EKS-RAN-00231

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-RAN-00231

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	415.4	1.1E-124	23	304	282

Status

Unreviewed

Ensembl Protein

ENSRNOP00000001817

UniProt Accession

F1LN87;

Protein Name

Protein Synonyms/Alias

Protein Mapkapk5;

Gene Name

Mapkapk5

Gene Synonyms/Alias

Mapkapk5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSRNOG00000001345	ENSRNOP00000001817	ENSRNOT00000001817
ENSRNOG00000001345	ENSRNOP00000061902	ENSRNOT00000065314

Organism

Rattus norvegicus

Functional Description

Protein Length

473

Protein Sequence
(FASTA)

MSEDSNMEKA IKETSILEEY SINWTQKLGA GISGPVRVCV KKSTQERFAL KILLDRPKAR 60

NEVRLHMMCA THSNIVEIIE VFANSVQFPH ESSPRARLLI VMEMMEGGEL FHRISQHRHF 120

TEKQASQVTK QIALALQHCH LLNIAHRDLK PENLLFKDNS LDAPVKLCDF GFAKVDQGDL 180

MTPQFTPYYV APQVLEAQRR HQKEKSGLIP TSPTPYTYNK SCDLWSLGVI IYVMLCGYPP 240

FYSKHHSRTI PKDMRKKIMT GSFEFPEEEW SQISEMAKDV VRKLLKVKPE ERLTIEGVLD 300

HPWLNSTEAL DNVLPSAQLM MDKAVVAGIQ QAHAEQLANM RIQDLKVSLK PLHSVNNPIL 360

RKRKLLGSKP KDGVYIHDHE NGVEDSNVAL EKLRDVIAQC ILPQAGKGEN EDEKLNEVMQ 420

EAWKYNRECK LLRDALQSFS WNGRGFTDKV DRLKLAEVVK QVIEEQTLPH EPQ 473

Nucleotide Sequence
(FASTA)

ATGTCGGAGG ATAGCAACAT GGAGAAAGCC ATCAAGGAGA CCTCCATTTT AGAAGAATAT 60

AGTATCAATT GGACTCAGAA ACTGGGAGCT GGAATTAGTG GTCCGGTTAG AGTCTGTGTA 120

AAGAAATCTA CTCAAGAACG GTTTGCACTG AAAATTCTTC TCGATCGTCC AAAAGCTAGA 180

AATGAGGTGC GCCTGCACAT GATGTGTGCC ACACACTCCA ACATAGTTGA GATTATTGAA 240

GTGTTTGCTA ACAGTGTACA GTTCCCTCAT GAGTCCAGCC CCAGGGCTCG ACTCTTAATT 300

GTAATGGAGA TGATGGAAGG GGGCGAGCTG TTTCACAGAA TCAGCCAGCA CCGGCACTTT 360

ACAGAGAAGC AAGCCAGCCA AGTAACAAAG CAGATAGCCC TGGCTCTACA GCACTGTCAC 420

TTGCTAAACA TTGCGCACAG AGACCTCAAG CCTGAAAATC TGCTTTTCAA GGATAACTCT 480

TTGGACGCCC CTGTGAAGTT ATGTGACTTT GGGTTTGCTA AAGTTGACCA AGGTGATTTG 540

ATGACGCCCC AGTTTACCCC TTACTATGTA GCACCTCAGG TACTGGAAGC ACAGAGAAGG 600

CACCAGAAGG AGAAGTCTGG CCTCATCCCT ACCTCGCCAA CGCCCTACAC TTACAACAAG 660

AGCTGTGACT TGTGGTCCCT CGGGGTGATA ATTTATGTGA TGCTATGCGG ATACCCTCCT 720

TTTTACTCCA AACACCACAG TCGGACCATC CCAAAGGACA TGCGGAAAAA GATCATGACA 780

GGGAGTTTTG AGTTCCCGGA GGAAGAGTGG AGCCAGATCT CAGAGATGGC CAAAGACGTG 840

GTGAGGAAGC TTCTAAAGGT CAAACCAGAG GAAAGACTCA CAATCGAGGG GGTGTTGGAC 900

CATCCCTGGC TCAACTCGAC AGAGGCCCTG GATAATGTGC TACCCTCTGC TCAGCTGATG 960

ATGGATAAGG CAGTGGTTGC AGGGATCCAG CAGGCTCATG CCGAGCAGCT GGCAAACATG 1020

AGGATCCAGG ACCTCAAAGT CAGCCTCAAA CCCCTGCACT CTGTGAACAA CCCCATTCTG 1080

AGGAAGAGGA AGCTACTGGG CTCCAAGCCA AAGGATGGTG TTTATATCCA CGACCATGAG 1140

AATGGAGTCG AGGATTCAAA TGTTGCCTTG GAAAAGCTTC GCGATGTCAT TGCCCAGTGC 1200

ATCCTTCCCC AGGCTGGTAA AGGAGAGAAT GAAGATGAGA AGCTCAATGA GGTAATGCAG 1260

GAGGCCTGGA AGTACAACCG GGAGTGCAAA CTCCTGCGGG ACGCGCTGCA GAGTTTTAGC 1320

TGGAATGGTC GTGGATTCAC AGATAAAGTG GACCGATTAA AGCTGGCAGA GGTTGTGAAG 1380

CAGGTGATCG AAGAGCAGAC CCTTCCCCAC GAGCCCCAGT AG 1422

Domain Profile

S: 2     lteevlGeGisgkvlecvkkktgekyalkilkdrkkvrrevelhvqasghknivelidvf  61

         +++++lG+Gisg v+ cvkk+t+e++alkil dr+k+r+ev+lh+++++h+nive+i+vf

Q: 23    NWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCATHSNIVEIIEVF  82

         689*********************************************************

S: 62    ensfe......dekrlllvlekleGGellsriqerkaftekeasevvkdiasalkflhsk  115

         +ns++      +++rll+v+e++eGGel++ri+++++ftek+as+v+k+ia al+++h

Q: 83    ANSVQfphessPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALQHCHLL  142

         ****99999999************************************************

S: 116   niahrDlkpenlLyeskeknapvklcDfglaketeeeeelktpcltaeyvaPevleaeke  175

         niahrDlkpenlL+++++ +apvklcDfg+ak   ++ +l+tp++t++yvaP+vlea+++

Q: 143   NIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK--VDQGDLMTPQFTPYYVAPQVLEAQRR  200

         ********************************..89***********************9

S: 176   e.............allydksCDlWslGvilyillcGypPfyskk.graiskklkeriqe  221

         +             +++y+ksCDlWslGvi+y++lcGypPfysk+ +r+i+k+++++i++

Q: 201   HqkeksgliptsptPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHhSRTIPKDMRKKIMT  260

         99*****************************************9979*************

S: 222   gkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         g++efPeeeWs++se+akd++rklLk++p+erltie vl+hpw+

Q: 261   GSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWL  304

         *******************************************6

Domain Sequence
(FASTA)

NWTQKLGAGI SGPVRVCVKK STQERFALKI LLDRPKARNE VRLHMMCATH SNIVEIIEVF 60

ANSVQFPHES SPRARLLIVM EMMEGGELFH RISQHRHFTE KQASQVTKQI ALALQHCHLL 120

NIAHRDLKPE NLLFKDNSLD APVKLCDFGF AKVDQGDLMT PQFTPYYVAP QVLEAQRRHQ 180

KEKSGLIPTS PTPYTYNKSC DLWSLGVIIY VMLCGYPPFY SKHHSRTIPK DMRKKIMTGS 240

FEFPEEEWSQ ISEMAKDVVR KLLKVKPEER LTIEGVLDHP WL 282

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0032007	; P:negative regulation of TOR signaling cascade
GO:0046777	; P:protein autophosphorylation
GO:0007265	; P:Ras protein signal transduction
GO:0006417	; P:regulation of translation
GO:0090400	; P:stress-induced premature senescence

KEGG

rno:498183

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013