EKS-PAT-00269

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-PAT-00269

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	388.9	1.3E-116	203	501	299

Status

Unreviewed

Ensembl Protein

ENSPTRP00000048858

UniProt Accession

H2R686;

Protein Name

Protein Synonyms/Alias

Bone morphogenetic protein receptor, type II (Serine/threonine kinase);

Gene Name

ENSG00000204217

Gene Synonyms/Alias

ENSG00000204217; BMPR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSPTRG00000029076	ENSPTRP00000048858	ENSPTRT00000056194

Organism

Pan troglodytes

Functional Description

Protein Length

1038

Protein Sequence
(FASTA)

MTSSLQRPWR VPWLPWTILL VSTAAASQNQ ERLCAFKDPY QQDLGIGESR ISHENGTILC 60

SKGSTCYGLW EKSKGDINLV KQGCWSHIGD PQECHYEECV VTTTPPSIQN GTYRFCCCST 120

DLCNVNFTEN FPPPDTTPLS PPHSFNRDET IIIALASVSV LAVLIVALCF GYRMLTGDRK 180

QGLHSMNMME AAASEPSLDL DNLKLLELIG RGRYGAVYKG SLDERPVAVK VFSFANRQNF 240

INEKNIYRVP LMEHDNIARF IVGDERVTAD GRMEYLLVME YYPNGSLCKY LSLHTSDWVS 300

SCRLAHSVTR GLAYLHTELP RGDHYKPAIS HRDLNSRNVL VKNDGTCVIS DFGLSMRLTG 360

NRLVRPGEED NAAISEVGTI RYMAPEVLEG AVNLRDCESA LKQVDMYALG LIYWEIFMRC 420

TDLFPGESVP EYQMAFQTEV GNHPTFEDMQ VLVSREKQRP KFPEAWKENS LAVRSLKETI 480

EDCWDQDAEA RLTAQCAEER MAELMMIWER NKSVSPTVNP MSTAMQNERN LSHNRRVPKI 540

GPYPDYSSSS YIEDSIHHTD SIVKNISSEH SMSSTPLTIG EKNRNSINYE RQQAQARIPS 600

PETSVTSLST NTTTTNTTGL TPSTGMTTIS EMPYPDETNL HTTNVAQSIG PTPVCLQLTE 660

EDLETNKLDP KEVDKNLKES SDENLMEHSL KQFSGPDPLS STSSSLLYPL IKLAVEATGQ 720

QDFTQAANGQ ACLIPDVLPT QIYPLPKQQN LPKRPTSLPL NTKNSTKEPR LKFGSKHKSN 780

LKQVETGVAK MNTINAAEPH VVTVTMNGVA GRNHSVNSHA ATTQYANGTV LSGQTTNIVT 840

HRAQEMLQNQ FIGEDTRLNI NSSPDEHEPL LRREQQAGHD EGVLDRLVDR RERPLEGGRT 900

NSNNNNSNPC SEQDVLAQGV PSTAADPGPS KPRRAQRPNS LDLSATNVLD GSSIQIGEST 960

QDGKSGSGEK IKKRVKTPYS LKRWRPSTWV ISTESLDCEV NNNGSNRAVH SKSSTAVYLA 1020

EGGTATTMVS KDIGMNCL 1038

Nucleotide Sequence
(FASTA)

ATGACTTCCT CGCTACAGCG GCCCTGGCGG GTGCCCTGGC TACCATGGAC CATCCTGCTG 60

GTCAGCACTG CGGCTGCTTC ACAGAATCAA GAACGGCTAT GTGCATTTAA AGATCCGTAT 120

CAGCAAGACC TTGGGATAGG TGAGAGTAGA ATCTCTCATG AAAATGGGAC AATATTATGC 180

TCGAAAGGTA GCACCTGCTA TGGCCTTTGG GAGAAATCAA AAGGGGACAT AAATCTTGTA 240

AAACAAGGAT GTTGGTCTCA CATTGGAGAT CCCCAAGAGT GTCACTATGA AGAATGTGTA 300

GTAACTACCA CTCCTCCCTC AATTCAGAAT GGAACATACC GTTTCTGCTG TTGTAGCACA 360

GATTTATGTA ATGTCAACTT TACTGAGAAT TTTCCACCTC CTGACACAAC ACCACTCAGT 420

CCACCTCATT CATTTAACCG AGATGAGACA ATAATCATTG CTTTGGCATC AGTCTCTGTA 480

TTAGCTGTTT TGATAGTTGC CTTATGCTTT GGATACAGAA TGTTGACAGG AGACCGTAAA 540

CAAGGTCTTC ACAGTATGAA CATGATGGAG GCAGCAGCAT CCGAACCCTC TCTTGATCTA 600

GATAATCTGA AACTGTTGGA GCTGATTGGC CGAGGTCGAT ATGGAGCAGT ATATAAAGGC 660

TCCTTGGATG AGCGTCCAGT TGCTGTAAAA GTGTTTTCCT TTGCAAACCG TCAGAATTTT 720

ATCAACGAAA AGAACATTTA CAGAGTGCCT TTGATGGAAC ATGACAACAT TGCCCGCTTT 780

ATAGTTGGAG ATGAGAGAGT CACTGCAGAT GGACGCATGG AATATTTGCT TGTGATGGAG 840

TACTATCCCA ATGGATCTTT ATGCAAGTAT TTAAGTCTCC ATACAAGTGA CTGGGTAAGC 900

TCTTGCCGTC TTGCTCATTC TGTTACTAGA GGACTGGCTT ATCTTCACAC AGAATTACCA 960

CGAGGAGATC ATTATAAACC TGCAATTTCC CATCGAGATT TAAACAGCAG AAATGTCCTA 1020

GTGAAAAATG ATGGAACCTG TGTTATTAGT GACTTTGGAC TGTCCATGAG GCTGACTGGA 1080

AATAGACTGG TGCGCCCAGG GGAGGAAGAT AATGCAGCCA TAAGCGAGGT TGGCACTATC 1140

AGATATATGG CACCAGAAGT GCTAGAAGGA GCTGTGAACT TGAGGGACTG TGAATCAGCT 1200

TTGAAACAAG TAGACATGTA TGCTCTTGGA CTAATCTATT GGGAGATATT TATGAGATGT 1260

ACAGACCTCT TCCCAGGGGA ATCCGTACCA GAGTACCAGA TGGCTTTTCA GACAGAGGTT 1320

GGAAACCATC CCACTTTTGA GGATATGCAG GTTCTCGTGT CTAGGGAAAA ACAGAGACCC 1380

AAGTTCCCAG AAGCCTGGAA AGAAAATAGC CTGGCAGTGA GGTCACTCAA GGAGACAATC 1440

GAAGACTGTT GGGACCAGGA TGCAGAGGCT CGGCTTACTG CACAGTGTGC TGAGGAAAGG 1500

ATGGCTGAAC TTATGATGAT TTGGGAAAGA AACAAATCTG TGAGCCCAAC AGTCAATCCA 1560

ATGTCTACTG CTATGCAGAA TGAACGCAAC CTGTCACATA ATAGGCGTGT GCCAAAAATT 1620

GGTCCTTATC CAGATTATTC TTCCTCCTCA TACATTGAAG ACTCTATCCA TCATACTGAC 1680

AGCATCGTGA AGAATATTTC CTCTGAGCAT TCTATGTCCA GCACACCTTT GACTATAGGG 1740

GAAAAAAACC GAAATTCAAT TAACTATGAA CGACAGCAAG CACAAGCTCG AATCCCCAGT 1800

CCTGAAACAA GTGTCACCAG CCTCTCCACC AACACAACAA CCACAAACAC CACAGGCCTC 1860

ACGCCAAGTA CTGGCATGAC TACTATATCT GAGATGCCAT ATCCAGATGA AACAAATCTG 1920

CATACCACAA ATGTTGCACA GTCAATTGGG CCAACCCCTG TCTGCTTACA GCTGACAGAA 1980

GAAGACTTGG AAACCAACAA GCTAGACCCA AAAGAAGTTG ATAAGAACCT CAAGGAAAGC 2040

TCTGATGAGA ATCTCATGGA GCACTCTCTT AAACAGTTCA GTGGCCCAGA CCCACTGAGC 2100

AGTACTAGTT CTAGCTTGCT TTACCCACTC ATAAAACTTG CAGTAGAAGC AACTGGACAG 2160

CAGGACTTCA CACAGGCTGC AAATGGCCAA GCATGTTTGA TTCCTGATGT TCTGCCTACT 2220

CAGATCTATC CTCTCCCCAA GCAGCAGAAC CTTCCCAAGA GACCTACTAG TTTGCCTTTG 2280

AACACCAAAA ATTCAACAAA AGAGCCCCGG CTAAAATTTG GCAGCAAGCA CAAATCAAAC 2340

TTGAAACAAG TCGAAACTGG AGTTGCCAAG ATGAATACAA TCAATGCAGC AGAACCTCAT 2400

GTGGTGACAG TCACCATGAA TGGTGTGGCA GGTAGAAACC ACAGTGTTAA CTCCCATGCT 2460

GCCACAACCC AATATGCCAA TGGGACAGTA CTATCTGGCC AAACAACCAA CATAGTGACA 2520

CATAGGGCCC AAGAAATGTT GCAGAATCAG TTTATCGGTG AGGACACCCG GCTGAATATT 2580

AATTCCAGTC CTGATGAGCA TGAGCCTTTA CTGAGACGAG AGCAACAAGC TGGCCATGAT 2640

GAAGGTGTTC TGGATCGTCT TGTGGACAGG AGGGAACGGC CACTAGAAGG TGGCCGAACT 2700

AATTCCAATA ACAACAACAG CAATCCATGT TCAGAACAAG ATGTTCTTGC ACAGGGTGTT 2760

CCAAGCACAG CAGCAGATCC TGGGCCATCA AAGCCCAGAA GAGCACAGAG GCCTAATTCT 2820

CTGGATCTTT CAGCCACAAA TGTCCTGGAT GGCAGCAGTA TACAGATAGG TGAGTCAACA 2880

CAAGATGGCA AATCAGGATC AGGTGAAAAG ATCAAGAAAC GTGTGAAAAC TCCCTATTCT 2940

CTTAAGCGGT GGCGCCCTTC CACCTGGGTC ATCTCCACTG AATCGCTGGA CTGTGAAGTC 3000

AACAATAATG GCAGTAACAG GGCAGTTCAT TCCAAATCCA GCACTGCTGT TTACCTTGCA 3060

GAAGGAGGCA CTGCCACAAC CATGGTGTCT AAAGATATAG GAATGAACTG TCTGTGA 3117

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         lkllelig+Gryg+V+k++l+++ vAvK+fs ++++++ +Ek+iy+++l++h+ni +fi+

Q: 203   LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIV  262

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

          d+  ++d ++e+llv+ey+++gsL++yL+ +t+d+ +++rla+s+++Gla+LH+e++

Q: 263   GDErVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG  322

         **9999**************************************************9766

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175

          +++Kpai+HRDl+s+N+lvk+d+tc+i+D+GL+++l+ ++ +    +d+aa+s+vGt R

Q: 323   -DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVrpgeEDNAAISEVGTIR  381

         .46***********************************999877787999**********

S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232

         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE+++Rc++  ++e+v+ey+++f+++vg

Q: 382   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEIFMRCTDlfPGESVPEYQMAFQTEVG  441

         *****************99*****************************************

S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291

         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r+

Q: 442   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETIEDCWDQDAEARLTAQCAEERM  501

         ***************************9999*************************9987

Domain Sequence
(FASTA)

LKLLELIGRG RYGAVYKGSL DERPVAVKVF SFANRQNFIN EKNIYRVPLM EHDNIARFIV 60

GDERVTADGR MEYLLVMEYY PNGSLCKYLS LHTSDWVSSC RLAHSVTRGL AYLHTELPRG 120

DHYKPAISHR DLNSRNVLVK NDGTCVISDF GLSMRLTGNR LVRPGEEDNA AISEVGTIRY 180

MAPEVLEGAV NLRDCESALK QVDMYALGLI YWEIFMRCTD LFPGESVPEY QMAFQTEVGN 240

HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETIED CWDQDAEARL TAQCAEERM 299

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Receptor; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

ptr:459885

;

InterPros

IPR000472	; Activin_rcpt.
IPR015770	; BMPRII.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013