| Tag | Content |
|---|
| EKPD ID | EPS-RAN-00136 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| PPP/PP1 | 413.5 | 1.5E-124 | 58 | 251 | 194 |
|
| Status | Reviewed |
| Ensembl Protein | ENSRNOP00000047912 |
| UniProt Accession | P63088; O09186; O09189; P37139; Q64679; |
| Protein Name | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit |
| Protein Synonyms/Alias | PP-1G; Protein phosphatase 1C catalytic subunit; |
| Gene Name | Ppp1cc |
| Gene Synonyms/Alias | Ppp1cc; |
| Ensembl Information | |
| Organism | Rattus norvegicus |
| Functional Description | Protein phosphatase that associates with over 200regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). |
| Protein Length | 337 |
Protein Sequence
(FASTA) | | MADIDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP ILLELEAPLK 60 | | ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS LETICLLLAY KIKYPENFFL 120 | | LRGNHECASI NRIYGFYDEC KRRYNIKLWK TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL 180 | | QSMEQIRRIM RPTDVPDQGL LCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD 240 | | LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAE 300 | | KKKPNATRPV TPPRVGSGLN PSIQKASNYR NNTVLYE 337 |
|
Nucleotide Sequence
(FASTA) | | ATGGCGGATA TCGATAAACT CAACATCGAC AGTATCATCC AACGGCTGCT GGAAGTGAGA 60 | | GGGTCCAAGC CAGGCAAGAA TGTCCAGCTC CAGGAGAATG AAATCCGGGG ACTGTGCTTG 120 | | AAGTCTCGGG AGATCTTCCT CAGTCAGCCT ATCCTTTTAG AACTTGAAGC ACCACTCAAG 180 | | ATATGTGGTG ACATCCACGG GCAGTACTAT GATTTGCTCC GTCTGTTTGA ATACGGTGGC 240 | | TTTCCTCCAG AAAGCAACTA TTTGTTTCTC GGGGACTATG TGGACAGGGG CAAACAGTCA 300 | | CTAGAGACGA TCTGCCTCTT GCTGGCCTAC AAAATCAAGT ATCCGGAGAA CTTTTTTCTT 360 | | CTTAGAGGGA ACCATGAGTG TGCCAGCATC AATAGAATCT ACGGATTTTA TGATGAGTGT 420 | | AAGAGAAGAT ACAACATTAA GCTGTGGAAA ACGTTCACAG ACTGTTTTAA CTGCTTACCG 480 | | ATAGCAGCCA TCGTGGACGA GAAGATATTC TGCTGTCATG GAGGTTTATC ACCAGATCTT 540 | | CAATCTATGG AGCAGATTCG GCGAATTATG AGACCAACTG ATGTACCAGA TCAAGGTCTT 600 | | CTTTGTGATC TTTTGTGGTC TGACCCCGAT AAAGATGTCT TAGGCTGGGG TGAAAATGAC 660 | | AGAGGAGTGT CCTTCACATT TGGTGCAGAA GTGGTTGCAA AATTTCTCCA TAAGCATGAT 720 | | TTGGATCTTA TATGTAGAGC CCATCAGGTG GTTGAAGATG GATATGAGTT TTTTGCAAAG 780 | | AGGCAGTTAG TCACTCTGTT TTCTGCACCC AACTACTGTG GCGAGTTTGA CAATGCGGGC 840 | | GCCATGATGA GTGTGGATGA GACCCTCATG TGCTCCTTCC AGATTTTAAA GCCTGCAGAG 900 | | AAAAAGAAGC CCAATGCCAC GAGACCTGTC ACACCGCCAC GGGTTGGATC AGGCCTGAAC 960 | | CCGTCCATTC AGAAAGCTTC AAATTATAGA AACAACACTG TCCTATACGA GTGA 1014 |
|
| Domain Profile | S: 1 pvkicgdihgqykdllrlfeyggfppeanylflgdyvdrgkqsleticlllaykikypen 60 | p+kicgdihgqy+dllrlfeyggfppe+nylflgdyvdrgkqsleticlllaykikypen | Q: 58 PLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPEN 117 | 89********************************************************** |
| S: 61 ffllrgnhesasinriygfydeckrrynvklwktftdcfnclpvaaiidekilcvhggls 120 | ffllrgnhe+asinriygfydeckrryn+klwktftdcfnclp+aai+deki+c+hggls | Q: 118 FFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLS 177 | ************************************************************ |
| S: 121 pdlksleqirrikrptdvpdegllcdllwsdpdkdvkgwgendrgvsftfgadvvakflk 180 | pdl+s+eqirri+rptdvpd+gllcdllwsdpdkdv gwgendrgvsftfga+vvakfl+ | Q: 178 PDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLH 237 | ************************************************************ |
| S: 181 khdldlicrahqvv 194 | khdldlicrahqvv | Q: 238 KHDLDLICRAHQVV 251 | *************8 |
|
Domain Sequence
(FASTA) | | PLKICGDIHG QYYDLLRLFE YGGFPPESNY LFLGDYVDRG KQSLETICLL LAYKIKYPEN 60 | | FFLLRGNHEC ASINRIYGFY DECKRRYNIK LWKTFTDCFN CLPIAAIVDE KIFCCHGGLS 120 | | PDLQSMEQIR RIMRPTDVPD QGLLCDLLWS DPDKDVLGWG ENDRGVSFTF GAEVVAKFLH 180 | | KHDLDLICRA HQVV 194 |
|
| Keyword | 3D-structure; Acetylation; Alternative splicing; Carbohydrate metabolism; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Direct protein sequencing; Glycogen metabolism; Hydrolase; Iron; Kinetochore; Manganese; Metal-binding; Mitochondrion; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |