EPS-PAT-00008

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-PAT-00008

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	149.3	6.7E-44	133	278	146

Status

Unreviewed

Ensembl Protein

ENSPTRP00000045402

UniProt Accession

H2R3E8;

Protein Name

Protein Synonyms/Alias

Gene Name

ENSG00000198842

Gene Synonyms/Alias

ENSG00000198842;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000022532	ENSPTRP00000045402	ENSPTRT00000049382

Organism

Pan troglodytes

Functional Description

Protein Length

1160

Protein Sequence
(FASTA)

MATKKDTEEE QVVPSEEDEA NLRAVQAHYL RSPSPSQYSM VSDAETESIF MEPIHLSSAM 60

AAKQIINEEL KPRGVRADAE CPGMLESAEQ LLVEDLYNRV REKMDDTSLY NTPCVLDLQR 120

ALVQDRQEAP WNEVDEVWPN VFIAEKSVAV NKGRLKRLGI THILNAAHGT GVYTGPEFYT 180

GLEIQYLGVE VDDFPEVDIS QHFRKAAEFL DEALLTYRGK VLVSSEMGIS RSAVLVVAYL 240

VIFHNMAILE ALMTVRKKRA IYPNDGFLKQ LRELNEKLME EREEDYGREG GSAEAEEGEG 300

TGSALGARVH ALTVEEEDDS ASHLSGSSLG KATQASKPLT LIDEEEEEKL YEQWKKGQGL 360

LSDKVPQDGG GWRSASAGQG GEELEDEDVE RIIQEWQSRN ERYQAEGYRR WGREEEEVKE 420

EESDAGSSVG RRRRTLSESS AWESVSSHDI WVLKQQLELN RPDHGRRRRA DSMSSESTWD 480

AWNERLLEIE KEASRRYHAK SKREEAADRS SEAGSRVRED DEDSVGSEAS SFYNFCSRNK 540

DKLTALERWK IKRIQFGFHK KDLGAGDSSS EPGAEEAVGE KNPSDISLTA YQAWKLKHQK 600

KVGSENKEEV VELSKGEDSA LAKKRQRRLE LLERSRQTLE ESQSMASWEA DSSTASGSIP 660

LSAFWSAAPS VSADGDTTSV LSTQSHRSHL SQAASNIAGC STSNPTTPLP NLPVGPGDTI 720

SIASIQNWIA NVVSETLAQK QNEMLLLSRS PSVASMKAVP AASCLGDDQV SMLSGQSSSS 780

LGGCLLPQSQ ARPSSDMQSV LSCNTTLSSP VESCRSKVRG TSKPIFSLFT DNVDLKELGR 840

KEKEMQMELR EKMSEYKMEK LASDNKRSSL FKKKKVKEDE DDGVGDGDED TDSAIGSFRY 900

SSRGNSQKPE TDTCSSLAVC DHYASGSRVG KEMDSSVNKW LSGLRTEEKP PFQSDWSGSS 960

RGKYTRSSLL RETESKSSSY KFSKSQSEEQ DTSSYHEANG NSVRSTSRFS SSSTREGREM 1020

HKFSRSTYNE TSSSREESPE PHFFRRTPES SEREESPEPQ RPNWARSRDW EDVEESSKSD 1080

FSEFGAKRKF TQSFMRSEEE GEKERTENRE EGRFASGRRS QYRRSTDREE EEEMDDEAII 1140

AAWRRRQEET RAKLQKRRED 1160

Nucleotide Sequence
(FASTA)

ATGGCGACCA AAAAGGACAC AGAGGAGGAG CAGGTAGTCC CAAGCGAGGA GGACGAAGCC 60

AACCTGAGGG CGGTGCAGGC CCACTACCTC CGAAGCCCCT CCCCTAGCCA GTATTCGATG 120

GTCTCAGATG CAGAAACAGA AAGCATTTTC ATGGAACCCA TTCACCTCTC CTCAGCCATG 180

GCAGCCAAAC AGATCATCAA TGAAGAACTC AAGCCACGGG GGGTCAGAGC AGACGCAGAG 240

TGTCCAGGCA TGCTGGAGTC TGCTGAACAG CTGCTGGTGG AGGACCTGTA CAACCGCGTC 300

AGGGAGAAGA TGGATGACAC CAGCCTCTAT AATACACCGT GTGTCCTGGA CCTACAGCGG 360

GCCCTGGTTC AGGATCGCCA AGAGGCGCCC TGGAATGAGG TGGATGAGGT CTGGCCCAAT 420

GTCTTCATAG CTGAGAAGAG TGTGGCTGTG AACAAGGGGA GGCTGAAGAG GCTGGGAATC 480

ACCCACATTC TGAATGCTGC GCATGGCACC GGCGTTTACA CTGGCCCCGA ATTCTACACT 540

GGCCTGGAGA TCCAGTACCT GGGTGTAGAG GTGGATGACT TTCCTGAGGT GGACATTTCC 600

CAGCATTTCC GGAAGGCGGC TGAGTTCCTG GATGAGGCGC TGCTGACTTA CAGAGGGAAA 660

GTCCTGGTCA GCAGCGAAAT GGGCATCAGC CGGTCAGCAG TGCTGGTGGT CGCCTACCTG 720

GTGATCTTCC ACAACATGGC CATCCTGGAG GCTTTGATGA CCGTGCGTAA GAAGCGGGCC 780

ATCTACCCCA ATGACGGCTT CCTGAAGCAG CTGCGGGAGC TCAATGAGAA GTTGATGGAG 840

GAGAGAGAAG AGGACTATGG CCGGGAGGGG GGATCAGCTG AGGCTGAGGA GGGCGAGGGC 900

ACTGGGAGCG CGCTCGGGGC CAGAGTGCAC GCCCTGACGG TGGAAGAGGA GGACGACAGC 960

GCCAGCCACC TGAGTGGCTC CTCCCTGGGG AAGGCCACCC AGGCCTCCAA GCCCCTCACC 1020

CTCATAGACG AGGAGGAGGA GGAGAAACTG TACGAGCAGT GGAAGAAGGG GCAGGGCCTC 1080

CTCTCAGACA AGGTCCCCCA GGATGGAGGT GGCTGGCGCT CAGCCTCCGC TGGCCAGGGT 1140

GGGGAGGAGC TCGAGGACGA GGACGTGGAG AGGATCATCC AGGAGTGGCA GAGCCGAAAC 1200

GAGAGGTACC AAGCAGAAGG GTACCGGAGG TGGGGAAGGG AGGAGGAGGA GGTGAAGGAG 1260

GAGGAGAGCG ACGCTGGCTC CTCGGTGGGG AGGCGGCGGC GCACCCTGAG CGAGAGCAGC 1320

GCCTGGGAGA GCGTGAGCAG CCACGACATC TGGGTCCTGA AGCAGCAGCT GGAGCTGAAC 1380

CGCCCGGACC ACGGCAGGAG GCGCCGCGCA GACTCGATGT CCTCGGAGAG CACCTGGGAC 1440

GCATGGAACG AGAGGCTGCT GGAGATTGAG AAGGAGGCTT CCCGGAGGTA CCACGCCAAG 1500

AGCAAGAGAG AGGAGGCGGC GGACAGGAGC TCAGAAGCAG GGAGCAGGGT GCGGGAGGAT 1560

GATGAGGACA GCGTGGGCTC TGAGGCCAGT TCCTTCTACA ACTTCTGCAG CAGGAACAAG 1620

GACAAGCTCA CTGCCCTGGA AAGATGGAAG ATCAAGAGAA TCCAATTTGG ATTTCACAAG 1680

AAAGACTTGG GAGCGGGAGA CAGCAGCAGT GAGCCCGGTG CAGAGGAGGC AGTAGGGGAG 1740

AAGAACCCCT CCGACATCAG CCTGACAGCC TACCAGGCCT GGAAGCTGAA ACACCAGAAG 1800

AAGGTGGGCA GTGAGAACAA GGAGGAGGTG GTGGAGCTCA GCAAGGGGGA GGACTCGGCC 1860

TTGGCTAAGA AGAGACAACG GAGGCTGGAG CTGCTGGAGA GAAGCCGGCA GACGCTGGAG 1920

GAGAGCCAGT CTATGGCAAG CTGGGAGGCG GACAGCTCCA CCGCCAGCGG GAGCATTCCC 1980

CTGTCTGCGT TCTGGTCTGC AGCCCCCTCA GTCAGTGCTG ATGGGGACAC GACGTCAGTA 2040

CTGAGCACCC AGAGCCACCG CTCCCACCTG TCTCAGGCTG CAAGCAACAT AGCGGGGTGT 2100

TCAACCTCCA ACCCCACCAC ACCCCTGCCT AACCTGCCAG TGGGGCCTGG AGACACCATT 2160

TCCATTGCCA GTATCCAGAA CTGGATTGCC AATGTAGTCA GCGAGACCCT TGCTCAGAAG 2220

CAAAATGAAA TGCTGCTGTT GTCCCGCTCA CCGTCTGTTG CAAGCATGAA GGCAGTACCA 2280

GCGGCCAGCT GCCTGGGGGA TGACCAAGTC TCCATGCTTA GTGGACAGAG CAGCTCCTCC 2340

CTGGGTGGCT GCCTGTTGCC TCAGAGCCAG GCAAGACCCA GCTCTGACAT GCAGTCTGTG 2400

CTGTCCTGCA ACACCACACT GAGCTCACCC GTGGAAAGTT GCAGAAGCAA AGTGAGGGGG 2460

ACCAGCAAGC CCATCTTCAG CCTCTTTACT GACAATGTGG ACCTAAAGGA ACTTGGCCGC 2520

AAGGAGAAGG AGATGCAGAT GGAGCTTAGG GAGAAGATGT CTGAGTACAA AATGGAAAAG 2580

CTGGCCTCAG ACAACAAACG CAGCTCCCTC TTCAAGAAGA AGAAGGTCAA GGAAGATGAG 2640

GATGATGGTG TGGGTGATGG GGATGAGGAC ACTGACAGTG CCATAGGGAG CTTCCGATAT 2700

TCTTCCCGCG GTAATTCCCA GAAACCTGAA ACAGACACAT GCTCCTCCCT GGCTGTCTGT 2760

GATCACTATG CAAGCGGCAG CAGAGTTGGC AAAGAGATGG ATAGCAGTGT TAATAAGTGG 2820

CTCAGTGGCC TCAGGACAGA GGAAAAACCT CCTTTCCAAA GTGACTGGTC TGGAAGTTCC 2880

AGAGGGAAGT ACACCAGATC GTCCCTGCTC AGGGAGACAG AGTCTAAATC CTCCAGTTAC 2940

AAGTTTTCCA AATCCCAGTC AGAGGAACAG GACACCTCCT CCTACCACGA GGCAAATGGC 3000

AACTCTGTAA GAAGCACTTC ACGGTTCTCA TCTTCCTCCA CCAGGGAGGG CAGAGAGATG 3060

CACAAGTTCT CCAGGTCCAC GTACAACGAG ACCTCAAGTT CCCGAGAGGA GAGCCCAGAG 3120

CCCCACTTCT TCCGCCGGAC CCCAGAGTCC TCAGAAAGGG AAGAGTCGCC AGAGCCACAG 3180

CGCCCAAATT GGGCCAGGTC CAGGGACTGG GAAGATGTGG AAGAGTCATC CAAGTCAGAC 3240

TTCTCTGAAT TTGGAGCCAA GAGGAAGTTC ACCCAGAGCT TTATGAGGTC TGAAGAAGAG 3300

GGAGAGAAAG AGAGGACAGA AAACAGAGAA GAAGGGAGGT TTGCATCTGG ACGGCGGTCC 3360

CAGTATCGGA GAAGCACTGA CAGGGAGGAA GAGGAAGAAA TGGACGATGA AGCCATCATT 3420

GCTGCTTGGA GACGCCGGCA AGAAGAAACC AGGGCCAAGC TGCAGAAAAG GAGGGAGGAC 3480

TGA 3483

Domain Profile

S: 1     evteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipv  60

         ev+e++p+++++++ +a+++  L++lgit+++na++++    ++Pe+++  +i+y++++v

Q: 133   EVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGV-YTGPEFYTGLEIQYLGVEV  191

         69**********************************8765.79*****************

S: 61    dDsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdA  119

         dD ++ d++q+f++aaef+dea  + +gkvlv +++G+sRSa+lv+aYL++++++++ +A

Q: 192   DDFPEVDISQHFRKAAEFLDEAlLTYRGKVLVSSEMGISRSAVLVVAYLVIFHNMAILEA  251

         **********************8999**********************************

S: 120   ieavkrkrpsiepnegfleQLlelekkl  147

         +++v++kr +i+pn+gfl+QL+el++kl

Q: 252   LMTVRKKR-AIYPNDGFLKQLRELNEKL  278

         ********.***************9987

Domain Sequence
(FASTA)

EVDEVWPNVF IAEKSVAVNK GRLKRLGITH ILNAAHGTGV YTGPEFYTGL EIQYLGVEVD 60

DFPEVDISQH FRKAAEFLDE ALLTYRGKVL VSSEMGISRS AVLVVAYLVI FHNMAILEAL 120

MTVRKKRAIY PNDGFLKQLR ELNEKL 146

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

ptr:457485

;

InterPros

IPR020417	; Atypical_DUSP.
IPR020405	; Atypical_DUSP_famA.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

PR01908	; ADSPHPHTASE.
PR01909	; ADSPHPHTASEA.

Created Date

20-Feb-2013