EKS-RAN-00014

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00014

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/PHK	530.6	8.9E-160	20	288	269

Status

Reviewed

Ensembl Protein

ENSRNOP00000001222

UniProt Accession

P13286;

Protein Name

Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform

Protein Synonyms/Alias

Phosphorylase kinase subunit gamma-1;

Gene Name

Phkg1

Gene Synonyms/Alias

Phkg1; Phkg;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000000920	ENSRNOP00000001222	ENSRNOT00000001222

Organism

Rattus norvegicus

Functional Description

Phosphorylase b kinase catalyzes the phosphorylation ofserine in certain substrates, including troponin I.

Protein Length

388

Protein Sequence
(FASTA)

MTRDEALPDS HSAQNFYENY EPKEILGRGV SSVVRRCIHK PTCQEYAVKI IDITGGGSFS 60

SEEVQELREA TLKEVDILQK VSGHPNIIQL KDTYETNTFF FLVFDLMKRG ELFDYLTEKV 120

TLTEKETRKI MRALLEVVCT LHKLNIVHRD LKPENILLDD NMNIKLTDFG FSCQLQPGEK 180

LREVCGTPSY LAPEIIQCSM DEGHPGYGKE VDMWSTGVIM YTLLAGSPPF WHRKQMLMLR 240

MIMDGKYQFG SPEWDDYSDT VKDLVSRFLV VQPQDRCSAE EALAHPFFQE YVVEEVRHFS 300

PRGKFKVICL TVLASVRIYY QYRRVKPVTR EIVIRDPYAL RPLRRLIDAY AFRIYGHWVK 360

KGQQQNRAAL FENTPKAVLL SLAEEEDF 388

Nucleotide Sequence
(FASTA)

ATGACCCGGG ATGAGGCCCT CCCTGACTCT CATTCTGCAC AGAATTTCTA TGAGAACTAC 60

GAGCCCAAGG AGATCCTGGG CAGGGGAGTC AGCAGCGTGG TCAGGAGATG CATTCACAAA 120

CCTACGTGCC AAGAATACGC AGTAAAAATC ATCGACATCA CCGGCGGAGG AAGCTTTAGC 180

TCCGAGGAGG TACAGGAGCT TCGGGAAGCC ACCCTGAAGG AGGTGGACAT TCTGCAGAAG 240

GTCTCAGGAC ACCCCAACAT CATACAGCTG AAGGACACTT ACGAGACCAA CACTTTCTTC 300

TTCTTGGTAT TTGATCTGAT GAAGAGAGGG GAACTCTTTG ACTATCTCAC AGAGAAGGTC 360

ACCTTGACTG AGAAGGAAAC CAGAAAGATC ATGCGGGCCC TGCTGGAGGT GGTCTGCACC 420

TTGCACAAAC TCAACATTGT CCATCGGGAC CTGAAGCCGG AGAACATCCT TCTGGATGAC 480

AACATGAACA TCAAGCTCAC TGACTTCGGG TTTTCCTGCC AGCTGCAGCC AGGAGAGAAG 540

CTCCGAGAGG TTTGTGGGAC TCCCAGTTAT CTGGCCCCCG AAATCATCCA GTGCTCCATG 600

GACGAAGGCC ATCCTGGCTA TGGAAAGGAG GTGGACATGT GGAGCACAGG AGTCATCATG 660

TATACGCTGC TGGCTGGCTC CCCGCCCTTC TGGCACCGGA AGCAAATGCT AATGTTGAGG 720

ATGATCATGG ATGGCAAATA CCAGTTCGGC TCACCAGAGT GGGATGACTA CTCAGATACC 780

GTGAAAGACT TGGTATCTCG CTTCTTGGTG GTGCAACCCC AGGACCGCTG CTCGGCGGAA 840

GAGGCCTTGG CGCATCCTTT CTTCCAGGAG TACGTGGTGG AAGAGGTGCG GCACTTCAGC 900

CCTCGAGGGA AGTTCAAGGT CATCTGTCTA ACTGTGCTGG CCTCGGTAAG GATCTACTAC 960

CAGTACCGTC GGGTGAAGCC GGTAACCAGG GAGATCGTCA TCCGAGACCC CTACGCCCTA 1020

CGGCCATTGC GCAGACTCAT CGACGCCTAT GCTTTCCGCA TCTACGGCCA CTGGGTGAAG 1080

AAAGGGCAAC AGCAGAACAG AGCTGCCCTC TTCGAGAACA CGCCCAAGGC AGTGCTCCTC 1140

TCCTTGGCTG AGGAGGAGGA CTTCTGA 1167

Domain Profile

S: 1     yepkeilGrGvssvvrrciekatgqefavkiidvs.aeklseeevkelreatlkeveilr  59

         yepkeilGrGvssvvrrci+k+t+qe+avkiid++ ++++s+eev+elreatlkev+il+

Q: 20    YEPKEILGRGVSSVVRRCIHKPTCQEYAVKIIDITgGGSFSSEEVQELREATLKEVDILQ  79

         9**********************************899**********************

S: 60    qvsGhpsiiklkdvyesssflflvfdlmkkGelfdyltekvtlseketrkimralleave  119

         +vsGhp+ii+lkd+ye+++f+flvfdlmk+Gelfdyltekvtl+eketrkimralle+v+

Q: 80    KVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLTEKETRKIMRALLEVVC  139

         ************************************************************

S: 120   ylhaknivhrdlkpenillddneniklsdfGfstqleeGeklrelcGtpgylapeilkcs  179

         +lh+ nivhrdlkpenillddn+nikl+dfGfs+ql++Geklre+cGtp+ylapei++cs

Q: 140   TLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLQPGEKLREVCGTPSYLAPEIIQCS  199

         ************************************************************

S: 180   mdeeapGyskevdlwalGvilytllaGsppfwhrkqllmlrlimeGkyqftspewddise  239

         mde++pGy+kevd+w++Gvi+ytllaGsppfwhrkq+lmlr+im+Gkyqf+spewdd+s+

Q: 200   MDEGHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMDGKYQFGSPEWDDYSD  259

         ************************************************************

S: 240   evkdliskllvvdpekrltaeealahpff  268

         +vkdl+s++lvv+p++r++aeealahpff

Q: 260   TVKDLVSRFLVVQPQDRCSAEEALAHPFF  288

         ****************************8

Domain Sequence
(FASTA)

YEPKEILGRG VSSVVRRCIH KPTCQEYAVK IIDITGGGSF SSEEVQELRE ATLKEVDILQ 60

KVSGHPNIIQ LKDTYETNTF FFLVFDLMKR GELFDYLTEK VTLTEKETRK IMRALLEVVC 120

TLHKLNIVHR DLKPENILLD DNMNIKLTDF GFSCQLQPGE KLREVCGTPS YLAPEIIQCS 180

MDEGHPGYGK EVDMWSTGVI MYTLLAGSPP FWHRKQMLML RMIMDGKYQF GSPEWDDYSD 240

TVKDLVSRFL VVQPQDRCSA EEALAHPFF 269

Keyword

ATP-binding; Calmodulin-binding; Carbohydrate metabolism; Complete proteome; Glycogen metabolism; Kinase; Muscle protein; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005964	; C:phosphorylase kinase complex
GO:0005524	; F:ATP binding
GO:0019899	; F:enzyme binding
GO:0004689	; F:phosphorylase kinase activity
GO:0005978	; P:glycogen biosynthetic process
GO:0005977	; P:glycogen metabolic process

KEGG

rno:29353

;

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR002291	; Phosph_kin_gamma.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01049

; PHOSPHBKNASE.

Created Date

20-Feb-2013