EKS-RAN-00387
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-RAN-00387
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src419.26.6E-126235488254
StatusReviewed
Ensembl ProteinENSRNOP00000000653
UniProt AccessionQ62662;
Protein NameTyrosine-protein kinase FRK
Protein Synonyms/Alias FYN-related kinase; Gastrointestinal-associated kinase; GASK; Gastrointestinal-associated tyrosine kinase; GTK;
Gene NameFrk
Gene Synonyms/Alias Frk; Gask;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSRNOG00000000543ENSRNOP00000000653ENSRNOT00000000653
OrganismRattus norvegicus
Functional DescriptionNon-receptor tyrosine-protein kinase that negativelyregulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).
Protein Length506
Protein Sequence
(FASTA)
MGSVCMRLWA YLQPFLPCWS QEADKSVVIE NPGAYCPPEA NRSQGQYFVA LFDYEARTAE 60
DLSFHAGDKL QVLDTSHEGW WLARHLEKKG PGLGQQLQGY IPSNYVAEDR SLQAEPWFFG 120
AIKRADAEKQ LLYSENQTGA FLIRESESQK GDFSLSVLDE GVVKHYRIRR LDEGGFFLTR 180
RKTFSTLNEF VNYYTTTSDG LCVKLEKPCL KIQVPTPFDL SYKTVDQWEI DRNSIQLLKR 240
LGSGQFGEVW EGLWNNTTPV AVKTLKPGSM DPNDFLREAQ IMKSLRHPKL IQLYAVCTLE 300
DPIYIITELM RHGSLQEYLQ NDGGSKIRLT QQVDMAAQVA SGMAYLESQN YIHRDLAARN 360
VLVGEHNIYK VADFGLARVF KVDNEDIYES KHEIKLPVKW TAPEAIRTNK FSIKSDVWSF 420
GILLYEIITY GKMPYSGMTG AQVIHMLGQN YRLPQPSNCP EQFYSIMMEC WNVEPKQRPT 480
FETLHWKLED YFEPDSSYSD TNNFIN 506
Nucleotide Sequence
(FASTA)
ATGGGCAGCG TCTGTATGAG GCTTTGGGCA TACCTTCAGC CTTTTCTCCC CTGCTGGTCC 60
CAAGAAGCAG ACAAATCAGT GGTGATTGAG AATCCAGGGG CCTACTGTCC TCCAGAGGCC 120
AATCGAAGCC AAGGTCAGTA TTTTGTGGCT CTGTTTGATT ACGAAGCTCG TACTGCAGAG 180
GACCTGAGCT TCCATGCCGG CGACAAGCTC CAAGTCTTGG ACACTTCTCA TGAGGGCTGG 240
TGGTTGGCCA GACATTTGGA AAAGAAGGGA CCCGGCTTAG GTCAGCAGCT GCAGGGCTAC 300
ATTCCTTCCA ATTACGTGGC AGAGGACCGG AGTCTCCAGG CAGAACCGTG GTTTTTCGGA 360
GCAATCAAAA GAGCAGATGC AGAAAAGCAA CTTCTGTATT CAGAAAACCA GACGGGCGCC 420
TTTCTAATCA GAGAGAGTGA GAGCCAGAAG GGTGACTTCT CCCTCTCAGT TTTAGATGAA 480
GGTGTTGTGA AACACTACAG GATAAGAAGG TTGGATGAAG GTGGCTTCTT CCTCACCAGG 540
AGAAAAACTT TTTCAACCTT GAATGAATTT GTGAACTACT ACACCACAAC AAGTGATGGG 600
CTGTGTGTCA AGCTGGAGAA GCCATGCTTA AAGATTCAGG TACCGACCCC TTTTGATTTG 660
TCATATAAAA CTGTGGACCA GTGGGAGATA GACCGCAACT CCATACAGCT TCTCAAGCGA 720
CTGGGATCTG GTCAGTTTGG AGAAGTTTGG GAAGGTCTGT GGAATAATAC CACTCCAGTG 780
GCTGTGAAAA CGTTAAAACC AGGTTCAATG GATCCAAATG ACTTCCTCAG GGAGGCACAG 840
ATAATGAAGA GCCTAAGACA CCCCAAGCTC ATCCAGCTCT ATGCTGTTTG CACATTAGAA 900
GATCCAATTT ATATTATTAC AGAATTGATG AGACATGGAA GTCTGCAAGA ATATCTCCAA 960
AATGATGGTG GGTCGAAAAT CCGTTTGACT CAACAGGTGG ACATGGCTGC ACAGGTAGCT 1020
TCTGGAATGG CCTATTTGGA GTCCCAGAAC TATATCCACA GAGATCTGGC TGCAAGAAAT 1080
GTCCTTGTTG GTGAACATAA TATCTATAAA GTAGCAGATT TTGGACTTGC AAGAGTTTTT 1140
AAGGTGGATA ATGAAGACAT CTATGAATCT AAACACGAAA TAAAGCTGCC AGTGAAGTGG 1200
ACTGCACCCG AAGCCATTCG TACTAATAAA TTCAGCATTA AGTCTGATGT GTGGTCTTTT 1260
GGAATCCTGC TTTATGAAAT CATTACTTAT GGCAAAATGC CTTACAGCGG GATGACAGGT 1320
GCTCAAGTAA TTCATATGTT GGGTCAAAAC TACAGACTAC CACAGCCATC TAACTGTCCA 1380
GAGCAATTCT ATAGCATCAT GATGGAATGC TGGAATGTAG AGCCCAAGCA ACGACCAACG 1440
TTCGAGACCC TGCACTGGAA ACTTGAAGAC TACTTTGAAC CAGACTCTTC CTATTCTGAT 1500
ACAAACAACT TCATAAACTA A 1521
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         ++l+k+lG+GqfGevw+g+w+++++vavktlk+g+++p++fl+eaqi+k+lrh+kl++ly
Q: 235   IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKLIQLY  294
         6899********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         av++ e+Piyi+telm++Gsl+++l+++ g+k++l+++vd+aaqva+Gmayle++n+ihr
Q: 295   AVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIRLTQQVDMAAQVASGMAYLESQNYIHR  354
         ************************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177
         dlaarnvlvge++++kvadfGlar+++   +d+y++k++ klP+kWtaPeai+++kf+ik
Q: 355   DLAARNVLVGEHNIYKVADFGLARVFKvdnEDIYESKHEIKLPVKWTAPEAIRTNKFSIK  414
         ************************998878999***************************
S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237
         sdvWsfGill+ei+t+Gk+Py+Gmt ++v++++ ++yrlp+p++cpe++y++++ecw+ +
Q: 415   SDVWSFGILLYEIITYGKMPYSGMTGAQVIHMLGQNYRLPQPSNCPEQFYSIMMECWNVE  474
         ************************************************************
S: 238   peerPtfetlqevl  251
         p++rPtfetl+++l
Q: 475   PKQRPTFETLHWKL  488
         **********9986
Domain Sequence
(FASTA)
IQLLKRLGSG QFGEVWEGLW NNTTPVAVKT LKPGSMDPND FLREAQIMKS LRHPKLIQLY 60
AVCTLEDPIY IITELMRHGS LQEYLQNDGG SKIRLTQQVD MAAQVASGMA YLESQNYIHR 120
DLAARNVLVG EHNIYKVADF GLARVFKVDN EDIYESKHEI KLPVKWTAPE AIRTNKFSIK 180
SDVWSFGILL YEIITYGKMP YSGMTGAQVI HMLGQNYRLP QPSNCPEQFY SIMMECWNVE 240
PKQRPTFETL HWKL 254
KeywordATP-binding; Complete proteome; Cytoplasm; Kinase; Lipoprotein; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; SH2 domain; SH3 domain; Transferase; Tumor suppressor; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00346
EKS-ANC-00361
EKS-BOT-00373
EKS-CAJ-00375
EKS-CAF-00374
EKS-CAP-00406
EKS-CII-00205
EKS-CIS-00120
EKS-DAR-00752
EKS-DAN-00036
EKS-DIO-00056
EKS-DRM-00174
EKS-EQC-00364
EKS-FEC-00360
EKS-GAM-00224
EKS-GAG-00315
EKS-GAA-00454
EKS-GOG-00362
EKS-HOS-00378
EKS-ICT-00352
EKS-LAC-00387
EKS-LOA-00380
EKS-MAM-00371
EKS-MEG-00305
EKS-MOD-00362
EKS-MUM-00405
EKS-MUP-00367
EKS-MYL-00370
EKS-NOL-00340
EKS-ORN-00481
EKS-ORC-00350
EKS-ORL-00442
EKS-OTG-00376
EKS-PAT-00351
EKS-PES-00330
EKS-PEM-00197
EKS-POA-00362
EKS-SAH-00343
EKS-SUS-00326
EKS-TAG-00444
EKS-TAR-00477
EKS-TAS-00041
EKS-TEN-00468
EKS-TUT-00100
EKS-XET-00486
EKS-XIM-00470
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0030154; P:cell differentiation
KEGG
rno:79209;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013