| Tag | Content |
|---|
| EKPD ID | EKS-RAN-00228 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| STE/STE7 | 366.0 | 1.4E-109 | 120 | 380 | 261 |
|
| Status | Reviewed |
| Ensembl Protein | ENSRNOP00000058535 |
| UniProt Accession | Q4KSH7; |
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 7 |
| Protein Synonyms/Alias | MAP kinase kinase 7; MAPKK 7; JNK-activating kinase 2; MAPK/ERK kinase 7; MEK 7; c-Jun N-terminal kinase kinase 2; JNK kinase 2; JNKK 2; |
| Gene Name | Map2k7 |
| Gene Synonyms/Alias | Map2k7; |
| Ensembl Information | |
| Organism | Rattus norvegicus |
| Functional Description | Dual specificity protein kinase which acts as anessential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. |
| Protein Length | 419 |
Protein Sequence
(FASTA) | | MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PTLQLPLAND GGSRSPSSES 60 | | SPQHPTPPSR PRHMLGLPST LFTPRSMESI EIDQKLQEIM KQTGYLTIGG QRYQAEINDL 120 | | ENLGEMGSGT CGQVWKMRFR KTGHIIAVKQ MRRSGNKEEN KRILMDLDVV LKSHDCPYIV 180 | | QCFGTFITNT DVFIAMELMG TCAEKLKKRM QGPIPERILG KMTVAIVKAL YYLKEKHGVI 240 | | HRDVKPSNIL LDERGQIKLC DFGISGRLVD SKAKTRSAGC AAYMAPERID PPDPTKPDYD 300 | | IRADVWSLGI SLVELATGQF PYKNCKTDFE VLTKVLQEEP PLLPGHMGFS GDFQSFVKDC 360 | | LTKDHRKRPK YNKLLEHSFI KHYETLEVDV ASWFKDVMAK TESPRTSGVL SQHHLPFFR 419 |
|
Nucleotide Sequence
(FASTA) | | ATGGCGGCGT CCTCCCTGGA GCAAAAGCTG TCCCGCCTGG AGGCCAAGCT GAAGCAGGAG 60 | | AATCGTGAGG CCCGCAGGAG GATCGACCTC AACCTGGATA TAAGCCCACA GCGGCCCAGG 120 | | CCCACCTTGC AGCTCCCACT GGCCAACGAT GGGGGCAGCC GCTCACCATC CTCAGAGAGC 180 | | TCCCCACAGC ACCCTACGCC CCCCAGCCGG CCCCGCCACA TGCTGGGGCT CCCGTCAACC 240 | | TTGTTCACAC CTCGCAGTAT GGAGAGCATC GAGATTGACC AAAAGCTGCA GGAGATCATG 300 | | AAGCAGACAG GGTACCTGAC TATCGGGGGC CAGCGTTATC AGGCAGAAAT CAATGACTTG 360 | | GAGAACCTGG GAGAGATGGG CAGTGGTACC TGTGGTCAGG TGTGGAAGAT GCGGTTCCGG 420 | | AAGACAGGCC ACATCATTGC TGTTAAGCAA ATGCGGCGCT CGGGGAACAA GGAAGAGAAT 480 | | AAGCGCATCC TAATGGACCT GGACGTAGTA CTCAAGAGCC ACGACTGCCC CTACATTGTT 540 | | CAGTGCTTTG GTACCTTCAT CACCAACACG GACGTCTTTA TTGCCATGGA GCTCATGGGC 600 | | ACGTGTGCGG AGAAGCTGAA GAAACGGATG CAGGGCCCCA TCCCAGAGCG AATCCTTGGC 660 | | AAGATGACCG TGGCGATTGT GAAAGCATTG TACTATCTGA AGGAGAAGCA TGGGGTCATC 720 | | CATCGTGATG TCAAACCCTC CAACATCCTG CTGGATGAGC GGGGTCAGAT CAAGCTCTGT 780 | | GACTTTGGCA TCAGTGGCCG CCTTGTTGAC TCCAAAGCCA AAACACGGAG TGCTGGCTGT 840 | | GCTGCCTATA TGGCTCCTGA GCGCATTGAC CCGCCAGACC CCACCAAGCC AGACTATGAC 900 | | ATCCGGGCCG ATGTGTGGAG CCTGGGCATC TCACTGGTGG AGCTGGCAAC AGGACAGTTC 960 | | CCCTATAAGA ACTGCAAGAC GGACTTTGAG GTCCTCACCA AAGTCCTACA GGAAGAGCCC 1020 | | CCGCTCCTGC CTGGTCACAT GGGCTTCTCA GGGGACTTCC AGTCATTTGT CAAAGACTGC 1080 | | CTTACTAAAG ACCACAGGAA GAGACCAAAG TATAACAAAC TACTTGAACA CAGCTTCATC 1140 | | AAGCACTATG AGACACTCGA AGTGGATGTC GCGTCCTGGT TTAAGGACGT CATGGCAAAG 1200 | | ACCGAGTCCC CAAGGACTAG TGGAGTCCTG AGCCAACACC ATCTGCCCTT CTTCAGGTAG 1260 |
|
| Domain Profile | S: 1 lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi 60 | le+l+e+G+G++g+V+k++++k+g+i+avK++r++ +kee+k+il++l+v+ ks+++pyi | Q: 120 LENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYI 179 | 7899******************************************************** |
| S: 61 vkfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylke 120 | v+++G+f++++dv+i+melm t+ +k+ k++ ++ ipe++lgk++va+vkal ylke | Q: 180 VQCFGTFITNTDVFIAMELMG-TCAEKLKKRM---QGPIPERILGKMTVAIVKALYYLKE 235 | *********************.*****99996...9************************ |
| S: 121 klkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg.... 175 | k+ +iHRDvKPsNiL++++G++KlCDFG+sg+lvds Ak++ +G+++YmaPEri++ | Q: 236 KHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRsAGCAAYMAPERIDPpdpt 295 | *******************************************************99999 |
| S: 176 kkkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpee.efseefqe 234 | k++Y++++dvWslG++lvelatg++py+++k+++e+l+++++eepp lp + fs +fq+ | Q: 296 KPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHmGFSGDFQS 355 | 9************************************************9999******* |
| S: 235 fvskClkkdekeRpklkellkhafi 259 | fv++Cl+kd+++Rpk+++ll+h+fi | Q: 356 FVKDCLTKDHRKRPKYNKLLEHSFI 380 | ************************7 |
|
Domain Sequence
(FASTA) | | LENLGEMGSG TCGQVWKMRF RKTGHIIAVK QMRRSGNKEE NKRILMDLDV VLKSHDCPYI 60 | | VQCFGTFITN TDVFIAMELM GTCAEKLKKR MQGPIPERIL GKMTVAIVKA LYYLKEKHGV 120 | | IHRDVKPSNI LLDERGQIKL CDFGISGRLV DSKAKTRSAG CAAYMAPERI DPPDPTKPDY 180 | | DIRADVWSLG ISLVELATGQ FPYKNCKTDF EVLTKVLQEE PPLLPGHMGF SGDFQSFVKD 240 | | CLTKDHRKRP KYNKLLEHSF I 261 |
|
| Keyword | Acetylation; Apoptosis; ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Stress response; Transferase; Tyrosine-protein kinase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
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| Prints | |
| Created Date | 20-Feb-2013 |