGCTGGC CTGCTGCTGC 1500

CTGCACCGCC GGGCCAAAAG GAGGCCTCCT ATGACCCAGG TGTACGAGAG GCTAGAGAAG 1560

CTGCAGGCAG TGGTGGCGGG GGTGCCCGGG CATTCGGAGG CCGCCAGCTG CATCCCCCCT 1620

TCCCCGCAGG AGAACTCCTA CGTGTCCAGC ACTGGCAGTG CCCACAGTGG GGCTGCTCCA 1680

TGGCAGCCCC TGGCAGCGCC ATCAGGAGCC AGTGCCCAGG CAGCAGAGCA GCTCCAGAGA 1740

GGCCCCAACC AGCCCGTGGA GAGTGACGAG AGCCTAGGCG GCCTCTCTGC TGCCCTGCGC 1800

TCCTGGCACT TGACTCCAAG CTGCCCTCTG GACCCAGCAC CCCTCAGGGA GGCCGGCTGT 1860

CCTCAGGGGG ACACGGCGGG AGAATCGAGC TGGGGGAGTG GCCCAGGATC CCGGCCCACA 1920

GCCGTGGAAG GACTGGCCCT TGGCAGCTCT GCATCATCGT CGTCAGAGCC ACCGCAGATT 1980

ATCATCAACC CTGCCCGACA GAAGATGGTC CAGAAGCTGG CCCTGTACGA GGATGGGGCC 2040

CTGGACAGCC TGCAGCTGCT GTCGTCCAGC TCCCTCCCAG GCTTGGGCCT GGAACAGGAC 2100

AGGCAGGGGC CCGAAGAAAG TGATGAATTT CAGAGCTGA 2139

Domain Profile

S: 1     fsednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdni  60

         fse+ +igeGgfg+vyr+ ++nt++avk+lke adl+++++kqsfltE+++l+rfrH+ni

Q: 212   FSEELKIGEGGFGCVYRAVMRNTVYAVKRLKEDADLEWTAVKQSFLTEVEQLSRFRHPNI  271

         899*********************************************************

S: 61    lellgysaeseklcLvYqymknGsLedrLqcq.kgsepLsWpqRlsillGtaraiefLHe  119

         ++++gy+a+++++cLvY++++nGsLedrL+cq ++++pLsWpqRl+illGtarai+fLH+

Q: 272   VDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQtQACPPLSWPQRLDILLGTARAIQFLHQ  331

         ********************************99**************************

S: 120   aspslihgdiksaNiLLDekltpKlgDfglar...fapesekqsstvlrtskvrgtlaYl  176

         +spslihgdiks+N+LLDe+ltpKlgDfglar   fa++s++qss+v+rt++vrgtlaYl

Q: 332   DSPSLIHGDIKSSNVLLDERLTPKLGDFGLARfsrFAGSSPSQSSMVARTQTVRGTLAYL  391

         ********************************98899***********************

S: 177   peefirvgqltvkvDvySfGiVllEvltGlra.vdedrktkyLkdllkeeieeekv....  231

         pee+i++g+l+v++D++SfG+V+lE+l+G+ra ++++++tkyLkdl++ee+ee++v

Q: 392   PEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAvKTHGARTKYLKDLVEEEAEEAGValrs  451

         ********************************77899***********************

S: 232   ....................eilekfldkkagkleeellealielalaclaekakkrPtm  271

                             +i++k+ld ++g++++el   l +la++cl+++ak+rP+m

Q: 452   tqstlhaglaadawaapiamQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPM  511

         ************************************************************

S: 272   sqvlell  278

         +qv+e+l

Q: 512   TQVYERL  518

         ****987

Domain Sequence
(FASTA)

FSEELKIGEG GFGCVYRAVM RNTVYAVKRL KEDADLEWTA VKQSFLTEVE QLSRFRHPNI 60

VDFAGYCAQN GFYCLVYGFL PNGSLEDRLH CQTQACPPLS WPQRLDILLG TARAIQFLHQ 120

DSPSLIHGDI KSSNVLLDER LTPKLGDFGL ARFSRFAGSS PSQSSMVART QTVRGTLAYL 180

PEEYIKTGRL AVDTDTFSFG VVVLETLAGQ RAVKTHGART KYLKDLVEEE AEEAGVALRS 240

TQSTLHAGLA ADAWAAPIAM QIYKKHLDPR PGPCPPELGL GLGQLACCCL HRRAKRRPPM 300

TQVYERL 307

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Erinaceus europaeus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

ptr:465935

;

InterPros

IPR000488	; Death.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00531	; Death; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013