EKS-RAN-00116

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00116

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	358.3	3.2E-107	41	313	273

Status

Unreviewed

Ensembl Protein

ENSRNOP00000000064

UniProt Accession

F1LMD9;

Protein Name

Protein Synonyms/Alias

Cyclin-G-associated kinase;

Gene Name

Gak

Gene Synonyms/Alias

Gak;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000000048	ENSRNOP00000000064	ENSRNOT00000000064

Organism

Rattus norvegicus

Functional Description

Protein Length

1305

Protein Sequence
(FASTA)

MSLLQSALDF LAGPGSLGGA AGRDQSDFVG QTVELGELRL RVRRVLAEGG FAFVYEAQDL 60

GSGREYALKR LLSNEEEKNR AIIQEVCFLK KLSGHPNIVQ FCSAASIGKE ESDTGQAEFL 120

LLTELCKGQL VEFLRRVECK GPLSCDSILK IFYQTCRAVQ HMHRQKPPII HRDLKVENLL 180

LSNQGTIKLC DFGSATTISH YPDYSWSAQK RAMVEEEITR NTTPMYRTPE IVDLYSNFPI 240

GEKQDIWALG CILYLLCFRQ HPFEDGAKLR IVNGKYSIPV NDTRYTVFHD LIRGMLKVNP 300

EERLSIAEVV RQLQEIAAAR NVNPKAPITE LLEQNGGYGN SGPSRAQPPS GGPVNSSGVL 360

ALAEYDQPYG GFLDILRGGT ERLFTNLKDT SSKVIQSVAN YAKGDLDISY ITSRIAVMSF 420

PAEGVESAIK NNIEDVRLFL DAKHPGHYAV YNLSPRIYRA SKFHNRVTEC GWAVRRAPHL 480

HSLYTLCRSM HAWLREDHRN VCVVHCMDGR AASAVAVCAF LCFCRLFSTA EAAVYMFSMK 540

RCPPGIWPSH KRYIEYVCDM VAEEPITPHS KPMLVKSVVM TPVPLFSKQR NGCRPFCEVY 600

VGEERVTTTS QEYDRMKEFK IEDGKAVIPL GITVQGDVLI IIYHARSTLG GRLQAKMASM 660

KMFQIQFHTG FVPRNATTVK FAKYDLDACD IQEKYPDLFQ VNLEVEVEPR DRPSRDVPPW 720

ENTSLRGLNP KILFSNREEQ QDILSKFGKP ELPRQPGSTA QYDAEAGSPE AEITESDSPQ 780

SSSTDTNHFL HTLDWQEEKD PETGVDNTSP KESQSNLIAD GDGSEVSDEE EASCPSEERK 840

PGAGEDTPRL AAGTRQQDLI FDVGMLAAPQ EPVQPEEGVD LLGLHSEGDL RPAAPLQASG 900

VQSSNTDLLS SLLEPSDASQ VGPPGDLLGG ETPLLLASPV SLLGVQSNLQ GKVPDTVDPF 960

DQFLLPSSSD TQPCSKPDLF GEFLNSDSVA SSTAFPSTHS APPPSCSTAF LHLGDLPAEP 1020

NKVIASSSHP DLLGGWDTWA ETALPGPASM PVPEGTLFSS AGHPAPPGPN PSQTKSQNPD 1080

PFADLSDLSS SLQGLPAGLP AGSFVGTSAT THKSNSSWQT TRPTAPGTSW PPQAKPAPRA 1140

SEQLRSHFSV IGAREERGVR APSFAQKPKV SENDFEDLLP NQGFSKSDKK GPKTMAEMRK 1200

QELARDTDPF KLKLLDWIEG KERNIRALLS TLHTVLWDGE SRWTPVSMAD LVTPEQVKKQ 1260

YRRAVLVVHP DKATGQPYEQ SAKMIFMELN DAWSEFENQG SRPLF 1305

Nucleotide Sequence
(FASTA)

ATGTCGCTGC TGCAGTCTGC ACTGGACTTC CTGGCGGGCC CTGGTTCTCT TGGCGGAGCT 60

GCCGGCCGTG ACCAGAGTGA CTTCGTGGGG CAGACTGTGG AGCTGGGCGA GCTGCGTCTG 120

CGGGTGCGGC GGGTCCTGGC CGAGGGAGGG TTTGCATTTG TTTATGAAGC TCAAGATCTG 180

GGAAGTGGCA GAGAGTATGC ATTAAAGAGA TTACTATCCA ATGAAGAGGA AAAGAACAGA 240

GCCATCATTC AGGAAGTATG TTTCTTGAAA AAACTTTCTG GCCACCCCAA TATTGTCCAG 300

TTCTGCTCTG CAGCATCCAT AGGAAAAGAG GAATCGGACA CTGGGCAGGC TGAGTTCCTC 360

CTGCTTACGG AGCTCTGTAA AGGACAGCTG GTGGAGTTTC TCAGGAGAGT TGAATGTAAA 420

GGCCCTCTAT CCTGCGACAG CATTCTGAAG ATCTTCTACC AGACATGCAG AGCAGTGCAG 480

CACATGCACA GGCAGAAACC ACCCATCATC CACAGGGATC TCAAGGTTGA AAACTTACTG 540

CTTAGTAACC AGGGGACCAT TAAGCTGTGT GACTTTGGCA GTGCCACAAC CATCTCCCAT 600

TATCCTGACT ACAGCTGGAG CGCCCAGAAG CGAGCAATGG TGGAGGAAGA GATCACGAGG 660

AACACCACAC CCATGTACAG AACGCCAGAA ATTGTAGACC TGTATTCTAA CTTCCCTATT 720

GGCGAAAAGC AGGATATCTG GGCACTGGGC TGTATCTTAT ACCTGCTGTG TTTCCGGCAG 780

CATCCTTTTG AAGATGGAGC AAAACTTCGG ATAGTCAATG GGAAGTATTC CATTCCTGTG 840

AATGACACTC GTTACACAGT CTTCCATGAC CTTATTCGTG GCATGCTAAA GGTCAATCCA 900

GAAGAGAGGC TATCCATTGC TGAAGTGGTC CGACAACTGC AGGAAATTGC AGCAGCCCGG 960

AATGTGAACC CCAAAGCCCC CATCACAGAG CTTCTGGAGC AGAATGGTGG CTATGGGAAC 1020

TCAGGGCCTT CCCGAGCACA ACCACCTTCT GGGGGCCCTG TGAACAGCAG TGGAGTTTTG 1080

GCTCTGGCAG AGTATGACCA GCCCTATGGT GGGTTTCTCG ATATCCTACG GGGTGGGACA 1140

GAACGGCTCT TCACCAACCT CAAGGATACT TCCTCCAAGG TCATCCAGTC TGTGGCTAAC 1200

TATGCAAAGG GCGATCTTGA CATATCTTAC ATCACATCCA GGATTGCAGT GATGTCGTTC 1260

CCAGCAGAAG GTGTGGAGTC AGCAATCAAA AACAATATAG AGGATGTACG ATTGTTTCTG 1320

GATGCCAAGC ATCCAGGACA TTATGCTGTC TACAACCTTT CTCCAAGAAT ATACCGGGCT 1380

TCCAAGTTCC ACAATCGGGT CACTGAGTGT GGCTGGGCAG TCAGGCGGGC ACCACATCTC 1440

CACAGTTTGT ATACTCTATG CAGGAGCATG CATGCCTGGC TCCGGGAAGA CCACAGGAAC 1500

GTCTGTGTTG TACATTGCAT GGATGGGAGA GCTGCGTCTG CTGTGGCAGT CTGTGCATTC 1560

CTGTGCTTCT GCCGTCTCTT CAGCACTGCA GAGGCTGCTG TGTACATGTT CAGCATGAAG 1620

CGCTGCCCAC CAGGCATTTG GCCATCCCAC AAAAGGTACA TTGAATACGT GTGTGACATG 1680

GTGGCAGAGG AACCCATCAC GCCCCACAGC AAGCCAATGC TGGTGAAATC TGTTGTCATG 1740

ACCCCTGTGC CACTGTTCAG CAAGCAGAGG AATGGCTGCC GACCATTCTG TGAGGTCTAT 1800

GTTGGGGAGG AGCGTGTAAC CACCACATCC CAGGAGTATG ACAGGATGAA GGAATTTAAA 1860

ATTGAGGATG GCAAGGCTGT CATCCCCCTG GGCATAACAG TTCAAGGCGA TGTCCTCATC 1920

ATCATTTACC ATGCCAGATC CACTTTAGGA GGGAGACTGC AGGCCAAGAT GGCGTCCATG 1980

AAAATGTTCC AGATTCAGTT CCACACTGGG TTCGTGCCTC GAAACGCAAC CACTGTGAAA 2040

TTTGCAAAGT ATGACCTGGA TGCTTGTGAC ATTCAAGAGA AGTACCCAGA TCTGTTCCAG 2100

GTGAACCTGG AAGTGGAGGT GGAGCCTAGA GACAGGCCCA GCCGAGACGT TCCACCTTGG 2160

GAGAATACCA GCCTAAGGGG GTTAAACCCC AAGATCCTCT TTTCCAACAG GGAAGAGCAA 2220

CAGGACATTC TGTCTAAGTT TGGGAAACCA GAGCTACCCC GGCAGCCGGG CTCCACAGCT 2280

CAGTATGATG CTGAGGCAGG GTCTCCAGAG GCTGAGATCA CAGAGTCGGA CTCACCACAG 2340

AGCAGCAGCA CGGACACCAA CCACTTTCTT CACACACTGG ATTGGCAGGA GGAAAAAGAC 2400

CCAGAGACTG GTGTAGACAA TACCTCTCCT AAGGAGAGTC AGTCTAACCT GATTGCAGAT 2460

GGAGATGGAA GTGAAGTATC AGATGAAGAA GAGGCTTCAT GCCCTAGTGA AGAGAGAAAG 2520

CCTGGGGCTG GAGAAGATAC ACCAAGGCTG GCAGCTGGGA CCAGACAGCA AGACTTAATA 2580

TTTGATGTGG GCATGCTGGC TGCCCCACAG GAGCCTGTAC AGCCTGAAGA AGGTGTCGAT 2640

CTCCTGGGGC TGCACTCTGA AGGGGACTTA AGGCCTGCTG CTCCCTTGCA GGCTAGCGGG 2700

GTCCAGTCTA GCAACACTGA CCTGTTGAGC TCCCTTCTTG AACCATCTGA TGCTTCTCAA 2760

GTGGGACCTC CTGGTGACCT GCTTGGTGGT GAGACTCCTC TGCTGTTAGC AAGCCCAGTT 2820

TCTCTTCTTG GGGTGCAGAG CAACCTGCAA GGAAAAGTCC CTGACACTGT GGACCCATTT 2880

GACCAGTTCC TGCTGCCATC CAGCTCGGAC ACCCAGCCCT GCTCCAAGCC TGATCTCTTT 2940

GGAGAGTTTC TCAACTCTGA CTCTGTAGCT TCCTCAACTG CCTTCCCATC GACCCACAGC 3000

GCCCCACCCC CATCCTGCAG CACTGCCTTC CTGCACCTGG GAGATCTGCC AGCAGAGCCC 3060

AACAAGGTGA TTGCTTCATC CAGCCACCCA GATCTGCTAG GAGGATGGGA TACGTGGGCT 3120

GAGACTGCTC TACCTGGGCC GGCCTCCATG CCAGTACCAG AAGGTACTCT CTTCTCTTCT 3180

GCAGGTCACC CAGCCCCTCC AGGCCCCAAC CCCAGCCAAA CCAAGTCTCA GAACCCAGAC 3240

CCATTTGCTG ACCTCAGTGA TCTCAGCTCT AGCCTCCAAG GCTTGCCTGC TGGACTTCCT 3300

GCAGGGAGCT TCGTTGGCAC ATCAGCCACC ACTCACAAAA GCAACAGCTC CTGGCAGACA 3360

ACTCGTCCCA CAGCCCCTGG AACCTCATGG CCCCCGCAGG CCAAGCCAGC CCCCAGAGCC 3420

TCTGAACAAC TAAGGTCTCA CTTTAGTGTG ATTGGGGCCC GAGAAGAGAG AGGTGTCCGT 3480

GCGCCCAGCT TTGCCCAAAA GCCAAAGGTC TCAGAAAATG ATTTTGAAGA TCTGCTGCCT 3540

AATCAAGGCT TCTCTAAGTC TGACAAGAAG GGGCCAAAGA CCATGGCAGA GATGCGGAAA 3600

CAGGAACTTG CCAGAGATAC AGACCCATTC AAATTGAAGC TTTTGGACTG GATTGAAGGC 3660

AAAGAGAGGA ATATTCGTGC ACTGCTGTCC ACTCTGCACA CAGTATTGTG GGATGGGGAG 3720

AGCCGCTGGA CACCTGTGAG TATGGCTGAC CTGGTGACTC CAGAGCAGGT GAAGAAGCAG 3780

TACCGCCGTG CAGTGCTGGT AGTGCATCCT GATAAGGCCA CAGGGCAGCC ATATGAACAG 3840

TCTGCCAAGA TGATCTTCAT GGAGCTGAAT GATGCATGGT CTGAGTTTGA AAACCAGGGC 3900

TCAAGGCCCC TCTTCTGA 3918

Domain Profile

S: 2     riekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghknivk  61

         r+++vlaeGGfa+vy a+d+ +g++yalKr+l+neee++++i++E++++kklsgh+niv+

Q: 41    RVRRVLAEGGFAFVYEAQDLGSGREYALKRLLSNEEEKNRAIIQEVCFLKKLSGHPNIVQ  100

         89**********************************************************

S: 62    lv..dssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrav  119

         ++  +s  kee+d+g++e+lll+e+ck g+lv++l++ + kg ls+++ilki+++++rav

Q: 101   FCsaASIGKEESDTGQAEFLLLTELCK-GQLVEFLRRVECKGPLSCDSILKIFYQTCRAV  159

         **877888999****************.8*******************************

S: 120   aalHalsvpliHRDlkveNillsdegelvlcDlGSattaileve...skqelsalqeeie  176

         +++H++++p+iHRDlkveN+lls++g+++lcD+GSatt+++ ++   s+q++++++eei+

Q: 160   QHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDyswSAQKRAMVEEEIT  219

         *******************************************99999************

S: 177   knttlsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiP  236

         +ntt++yr+PE++dlysn++i+ek+DiWaLGc+lY lcf+++Pfe+++kl+i+ngkysiP

Q: 220   RNTTPMYRTPEIVDLYSNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIP  279

         ************************************************************

S: 237   ensryseklkslikkmlevdpeeRptiaqvlell  270

          n++ ++ +++li+ ml+v+peeR++ia+v+++l

Q: 280   VNDTRYTVFHDLIRGMLKVNPEERLSIAEVVRQL  313

         ******************************9875

Domain Sequence
(FASTA)

RVRRVLAEGG FAFVYEAQDL GSGREYALKR LLSNEEEKNR AIIQEVCFLK KLSGHPNIVQ 60

FCSAASIGKE ESDTGQAEFL LLTELCKGQL VEFLRRVECK GPLSCDSILK IFYQTCRAVQ 120

HMHRQKPPII HRDLKVENLL LSNQGTIKLC DFGSATTISH YPDYSWSAQK RAMVEEEITR 180

NTTPMYRTPE IVDLYSNFPI GEKQDIWALG CILYLLCFRQ HPFEDGAKLR IVNGKYSIPV 240

NDTRYTVFHD LIRGMLKVNP EERLSIAEVV RQL 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00226	; DnaJ; 1.
PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

SM00271

; DnaJ; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS50076	; DNAJ_2; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013